| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yesim Akdemir, Meryem Akpolat, Ozlem Elmas, Mete Kececi, Cagatay Buyukuysal, Busra Cetinkaya, Nurten Guleryu. Capsaicin prevents radiotherapy-induced premature ovarian failure in rats. Reproduction, fertility, and development. 2022-02-01. PMID:35101163. |
capsaicin significantly ameliorated oxidative stress by decreasing serum total oxidant status, oxidative stress index, disulphide, and malondialdehyde levels (p≤0.001); ovarian inflammatory status by decreasing expressions of tnf-α, il-1β, parp-1 (p=0.002); apoptosis by decreasing expressions of active caspase-3 and p53 (p=0.015, p=0.002); and follicle counts by increasing primordial follicles and decreasing apoptotic follicles (p≤0.001) in rats when administered before radiation exposure. |
2022-02-01 |
2023-08-13 |
rat |
| Karla F Meza-Sosa, Rui Miao, Francisco Navarro, Zhibin Zhang, Ying Zhang, Jun Jacob Hu, Corrine Corrina R Hartford, Xiao Ling Li, Gustavo Pedraza-Alva, Leonor Pérez-Martínez, Ashish Lal, Hao Wu, Judy Lieberma. SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Molecular cell. 2022-02-01. PMID:35104452. |
p53, master transcriptional regulator of the genotoxic stress response, controls cell-cycle arrest and apoptosis following dna damage. |
2022-02-01 |
2023-08-13 |
Not clear |
| Karla F Meza-Sosa, Rui Miao, Francisco Navarro, Zhibin Zhang, Ying Zhang, Jun Jacob Hu, Corrine Corrina R Hartford, Xiao Ling Li, Gustavo Pedraza-Alva, Leonor Pérez-Martínez, Ashish Lal, Hao Wu, Judy Lieberma. SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Molecular cell. 2022-02-01. PMID:35104452. |
despite low expression (<16 copies/cell), sparcle deletion increases dna repair and reduces dna-damage-induced apoptosis as much as p53 deficiency, while its overexpression restores apoptosis in p53-deficient cells. |
2022-02-01 |
2023-08-13 |
Not clear |
| Xiaoyu Li, Peng Zhou, Zhen Luo, Ru Feng, Lu Wan. Hohenbuehelia serotina polysaccharides self-assembled nanoparticles for delivery of quercetin and their anti-proliferative activities during gastrointestinal digestion in vitro. International journal of biological macromolecules. 2022-01-30. PMID:35093441. |
compared with undigested ones, qc-hsp nps after gastrointestinal digestion exhibited the more significant anti-proliferative activity on hela cells through accumulation of intracellular ros, arrest of cell cycle at g2/m phase by regulation of cyclin b1, cdk1, p53 and p21 and induction of apoptosis by er apoptosis pathway. |
2022-01-30 |
2023-08-13 |
Not clear |
| Srishti Srivastava, Hima Makala, Vikas Sharma, Vaishali Suri, Chitra Sarkar, Ritu Kulshreshth. MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis. Cellular and molecular life sciences : CMLS. vol 79. issue 2. 2022-01-29. PMID:35091793. |
we further show that med12 brings about the inhibition of p53 levels and apoptosis partly through induction of bcl6 in glioblastoma. |
2022-01-29 |
2023-08-13 |
Not clear |
| Yanqing Liu, Wei G. p53 in ferroptosis regulation: the new weapon for the old guardian. Cell death and differentiation. 2022-01-28. PMID:35087226. |
although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. |
2022-01-28 |
2023-08-13 |
human |
| Nanxing Yi, Yilin Mi, Xiaotong Xu, Naping Li, Fan Zeng, Ke Yan, Kaiyun Tan, Gaoyan Kuang, Min L. Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology. Frontiers in pharmacology. vol 12. 2022-01-27. PMID:35082670. |
go and kegg analyses showed that 19 anti-oa targets were mainly involved in the response to oxidative stress, the response to hypoxia and apoptosis, and the pi3k-akt and p53 signaling pathways. |
2022-01-27 |
2023-08-13 |
mouse |
| Jiaan Xu, Xiujuan Xiao, Bo Yan, Qiang Yuan, Xiaoqiao Dong, Quan Du, Jin Zhang, Letian Shan, Zhishan Ding, Li Zhou, Thomas Effert. Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling suppression. Cancer cell international. vol 22. issue 1. 2022-01-26. PMID:35078476. |
green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed jnk signaling suppression. |
2022-01-26 |
2023-08-13 |
human |
| Fuwei Cheng, Shuangping Zhao, Jiachen Li, Yuyu Niu, Haiping Huang, Jicheng Yang, Shiyin Ma, Jisheng Liu, Peng Su. Enhanced effect of recombinant adenoviruses co-expression of ING4 and OSM on anti-tumour activity of laryngeal cancer. Journal of cellular and molecular medicine. 2022-01-25. PMID:35075768. |
in vitro, ad-ing4-osm significantly inhibited the growth, enhanced apoptosis, altered cell cycle with g1 and g2/m phase arrest, and upregulated the expression of p21, p27, p53 and downregulated survivin in laryngeal cancer hep-2 cells. |
2022-01-25 |
2023-08-13 |
mouse |
| Siyu Zhang, Yifan Wang, Yujie Sun, Guangjian Zhao, Juan Wang, Lu Liu, Fang Liu, Peng Wang, Jinbo Yang, Ximing X. Hinokiflavone, as a MDM2 inhibitor, activates p53 signaling pathway to induce apoptosis in human colon cancer HCT116 cells. Biochemical and biophysical research communications. vol 594. 2022-01-25. PMID:35078113. |
hinokiflavone, as a mdm2 inhibitor, activates p53 signaling pathway to induce apoptosis in human colon cancer hct116 cells. |
2022-01-25 |
2023-08-13 |
human |
| Siyu Zhang, Yifan Wang, Yujie Sun, Guangjian Zhao, Juan Wang, Lu Liu, Fang Liu, Peng Wang, Jinbo Yang, Ximing X. Hinokiflavone, as a MDM2 inhibitor, activates p53 signaling pathway to induce apoptosis in human colon cancer HCT116 cells. Biochemical and biophysical research communications. vol 594. 2022-01-25. PMID:35078113. |
then, this mdm2 inhibition led in turn to increase p53 protein expression and activate p53 pathway, which could decrease the survival of hct116 colon cells by g2/m phase arrest and apoptosis induction. |
2022-01-25 |
2023-08-13 |
human |
| Ahmad Ghasemi, Amir Salari, Mahboube Kalantarmahdavi, Mohammad Reza Amiryousef. Sodium metabisulfite in dried plum and its cytotoxic effects on K-562 and L-929 normal cell lines. Journal of food science. 2022-01-24. PMID:35067933. |
the expression analysis of apoptosis marker genes (bax, bcl-2, and p53) was also assessed. |
2022-01-24 |
2023-08-13 |
human |
| Xiaogang Zheng, Bingtao Liu, Xiongxiong Liu, Ping Li, Pengcheng Zhang, Fei Ye, Ting Zhao, Yanbei Kuang, Weiqiang Chen, Xiaodong Jin, Qiang L. PERK Regulates the Sensitivity of Hepatocellular Carcinoma Cells to High-LET Carbon Ions via either Apoptosis or Ferroptosis. Journal of Cancer. vol 13. issue 2. 2022-01-24. PMID:35069910. |
on the one hand, perk promoted autophagy via regulating atf4 expression; on the other hand, perk regulated p53 expression, and the latter either induced autophagy through up-regulating dram, or directly promoting apoptosis through the mitochondrial pathway or facilitating ferroptosis via down-regulating |
2022-01-24 |
2023-08-13 |
Not clear |
| Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamni. Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication. Emergency medicine international. vol 2022. 2022-01-24. PMID:35070453. |
aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing dna repair, altering the stability of dna organization, inhibition of the protein phosphatase 2a (pp2a) activity, increasing reactive oxygen species (ros) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing nf-kb, p53, and jnk pathway leading to apoptosis. |
2022-01-24 |
2023-08-13 |
Not clear |
| Weihong Li, Shixiang Zhou, Meng Jia, Xiaoxin Li, Lin Li, Qi Wang, Zhenhua Qi, Pingkun Zhou, Yaqiong Li, Zhidong Wan. Early Biomarkers Associated with P53 Signaling for Acute Radiation Injury. Life (Basel, Switzerland). vol 12. issue 1. 2022-01-21. PMID:35054492. |
p53 signaling pathway plays an important role in dna damage repair and cell apoptosis induced by ionizing radiation. |
2022-01-21 |
2023-08-13 |
human |
| Lei Duan, Ricardo E Perez, Sarah Calhoun, Carl G Mak. RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC. Scientific reports. vol 12. issue 1. 2022-01-21. PMID:35058503. |
p53 activates or represses genes involved in cell cycle progression or apoptosis in order to arrest the cell cycle or induce cell death. |
2022-01-21 |
2023-08-13 |
Not clear |
| Lavanya Ponnusamy, Sathan Raj Natarajan, Ravi Manohara. MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1α and p53 pathways. Journal of cellular biochemistry. 2022-01-20. PMID:35048405. |
conclusively, our study demonstrated that mark2 promotes breast cancer aerobic glycolysis and cell proliferation, and inhibits apoptosis, in part, through regulating mtor/hif-1α and p53 signaling pathways. |
2022-01-20 |
2023-08-13 |
Not clear |
| Dehua Lu, Lailiang Qu, Cheng Wang, Heng Luo, Shang Li, Fucheng Yin, Xingchen Liu, Xinye Chen, Zhongwen Luo, Ningjie Cui, Wan Peng, Limei Ji, Lingyi Kong, Xiaobing Wan. Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy. Bioorganic chemistry. vol 120. 2022-01-20. PMID:35051708. |
furthermore 27 caused cells apoptosis through p53 signaling pathway, and exhibited significant anti-proliferation effects against hct-116 cells (ic |
2022-01-20 |
2023-08-13 |
Not clear |
| Yongtao Li, Wenshan Bian, Yang Jiang, Danyang Liu, Lei She. hMSCs Migrate under the Chemotaxis of CXCL-13 and Enhance Islet B Cell Activity through p-AKT Signaling Pathway in High-Glucose Environment. Journal of healthcare engineering. vol 2022. 2022-01-17. PMID:35035844. |
after coculture of hmscs and islet b cells, the activity of cells was detected by cck8 assay, the expression of ki-67 in cells was detected by rt-pcr, and the expression of p53 was detected by western blot to investigate the effect of hmscs on the proliferation and apoptosis of islet b cells. |
2022-01-17 |
2023-08-13 |
human |
| Ni An, Zhenjie Li, Xiaodi Yan, Hainan Zhao, Yajie Yang, Ruling Liu, Yanyong Yang, Fu Gao, Bailong Li, Hu Liu, Hongbin Yua. Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice. Cell death discovery. vol 8. issue 1. 2022-01-15. PMID:35031595. |
the results showed that ionizing radiation induces the nuclear translocation of rac1, the latter then promotes nuclear translocation of p53 and prolongs the residence time of p53 in the nucleus, thereby promoting the transcription of trp53inp1 which mediates p53-dependent apoptosis. |
2022-01-15 |
2023-08-13 |
mouse |