| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Rodrigues, Terezinha de Souza, Luke Coyle, Matteo Di Piazza, Bram Herpers, Sofia Ferreira, Mian Zhang, Johanna Vappiani, Daniel C Sévin, Attila Gabor, Anthony Lynch, Seung-Wook Chung, Julio Saez-Rodriguez, Danyel G J Jennen, Jos C S Kleinjans, Theo M de Ko. New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Archives of toxicology. vol 95. issue 8. 2021-11-12. PMID:34151400. |
based on analysis of the differentially expressed genes, the most prominent molecular pathways affected by 5-fu included cell cycle, p53 signalling, mitochondrial atp synthesis and apoptosis. |
2021-11-12 |
2023-08-13 |
human |
| Miaomiao Chai, Mingli Jiang, Ce Gu, Qiaohui Lu, Yi Zhou, Ziyang Jin, Yan Zhou, Wensong Ta. Osteogenically differentiated mesenchymal stem cells promote the apoptosis of human umbilical vein endothelial cells in vitro. Biotechnology and applied biochemistry. 2021-11-12. PMID:34694656. |
based on further experiments, pedf mediated the apoptosis and proliferation of huvecs through p53, bax/bcl-2, fas, and c-caspase-3. |
2021-11-12 |
2023-08-13 |
human |
| Yu-Peng Yang, Rui-Huan Qin, Jun-Jie Zhao, Xin-Yu Qi. BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation. Current medical science. vol 41. issue 2. 2021-11-11. PMID:33877544. |
it blocked cell cycle at g0/g1 phase and led to apoptosis of gc cells via upregulating p53 and p21. |
2021-11-11 |
2023-08-13 |
mouse |
| Seung Jae Hyeon, Jinyoung Park, Junsang Yoo, Su-Hyun Kim, Yu Jin Hwang, Seung-Chan Kim, Tian Liu, Hyun Soo Shim, Yunha Kim, Yakdol Cho, Jiwan Woo, Key-Sun Kim, Richard H Myers, Hannah L Ryu, Neil W Kowall, Eun Joo Song, Eun Mi Hwang, Hyemyung Seo, Junghee Lee, Hoon Ry. Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease. Progress in neurobiology. vol 204. 2021-11-11. PMID:34166773. |
dysfunction of x-linked inhibitor of apoptosis protein (xiap) triggers neuropathological processes via altered p53 activity in huntington's disease. |
2021-11-11 |
2023-08-13 |
mouse |
| Ping Niu, Yuxuan Sun, Shiyi Wang, Guang Li, Xiaomin Tang, Jiaqiang Sun, Chunchen Pan, Jingwu Su. Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway. Molecular medicine reports. vol 24. issue 6. 2021-11-11. PMID:34651662. |
gm‑induced ototoxicity may be closely related to the upregulation of p53 expression and the activation of endogenous mitochondrial apoptosis pathways, and pu could protect cochlear hair cells from gm‑mediated damage by reducing the production of ros and inhibiting the mitochondria‑dependent apoptosis pathway. |
2021-11-11 |
2023-08-13 |
mouse |
| Emmanuel N Kontomanolis, Antonios Koutras, Athanasios Syllaios, Dimitrios Schizas, Sofia Kalagasidou, Athanasios Pagkalos, Dimitra Alatzidou, Pelagia Kantari, Thomas Ntounis, Zacharias Fasoulaki. Basic principles of molecular biology of cancer cell-Molecular cancer indicators. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 26. issue 5. 2021-11-11. PMID:34761575. |
central role to these paths, concerning the cell cycle and the process of apoptosis, has the protein p53. |
2021-11-11 |
2023-08-13 |
Not clear |
| Kalishwaralal Kalimuthu, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M Haroon A Choudry, Yong J Le. Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. Journal of cellular physiology. vol 236. issue 9. 2021-11-10. PMID:33586156. |
studies with activating transcription factor 4 (atf4), c/ebp-homologous protein (chop), p53 upregulated modulator of apoptosis (puma), or death receptor 5 (dr5)-deficient mouse embryonic fibroblasts or hct116 cells suggest that the atf4-chop-puma axis and the atf4-chop-dr5 axis are involved in the combined treatment-induced apoptosis. |
2021-11-10 |
2023-08-13 |
mouse |
| Guofeng Xu, Linfeng Fan, Shufeng Zhao, Canhui OuYan. Neuronal pentraxin II (NPTX2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:33896384. |
neuronal pentraxin ii (nptx2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway. |
2021-11-10 |
2023-08-13 |
human |
| Guofeng Xu, Linfeng Fan, Shufeng Zhao, Canhui OuYan. Neuronal pentraxin II (NPTX2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:33896384. |
therefore, nptx2 hypermethylation caused the downregulation of nptx2 expression, which could promote cell proliferation, inhibit apoptosis and cause cell cycle arrest in gastric cancer cells by suppressing the p53 signaling pathway. |
2021-11-10 |
2023-08-13 |
human |
| Wen Zhang, Ruiqian Sun, Yongjun Zhang, Rong Hu, Qian Li, Weili Wu, Xinyu Cao, Jiajian Zhou, Jianfeng Pei, Ping Yua. Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 antitumor pathway. FEBS open bio. vol 11. issue 11. 2021-11-10. PMID:34496154. |
the expression of several p53 downstream genes that are associated with cell cycle arrest, apoptosis, and inhibition of angiogenesis and metastasis is induced by cbt in colorectal cancer cells. |
2021-11-10 |
2023-08-13 |
Not clear |
| Zhenyu You, Dandan Peng, Yixin Cao, Yuanzhe Zhu, Jianjun Yin, Guangxing Zhang, Xiaodong Pen. P53 suppresses the progression of hepatocellular carcinoma via miR-15a by decreasing OGT expression and EZH2 stabilization. Journal of cellular and molecular medicine. vol 25. issue 19. 2021-11-10. PMID:34510715. |
p53 upregulated mir-15a expression, which inhibited the proliferation, migration and invasion of hcc cells, while inducing apoptosis and triggering a g0/g1 cell cycle phase arrest. |
2021-11-10 |
2023-08-13 |
mouse |
| Hongli Wang, Min Zhang, Xiuduan Xu, Shaojun Hou, Zhihui Liu, Xuejiao Chen, Chongchong Zhang, Huan Xu, Lin Wu, Kun Liu, Lun Son. IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activation. Ecotoxicology and environmental safety. vol 227. 2021-11-10. PMID:34649141. |
ikkα mediates uvb-induced cell apoptosis by regulating p53 pathway activation. |
2021-11-10 |
2023-08-13 |
mouse |
| Hongli Wang, Min Zhang, Xiuduan Xu, Shaojun Hou, Zhihui Liu, Xuejiao Chen, Chongchong Zhang, Huan Xu, Lin Wu, Kun Liu, Lun Son. IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activation. Ecotoxicology and environmental safety. vol 227. 2021-11-10. PMID:34649141. |
taken together, we have identified a novel nf-κb-independent role of ikkα in mediating uvb-induced apoptosis by regulating p53 pathway activation. |
2021-11-10 |
2023-08-13 |
mouse |
| b' Manuel Humberto Ch\\xc3\\xa1irez-Ram\\xc3\\xadrez, Karen Griselda de la Cruz-L\\xc3\\xb3pez, Alejandro Garc\\xc3\\xada-Carranc\\xc3\\xa. Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways. Frontiers in pharmacology. vol 12. 2021-11-10. PMID:34744708.' |
modifications of p53 induced by these polyphenols regulate p53 gene expression and protein levels and posttranslational modifications such as phosphorylation, acetylation, and ubiquitination that influence stability, subcellular location, activation of new transcriptional targets, and the role of p53 in response to dna damage, apoptosis control, cell- cycle regulation, senescence, and cell fate. |
2021-11-10 |
2023-08-13 |
Not clear |
| Xiaohong Xiang, Jiefu Zhu, Gang Zhang, Zhengwei Ma, Man J Livingston, Zheng Don. Proximal Tubule p53 in Cold Storage/Transplantation-Associated Kidney Injury and Renal Graft Dysfunction. Frontiers in medicine. vol 8. 2021-11-10. PMID:34746182. |
pifithrin-α, a pharmacologic p53 inhibitor, could reduce acute tubular injury, apoptosis and inflammation at 24 h after cold storage/transplantation. |
2021-11-10 |
2023-08-13 |
mouse |
| Mengmeng Wang, Ying Bai, Haitao Chi, Ping Lin, Yu Wu, Jiahui Cui, Yi Wang, Jing Sun, Ming-Fei Lan. miR-451 protects against ischemic stroke by targeting Phd3. Experimental neurology. vol 343. 2021-11-09. PMID:34058227. |
in addition, the levels of p53 (a known phd3 target) were significantly downregulated when the levels of phd3 were reduced, suggesting its participation in reducing apoptosis after the mir-451 administration. |
2021-11-09 |
2023-08-13 |
mouse |
| Mengmeng Wang, Ying Bai, Haitao Chi, Ping Lin, Yu Wu, Jiahui Cui, Yi Wang, Jing Sun, Ming-Fei Lan. miR-451 protects against ischemic stroke by targeting Phd3. Experimental neurology. vol 343. 2021-11-09. PMID:34058227. |
in conclusion, this study demonstrated a new protective role of mir-451 in cerebral ischemia and identified phd3 as a novel mir-451 target, linking the mechanism to the involvement of p53 in the regulation of apoptosis during the pathogenesis of ischemic stroke. |
2021-11-09 |
2023-08-13 |
mouse |
| Nan-Ying Chen, Ke Lu, Jing-Mei Yuan, Xiao-Juan Li, Zi-Yu Gu, Cheng-Xue Pan, Dong-Liang Mo, Gui-Fa S. 3-Arylamino-quinoxaline-2-carboxamides inhibit the PI3K/Akt/mTOR signaling pathways to activate P53 and induce apoptosis. Bioorganic chemistry. vol 114. 2021-11-09. PMID:34175723. |
3-arylamino-quinoxaline-2-carboxamides inhibit the pi3k/akt/mtor signaling pathways to activate p53 and induce apoptosis. |
2021-11-09 |
2023-08-13 |
human |
| Hongling Li, Yuna Meng, Shuping Ma, Chunyan Dang, Li Xu. VALD-3 inhibits proliferation and induces apoptosis of colorectal cancer cells via upregulating tumor suppressor activity of p53 to inhibit Wnt/β-catenin signal pathway. Anti-cancer drugs. vol 32. issue 10. 2021-11-09. PMID:34419958. |
vald-3 inhibits proliferation and induces apoptosis of colorectal cancer cells via upregulating tumor suppressor activity of p53 to inhibit wnt/β-catenin signal pathway. |
2021-11-09 |
2023-08-13 |
mouse |
| Hongling Li, Yuna Meng, Shuping Ma, Chunyan Dang, Li Xu. VALD-3 inhibits proliferation and induces apoptosis of colorectal cancer cells via upregulating tumor suppressor activity of p53 to inhibit Wnt/β-catenin signal pathway. Anti-cancer drugs. vol 32. issue 10. 2021-11-09. PMID:34419958. |
protein expression of p53, wnt/β-catenin signaling pathway proteins, apoptosis proteins and cell cycle-related protein were viewed by western blotting. |
2021-11-09 |
2023-08-13 |
mouse |