| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jisheng Nie, Yu Zhang, Lijun Ning, Zhiwei Yan, Lei Duan, Huaxing Xi, Qiao Niu, Qunwei Zhan. Phosphorylation of p53 by Cdk5 contributes to benzo[a]pyrene-induced neuronal apoptosis. Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34529316. |
in the present study, we explored the potential involvement of p53 phosphorylation by cdk5 in b[a]p-induced neuronal apoptosis at both in vitro and in vivo settings. |
2021-12-06 |
2023-08-13 |
rat |
| Jisheng Nie, Yu Zhang, Lijun Ning, Zhiwei Yan, Lei Duan, Huaxing Xi, Qiao Niu, Qunwei Zhan. Phosphorylation of p53 by Cdk5 contributes to benzo[a]pyrene-induced neuronal apoptosis. Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34529316. |
the results showed that pretreatment of neurons with roscovitine partially rescued cells from b[a]p-induced apoptosis, and alleviated b[a]p-induced upregulation of phosphorylated p53 at ser15. |
2021-12-06 |
2023-08-13 |
rat |
| Ali Pourgholi, Mehdi Dadashpour, Akram Mousapour, Akram Firouzi Amandi, Nosratollah Zargham. Anticancer Potential of Silibinin Loaded Polymeric Nanoparticles against Breast Cancer Cells: Insight into the Apoptotic Genes Targets. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 8. 2021-12-04. PMID:34452574. |
moreover, the results demonstrated that sil-nps could induce apoptosis in breast cancer cells by upregulation of caspase-3, caspase-7, p53 and bax, along with bcl-2, htert, survivin and cyclin d1 down regulation. |
2021-12-04 |
2023-08-13 |
Not clear |
| Taiki Hayasaka, Naofumi Takehara, Tatsuya Aonuma, Kohei Kano, Kiwamu Horiuchi, Naoki Nakagawa, Hiroki Tanaka, Jun-Ichi Kawabe, Naoyuki Haseb. Sarcopenia-derived exosomal micro-RNA 16-5p disturbs cardio-repair via a pro-apoptotic mechanism in myocardial infarction in mice. Scientific reports. vol 11. issue 1. 2021-12-03. PMID:34580402. |
additionally, in neonatal rat ventricular myocytes (nrvms) cultured in vitro under hypoxic conditions in the presence of a mir-16-5p mimic, we observed increased apoptosis through p53 and caspase3 upregulation, and also clarified that autophagosomes were decreased in nrvms via sesn1 transcript interference-mediated mtor activation. |
2021-12-03 |
2023-08-13 |
mouse |
| Teruyuki Kobayashi, Tomoki Makino, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Eiichi Morii, Hidetoshi Eguchi, Yuichiro Dok. APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation. British journal of cancer. vol 125. issue 11. 2021-12-03. PMID:34599296. |
apr-246 induces apoptosis by restoring transcriptional ability of mutant p53, and may be a promising therapeutic agent to overcome chemo-resistance in escc. |
2021-12-03 |
2023-08-13 |
Not clear |
| Aijiao Zhang, Yucheng Yang, Liang Zeng, Zehui Zhao, Yinyin Zhou, Zhuo Yang, Qingliang Liao, Shu Xiao, Haitao Ma, Jun Li, Fan Mao, Yanping Qin, Yuehuan Zhang, Yang Zhang, Ziniu Yu, Zhiming Xian. MDM2 is involved in the regulation of p53 expression in the immune response of oyster Crassostrea hongkongensis. Developmental and comparative immunology. vol 128. 2021-12-03. PMID:34798199. |
mdm2 (mouse double-minute) and p53 form a negative feedback loop and play a prominent role in preventing the induction of uncontrolled apoptosis. |
2021-12-03 |
2023-08-13 |
mouse |
| Nan Liu, Hongli Yang, Liangui Yan. Dual roles of SIRT1 in the BAX switch through the P53 module: A mathematical modeling study. Computational and structural biotechnology journal. vol 19. 2021-12-03. PMID:34849192. |
it has been found that sirt1 is involved in apoptosis by regulating the activity and intracellular location of p53. |
2021-12-03 |
2023-08-13 |
Not clear |
| Yan Li, Chen Wang, Hong-Min Xi, Wen-Ting Li, Ya-Jun Liu, Shan Feng, Yi-Jing Chu, Yi-Hao Wan. Chorionic villus-derived mesenchymal stem cells induce E3 ligase TRIM72 expression and regulate cell behaviors through ubiquitination of p53 in trophoblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 12. 2021-12-02. PMID:34788479. |
subsequent study confirms that trm72 can directly interact with p53 and promote p53 ubiquitination and proteasomal degradation, reducing apoptosis rate and elevating proliferation and migration in trophoblasts. |
2021-12-02 |
2023-08-13 |
Not clear |
| Heri Suroto, Asyumaredha Asriel, Brigita De Vega, Steven K Samij. Early and late apoptosis protein expression (Bcl-2, BAX and p53) in traumatic brachial plexus injury. Journal of musculoskeletal & neuronal interactions. vol 21. issue 4. 2021-12-02. PMID:34854392. |
early and late apoptosis protein expression (bcl-2, bax and p53) in traumatic brachial plexus injury. |
2021-12-02 |
2023-08-13 |
Not clear |
| Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Ga. p53: A Double-Edged Sword in Tumor Ferroptosis. Pharmacological research. 2021-12-02. PMID:34856333. |
in addition to its effects on apoptosis, autophagy, and cell cycle, p53, through the way of transcription dependent or independent two-way, also regulates the biological processes of tumor cell sensitivity to ferroptosis, including the metabolism of amino acids, nicotinamide adenine dinucleotide phosphate, and lipid peroxidation, as well as the biosynthesis of glutathione, phospholipids, nadph and coenzyme q10.as reviewed here, we summarized the metabolic network of p53 and its signaling pathway in regulating ferroptosis and elucidated possible factors and potential clinical application of p53 regulating ferroptosis. |
2021-12-02 |
2023-08-13 |
Not clear |
| Nan Su, Pingping Wang, Yan L. Role of Wnt/β-catenin pathway in inducing autophagy and apoptosis in multiple myeloma cells. Oncology letters. vol 12. issue 6. 2021-12-01. PMID:28105169. |
in addition, there was an increase in the rate of apoptosis of mm cells following β-catenin silencing, accompanied by increased protein expression of phosphorylated p53, active caspase-3 and b-cell lymphoma (bcl)-2-associated x protein, and decreased protein expression of bcl-2. |
2021-12-01 |
2023-08-13 |
Not clear |
| Man-Li Li, You-Zhi Xu, Wen-Jie Lu, Yong-Huai Li, Shi-Sheng Tan, Hong-Jun Lin, Tian-Ming Wu, Yan Li, Si-Ying Wang, Ying-Lan Zha. Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis. Oncology letters. vol 15. issue 3. 2021-12-01. PMID:29435010. |
the inhibition of autophagy by cq enhanced sunitinib-induced apoptosis, which was characterized by the activation of caspase-3, caspase-9, bcl-2 and p53. |
2021-12-01 |
2023-08-13 |
Not clear |
| Antonella Muscella, Erika Stefàno, Luigi De Bellis, Eliana Nutricati, Carmine Negro, Santo Marsigliant. Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells. Annals of the New York Academy of Sciences. vol 1500. issue 1. 2021-12-01. PMID:33960434. |
the extract reduced osteosarcoma cell viability mainly by way of apoptosis, as we observed (1) upregulation of gene and protein expression of p53, cyclin-dependent kinase inhibitors p21 |
2021-12-01 |
2023-08-13 |
Not clear |
| Dina Alzhanova, James O Meyo, Angelica Juarez, Dirk P Dittme. The ORF45 Protein of Kaposi Sarcoma-Associated Herpesvirus Is an Inhibitor of p53 Signaling during Viral Reactivation. Journal of virology. vol 95. issue 23. 2021-12-01. PMID:34523970. |
to prevent premature apoptosis and support its replication cycle, kshv expresses a series of open reading frames (orfs) that regulate signaling by the p53 tumor suppressor protein. |
2021-12-01 |
2023-08-13 |
Not clear |
| Christina M Termini, Amara Pang, Tiancheng Fang, Martina Roos, Vivian Y Chang, Yurun Zhang, Nicollette J Setiawan, Lia Signaevskaia, Michelle Li, Mindy M Kim, Orel Tabibi, Paulina K Lin, Joshua P Sasine, Avradip Chatterjee, Ramachandran Murali, Heather A Himburg, John P Chut. Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution. Nature communications. vol 12. issue 1. 2021-12-01. PMID:34848712. |
we report that bm vascular endothelial cells secrete semaphorin 3 a (sema3a) in response to myeloablation and sema3a induces p53 - mediated apoptosis in bm endothelial cells via signaling through its receptor, neuropilin 1 (nrp1), and activation of cyclin dependent kinase 5. |
2021-12-01 |
2023-08-13 |
mouse |
| Danyan Chen, Zhaonan Shen, Xi Cheng, Qi Wang, Junlin Zhou, Fang Ren, Yue Sun, Hongman Wang, Rongxi Huan. Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression. Bioengineered. vol 12. issue 1. 2021-11-30. PMID:34027794. |
homeobox a5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing aldo-keto reductase family 1 member b10 expression. |
2021-11-30 |
2023-08-13 |
Not clear |
| Danyan Chen, Zhaonan Shen, Xi Cheng, Qi Wang, Junlin Zhou, Fang Ren, Yue Sun, Hongman Wang, Rongxi Huan. Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression. Bioengineered. vol 12. issue 1. 2021-11-30. PMID:34027794. |
then, nci-h295r cells were overexpressed to detect the alteration of cell proliferation, apoptosis and the expression of p53 and p21 proteins. |
2021-11-30 |
2023-08-13 |
Not clear |
| Danyan Chen, Zhaonan Shen, Xi Cheng, Qi Wang, Junlin Zhou, Fang Ren, Yue Sun, Hongman Wang, Rongxi Huan. Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression. Bioengineered. vol 12. issue 1. 2021-11-30. PMID:34027794. |
akr1b10 significantly inhibited cell viability, colony formation and expression of ki67 and pcna, but promoted apoptosis and expression of p53 and p21 in nci-h295r cells. |
2021-11-30 |
2023-08-13 |
Not clear |
| Danyan Chen, Zhaonan Shen, Xi Cheng, Qi Wang, Junlin Zhou, Fang Ren, Yue Sun, Hongman Wang, Rongxi Huan. Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression. Bioengineered. vol 12. issue 1. 2021-11-30. PMID:34027794. |
in conclusion, hoxa5 could bind to akr1b10 promotor to increase its expression, activate p53 signaling, thereby inhibiting proliferation and promoting apoptosis of acc cells. |
2021-11-30 |
2023-08-13 |
Not clear |
| Francisco J Sánchez-Rivera, Jeremy Ryan, Yadira M Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M Feldser, Michael T Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jack. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 23. 2021-11-30. PMID:34074758. |
reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. |
2021-11-30 |
2023-08-13 |
mouse |