| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhang Li, Ming Li, Pengcheng Xia, Lili Wang, Zhiming L. Targeting long non-coding RNA PVT1/TGF-β/Smad by p53 prevents glioma progression. Cancer biology & therapy. vol 23. issue 1. 2022-03-11. PMID:35275031. |
short interfering rna (sirna) against lncrna pvt1 (sirna-pvt1), sirna-p53 or both was transfected into the glioma cells to evaluate effects of lncrna pvt1 and p53 on cell proliferation, migration, invasion, and apoptosis. |
2022-03-11 |
2023-08-13 |
mouse |
| Soumya Ranjan Jena, Ganeswar Dalei, Subhraseema Das, Jasmine Nayak, Manoranjan Pradhan, Luna Samant. Harnessing the potential of dialdehyde alginate-xanthan gum hydrogels as niche bioscaffolds for tissue engineering. International journal of biological macromolecules. 2022-03-11. PMID:35276297. |
the western blot analysis of p53 gene indicated no growth arrest or apoptosis in 3t3 cells thus, signifying the non-toxic nature of the scaffolds. |
2022-03-11 |
2023-08-13 |
Not clear |
| Adeoluwa A Adeluola, Nana Bosomtwe, Timothy E Long, A R M Ruhul Ami. Context-dependent activation of p53 target genes and induction of apoptosis by actinomycin D in aerodigestive tract cancers. Apoptosis : an international journal on programmed cell death. 2022-03-10. PMID:35267106. |
context-dependent activation of p53 target genes and induction of apoptosis by actinomycin d in aerodigestive tract cancers. |
2022-03-10 |
2023-08-13 |
human |
| Jang Mi Han, Yu Jin Kim, Hye Jin Jun. Discovery of a New CaMKII-Targeted Synthetic Lethal Therapy against Glioblastoma Stem-like Cells. Cancers. vol 14. issue 5. 2022-03-10. PMID:35267623. |
notably, the synthetic lethal effects in gscs are associated with the activation of caspase-mediated apoptosis by inducing p53 expression and reactive oxygen species generation, as well as the suppression of stemness marker expression by reducing nuclear factor-kappa b (nf-κb) activity. |
2022-03-10 |
2023-08-13 |
chicken |
| Luying Lai, Yongwei Wang, Shenghui Peng, Wenjing Guo, Fengxian Li, Shiyuan X. P53 and taurine upregulated gene 1 promotes the repair of the DeoxyriboNucleic Acid damage induced by bupivacaine in murine primary sensory neurons. Bioengineered. vol 13. issue 3. 2022-03-10. PMID:35271399. |
our work treated dorsal root ganglion (drg) cells with bup, detected cell viability through cck-8, apoptosis through tunel assays, deoxyribonucleic acid (dna) damage through γ-h2ax protein and comet assay, including p53 mrna, protein and tug1 expression through q-pcr and western blot, furthermore, cell viability and dna damage were determined after the silencing of p53 and tug1, biological information and tug1 fish combined with p53 protein immunofluorescence (if) was performed to determine the cellular localization of these molecule. |
2022-03-10 |
2023-08-13 |
Not clear |
| Min Li, Yidan Su, Xiaoyuan Gao, Jiarong Yu, Zhiyong Wang, Xiqiao Wan. Transition of autophagy and apoptosis in fibroblasts depends on dominant expression of HIF-1α or p53. Journal of Zhejiang University. Science. B. vol 23. issue 3. 2022-03-09. PMID:35261216. |
transition of autophagy and apoptosis in fibroblasts depends on dominant expression of hif-1α or p53. |
2022-03-09 |
2023-08-13 |
Not clear |
| Yun Zhao, Chanlin Fang, Cuiyuan Jin, Zhiwei Bao, Guiling Yang, Yuanxiang Ji. Catechin from green tea had the potential to decrease the chlorpyrifos induced oxidative stress in larval zebrafish (Danio rerio). Pesticide biochemistry and physiology. vol 182. 2022-03-07. PMID:35249660. |
catechin also could reduce the transcription of p53 and bax, which are tightly related to the apoptosis induced by cpf in zebrafish larvae. |
2022-03-07 |
2023-08-13 |
cat |
| b' Ilias Tsochantaridis, Aglaia Pappa, Egemen Dere, Ferda Ar\\xc4\\xb. Zn(II) 5,5-Diethylbarbiturate complex selectively induces apoptosis in breast cancer and breast cancer stem-like cells. Chemistry & biodiversity. 2022-03-07. PMID:35254725.' |
intrinsic apoptosis pathway in mcf-7 cells and extrinsic apoptosis pathway in mda-mb-231 cells was determined by western blot (parp, cleave parp, bax, cox4, rip, caspase 8, split caspase 8, dr4 and b-actin) and rt-pcr (parp, fas, bcl-2, tnf10a, p53) analysis. |
2022-03-07 |
2023-08-13 |
human |
| Suyash M Patil, Nitesh K Kund. Nisin ZP, an Antimicrobial Peptide, Induces Cell Death and Inhibits Non-Small Cell Lung Cancer (NSCLC) Progression in vitro in 2D and 3D Cell Culture. Pharmaceutical research. 2022-03-05. PMID:35246758. |
nisin zp exposure induced apoptosis and cell cycle arrest (g0/g1 phase) in nsclc cells irrespective of tumor protein p53 expression. |
2022-03-05 |
2023-08-13 |
Not clear |
| Ying Liu, Guangwei Ma, Zenghong Gao, Jian Li, Jin Wang, Xiangping Zhu, Ruowu Ma, Jiawen Yang, Yiting Zhou, Kaishun Hu, Yin Zhang, Yabin Gu. Global chromosome rearrangement induced by CRISPR-Cas9 reshapes the genome and transcriptome of human cells. Nucleic acids research. 2022-03-04. PMID:35244719. |
gene expressions related to p53 pathway, dna repair, cell cycle and apoptosis were greatly altered to facilitate the cell survival. |
2022-03-04 |
2023-08-13 |
human |
| Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tia. ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation. Journal of experimental & clinical cancer research : CR. vol 41. issue 1. 2022-03-01. PMID:35227287. |
znf498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 ser46 phosphorylation. |
2022-03-01 |
2023-08-13 |
Not clear |
| Xiaoli Yin, Yinghao Ren, Weitao Luo, Meiqiu Liao, Lin Huang, Xueqi Zhuang, Yuan Liu, Weina Wan. Nemo-like kinase (NLK) gene regulates apoptosis via the p53 signaling pathway in Litopenaeus vannamei under low-temperature stress. Developmental and comparative immunology. 2022-03-01. PMID:35231467. |
nemo-like kinase (nlk) gene regulates apoptosis via the p53 signaling pathway in litopenaeus vannamei under low-temperature stress. |
2022-03-01 |
2023-08-13 |
Not clear |
| Xiaoli Yin, Yinghao Ren, Weitao Luo, Meiqiu Liao, Lin Huang, Xueqi Zhuang, Yuan Liu, Weina Wan. Nemo-like kinase (NLK) gene regulates apoptosis via the p53 signaling pathway in Litopenaeus vannamei under low-temperature stress. Developmental and comparative immunology. 2022-03-01. PMID:35231467. |
additionally, qpcr results indicated that lvnlk might participate in apoptosis via the p53 signaling pathway in vitro and in vivo. |
2022-03-01 |
2023-08-13 |
Not clear |
| Linzi Long, Xiuli Zhang, Ying Wen, Jiapeng Li, Lihui Wei, Ying Cheng, Huixin Liu, Jianfeng Chu, Yi Fang, Qiurong Xie, Aling Shen, Jun Pen. Qingda Granule Attenuates Angiotensin II-Induced Renal Apoptosis and Activation of the p53 Pathway. Frontiers in pharmacology. vol 12. 2022-02-28. PMID:35222007. |
qingda granule attenuates angiotensin ii-induced renal apoptosis and activation of the p53 pathway. |
2022-02-28 |
2023-08-13 |
Not clear |
| Jyotirekha Das, Fayaz Shaik Mahammad, Rajanikant Golgodu Krishnamurth. An integrated chemo-informatics and in vitro experimental approach repurposes acarbose as a post-ischemic neuro-protectant. 3 Biotech. vol 12. issue 3. 2022-02-28. PMID:35223357. |
death-associated protein kinase 1 (dapk1) and p53 protein-protein interaction serve as a signaling point for the convergence of apoptosis and necrosis in cerebral ischemia. |
2022-02-28 |
2023-08-13 |
Not clear |
| Shunsuke Takahashi, Takahisa Shinomiya, Yukitoshi Nagahar. Azoxystrobin Induces Apoptosis and Cell Cycle Arrest in Human Leukemia Cells Independent of p53 Expression. Anticancer research. vol 42. issue 3. 2022-02-27. PMID:35220221. |
azoxystrobin induces apoptosis and cell cycle arrest in human leukemia cells independent of p53 expression. |
2022-02-27 |
2023-08-13 |
human |
| Daniela Rodrigues, Bram Herpers, Sofia Ferreira, Heeseung Jo, Ciarán Fisher, Luke Coyle, Seung-Wook Chung, Jos C S Kleinjans, Danyel G J Jennen, Theo M de Ko. A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216325. |
differential gene expression analysis showed that gefitinib perturbed signal transduction pathways, apoptosis, cell cycle, foxo-mediated transcription, p53 signalling pathway, and metabolic pathways. |
2022-02-26 |
2023-08-13 |
human |
| Tirthankar Koley, Sanghati Roy Chowdhury, Tushar Kushwaha, Manoj Kumar, Krishna Kishore Inampudi, Punit Kaur, Tej Pal Singh, Héctor Viadiu, Abdul Samath Ethayathull. Deciphering the mechanism of p73 recognition of p53 response elements using the crystal structure of p73-DNA complexes and computational studies. International journal of biological macromolecules. 2022-02-26. PMID:35217090. |
p73 belongs to p53 family transcription factor activating more than 50% of cell fate p53 target genes involved in cell cycle, apoptosis, dna damage response alongside neuronal system development and differentiation by binding to 20-bp response elements (res) having sequence motif (pppca/t-t/agyyy) where p-purines and y-pyrimidines with each 10-bp separated by minimum 0 to 13-bp spacer. |
2022-02-26 |
2023-08-13 |
Not clear |
| Rosa Nguyen, Hong Wang, Ming Sun, Dong Geun Lee, Junmin Peng, Carol J Thiel. Combining selinexor with alisertib to target the p53 pathway in neuroblastoma. Neoplasia (New York, N.Y.). vol 26. 2022-02-26. PMID:35217309. |
we found that selinexor induced its cytotoxic effects in neuroblastoma through the predominantly nuclear accumulation of p53 and global activation of apoptosis pathways. |
2022-02-26 |
2023-08-13 |
mouse |
| Xiao Wang, Wei Liu, Guozhong Jin, Zhanjun Wu, Di Zhang, Yongzhan Bao, Wanyu Sh. Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis. Ecotoxicology and environmental safety. vol 233. 2022-02-26. PMID:35219255. |
the results showed that, smps increased the average weight gain and renal index of chicks, alleviated the pathological changes of renal structure induced by ffc, decreased the contents of uric acid, blood urea nitrogen and creatinine in serum and malondialdehyde in renal tissue, increased the levels of glutathione, superoxide dismutase and catalase in renal tissue, up-regulated the relative expression levels of nuclear factor erythroid 2 related factor 2 (nrf2), heme oxygenase-1 (ho-1) and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase-1 (nqo-1) mrna and protein, and down-regulated the relative expression levels of p53, caspase-3 and caspase-6 mrna and protein and the apoptosis rate of renal histiocytes. |
2022-02-26 |
2023-08-13 |
Not clear |