| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongling Li, Yuna Meng, Shuping Ma, Chunyan Dang, Li Xu. VALD-3 inhibits proliferation and induces apoptosis of colorectal cancer cells via upregulating tumor suppressor activity of p53 to inhibit Wnt/β-catenin signal pathway. Anti-cancer drugs. vol 32. issue 10. 2021-11-09. PMID:34419958. |
these results suggested that vald-3 represses cell proliferation and induces apoptosis associated with upregulating tumor suppressor activity of p53 to inhibit wnt/β-catenin signal pathway, and it is a potential anticancer agent for colorectal cancer. |
2021-11-09 |
2023-08-13 |
mouse |
| Dongjuan Si, Huijuan Luo, Xiaomeng Zhang, Kundi Yang, Hongmei Wen, Wei Li, Jian Li. Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors. Bioorganic chemistry. vol 115. 2021-11-09. PMID:34426149. |
the further antitumor mechanism studies were indicated that compound 4 h could successfully induce the activation of p53 and corresponding downstream p21 proteins, thus successfully causing hct116 cell cycle arrest in the g1/m phase and apoptosis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Ritu Ghildiyal, Reema Gabran. Computational analysis of human host binding partners of chikungunya and dengue viruses during coinfection. Pathogens and disease. vol 79. issue 8. 2021-11-09. PMID:34550340. |
the functional and biological analyses of the 40 hub-bottlenecks revealed that they are associated with phosphoinositide 3-kinases (pi3k)/akt, p53 signaling pathways, regulation of cell cycle and apoptosis during coinfection. |
2021-11-09 |
2023-08-13 |
human |
| Ji Eun Lee, Sungjin Ahn, Haengdueng Jeong, Seungchan An, Cheol Hwan Myung, Jeong Ah Lee, Sung Chan Hong, Youn Jin Kim, Jin Young Kim, Jong Hyuk Ryu, Minsoo Noh, Ki Taek Nam, Jae Sung Hwan. Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33833342. |
reduction of olig2 increased apoptosis in melanoma cells by increasing p53 level and caspase-3/-7 enzyme activity. |
2021-11-08 |
2023-08-13 |
Not clear |
| Guzhalinuer Maitisha, Mutalifu Aimaiti, Zechong An, Xinxia L. Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway. Molecular biology reports. vol 48. issue 11. 2021-11-08. PMID:34626309. |
allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ji Hoon Jung, Duckgue Lee, Hyun Min Ko, Hyeung-Jin Jan. Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680125. |
inhibition of cnot2 induces apoptosis via mid1ip1 in colorectal cancer cells by activating p53. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ji Hoon Jung, Duckgue Lee, Hyun Min Ko, Hyeung-Jin Jan. Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680125. |
herein, for the first time, we report that cnot2 inhibition can induce apoptosis in colorectal cancer cells by activating p53. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ji Hoon Jung, Duckgue Lee, Hyun Min Ko, Hyeung-Jin Jan. Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680125. |
inhibition of cnot2 markedly induced apoptosis in various cancer cells like that of the wild-type p53. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ji Hoon Jung, Duckgue Lee, Hyun Min Ko, Hyeung-Jin Jan. Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680125. |
interestingly, inhibition of cnot2 cannot induce p53 expression without mid1ip1 or apoptosis in cancer cells. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ji Hoon Jung, Duckgue Lee, Hyun Min Ko, Hyeung-Jin Jan. Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. Biomolecules. vol 11. issue 10. 2021-11-08. PMID:34680125. |
in conclusion, our results demonstrate that cnot2 inhibition induces apoptosis through mid1ip1 by activating p53. |
2021-11-08 |
2023-08-13 |
Not clear |
| Huanxin Xue, Jiaye Lu, Hongwei Yan, Ju Huang, Hai-Bin Luo, Man Shing Wong, Yuqi Gao, Xiaolei Zhang, Lei Gu. γ-Glutamyl transpeptidase-activated indole-quinolinium based cyanine as a fluorescence turn-on nucleolus-targeting probe for cancer cell detection and inhibition. Talanta. vol 237. 2021-11-08. PMID:34736714. |
hqi also intervenes in rrna biogenesis by declining the rna polymerase i transcription, thus resulting in cell apoptosis via a p53 dependent signaling pathway. |
2021-11-08 |
2023-08-13 |
Not clear |
| Cheng Xu, Heng Liu, Christopher J Pirozzi, Lee H Chen, Paula K Greer, Bill H Diplas, Liwei Zhang, Matthew S Waitkus, Yiping He, Hai Ya. TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist. Acta neuropathologica communications. vol 9. issue 1. 2021-11-07. PMID:34732238. |
rg7388 reactivated the p53 pathway and induced apoptosis as well as g1 arrest. |
2021-11-07 |
2023-08-13 |
Not clear |
| Chongyang Xiao, Yunfei Zhang, Fei Zh. Immunotoxicity of polychlorinated biphenyls (PCBs) to the marine crustacean species, Scylla paramamosain. Environmental pollution (Barking, Essex : 1987). vol 291. 2021-11-05. PMID:34582922. |
after pcbs exposure, the expression levels of p53 and caspase-3 in hemocytes were significantly up-regulated, which suggests that apoptosis was occurring. |
2021-11-05 |
2023-08-13 |
Not clear |
| Preedakorn Chunhacha, Decha Pinkaew, Patuma Sinthujaroen, Dawn E Bowles, Ken Fujis. Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure. Cell death discovery. vol 7. issue 1. 2021-11-05. PMID:34689154. |
fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure. |
2021-11-05 |
2023-08-13 |
mouse |
| Hui Qin Wang, Iain J Mulford, Fiona Sharp, Jinsheng Liang, Sema Kurtulus, Gina Trabucco, David S Quinn, Tyler A Longmire, Nidhi Patel, Roshani Patil, Matthew D Shirley, Yan Chen, Hao Wang, David A Ruddy, Claire Fabre, Juliet A Williams, Peter S Hammerman, Jennifer Mataraza, Barbara Platzer, Ensar Halilovi. Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment. Cancer research. vol 81. issue 11. 2021-11-04. PMID:33504557. |
p53 is a transcription factor that plays a central role in guarding the genomic stability of cells through cell-cycle arrest or induction of apoptosis. |
2021-11-04 |
2023-08-13 |
Not clear |
| Jie Wen, Wenqian Chen, Baoxiang Zhao, Qiuping Xu, Chang Liu, Qun Zhang, Zhiwei Xie, Yonggan Yan, Jing Guo, Jun Huang, Junying Miao, Xunwei W. A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells. Cell death & disease. vol 12. issue 6. 2021-11-04. PMID:34103468. |
rna-seq analysis identified several pathways related to cell apoptosis that were affected by ecca, notably, activation of the p53 signaling pathway. |
2021-11-04 |
2023-08-13 |
human |
| Jie Wen, Wenqian Chen, Baoxiang Zhao, Qiuping Xu, Chang Liu, Qun Zhang, Zhiwei Xie, Yonggan Yan, Jing Guo, Jun Huang, Junying Miao, Xunwei W. A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells. Cell death & disease. vol 12. issue 6. 2021-11-04. PMID:34103468. |
biochemical assays demonstrated that ecca enhanced the phosphorylation of p53 at ser15 in melanoma cells harboring wild-type p53, and importantly, the knockdown or deletion of p53 in those cells counteracted the ecca-induced apoptosis, as well as senescence. |
2021-11-04 |
2023-08-13 |
human |
| Jie Wen, Wenqian Chen, Baoxiang Zhao, Qiuping Xu, Chang Liu, Qun Zhang, Zhiwei Xie, Yonggan Yan, Jing Guo, Jun Huang, Junying Miao, Xunwei W. A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells. Cell death & disease. vol 12. issue 6. 2021-11-04. PMID:34103468. |
in summary, our study demonstrates that the carbazole derivative, ecca, induces melanoma cell apoptosis and senescence through the activation of p53 to significantly and selectively suppress the growth of melanoma cells without affecting normal human melanocytes, suggesting its potential to develop a new drug for melanoma therapy. |
2021-11-04 |
2023-08-13 |
human |
| Jingbo Fu, Yang Liu, Chen Wang, Hongxia Zhang, Bin Yu, Ye Wang, Haiying Zh. Persistent follicular granulosa cell senescence and apoptosis induced by methotrexate leading to oocyte dysfunction and aberrant embryo development. Clinical and translational science. vol 14. issue 5. 2021-11-03. PMID:33982403. |
supportive evidence indicated that mtx administration induced senescence and apoptosis of human gcs in vitro, and the effects were consistent with the high levels of p21, p53, and oxidative stress. |
2021-11-03 |
2023-08-13 |
mouse |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
sting-mediated degradation of ifi16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. |
2021-11-03 |
2023-08-13 |
Not clear |