| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Girija Pawge, Gopal L Khati. p53 regulated senescence mechanism and role of its modulators in age-related disorders. Biochemical pharmacology. vol 190. 2021-11-17. PMID:34118220. |
p53 also plays a role in apoptosis and negative regulation of sasp. |
2021-11-17 |
2023-08-13 |
Not clear |
| Girija Pawge, Gopal L Khati. p53 regulated senescence mechanism and role of its modulators in age-related disorders. Biochemical pharmacology. vol 190. 2021-11-17. PMID:34118220. |
few upstream targets like foxo4, mdm2, mdm4, usp7 control the availability of p53 for apoptosis. |
2021-11-17 |
2023-08-13 |
Not clear |
| Ying Ding, Dao-Yang Zhou, Hong Yu, Tao Zhu, Feng Guo, Yang He, Xiu-Liu Guo, Yong-Jun Lin, Yu-Jiao Liu, Yun-Song Y. Upregulation of lncRNA NONRATG019935.2 suppresses the p53-mediated apoptosis of renal tubular epithelial cells in septic acute kidney injury. Cell death & disease. vol 12. issue 8. 2021-11-17. PMID:34719669. |
the overexpression of 9935 suppressed cell apoptosis and p53 protein level in lps-treated nrk-52e cells, and retarded septic aki development in the rat model of septic aki. |
2021-11-17 |
2023-08-13 |
human |
| Guoxi Zhang, Junrong Zou, Jinglin Shi, Biao Qian, Kaiyang Qiu, Quanliang Liu, Tianpeng Xie, Zhihua He, Hui Xu, Yunfeng Liao, Yuting Wu, Yanmin Li, Guancheng Xiao, Yuanhu Yuan, Rihai Xiao, Gengqing Wu, Xiaofeng Zo. Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753901. |
uba2 knockdown inhibited ccrcc cell growth, promoted apoptosis in vitro and in vivo, and decreased the abundance of a p53 mutant, c-myc, and key enzymes of the sumo modification system. |
2021-11-17 |
2023-08-13 |
Not clear |
| Guoxi Zhang, Junrong Zou, Jinglin Shi, Biao Qian, Kaiyang Qiu, Quanliang Liu, Tianpeng Xie, Zhihua He, Hui Xu, Yunfeng Liao, Yuting Wu, Yanmin Li, Guancheng Xiao, Yuanhu Yuan, Rihai Xiao, Gengqing Wu, Xiaofeng Zo. Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753901. |
overexpression of the p53 mutant or c-myc alleviated the effects of uba2 knockdown on ccrcc cell proliferation and apoptosis. |
2021-11-17 |
2023-08-13 |
Not clear |
| Tapas Patra, Keith Meyer, Ratna B Ray, Tatsuo Kanda, Ranjit Ra. Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34759291. |
mechanistic insights indicate that a combination of azd5363 and azd8055 activated foxo3a to induce bim-associated apoptosis in p53 mutated hcc cells, whereas cells retaining functional p53 enhanced bax. |
2021-11-17 |
2023-08-13 |
Not clear |
| Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Young-Seuk Bae, Sang Hyun Kim, Seung-Soon Im, Ji Hae Seo, Kyoung-Jin Min, Taeg Kyu Kwo. Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo. Oncogene. 2021-11-17. PMID:34785775. |
our results demonstrate that cathepsin k inhibition enhances oxaliplatin-induced apoptosis by increasing otub1 phosphorylation via ck2 activation, thereby promoting p53 stabilization, and hence upregulating bax. |
2021-11-17 |
2023-08-13 |
mouse |
| Yuta Kanamori, Alessia Finotti, Laura Di Magno, Gianluca Canettieri, Tomoaki Tahara, Fabio Timeus, Antonio Greco, Paola Tirassa, Jessica Gasparello, Pasquale Fino, Carlo Maria Di Liegro, Patrizia Proia, Gabriella Schiera, Italia Di Liegro, Roberto Gambari, Enzo Agostinell. Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5. Cells. vol 10. issue 8. 2021-11-16. PMID:34440719. |
enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and mir-34a in both neuroblastoma cells, sjnkp and the n-myc-amplified form imr5. |
2021-11-16 |
2023-08-13 |
Not clear |
| Shuyu Mei, Shuang Ge, Jun Wang, Hailing Li, Xiaotong Jing, Ke Liang, Xiaoying Zhang, Chaoshuai Xue, Cuijuan Zhang, Tingguo Zhan. PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways. The journal of pathology. Clinical research. vol 7. issue 2. 2021-11-15. PMID:33416213. |
knockdown of prmt5 significantly inhibited the growth and migration ability of eac cells and promoted their apoptosis by regulating cyclin d1, c-myc, p53, and bcl2 proteins. |
2021-11-15 |
2023-08-13 |
Not clear |
| Yuan Yang, Chunyan Liu, Tingting Xie, Dapeng Wang, Xiong Chen, Lu Ma, Aihua Zhan. Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning. Human & experimental toxicology. vol 40. issue 7. 2021-11-15. PMID:33501840. |
abnormal apoptosis is closely related to liver-related diseases, and p53 is one of the important hallmark proteins in apoptosis progression. |
2021-11-15 |
2023-08-13 |
rat |
| Yuan Yang, Chunyan Liu, Tingting Xie, Dapeng Wang, Xiong Chen, Lu Ma, Aihua Zhan. Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning. Human & experimental toxicology. vol 40. issue 7. 2021-11-15. PMID:33501840. |
this study was to investigate whether arsenic poisoning-induced hepatocyte apoptosis and the underlying role of p53 signaling pathway. |
2021-11-15 |
2023-08-13 |
rat |
| Jin Wook Kang, Zhiyan Zhan, Guangzhen Ji, Youzhou Sang, Daohong Zhou, Yanxin Li, Haizhong Feng, Tao Chen. PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells. Signal transduction and targeted therapy. vol 6. issue 1. 2021-11-15. PMID:33785736. |
this finding suggests that puma (p53 upregulated modulator of apoptosis) may have a function other than regulates apoptosis. |
2021-11-15 |
2023-08-13 |
mouse |
| Chrisanta Harakandi, Lauraine Nininahazwe, Haiwei Xu, Bingrui Liu, Chenghua He, Yi-Chao Zheng, Hang Zhan. Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34474304. |
the ubiquitin-specific protease 7 (usp7)-murine double minute 2 (mdm2)-p53 network plays an important role in the regulation of p53, a tumor suppressor which plays critical roles in regulating cell growth, proliferation, cell cycle progression, apoptosis and immune response. |
2021-11-15 |
2023-08-13 |
human |
| Chrisanta Harakandi, Lauraine Nininahazwe, Haiwei Xu, Bingrui Liu, Chenghua He, Yi-Chao Zheng, Hang Zhan. Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34474304. |
the overexpression of usp7 and mdm2 in human cancers contributes to cancer initiation and progression, and their inhibition reactivates p53 signalings and causes cell cycle arrest and apoptosis. |
2021-11-15 |
2023-08-13 |
human |
| Retraction: Silencing SUMO2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. Bioscience reports. vol 41. issue 10. 2021-11-15. PMID:34612481. |
retraction: silencing sumo2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. |
2021-11-15 |
2023-08-13 |
Not clear |
| Sabrina Dallavalle, Loana Musso, Raffaella Cincinelli, Nadine Darwiche, Silvia Gervasoni, Giulio Vistoli, Mario B Guglielmi, Ilaria La Porta, Maddalena Pizzulo, Elisa Modica, Federica Prosperi, Giacomo Signorino, Fabiana Colelli, Francesco Cardile, Alessandra Fucci, Egildo Luca D'Andrea, Assunta Riccio, Claudio Pisan. Antitumor activity of novel POLA1-HDAC11 dual inhibitors. European journal of medicinal chemistry. 2021-11-13. PMID:34772529. |
mechanistically, mir002 and gem144 induced acetylation of p53, activation of p21, g1/s cell cycle arrest, and apoptosis. |
2021-11-13 |
2023-08-13 |
mouse |
| Xiaohui Niu, Kaixuan Deng, Lifen Liu, Kun Yang, Xuehai H. A statistical framework for predicting critical regions of p53-dependent enhancers. Briefings in bioinformatics. vol 22. issue 3. 2021-11-12. PMID:32392580. |
p53 is the 'guardian of the genome' and is responsible for regulating cell cycle and apoptosis. |
2021-11-12 |
2023-08-13 |
Not clear |
| Fucai Li, Shengrong Yu, Xiangyi Huang, Chaoqing Dong, Jicun Re. Studying Homo-oligomerization and Hetero-oligomerization of MDMX and MDM2 Proteins in Single Living Cells by Using In Situ Fluorescence Correlation Spectroscopy. Biochemistry. vol 60. issue 19. 2021-11-12. PMID:33870698. |
p53 acts as a key tumor suppressor by regulating cell cycle arrest, dna repair, and apoptosis, and its antitumor activity is regulated by the hetero- and homo-oligomerization of mdmx and mdm2 proteins. |
2021-11-12 |
2023-08-13 |
Not clear |
| Taojie Zhang, Wang-Dui BaSang, Weihua Chang, Shengdong Huo, Xingbin Ma, Xianghong Ju, Sijiu Yu, Sheng Cu. Dynamics of apoptosis-related gene expression during follicular development in yak. Journal of animal physiology and animal nutrition. vol 105. issue 6. 2021-11-12. PMID:33899975. |
p53, caspase-9 (casp9), bax, bcl-2 and fas play a crucial role in the ovarian mitochondrion-dependent apoptosis and death receptor pathway. |
2021-11-12 |
2023-08-13 |
Not clear |
| Taojie Zhang, Wang-Dui BaSang, Weihua Chang, Shengdong Huo, Xingbin Ma, Xianghong Ju, Sijiu Yu, Sheng Cu. Dynamics of apoptosis-related gene expression during follicular development in yak. Journal of animal physiology and animal nutrition. vol 105. issue 6. 2021-11-12. PMID:33899975. |
overall, p53 and fas play an essential role in inducing gc apoptosis, and bax, bcl-2, casp9 and p53 are involved in oviduct epithelial regeneration in yak. |
2021-11-12 |
2023-08-13 |
Not clear |