| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bu-Yeo Kim, Seo-Young Lee, Sun-Ku Chun. Differential Transcriptional Regulation of Polymorphic p53 Codon 72 in Metabolic Pathways. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639134. |
we found that there was no significant functional difference between p72 and r72 cells in growth arrest or apoptosis as a representative function of p53. |
2021-10-25 |
2023-08-13 |
Not clear |
| Bu-Yeo Kim, Seo-Young Lee, Sun-Ku Chun. Differential Transcriptional Regulation of Polymorphic p53 Codon 72 in Metabolic Pathways. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639134. |
in the comprehensive analysis, the expression pattern of the common p53 target genes, including cell cycle arrest or apoptosis, was also increased regardless of the polymorphic p53 codon 72 status, whereas the expression pattern involved in metabolism was decreased and more significant in r72 than in p72 cells. |
2021-10-25 |
2023-08-13 |
Not clear |
| Bu-Yeo Kim, Seo-Young Lee, Sun-Ku Chun. Differential Transcriptional Regulation of Polymorphic p53 Codon 72 in Metabolic Pathways. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639134. |
this study noted that polymorphic p53 codon 72 differentially regulated the functional categories of metabolism and not the pathways that determine cell fate, such as growth arrest and apoptosis in cells exposed to genotoxic stress. |
2021-10-25 |
2023-08-13 |
Not clear |
| Jinbing Xue, Gang Wu, Umer Ejaz, Fahad Akhtar, Xinyu Wan, Yong Zhu, Aixing Geng, Yadong Chen, Shuying H. A novel histone deacetylase inhibitor LT-548-133-1 induces apoptosis by inhibiting HDAC and interfering with microtubule assembly in MCF-7 cells. Investigational new drugs. vol 39. issue 5. 2021-10-23. PMID:33788074. |
the decreased expression of bcl-2 and the increased expression of bax, p53, p21, and cleaved-caspase3 indicated the occurrence of apoptosis. |
2021-10-23 |
2023-08-13 |
Not clear |
| Yan Cheng, Yanxia Zhu, Linli M. LncRNA LINC00673 is Downregulated in Diabetic Retinopathy and Regulates the Apoptosis of Retinal Pigment Epithelial Cells via Negatively Regulating p53. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 14. 2021-10-23. PMID:34675574. |
lncrna linc00673 is downregulated in diabetic retinopathy and regulates the apoptosis of retinal pigment epithelial cells via negatively regulating p53. |
2021-10-23 |
2023-08-13 |
Not clear |
| Masumeh Sanaei, Fraidoon Kavoos. Effects of trichostatin A on the intrinsic and extrinsic apoptotic pathway, cell viability, and apoptosis induction in hepatocellular carcinoma cell lines. Gastroenterology and hepatology from bed to bench. vol 14. issue 4. 2021-10-22. PMID:34659660. |
the current study investigated the effect of trichostatin a (tsa) on mitochondrial/intrinsic [pro- (bax, bak, and bim) and anti- (bcl-2, bcl-xl, and mcl-1) apoptotic genes] and cytoplasmic/extrinsic (dr4, dr5, fas, fas-l, and trail genes) pathways, histone deacetylase 1, 2, and 3, p53, p73, cell viability, and apoptosis in hepatocellular carcinoma (hcc) hcclm3, mhcc97h, and mhcc97l cell lines. |
2021-10-22 |
2023-08-13 |
Not clear |
| Que Thanh Thanh Nguyen, Thi Xoan Hoang, Hyunjin Ryu, Kook-Hwan Oh, Jae Young Ki. Synergistic Antiproliferative Effects of All-Trans Retinoic Acid and Paclitaxel on Autosomal Dominant Polycystic Kidney Disease Epithelial Cells. BioMed research international. vol 2021. 2021-10-22. PMID:34660779. |
treatment with pac and atra induced cell cycle arrest at the g2/m phase and apoptosis by upregulating p53 and caspase-8 expression and increased the intracellular calcium (ca |
2021-10-22 |
2023-08-13 |
Not clear |
| Omar S El-Masry, Barry L Brown, Pauline R M Dobso. Effects of activation of AMPK on human breast cancer cell lines with different genetic backgrounds. Oncology letters. vol 3. issue 1. 2021-10-21. PMID:22740885. |
we assessed the possible different effects of ampk action on breast cancer cells by studying their impact on proliferation, apoptosis and the mitochondrial membrane potential in three breast cancer cell lines (mcf-7, mda-mb-231 and t47d) differing in their p53 and estrogen receptor (er) status. |
2021-10-21 |
2023-08-12 |
human |
| Katsuhiro Yasuda, Shunsuke Kato, Yasuhiro Sakamoto, Gou Watanabe, Satsuki Mashiko, Atsuko Sato, Yuichi Kakudo, Chikashi Ishiok. Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783376. |
induction of apoptosis by cytoplasmically localized wild-type p53 and the s121f mutant super p53. |
2021-10-21 |
2023-08-12 |
Not clear |
| Katsuhiro Yasuda, Shunsuke Kato, Yasuhiro Sakamoto, Gou Watanabe, Satsuki Mashiko, Atsuko Sato, Yuichi Kakudo, Chikashi Ishiok. Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783376. |
after dna damage, p53 is accumulated in the nucleus and transactivates downstream genes and induces apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Katsuhiro Yasuda, Shunsuke Kato, Yasuhiro Sakamoto, Gou Watanabe, Satsuki Mashiko, Atsuko Sato, Yuichi Kakudo, Chikashi Ishiok. Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783376. |
in this study, we constructed p53-inducible glioblastoma cell lines and analyzed them for the induction of apoptosis and transactivation of p53-downstream genes after the nuclear or cytoplasmic expression of p53. |
2021-10-21 |
2023-08-12 |
Not clear |
| Katsuhiro Yasuda, Shunsuke Kato, Yasuhiro Sakamoto, Gou Watanabe, Satsuki Mashiko, Atsuko Sato, Yuichi Kakudo, Chikashi Ishiok. Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783376. |
wild-type p53 retained the ability to arrest the cell cycle, and a p53 mutant with serine to phenylalanine substitution at residue 121 (s121f), which has a strong ability to induce apoptosis, retained this ability even when both the wild-type and p53 and s121f mutant were exclusively sequestered from the nucleus into the cytoplasm. |
2021-10-21 |
2023-08-12 |
Not clear |
| Katsuhiro Yasuda, Shunsuke Kato, Yasuhiro Sakamoto, Gou Watanabe, Satsuki Mashiko, Atsuko Sato, Yuichi Kakudo, Chikashi Ishiok. Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783376. |
these results underscore the existence of transactivation-independent apoptosis and cytoplasmic function of p53. |
2021-10-21 |
2023-08-12 |
Not clear |
| Xianli Wei, Lunbin Zhou, Liangyong Hu, Yaoxiong Huan. Tanshinone IIA arrests cell cycle and induces apoptosis in 786-O human renal cell carcinoma cells. Oncology letters. vol 3. issue 5. 2021-10-21. PMID:22783408. |
these results suggest that the activation of p53 and the upregulation of its target genes, including p21 and bax, may be involved in the mitochondrial apoptosis induced by tan iia in 786-o cells. |
2021-10-21 |
2023-08-12 |
human |
| Zhe Ji, Qingjiu Tang, Ruixia Hao, Jinsong Zhang, Yingjie Pa. Induction of apoptosis in the SW620 colon carcinoma cell line by triterpene-enriched extracts from Ganoderma lucidum through activation of caspase-3. Oncology letters. vol 2. issue 3. 2021-10-21. PMID:22866120. |
conversely, glai up-regulates the expression of the apoptosis enhancer bax gene and p53 protein. |
2021-10-21 |
2023-08-12 |
human |
| Mark Schneider, Motoko Tanaka-Nozaki, Shunji Kato, Brunhilde Blömek. Influence of 5-fluorouracil on ferredoxin reductase mRNA splice variants in colorectal carcinomas. Oncology letters. vol 1. issue 2. 2021-10-21. PMID:22966307. |
the induction is mediated by p53 and enhanced reactive oxygen species (ros)-associated apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| M Kenan Kinaci, Nilufer Erkasap, Aysegul Kucuk, Tulay Koken, Murat Tosu. Effects of quercetin on apoptosis, NF-κB and NOS gene expression in renal ischemia/reperfusion injury. Experimental and therapeutic medicine. vol 3. issue 2. 2021-10-21. PMID:22969877. |
p53, endothelial nos (enos) and nf-κb expression were assessed immunohistochemically, and apoptosis assesment was performed using terminal deoxynucleotidyl transferase dutp nick end-labeling (tunel) assay. |
2021-10-21 |
2023-08-12 |
rat |
| Yunbo Jiang, Huihua Chen, Haiquan Jia, Yuanji Xu, Gang Liu, Yan Wang, Xiaohe Yang, Yinglin L. Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2 interactions. Experimental and therapeutic medicine. vol 1. issue 2. 2021-10-21. PMID:22993550. |
in particular, we discovered that p53aip1 overexpression up-regulated the protein levels of p53 in hepg2 cells, which was accompanied by down-regulation of mdm2 mrna and protein, suggesting an interaction between mdm2 and p53 in p53aip1-induced apoptosis and cell cycle arrest. |
2021-10-21 |
2023-08-12 |
mouse |
| Wei Li, Hongfei Tong, Xiaojie Huang, Wen Wang, Hao Wu, Shengzhang Li. High levels of β-catenin promote IFNγ-induced apoptosis in hepatocellular carcinoma cells. Oncology letters. vol 4. issue 5. 2021-10-21. PMID:23162658. |
therefore, we report that high levels of β-catenin promote ifnγ-induced apoptosis in hcc in a caspase- and stat3-dependent manner, and facilitate the activation of executor caspases, possibly via regulation of p53 and bcl-xl levels. |
2021-10-21 |
2023-08-12 |
Not clear |
| Se-Mi Oh, Jinhee Kim, Jun Lee, Jin-Mu Yi, Dal-Seok Oh, Ok-Sun Bang, No Soo Ki. Anticancer potential of an ethanol extract of Asiasari radix against HCT-116 human colon cancer cells in vitro. Oncology letters. vol 5. issue 1. 2021-10-21. PMID:23255939. |
eear-induced apoptosis in hct-116 cells was dependent on p53 expression, as determined by sirna-mediated p53 knockdown. |
2021-10-21 |
2023-08-12 |
human |