| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Zheng, Xue Qin, Rui Feng, Qi Li, Fushuo Huang, Yulong Li, Qian Zhao, He Huan. Alleviative effect of melatonin on the decrease of uterine receptivity caused by blood ammonia through ROS/NF-κB pathway in dairy cow. Ecotoxicology and environmental safety. vol 231. 2022-01-14. PMID:35030520. |
cell viability, apoptosis, oxidative stress and mitochondrial membrane potential were measured and the expression of apoptosis-related genes (p53, cyt-c, bax, bcl-2, caspase-8, caspase-9 and caspase-3), uterus receptivity related genes (vegf, lif and egf) and inflammatory factors (tlr-4, il-6 and nf-κb) were detected. |
2022-01-14 |
2023-08-13 |
cattle |
| Peng Zheng, Xue Qin, Rui Feng, Qi Li, Fushuo Huang, Yulong Li, Qian Zhao, He Huan. Alleviative effect of melatonin on the decrease of uterine receptivity caused by blood ammonia through ROS/NF-κB pathway in dairy cow. Ecotoxicology and environmental safety. vol 231. 2022-01-14. PMID:35030520. |
the results showed that ammonia significantly increased intracellular ros level, mrna and protein expression of bax, p53, cyt-c, caspase-9, caspase-8, caspase-3, tlr-4, nf-κb and il-6, promoted cell apoptosis, while decreased mitochondrial membrane potential, the mrna and protein expression of vegf and egf. |
2022-01-14 |
2023-08-13 |
cattle |
| Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Che. USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell biology and toxicology. 2022-01-13. PMID:35022897. |
rescue experiment was used to determine the key role of of p53 in cell cycle, apoptosis, and autophagy. |
2022-01-13 |
2023-08-13 |
Not clear |
| Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Che. USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell biology and toxicology. 2022-01-13. PMID:35022897. |
dub-in-1, an usp8 inhibitor, caused dna damage, led to g2/m phase block by p53-p21 axis, and triggered apoptosis by regulating the p53 target proteins including bax, noxa, and puma. |
2022-01-13 |
2023-08-13 |
Not clear |
| Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Che. USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell biology and toxicology. 2022-01-13. PMID:35022897. |
usp8 inhibitor, dub-in-1, treatment could inhibit esophageal squamous cell carcinoma cell growth and induce g2/m cell cycle arrest, apoptosis, and autophagy by dna damage-induced p53 activation. |
2022-01-13 |
2023-08-13 |
Not clear |
| Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Che. USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell biology and toxicology. 2022-01-13. PMID:35022897. |
dub-in-1 treatment led to g2/m cell cycle arrest by upregulating the protein level of p21 and triggered apoptosis by modulating the p53 target proteins including bax, noxa, and puma. |
2022-01-13 |
2023-08-13 |
Not clear |
| Jianli Yu, Yang Guo, Yi Gu, Fei Li, Haipeng Song, Rui Nian, Xiying Fan, Wenshuai Li. Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance. International journal of biological macromolecules. 2022-01-12. PMID:35016970. |
treatment with the anti-he4 nanobody 1g8 decreased bcl-2 expression and increased bax, cleaved parp, and p53 levels, resulting in apoptosis of ovcar3 cells. |
2022-01-12 |
2023-08-13 |
human |
| Jin Wu, Guanting Lu, Xinjiang Wan. MDM4 alternative splicing and implication in MDM4 targeted cancer therapies. American journal of cancer research. vol 11. issue 12. 2022-01-12. PMID:35018230. |
mdm4 is frequently amplified and upregulated in human cancers, contributing to overgrowth and apoptosis inhibition by blocking the expression of downstream target genes of p53 pathway. |
2022-01-12 |
2023-08-13 |
human |
| Victoria Chamberlain, Yvette Drew, John Lune. Tipping Growth Inhibition into Apoptosis by Combining Treatment with MDM2 and WIP1 Inhibitors in p53 Cancers. vol 14. issue 1. 2022-01-11. PMID:35008180. |
tipping growth inhibition into apoptosis by combining treatment with mdm2 and wip1 inhibitors in p53 as there is no optimal therapeutic strategy defined for women with advanced or recurrent ulms, there is an urgent need for the discovery of novel, targeted approaches. |
2022-01-11 |
2023-08-13 |
Not clear |
| Svetlana V Demyanenko, Maria A Pitinova, Valentina A Dzreyan, Yuliya N Kalyuzhnaya, Moez A Eid, Andrey Y Abramov, Michael B Evgen'ev, David G Garbu. The Role of p53 Protein in the Realization of the Exogenous Heat Shock Protein 70 Anti-Apoptotic Effect during Axotomy. Cells. vol 11. issue 1. 2022-01-11. PMID:35011655. |
at the same time, co-localization of ehsp70 with p53 protein, one of the key regulators of apoptosis, was noted. |
2022-01-11 |
2023-08-13 |
Not clear |
| Svetlana V Demyanenko, Maria A Pitinova, Valentina A Dzreyan, Yuliya N Kalyuzhnaya, Moez A Eid, Andrey Y Abramov, Michael B Evgen'ev, David G Garbu. The Role of p53 Protein in the Realization of the Exogenous Heat Shock Protein 70 Anti-Apoptotic Effect during Axotomy. Cells. vol 11. issue 1. 2022-01-11. PMID:35011655. |
ehsp70 reduces the level of the p53 protein apoptosis promoter both in glial cells and in the nuclei and cytoplasm of neurons, which indicates its neuroprotective effect. |
2022-01-11 |
2023-08-13 |
Not clear |
| Sonali Rath, Manaswini Jagadeb, Ruchi Bhuya. Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. Genomics & informatics. vol 19. issue 4. 2022-01-11. PMID:35012289. |
molecular docking of bioactive compounds derived from moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. |
2022-01-11 |
2023-08-13 |
Not clear |
| Sonali Rath, Manaswini Jagadeb, Ruchi Bhuya. Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. Genomics & informatics. vol 19. issue 4. 2022-01-11. PMID:35012289. |
some bioactive compounds of m. oleifera possess potential anti-cancer properties which interact with the apoptosis protein p53 in cancer cell lines of oral squamous cell carcinoma. |
2022-01-11 |
2023-08-13 |
Not clear |
| Sonali Rath, Manaswini Jagadeb, Ruchi Bhuya. Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. Genomics & informatics. vol 19. issue 4. 2022-01-11. PMID:35012289. |
this research work focuses on the interaction among the selected bioactive compounds derived from m. oleifera with targeted apoptosis protein p53 from the apoptosis pathway to check whether the bioactive compound will induce apoptosis after the mutation in p53. |
2022-01-11 |
2023-08-13 |
Not clear |
| Sonali Rath, Manaswini Jagadeb, Ruchi Bhuya. Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. Genomics & informatics. vol 19. issue 4. 2022-01-11. PMID:35012289. |
detailed analysis of the 3d structure of apoptosis protein p53. |
2022-01-11 |
2023-08-13 |
Not clear |
| Sonali Rath, Manaswini Jagadeb, Ruchi Bhuya. Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. Genomics & informatics. vol 19. issue 4. 2022-01-11. PMID:35012289. |
this study shows the docking between the potential bioactive compounds with targeted apoptosis protein p53. |
2022-01-11 |
2023-08-13 |
Not clear |
| Sonali Rath, Manaswini Jagadeb, Ruchi Bhuya. Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. Genomics & informatics. vol 19. issue 4. 2022-01-11. PMID:35012289. |
quercetin was the most potential bioactive compound whereas kaempferol shows poor affinity towards the targeted p53 protein in the apoptosis pathway. |
2022-01-11 |
2023-08-13 |
Not clear |
| Sonali Rath, Manaswini Jagadeb, Ruchi Bhuya. Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma. Genomics & informatics. vol 19. issue 4. 2022-01-11. PMID:35012289. |
thus, the objective of this research can provide an insight prediction towards m. oleifera derived bioactive compounds and target apoptosis protein p53 in the structural analysis for compound isolation and in-vivo experiments on the cancer cell line. |
2022-01-11 |
2023-08-13 |
Not clear |
| Jingjing Ma, Peng Li, Lipei An, Teng Zhang, Guodong L. Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters. Journal of food biochemistry. 2022-01-11. PMID:35014039. |
the mrna expression of p38 mitogen-activated protein kinase (p38mapk), p53, and apoptosis was also estimated at the end of the experimental study. |
2022-01-11 |
2023-08-13 |
rat |
| Yuanshan Han, Yang Yang, Sanqian Huang, Lei Yao, Lile W. The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity. Biochemical and biophysical research communications. vol 591. 2022-01-09. PMID:34999254. |
p53 knockdown enhanced cell viability and suppressed cell apoptosis, whereas mir-34a-5p overexpression exerted opposite effects; mir-34a-5p overexpression partially attenuated p53 knockdown effects on pdt-treated cholangiocarcinoma cells. |
2022-01-09 |
2023-08-13 |
Not clear |