| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pingping Yang, Xingran Yang, Liran Sun, Xiaobing Han, Lu Xu, Wei Gu, Min Zhan. Effects of cadmium on oxidative stress and cell apoptosis in Drosophila melanogaster larvae. Scientific reports. vol 12. issue 1. 2022-03-21. PMID:35307728. |
in addition, the expression of mitochondrial adenine nucleotide transferase coding gene (sesb and ant2) and apoptosis related genes (debcl, hid, rpr, p53, sce and diap1) changed, which may lead to increased apoptosis. |
2022-03-21 |
2023-08-13 |
human |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. |
2022-03-21 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
we examined the apoptotic response of two glioblastoma cells, p53 wild type u87 and p53 mutated t98g, to doxorubicin, bortezomib, and vorinostat, which respectively target dna, 26s proteasome and histone deacetylase, to clarify p53's function in apoptosis. |
2022-03-21 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
the level of p53 was definitively correlated to the extent of dna damage and apoptosis initiation. |
2022-03-21 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
dominant-negative p53 reduced p21 expression, but did not affect doxorubicin-induced apoptosis, so the transcriptional activity of p53 seemed not to participate in doxorubicin-induced apoptosis. |
2022-03-21 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
however, p53 concentrated into the nucleus during heavy apoptosis. |
2022-03-21 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
in contrast, vorinostat promoted apoptosis in both u87 and t98g cells and reduced the basal level of p53 in u87 cells, indicating that p53 played no role in the vorinostat-induced apoptosis. |
2022-03-21 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
to clearly define the role of p53 in bortezomib- and doxorubicin-induced apoptosis, we combined doxorubicin with bortezomib to treat u87 cells to assess this combination's effect on apoptosis and p53 status. |
2022-03-21 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Cheng-Yu Tsai, Wei-Hua Zhu, Yu-Hsuan Pao, Hsin-Wen Chen, Chieh-Ju Hu, Yi-Lin Lee, Tzu-Shuo Huang, Chung-Hwan Chen, Joon-Khim Loh, Yi-Ren Hong, Chihuei Wan. Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma. Cell cycle (Georgetown, Tex.). 2022-03-21. PMID:35311459. |
however, the amounts of p53 in the total count and in the nucleus were much lower with the combination than with doxorubicin alone, suggesting that p53 played no role in either the compound stress, doxorubicin-only or bortezomib-induced apoptosis. |
2022-03-21 |
2023-08-13 |
Not clear |
| Selçuk Özdemir, Harun Arsla. circRNA-based biomarker candidates for acute cypermethrin and chlorpyrifos toxication in the brain of Zebrafish (Danio rerio). Chemosphere. 2022-03-19. PMID:35304207. |
it was revealed that the detected circrnas specifically regulated the mapk signaling pathway, endocytosis mechanism, apoptosis, and p53 signaling pathway. |
2022-03-19 |
2023-08-13 |
human |
| Jiming Si, Jianjun Jin, Jingjing Sai, Xiaoting Liu, Xiao Luo, Zhenqiang Fu, Jing Wan. Circular RNA circ-PLCD1 functions as a tumor suppressor in non-small cell lung cancer by inactivation of PI3K/AKT signaling pathway. Human cell. 2022-03-18. PMID:35301686. |
circ-plcd1 was transcriptionally activated by tumor-inhibiting protein p53, and exogenous expression of circ-plcd1 inhibited nsclc cell proliferation, invasion and induced apoptosis. |
2022-03-18 |
2023-08-13 |
Not clear |
| Dongqin Bao, Chaohui Zhuang, Yan Jiao, Li Yan. The possible involvement of circRNA DMNT1/p53/JAK/STAT in gestational diabetes mellitus and preeclampsia. Cell death discovery. vol 8. issue 1. 2022-03-17. PMID:35296654. |
when the expression of circ-dmnt1 or p53 was abnormal, cell counting kit-8 (cck-8) assay, bromodeoxyuridine (brdu) staining, flow cytometry, cell scratch, and transwell assays were used to assess cell viability, proliferation, cell cycle, apoptosis, migration, and invasion of trophoblast cells, respectively. |
2022-03-17 |
2023-08-13 |
Not clear |
| Dongqin Bao, Chaohui Zhuang, Yan Jiao, Li Yan. The possible involvement of circRNA DMNT1/p53/JAK/STAT in gestational diabetes mellitus and preeclampsia. Cell death discovery. vol 8. issue 1. 2022-03-17. PMID:35296654. |
upregulation of circ-dmnt1 or p53 inhibited trophoblast cell viability, proliferation, migration, and invasion, meanwhile promoting cell apoptosis but blocking cell cycle progression. |
2022-03-17 |
2023-08-13 |
Not clear |
| B Handan Özdemi. Tumor Microenvironment: Necroptosis Switches the Subtype of Liver Cancer While Necrosis Promotes Tumor Recurrence and Progression. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2022-03-17. PMID:35297332. |
cancer cells are known to be resistant to apoptosis as a result of p53 mutation. |
2022-03-17 |
2023-08-13 |
Not clear |
| Qin Guo, Yujia Li, Yuan Chen, Jin Ji, Shizhong Zheng, Xuefen Xu, Biyun Zhang, Jianzhou Y. β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts. IUBMB life. 2022-03-16. PMID:35294085. |
β-elemene induces apoptosis by activating the p53 pathway in human hypertrophic scar fibroblasts. |
2022-03-16 |
2023-08-13 |
human |
| Li Chen, Wenting Luo, Peijun Ji, Zhujuan Li, Yi Yan, Qin Zho. Effects of BMI1 Gene on Regulating Apoptosis, Invasion, and Migration of HEC-1B Cells Induced by Ionizing Radiation. Journal of healthcare engineering. vol 2022. 2022-03-14. PMID:35281533. |
cell proliferation was detected by cell counting kit-8 (cck-8); cell migration and invasion were detected by transwell test; cell apoptosis was detected by flow cytometry; and the expression of mmp2, mmp7, mmp9, rock1, rhoa, p53, p21, and bax protein was detected by the western blot. |
2022-03-14 |
2023-08-13 |
human |
| Fuquan Ma, Jin Huang, Weizhi Li, Peijie Li, Mengying Liu, Hui Xu. MicroRNA-455-3p functions as a tumor suppressor by targeting HDAC2 to regulate cell cycle in hepatocellular carcinoma. Environmental toxicology. 2022-03-14. PMID:35286011. |
overexpression of hdac2 reversed the inhibitory effects of mir-455-3p on cell proliferation, migration and cell cycle protein (cdk6 and cyclin d1) expression, and neutralized the promotion effects of mir-455-3p on cell apoptosis and the activation of p53 pathway. |
2022-03-14 |
2023-08-13 |
mouse |
| Fuquan Ma, Jin Huang, Weizhi Li, Peijie Li, Mengying Liu, Hui Xu. MicroRNA-455-3p functions as a tumor suppressor by targeting HDAC2 to regulate cell cycle in hepatocellular carcinoma. Environmental toxicology. 2022-03-14. PMID:35286011. |
in summary, our results suggested that mir-455-3p targeted hdac2 to inhibit cell proliferation, migration and promote cell apoptosis via the activation of p53 pathway. |
2022-03-14 |
2023-08-13 |
mouse |
| Xiang Cao, Na Yao, Zidan Zhao, Yue Fu, Yuting Hu, Ping Zhu, Weihai Shi, Liming Tan. LEM domain containing 1 promotes pancreatic cancer growth and metastasis by p53 and mTORC1 signaling pathway. Bioengineered. vol 13. issue 3. 2022-03-14. PMID:35286235. |
mechanistically, gsea identified that lemd1 promoted pc aggressiveness, as well as affecting cell cycle dysregulation and apoptosis resistance, by p53 suppression and the activation of the mtorc1 signal pathway. |
2022-03-14 |
2023-08-13 |
Not clear |
| Sonja Srdanovic, Madita Wolter, Chi H Trinh, Christian Ottmann, Stuart L Warriner, Andrew J Wilso. Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. The FEBS journal. 2022-03-14. PMID:35286747. |
p53 plays a critical role in regulating diverse biological processes: dna repair, cell cycle arrest, apoptosis, and senescence. |
2022-03-14 |
2023-08-13 |
Not clear |