| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco J Sánchez-Rivera, Jeremy Ryan, Yadira M Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M Feldser, Michael T Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jack. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 23. 2021-11-30. PMID:34074758. |
we hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would lead to survival and cell cycle arrest. |
2021-11-30 |
2023-08-13 |
mouse |
| Francisco J Sánchez-Rivera, Jeremy Ryan, Yadira M Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M Feldser, Michael T Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jack. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 23. 2021-11-30. PMID:34074758. |
using a panel of kras-driven, p53 restorable cell lines derived from genetically engineered mouse models of lung adenocarcinoma and sarcoma (both of which undergo cell cycle arrest upon p53 restoration), as well as lymphoma (which instead undergo apoptosis), we show that the level of mitochondrial apoptotic priming is a critical determinant of p53 reactivation outcome. |
2021-11-30 |
2023-08-13 |
mouse |
| Francisco J Sánchez-Rivera, Jeremy Ryan, Yadira M Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M Feldser, Michael T Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jack. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 23. 2021-11-30. PMID:34074758. |
cells with high initial priming (e.g., lymphomas) lacked sufficient reserve antiapoptotic capacity and underwent apoptosis after p53 restoration. |
2021-11-30 |
2023-08-13 |
mouse |
| Francisco J Sánchez-Rivera, Jeremy Ryan, Yadira M Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M Feldser, Michael T Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jack. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 23. 2021-11-30. PMID:34074758. |
when primed by inhibition of their antiapoptotic proteins using genetic (bcl-2 or bcl-xl deletion or bad overexpression) or pharmacologic (navitoclax) means, apoptosis resulted upon p53 restoration in vitro and in vivo. |
2021-11-30 |
2023-08-13 |
mouse |
| Francyelli Mello-Andrade, Adriana P M Guedes, Wanessa C Pires, Vivianne S Velozo-Sá, Kezia A Delmond, Davi Mendes, Matheus S Molina, Larissa Matuda, Maria Alice Montes de Sousa, Paulo Melo-Reis, Clever C Gomes, Carlos Henrique Castro, Márcio Aurélio P Almeida, Carlos F M Menck, Alzir A Batista, Ravshan Burikhanov, Vivek M Rangnekar, Elisângela Silveira-Lacerd. Ru(II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis. Journal of inorganic biochemistry. vol 226. 2021-11-30. PMID:34655962. |
the study also demonstrated that the rumet and rutrp complexes induce cell cycle blockage and apoptosis of mda-mb-231 cells, as evidenced by an increase in the number of annexin v-positive cells, p53 phosphorylation, caspase 3 activation, and poly(adp-ribose) polymerase cleavage. |
2021-11-30 |
2023-08-13 |
human |
| Baskaran Stephen Inbaraj, Leng-Huei Hua, Bing-Huei Che. Comparative Study on Inhibition of Pancreatic Cancer Cells by Resveratrol Gold Nanoparticles and a Resveratrol Nanoemulsion Prepared from Grape Skin. Pharmaceutics. vol 13. issue 11. 2021-11-30. PMID:34834286. |
western blot analysis implied that both can down-regulate expressions of cyclin a, cyclin b, cdk1, and cdk2 and up-regulate expressions of p53 and p21, accompanied by enhancing cytochrome c expression, decreasing bcl-2 expression, increasing bax expression, and leading to the elevation of caspase-8, caspase-9, and caspase-3 activities for cell apoptosis execution. |
2021-11-30 |
2023-08-13 |
Not clear |
| Yiqun Li, Yuding Fan, Yong Zhou, Nan Jiang, Mingyang Xue, Yan Meng, Wenzhi Liu, Jingjing Zhang, Ge Lin, Lingbing Zen. Bcl-xL Reduces Chinese Giant Salamander Iridovirus-Induced Mitochondrial Apoptosis by Interacting with Bak and Inhibiting the p53 Pathway. Viruses. vol 13. issue 11. 2021-11-30. PMID:34835028. |
bcl-xl reduces chinese giant salamander iridovirus-induced mitochondrial apoptosis by interacting with bak and inhibiting the p53 pathway. |
2021-11-30 |
2023-08-13 |
Not clear |
| Qiang Zhou, Jianxia Yuan, Yi Liu, Yayun W. Cisatracurium besilate enhances the TRAIL-induced apoptosis of gastric cancer cells via p53 signaling. Bioengineered. vol 12. issue 2. 2021-11-30. PMID:34845969. |
cisatracurium besilate enhances the trail-induced apoptosis of gastric cancer cells via p53 signaling. |
2021-11-30 |
2023-08-13 |
Not clear |
| Qiang Zhou, Jianxia Yuan, Yi Liu, Yayun W. Cisatracurium besilate enhances the TRAIL-induced apoptosis of gastric cancer cells via p53 signaling. Bioengineered. vol 12. issue 2. 2021-11-30. PMID:34845969. |
furthermore, the expression levels of p53 and p53 upregulated modulator of apoptosis (puma) were measured by western blotting to determine the effect of cisatracurium besilate on p53/puma signaling. |
2021-11-30 |
2023-08-13 |
Not clear |
| Qiang Zhou, Jianxia Yuan, Yi Liu, Yayun W. Cisatracurium besilate enhances the TRAIL-induced apoptosis of gastric cancer cells via p53 signaling. Bioengineered. vol 12. issue 2. 2021-11-30. PMID:34845969. |
after co-treatment with p53 inhibitor, cisatracurium besilate and pifithrin-α/trail, cell apoptosis was detected. |
2021-11-30 |
2023-08-13 |
Not clear |
| Qiang Zhou, Jianxia Yuan, Yi Liu, Yayun W. Cisatracurium besilate enhances the TRAIL-induced apoptosis of gastric cancer cells via p53 signaling. Bioengineered. vol 12. issue 2. 2021-11-30. PMID:34845969. |
therefore, the present study suggested that cisatracurium besilate enhanced the trail-induced apoptosis of gc cells via p53 signaling, and the synergistic effects of cisatracurium besilate and trail may achieve maximal therapeutic efficacy in gc management. |
2021-11-30 |
2023-08-13 |
Not clear |
| Amir Khodavirdipour, Motahareh Piri, Sarvin Jabbari, Shiva Keshavarzi, Reza Safaralizadeh, Mohammad Yousef Alikhan. Apoptosis Detection Methods in Diagnosis of Cancer and Their Potential Role in Treatment: Advantages and Disadvantages: a Review. Journal of gastrointestinal cancer. vol 52. issue 2. 2021-11-29. PMID:33392962. |
one famous example can be p53's downregulation, which is a tumor suppressor gene, which consequently can cause a decrease in apoptosis rate and intense tumor growth and progression and development and inactivation of 53; it can be extended to many cancers in human. |
2021-11-29 |
2023-08-13 |
human |
| Fatemeh Asgharzadeh, Shiva Roshan-Milani, Amin Abdollahzade Fard, Kimia Ahmadi, Ehsan Saboory, Masoumeh Pourjabali, Leila Chodari, Mohammad Amin. The protective effect of zinc on morphine-induced testicular toxicity via p53 and Akt pathways: An in vitro and in vivo approach. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 67. 2021-11-29. PMID:33984544. |
therefore, the purpose of this study was to investigate the effect of morphine (alone and co-administered with zinc) on cell viability and apoptosis of the testicular (sertoli) cells as well as the tumor suppressor p53 and phosphorylated-protein kinase b (p-akt) protein levels in both in vitro and in vivo models. |
2021-11-29 |
2023-08-13 |
Not clear |
| Apurva Patel, Mital Bhatt, Anjali Soni, Preeti Sharm. Identification of steroidal saponins from Tribulus terrestris and their in silico docking studies. Journal of cellular biochemistry. vol 122. issue 11. 2021-11-29. PMID:34337761. |
docking studies revealed the high binding affinity of nuatigenin at significant sites with apoptotic proteins bcl-2, bax, caspase-3, caspase-8, p53 and apoptosis inducing factor along with cell surface receptors estrogen receptor, projesterone receptor, epidermal growth factor receptor, and human epidermal growth factor receptor-2. |
2021-11-29 |
2023-08-13 |
human |
| Claude J Rogers, Espoir M Kyubwa, Agnes I Lukaszewicz, Mark A Starbird, Michelle Nguyen, Ben T Copeland, Jason Yamada-Hanff, Naresh Meno. Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation. Radiation research. vol 196. issue 5. 2021-11-29. PMID:34525208. |
a common signature of radiation-induced injury was observed in both models: apoptosis, dna damage repair, p53 signaling, pro-inflammatory response, and growth factor/cytokine signaling pathways were predicted to be disrupted. |
2021-11-29 |
2023-08-13 |
human |
| Sumera Zaib, Aqsa Hayyat, Naba Ali, Asma Gul, Muhammad Naveed, Imtiaz Kha. Role of Mitochondrial Membrane Potential and Lactate Dehydrogenase A in Apoptosis. Anti-cancer agents in medicinal chemistry. 2021-11-26. PMID:34825878. |
apoptosis mainly occurs due to p53 protein that allows the abnormal cells to proliferate. |
2021-11-26 |
2023-08-13 |
Not clear |
| Rasha R Radwan, Hussein E Al. Radiation-synthesis of chitosan/poly (acrylic acid) nanogel for improving the antitumor potential of rutin in hepatocellular carcinoma. Drug delivery and translational research. vol 11. issue 1. 2021-11-25. PMID:32488816. |
the following parameters were measured: aspartate and alanine aminotransferase, alkaline phosphatase, gamma glutamyltransferase, and total bilirubin as liver function test; vascular endothelial growth factor as an angiogenesis marker; α-fetoprotein as a tumor marker; and p53, caspase-3, bax, and bcl-2 as apoptosis markers. |
2021-11-25 |
2023-08-13 |
rat |
| J Y Lee, H M Lim, C M Lee, S-H Park, M J Na. Indole-3-carbinol inhibits the proliferation of colorectal carcinoma LoVo cells through activation of the apoptotic signaling pathway. Human & experimental toxicology. vol 40. issue 12. 2021-11-25. PMID:34085558. |
these results indicate that i3c induces apoptosis in lovo cells by upregulating p53, leading to the activation of bax and caspases. |
2021-11-25 |
2023-08-13 |
human |
| Jeerati Prompipak, Thanaset Senawong, Banchob Sripa, Albert J Ketterman, Suppawit Utaiwat, Khanutsanan Woranam, Jarckrit Jeeunngoi, Gulsiri Senawon. Anticancer effects of the combined Thai noni juice ethanolic extracts and 5-fluorouracil against cholangiocarcinoma cells in vitro and in vivo. Scientific reports. vol 11. issue 1. 2021-11-25. PMID:34290264. |
the mechanism underlying a combination treatment was apoptosis induction through an activation of p53 and bax proteins. |
2021-11-25 |
2023-08-13 |
mouse |
| Ephrath Tesfaye, Elena Martinez-Terroba, Jordan Bendor, Lauren Winkler, Christiane Olivero, Kevin Chen, David M Feldser, Jesse R Zamudio, Nadya Dimitrov. The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 31. 2021-11-25. PMID:34326251. |
the p53 pathway is a universal tumor suppressor mechanism that limits tumor progression by triggering apoptosis or permanent cell cycle arrest, called senescence. |
2021-11-25 |
2023-08-13 |
Not clear |