| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Agnese Della-Fazia, Marilena Castelli, Danilo Piobbico, Stefania Pieroni, Giuseppe Servill. HOPS and p53: thick as thieves in life and death. Cell cycle (Georgetown, Tex.). vol 19. issue 22. 2021-10-29. PMID:33112208. |
recently, hops/tmub1 a novel small ubiquitin-like protein has been described as a vital molecule stabilizing p53 half-life, directing it to the mitochondria and favoring p53-mediated apoptosis. |
2021-10-29 |
2023-08-13 |
Not clear |
| Maria Agnese Della-Fazia, Marilena Castelli, Danilo Piobbico, Stefania Pieroni, Giuseppe Servill. HOPS and p53: thick as thieves in life and death. Cell cycle (Georgetown, Tex.). vol 19. issue 22. 2021-10-29. PMID:33112208. |
hops/tmub1 as p53 modifiers could be attractive candidates to elucidate apoptosis or other important transcriptional-independent functions which are key in cancer research in order to develop new therapeutic approaches. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yusuke Hirata, Miki Takahashi, Yuto Yamada, Ryosuke Matsui, Aya Inoue, Ryo Ashida, Takuya Noguchi, Atsushi Matsuzaw. trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway. Scientific reports. vol 11. issue 1. 2021-10-29. PMID:33990641. |
we previously reported that tfas promote apoptosis induced by doxorubicin (dox), a double strand break (dsb)-inducing agent, via a non-canonical apoptotic pathway independent of tumor suppressor p53 and apoptosis signal-regulating kinase (ask1), a reactive oxygen species (ros)-responsive kinase. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yusuke Hirata, Miki Takahashi, Yuto Yamada, Ryosuke Matsui, Aya Inoue, Ryo Ashida, Takuya Noguchi, Atsushi Matsuzaw. trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway. Scientific reports. vol 11. issue 1. 2021-10-29. PMID:33990641. |
however, here we found that in the case of cddp-induced apoptosis, ea-mediated pro-apoptotic action was reversed by knockout of either p53 or ask1, despite no increase in p53 apoptotic activity. |
2021-10-29 |
2023-08-13 |
Not clear |
| Sheng Huang, Changye Zou, Shangyan Xie, Bin Wang, Xitao LingHu, Yixiao Wang, Xiaohong Xu, Shuai Huang, Qingde W. Anticancer Activity of Sweroside Nanoparticles in Prostate Cancer Bone Metastasis in PC-3 Cells Involved in Wnt/ Journal of biomedical nanotechnology. vol 17. issue 10. 2021-10-29. PMID:34706796. |
apoptosis was assessed with flow cytometry using the annexin v/propidium iodide binding assay; proteins, including p53, p21, bcl-2, and bax; and induction of intracellular reactive oxygen species (ros). |
2021-10-29 |
2023-08-13 |
Not clear |
| Yu-Xiao Liu, Wei-Tong Su, Yu L. [Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708233. |
intriguingly, crebzf also regulates cell proliferation and apoptosis via interaction with several transcription factors including stat3, p53 and hcf-1. |
2021-10-29 |
2023-08-13 |
mouse |
| Zijie Ye, Danyang Chen, Ruilin Zheng, Haiyang Chen, Tiantian Xu, Changbing Wang, Shibo Zhu, Xiaofeng Gao, Jin Zhang, Dian Li, Yueyin Pang, Bing Zhu, Yinghua Li, Wei Ji. Curcumin induced G2/M cycle arrest in SK-N-SH neuroblastoma cells through the ROS-mediated p53 signaling pathway. Journal of food biochemistry. vol 45. issue 9. 2021-10-28. PMID:34331475. |
furthermore, curcumin promoted the overproduction of intracellular ros and apoptosis induced by activating p53 and bcl-2 signal pathways. |
2021-10-28 |
2023-08-13 |
Not clear |
| Maria Czarnek, Katarzyna Sarad, Agnieszka Karaś, Jakub Kochan, Joanna Beret. Non-targeting control for MISSION shRNA library silences Molecular therapy. Nucleic acids. vol 26. 2021-10-28. PMID:34703654. |
here, we used a lentiviral vector with inducible shc016 expression to confirm that this shrna induces apoptosis in murine cells and senescence or mitotic catastrophe depending on the p53 status in human tumor cells. |
2021-10-28 |
2023-08-13 |
human |
| Yu Jiang, Lingqi Gu, Zilin Zhang, Jianya Zhao, Chunhua Wa. Severe Zinc Deficiency Causes the Loss and Apoptosis of Olfactory Ensheathing Cells (OECs) and Olfactory Deficit. Journal of molecular neuroscience : MN. vol 71. issue 4. 2021-10-27. PMID:32940875. |
the apoptosis of oecs was correlated with significantly elevated expression of p53. |
2021-10-27 |
2023-08-13 |
rat |
| Yu Jiang, Lingqi Gu, Zilin Zhang, Jianya Zhao, Chunhua Wa. Severe Zinc Deficiency Causes the Loss and Apoptosis of Olfactory Ensheathing Cells (OECs) and Olfactory Deficit. Journal of molecular neuroscience : MN. vol 71. issue 4. 2021-10-27. PMID:32940875. |
importantly, tunel and cck-8 assays both demonstrated that treatment with p53 antagonist pifithrin-α (pft-α) markedly attenuated tpen-induced oec apoptosis. |
2021-10-27 |
2023-08-13 |
rat |
| Eva C Bunk, Hans-Georg König, Jochen H M Prehn, Brian P Kirb. p53 upregulated mediator of apoptosis (Puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion. Journal of basic and clinical physiology and pharmacology. vol 32. issue 2. 2021-10-27. PMID:33155994. |
p53 upregulated mediator of apoptosis (puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion. |
2021-10-27 |
2023-08-13 |
mouse |
| Abdullah Alatawi, SoonJye Kho, Michael P Marke. MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A. Journal of skin cancer. vol 2021. 2021-10-27. PMID:34697572. |
the p53 tumor suppressor integrates upstream signals such as dna damage and active oncogenes to initiate cell cycle arrest or apoptosis. |
2021-10-27 |
2023-08-13 |
human |
| Jinjun Hou, Yang Yang, Tingting Zhang, Chenghai Zhu, Kangtai L. The Effects of P53 in the Globular Heads of the C1q Receptor in Gastric Carcinoma Cell Apoptosis Are Exerted via a Mitochondrial-Dependent Pathway. Doklady. Biochemistry and biophysics. vol 500. issue 1. 2021-10-27. PMID:34697746. |
the effects of p53 in the globular heads of the c1q receptor in gastric carcinoma cell apoptosis are exerted via a mitochondrial-dependent pathway. |
2021-10-27 |
2023-08-13 |
Not clear |
| Hongbo Gao, Hongyang Li, Wen Liu, Siddhartha Kumar Mishra, Chengzhen L. Andrographolide Induces Apoptosis in Gastric Cancer Cells through Reactivation of p53 and Inhibition of Mdm-2. Doklady. Biochemistry and biophysics. vol 500. issue 1. 2021-10-27. PMID:34697748. |
andrographolide induces apoptosis in gastric cancer cells through reactivation of p53 and inhibition of mdm-2. |
2021-10-27 |
2023-08-13 |
human |
| Khaled Gouda, Sherihan AbdelHamid, Ahmed Mansour, Nesreen Omar, Hala El-Mesallam. Amelioration of Diabetic Nephropathy by Targeting Autophagy via Rapamycin or Fasting: Relation to Cell Apoptosis/Survival. Current issues in molecular biology. vol 43. issue 3. 2021-10-27. PMID:34698133. |
the extent of autophagy and apoptosis were investigated by measuring the level of lc3b and p53 proteins, respectively, in pancreatic and kidney tissues using western blotting (wb) technique and imaging the renal cells under transmission electron microscope. |
2021-10-27 |
2023-08-13 |
rat |
| Jara Moreno-Lorite, Sara Pérez-Luz, Yurika Katsu-Jiménez, Daniel Oberdoerfer, Javier Díaz-Nid. DNA repair pathways are altered in neural cell models of frataxin deficiency. Molecular and cellular neurosciences. vol 111. 2021-10-26. PMID:33418083. |
in both proliferating and differentiated ifkd-sy cells, the induction of fxn deficiency is accompanied by increases in oxidative stress and dna damage, reduced aconitase enzyme activity, higher levels of p53 and p21, activation of caspase-3, and subsequent apoptosis. |
2021-10-26 |
2023-08-13 |
mouse |
| Jir-You Wang, Chao-Ming Chen, Cheng-Fong Chen, Po-Kuei Wu, Wei-Ming Che. Suppression of Estrogen Receptor Alpha Inhibits Cell Proliferation, Differentiation and Enhances the Chemosensitivity of P53-Positive U2OS Osteosarcoma Cell. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681897. |
cell cycle arrest in the s phase was observed in p53(+) u2os cells cotreated with low doses of doxorubicin and tamoxifen, while increased levels of apoptosis factors indicated cell death. |
2021-10-26 |
2023-08-13 |
Not clear |
| Akinori Morita, Shintaro Ochi, Hidetoshi Satoh, Shohei Ujita, Yosuke Matsushita, Kasumi Tada, Mihiro Toyoda, Yuichi Nishiyama, Kosuke Mizuno, Yuichi Deguchi, Keiji Suzuki, Yoshimasa Tanaka, Hiroshi Ueda, Toshiya Inaba, Yoshio Hosoi, Shin Aok. A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis. Life (Basel, Switzerland). vol 11. issue 10. 2021-10-26. PMID:34685458. |
a novel rna synthesis inhibitor, stk160830, has negligible dna-intercalating activity for triggering a p53 response, and can inhibit p53-dependent apoptosis. |
2021-10-26 |
2023-08-13 |
human |
| Mehmet Kadir Erdogan, Ibrahim Halil Gecibesler, Yakup Yapar, Ramazan Gundogdu, Mahinur Kirici, Lutfi Behcet, Parham Taslim. Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE. Bioorganic chemistry. vol 113. 2021-10-25. PMID:34089947. |
in addition, human vegf elisa method was used to determine the anti-angiogenic effect, and the quantitative real-time pcr (qrt-pcr) method on p53, bax and bcl-2 mrna levels were used to evaluate apoptosis. |
2021-10-25 |
2023-08-13 |
human |
| Yu Feng, Hantao Wang, Zhi Chen, Bin Che. High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration. Bone. vol 153. 2021-10-25. PMID:34461288. |
using a microarray assay to detect the dysregulated genes in idd patients with obesity, we identified 33 differentially expressed genes and verified only two proapoptotic genes, including puma (p53 upregulated modulator of apoptosis) and bax (bcl2 associated x) responded to glucose. |
2021-10-25 |
2023-08-13 |
rat |