| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aixin Ou, Xiangxuan Zhao, Zaiming L. The potential roles of p53 signaling reactivation in pancreatic cancer therapy. Biochimica et biophysica acta. Reviews on cancer. vol 1877. issue 1. 2021-12-11. PMID:34861354. |
transcription factor p53 is known to play key roles in many important biological processes in vertebrates, including normal cell growth, differentiation, cell cycle progression, senescence, apoptosis, metabolism, and dna damage repair. |
2021-12-11 |
2023-08-13 |
Not clear |
| Timur Yagudin, Yue Zhao, Haiyu Gao, Yang Zhang, Ying Yang, Xiaofang Zhang, Wenbo Ma, Tolessa Muleta Daba, Vladimir Ishmetov, Kai Kang, Baofeng Yang, Zhenwei Pa. Corrigendum to: iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. Acta biochimica et biophysica Sinica. vol 53. issue 12. 2021-12-10. PMID:33336692. |
corrigendum to: iaspp protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. |
2021-12-10 |
2023-08-13 |
Not clear |
| Patrizia Malkomes, Ilaria Lunger, Elsie Oppermann, Khalil Abou-El-Ardat, Thomas Oellerich, Stefan Günther, Can Canbulat, Sabrina Bothur, Frank Schnütgen, Weijia Yu, Susanne Wingert, Nadine Haetscher, Claudia Catapano, Marina S Dietz, Mike Heilemann, Hans-Michael Kvasnicka, Katharina Holzer, Hubert Serve, Wolf Otto Bechstein, Michael A Riege. Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53. Oncogene. vol 40. issue 25. 2021-12-10. PMID:34103685. |
transcriptomic and protein-protein interaction analyses applying various methods including super-resolution and time-lapse microscopy showed that tgm2 directly binds to the tumor suppressor p53, leading to its inactivation and escape of apoptosis induction.we demonstrate here that tgm2 is an essential survival factor in crc, highlighting the therapeutic potential of tgm2 inhibitors in crc patients with high tgm2 expression. |
2021-12-10 |
2023-08-13 |
human |
| Yi Liu, Jing Guo, June Zhang, Yunyun Deng, Guanghua Xiong, Jianpin Fu, Lili Wei, Huiqiang L. Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). vol 242. 2021-12-10. PMID:34856462. |
the results of western blotting analysis showed that cga inhibited cell apoptosis by increasing the levels of bcl2 apoptosis regulator and decreasing the levels of bcl2 associated x (bax), apoptosis regulator and tumor protein p53. |
2021-12-10 |
2023-08-13 |
cat |
| Adam Neal, Tiffany Lai, Tanya Singh, Neela Rahseparian, Tristan Grogan, David Elashoff, Peter Scott, Matteo Pellegrini, Sanaz Memarzade. Combining ReACp53 with Carboplatin to Target High-Grade Serous Ovarian Cancers. Cancers. vol 13. issue 23. 2021-12-10. PMID:34885017. |
as p53 regulates apoptosis, combining reacp53 with carboplatin represents a logical therapeutic strategy. |
2021-12-10 |
2023-08-13 |
mouse |
| Chih-Chiang Chien, Ming-Shun Wu, Shih-Wei Chou, Ganbolor Jargalsaikhan, Yen-Chou Che. Roles of reactive oxygen species, mitochondrial membrane potential, and p53 in evodiamine-induced apoptosis and G2/M arrest of human anaplastic thyroid carcinoma cells. Chinese medicine. vol 16. issue 1. 2021-12-10. PMID:34886886. |
roles of reactive oxygen species, mitochondrial membrane potential, and p53 in evodiamine-induced apoptosis and g2/m arrest of human anaplastic thyroid carcinoma cells. |
2021-12-10 |
2023-08-13 |
human |
| Nina Richartz, Wojciech Pietka, Karin M Gilljam, Seham Skah, Bjorn S Skalhegg, Sampada Bhagwat, Elin Hallan Naderi, Ellen Ruud, Heidi Kiil Blomhof. cAMP-mediated autophagy promotes cell survival via ROS-induced activation of PARP1: Implications for treatment of acute lymphoblastic leukemia. Molecular cancer research : MCR. 2021-12-09. PMID:34880123. |
we have previously shown that camp-activating factors present in the bone marrow render all cells less sensitive to dna damage-induced apoptosis, by enhancing autophagy and suppressing p53. |
2021-12-09 |
2023-08-13 |
mouse |
| Joo-Hui Han, Kyung-Sun Heo, Chang-Seon Myun. Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) accelerates vascular remodelling via p53 and JAK2-STAT3 regulation in vascular smooth muscle cells. British journal of pharmacology. vol 178. issue 22. 2021-12-08. PMID:34289085. |
cytokine-induced apoptosis inhibitor 1 (ciapin1) accelerates vascular remodelling via p53 and jak2-stat3 regulation in vascular smooth muscle cells. |
2021-12-08 |
2023-08-13 |
Not clear |
| Jayanthi P Gudikote, Tina Cascone, Alissa Poteete, Piyada Sitthideatphaiboon, Qiuyu Wu, Naoto Morikawa, Fahao Zhang, Shaohua Peng, Pan Tong, Lerong Li, Li Shen, Monique Nilsson, Phillip Jones, Erik P Sulman, Jing Wang, Jean-Christophe Bourdon, Faye M Johnson, John V Heymac. Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers. The Journal of biological chemistry. vol 297. issue 5. 2021-12-08. PMID:34481841. |
consistent with p53 pathway activation, nmd inhibition induces tumor suppressive activities such as apoptosis, reduced cell viability, and enhanced tumor radiosensitivity, in a relatively p53-dependent manner. |
2021-12-08 |
2023-08-13 |
Not clear |
| Heron F V Torquato, Manoel Trindade Rodrigues Junior, Cauê Santos Lima, Roberto Theodoro de Araujo Júnior, Fernanda Talhati, Dhebora Albuquerque Dias, Giselle Zenker Justo, Alice Teixeira Ferreira, Ronaldo Aloise Pilli, Edgar J Paredes-Gamer. A canthin-6-one derivative induces cell death by apoptosis/necroptosis-like with DNA damage in acute myeloid cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 145. 2021-12-08. PMID:34808555. |
our results identify reactive oxygen species production, mitochondrial depolarization, annexin v-fitc/7-aad double staining, caspase cleave and upregulation of mitochondria-dependent apoptosis proteins (bax, bim, bik, puma and phosphorylation of p53) for both cell lineages. |
2021-12-08 |
2023-08-13 |
Not clear |
| Gustavo Martínez-Noël, Patricia Szajner, Rebecca E Kramer, Kathleen A Boyland, Asma Sheikh, Jennifer A Smith, Peter M Howle. Identification of microRNAs that stabilize p53 in HPV-positive cancer cells. Journal of virology. 2021-12-08. PMID:34878887. |
inhibition of the hrhpv e6-mediated ubiquitylation of p53 through the e6ap ubiquitin ligase results in the stabilization of p53, leading to cellular apoptosis. |
2021-12-08 |
2023-08-13 |
human |
| Dan Luo, Chune Yu, Jing Yu, Chao Su, Shun Li, Peng Lian. p53-mediated G1 arrest requires the induction of both p21 and Killin in human colon cancer cells. Cell cycle (Georgetown, Tex.). 2021-12-08. PMID:34878965. |
the main biological function of the tumor suppressor p53 is to control cell cycle arrest and apoptosis. |
2021-12-08 |
2023-08-13 |
human |
| Shruthi Kanthaje, Nandakishore Baikunje, Irfan Kandal, Chandrahas Koumar Ratnacara. Repertoires of MicroRNA-30 family as gate-keepers in lung cancer. Frontiers in bioscience (Scholar edition). vol 13. issue 2. 2021-12-08. PMID:34879467. |
they regulate several imperative signalling pathways like p53, pi3k/akt, resulting in the modulation of key carcinogenic events involving cell proliferation, apoptosis, metastasis, epithelial-mesenchymal transition, and drug resistance. |
2021-12-08 |
2023-08-13 |
Not clear |
| Jiadong Chen, Lian Kang, Junke Wang, Yuhao Wu, Lindong Han, Xiangqin Zheng, Yuexin Wei, Tianxin Zhao, Lianju Shen, Chunlan Long, Guanghui Wei, Shengde W. Weighted gene coexpression network analysis reveals ESR1, FLNA and Furin as hub genes for DEHP-induced prepubertal testicular injury. Reproductive toxicology (Elmsford, N.Y.). vol 106. 2021-12-07. PMID:34718101. |
furthermore, kyoto encyclopedia of genes and genomes (kegg) pathway analyses showed enrichment mainly in mapk signaling pathways, p53 signaling pathways, hif-1 signaling pathways, protein processing in the endoplasmic reticulum, apoptosis, the cell cycle, rna degradation, etc. |
2021-12-07 |
2023-08-13 |
Not clear |
| Jieli Pan, Meiya Li, Fenglin Yu, Feiye Zhu, Linyan Wang, Dandan Ning, Xiaoli Hou, Fusheng Jian. Up-Regulation of p53/miR-628-3p Pathway, a Novel Mechanism of Shikonin on Inhibiting Proliferation and Inducing Apoptosis of A549 and PC-9 Non-Small Cell Lung Cancer Cell Lines. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867391. |
considering the regulatory effect of shk on p53, we speculate that shk may inhibit the growth and induce apoptosis of nsclc cells by up-regulating mir-628-3p. |
2021-12-07 |
2023-08-13 |
Not clear |
| Jieli Pan, Meiya Li, Fenglin Yu, Feiye Zhu, Linyan Wang, Dandan Ning, Xiaoli Hou, Fusheng Jian. Up-Regulation of p53/miR-628-3p Pathway, a Novel Mechanism of Shikonin on Inhibiting Proliferation and Inducing Apoptosis of A549 and PC-9 Non-Small Cell Lung Cancer Cell Lines. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867391. |
overexpression of p53 or mir-628-3p can inhibit the growth and promote apoptosis of a549 and pc-9 cells, while silencing p53 or mir-628-3p has the opposite effect. |
2021-12-07 |
2023-08-13 |
Not clear |
| Jieli Pan, Meiya Li, Fenglin Yu, Feiye Zhu, Linyan Wang, Dandan Ning, Xiaoli Hou, Fusheng Jian. Up-Regulation of p53/miR-628-3p Pathway, a Novel Mechanism of Shikonin on Inhibiting Proliferation and Inducing Apoptosis of A549 and PC-9 Non-Small Cell Lung Cancer Cell Lines. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867391. |
gene knockdown for p53 or mir-628-3p confirmed that shk inhibits the growth and induces apoptosis of a549 and pc-9 cells at least partly by up-regulating p53/mir-628-3p signaling pathway. |
2021-12-07 |
2023-08-13 |
Not clear |
| Danrui Cui, Ruirui Qu, Dian Liu, Xiufang Xiong, Tingbo Liang, Yongchao Zha. The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses. Frontiers in cell and developmental biology. vol 9. 2021-12-07. PMID:34869377. |
the tumor suppressor p53 is activated upon multiple cellular stresses, including dna damage, oncogene activation, ribosomal stress, and hypoxia, to induce cell cycle arrest, apoptosis, and senescence. |
2021-12-07 |
2023-08-13 |
human |
| Arijit Chakraborty, Vertika Singh, Kiran Singh, Singh Rajende. Excess iodine impairs spermatogenesis by inducing oxidative stress and perturbing the blood testis barrier. Reproductive toxicology (Elmsford, N.Y.). vol 96. 2021-12-06. PMID:32593569. |
further investigations showed increased apoptosis evidenced by reduced expression of anti-apoptotic (bcl-2, survivin), increased expression of pro-apoptotic (bid, bax) markers, and increased expression of p53 and other modulators/effectors of apoptosis (cytochrome c, cleaved parp, caspase3 and caspase9). |
2021-12-06 |
2023-08-13 |
rat |
| Jisheng Nie, Yu Zhang, Lijun Ning, Zhiwei Yan, Lei Duan, Huaxing Xi, Qiao Niu, Qunwei Zhan. Phosphorylation of p53 by Cdk5 contributes to benzo[a]pyrene-induced neuronal apoptosis. Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34529316. |
phosphorylation of p53 by cdk5 contributes to benzo[a]pyrene-induced neuronal apoptosis. |
2021-12-06 |
2023-08-13 |
rat |