| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sahand Mazloum-Ravasan, Maryam Mohammadi, Elaheh Madadi Hiagh, Alireza Ebrahimi, Joo-Hyun Hong, Hamed Hamishehkar, Ki Hyun Ki. Nano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment. Drug delivery. vol 29. issue 1. 2022-04-01. PMID:35363101. |
they induced apoptosis via cell cycle arrest at the g0 phase, as well as significant increases in pro-apoptotic genes, such as bax, caspase-3, -8, -9, and p53, accompanied with significant decreases in the anti-apoptotic marker bcl-2. |
2022-04-01 |
2023-08-13 |
human |
| Naoko Murata-Kamiya, Masanori Hatakeyam. Helicobacter pylori-induced DNA double-strand break in the development of gastric cancer. Cancer science. 2022-03-31. PMID:35359025. |
infection with h. pylori additionally inhibits the function of the p53 tumor suppressor, thereby dampening dna damage-induced apoptosis while promoting proliferation of caga-delivered cells. |
2022-03-31 |
2023-08-13 |
Not clear |
| Pavana Lakshmi Vaddavalli, Björn Schumache. The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends in genetics : TIG. 2022-03-29. PMID:35346511. |
p53 plays a central role in responding to dna damage and determines the outcome of the dna damage checkpoint response by regulating cell cycle arrest and apoptosis. |
2022-03-29 |
2023-08-13 |
human |
| Hai Duc Nguyen, Min-Sun Ki. Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved. Toxicology. 2022-03-29. PMID:35346790. |
although prevalent genes obtained from investigated heavy metals of cognitive impairment were different, the "pi3k-akt signaling pathway", "pathways of neurodegeneration-multiple diseases", "apoptosis", "apoptosis-multiple species", "p53 signaling pathway", "nf-kappa b signaling pathway", and "alzheimer's disease pathway" were highlighted. |
2022-03-29 |
2023-08-13 |
Not clear |
| Bharathi Priya Lohanathan, Baskaran Rathinasamy, Chih-Yang Huang, Vijaya Padma Viswanadh. Neferine attenuates doxorubicin-induced fibrosis and hypertrophy in H9c2 cells. Journal of biochemical and molecular toxicology. 2022-03-29. PMID:35347819. |
finally, dox treatment resulted in apoptosis through activation of p53. |
2022-03-29 |
2023-08-13 |
Not clear |
| Bharathi Priya Lohanathan, Baskaran Rathinasamy, Chih-Yang Huang, Vijaya Padma Viswanadh. Neferine attenuates doxorubicin-induced fibrosis and hypertrophy in H9c2 cells. Journal of biochemical and molecular toxicology. 2022-03-29. PMID:35347819. |
pretreatment with neferine markedly activated sirt1 expression and modulated the expression levels of tgf-β1 and p53, thereby significantly reducing dox-induced fibrosis, hypertrophy, and apoptosis in h9c2 cardiomyoblasts. |
2022-03-29 |
2023-08-13 |
Not clear |
| Zhongtang Xie, Guanghua Lu, Ranran Zhou, Yuchen M. Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 246. 2022-03-29. PMID:35349858. |
thiacloprid-induced hepatotoxicity in zebrafish: activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway. |
2022-03-29 |
2023-08-13 |
zebrafish |
| Zhongtang Xie, Guanghua Lu, Ranran Zhou, Yuchen M. Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 246. 2022-03-29. PMID:35349858. |
the addition of p53 inhibitor pifithrin-α (10 μm) exerted protection against of thcp-induced hepatotoxicity by reducing oxidative stress and inhibiting the p53 signaling pathway and apoptosis. |
2022-03-29 |
2023-08-13 |
zebrafish |
| Zhongtang Xie, Guanghua Lu, Ranran Zhou, Yuchen M. Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 246. 2022-03-29. PMID:35349858. |
moreover, gene expression analyses indicated that both the extrinsic and intrinsic apoptosis pathways were involved in apoptosis induced by p53 activation. |
2022-03-29 |
2023-08-13 |
zebrafish |
| Yingwei Liu, Jiangnan Yi, Yuanliang Li, Riaz Hussain, Shanshan Zhu, Yangwei Li, Zhuanxu Ouyang, Khalid Mehmood, Lianmei Hu, Jiaqing Pan, Zhaoxin Tang, Ying Li, Hui Zhan. Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens. Veterinary immunology and immunopathology. vol 247. 2022-03-28. PMID:35344810. |
the expressions of bax, p53 and m-tor were up-regulated in the thymus while the expressions of atg5 and beclin1 were down-regulated to mediate cell apoptosis and inhibit autophagy. |
2022-03-28 |
2023-08-13 |
mouse |
| Hongyan Xue, Yuannan Huo, Yu Hu, Jinlong Zhang, Chengchen Deng, Jiaojiao Zhang, Xianzhong Wan. The role of ALOX15B in heat stress-induced apoptosis of porcine sertoli cells. Theriogenology. vol 185. 2022-03-28. PMID:35344833. |
interestingly, a p38 inhibitor decreased the expression of alox15b, reduced the content of 8-hete and 15-hete, and decreased the expression of p53 and the apoptosis rate in heat stress treated porcine sertoli cells. |
2022-03-28 |
2023-08-13 |
Not clear |
| Mohamed A Abdelgawad, Fatma E A Mohamed, Phoebe F Lamie, Syed N A Bukhari, Mohammad M Al-Sanea, Arafa Musa, Mohammed Elmowafy, A A Nayl, Ahmed Karam Farag, Sameeha M Ali, Mohamed E Shaker, Hany A Omar, Mohammed K Abdelhameid, Manal M Kandee. Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells. Bioorganic chemistry. vol 122. 2022-03-27. PMID:35339926. |
furthermore, 19 and 20 upregulated several apoptosis biomarkers such as p53, tnfα, caspase 3/7 and increased the bax/bcl-2 ratio. |
2022-03-27 |
2023-08-13 |
Not clear |
| Pallavi Goel, Shivani Malpotra, Songyukta Shyam, Deepak Kumar, Manoj Kumar Singh, Prabhat Palt. Global MicroRNA Expression Profiling of Buffalo ( Genes. vol 13. issue 3. 2022-03-25. PMID:35328007. |
the major pathways related to embryonic development, such as the wnt signaling pathway, the apoptosis signaling pathway, the fgf signaling pathway, the p53 pathway, etc., were found to be affected in cloned relative to ivf embryos. |
2022-03-25 |
2023-08-13 |
Not clear |
| Qinghuan Kong, Xiaoyu Yan, Meiyu Cheng, Xin Jiang, Long Xu, Luyan Shen, Huimei Yu, Liankun Su. p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328718. |
we found that the combined use of the proteasome inhibitor epoxomicin and cisplatin led to the accumulation of p53 and sequestosome1(p62) in the mitochondria, downregulated mitochondrial dna (mtdna) transcription, inhibited mitochondrial functions, and ultimately promoted apoptosis by enhancing cisplatin sensitivity in ovarian cancer cells. |
2022-03-25 |
2023-08-13 |
Not clear |
| Qinghuan Kong, Xiaoyu Yan, Meiyu Cheng, Xin Jiang, Long Xu, Luyan Shen, Huimei Yu, Liankun Su. p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328718. |
our study demonstrates the important role of p53 localization in tumor cell survival and apoptosis, and provides new insights into understanding the anti-tumor mechanism of targeting the ubiquitin-proteasome system in tumor cells. |
2022-03-25 |
2023-08-13 |
Not clear |
| Naveenkumar Chandrashekar, Raghunandhakumar Subramanian, Devaki Thiruvengada. Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene-induced pulmonary carcinogenesis in mice. Journal of biochemical and molecular toxicology. 2022-03-25. PMID:35332611. |
be induces caspase-dependent apoptosis by increasing the levels of cytosolic cytochrome c accompanied by upregulating the outflow of p53, bax, and caspase-3 with a concomitant abatement in the outflow of bcl-2 in both in vitro and in vivo. |
2022-03-25 |
2023-08-13 |
mouse |
| Lais Ghiraldeli, Rebecca Anderson, Kristin Pladna, Timothy S Parde. Adenosine Monophosphate Activated Protein Kinase (AMPK) enhances chemotherapy response in Acute Myeloid Leukemia (AML). Cancer letters. 2022-03-24. PMID:35321842. |
mechanistically, ampk knock out cells demonstrated a diminished dna damage response with significantly lower γh2ax foci, p53 and p21 induction as well as decreased apoptosis following chemotherapy exposure. |
2022-03-24 |
2023-08-13 |
Not clear |
| Kirthiram K Sivakumar, Jone A Stanley, Jonathan C Behlen, Liga Wuri, Sudipta Dutta, John Wu, Joe A Arosh, Sakhila K Ban. Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates SIRT1-p53 interaction in Cr(VI)-Induced Apoptosis in the ovary. Reproductive toxicology (Elmsford, N.Y.). 2022-03-21. PMID:35307491. |
inhibition of sirtuin-1 hyperacetylates p53 and abrogates sirt1-p53 interaction in cr(vi)-induced apoptosis in the ovary. |
2022-03-21 |
2023-08-13 |
human |
| Kirthiram K Sivakumar, Jone A Stanley, Jonathan C Behlen, Liga Wuri, Sudipta Dutta, John Wu, Joe A Arosh, Sakhila K Ban. Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates SIRT1-p53 interaction in Cr(VI)-Induced Apoptosis in the ovary. Reproductive toxicology (Elmsford, N.Y.). 2022-03-21. PMID:35307491. |
the current study determines a role for the sirt1-p53 network in apoptosis induced by cr(vi) in the ovary and establishes physical interaction between sirt1 and p53. |
2022-03-21 |
2023-08-13 |
human |
| Kirthiram K Sivakumar, Jone A Stanley, Jonathan C Behlen, Liga Wuri, Sudipta Dutta, John Wu, Joe A Arosh, Sakhila K Ban. Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates SIRT1-p53 interaction in Cr(VI)-Induced Apoptosis in the ovary. Reproductive toxicology (Elmsford, N.Y.). 2022-03-21. PMID:35307491. |
for the first time, the current study shows a novel mechanism for cr(vi)-induced apoptosis in the ovary, mediated through the p53-sirt1 network, suggesting that targeting the p53 pathway may be an ideal approach to rescue ovaries from cr(vi)-induced apoptosis. |
2022-03-21 |
2023-08-13 |
human |