| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
sting-mediated degradation of ifi16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. |
2021-11-03 |
2023-08-13 |
Not clear |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
here, our results from flow cytometry apoptosis detection and immunoblot assays show that ifi16 and nutlin-3, a p53 pathway activator, synergistically induce apoptosis in u2os and a549 cells. |
2021-11-03 |
2023-08-13 |
Not clear |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
protein kinase r-triggered phosphorylation of p53 at serine 392 is critical for the ifi16-p53-dependent apoptosis. |
2021-11-03 |
2023-08-13 |
Not clear |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
however, overexpression of sting suppresses p53 serine 392 phosphorylation, p53 transcriptional activity, expression of p53 target genes, and p53-dependent mitochondrial depolarization and apoptosis. |
2021-11-03 |
2023-08-13 |
Not clear |
| Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Midori Sato, Ko Abe, Shun Furusawa, Kosei Ishimaru, Shouji Matsushima, Hiroyuki Tsutsu. Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction. Journal of the American Heart Association. vol 10. issue 17. 2021-11-03. PMID:34472375. |
background apoptosis plays a pivotal role in cardiac rupture after myocardial infarction (mi), and p53 is a key molecule in apoptosis during cardiac rupture. |
2021-11-03 |
2023-08-13 |
mouse |
| Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Midori Sato, Ko Abe, Shun Furusawa, Kosei Ishimaru, Shouji Matsushima, Hiroyuki Tsutsu. Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction. Journal of the American Heart Association. vol 10. issue 17. 2021-11-03. PMID:34472375. |
however, the role of hif-1α in the regulatory mechanisms underlying p53 upregulation, apoptosis, and cardiac rupture after mi is unclear. |
2021-11-03 |
2023-08-13 |
mouse |
| Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Midori Sato, Ko Abe, Shun Furusawa, Kosei Ishimaru, Shouji Matsushima, Hiroyuki Tsutsu. Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction. Journal of the American Heart Association. vol 10. issue 17. 2021-11-03. PMID:34472375. |
hif-1α and p53 expressions were upregulated in the border zone at day 5 after mi, accompanied by apoptosis. |
2021-11-03 |
2023-08-13 |
mouse |
| Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Midori Sato, Ko Abe, Shun Furusawa, Kosei Ishimaru, Shouji Matsushima, Hiroyuki Tsutsu. Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction. Journal of the American Heart Association. vol 10. issue 17. 2021-11-03. PMID:34472375. |
in cardiac-specific hif-1α hetero-knockout mice, expression of p53 and cleavage of caspase-3 and poly (adp-ribose) polymerase were reduced, and apoptosis was suppressed on day 5. |
2021-11-03 |
2023-08-13 |
mouse |
| Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Midori Sato, Ko Abe, Shun Furusawa, Kosei Ishimaru, Shouji Matsushima, Hiroyuki Tsutsu. Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction. Journal of the American Heart Association. vol 10. issue 17. 2021-11-03. PMID:34472375. |
conclusions hif-1α plays a pivotal role in apoptosis, inflammation, and cardiac rupture after mi, in which p53 is a critical mediator, and may be a prospective therapeutic target for preventing cardiac rupture. |
2021-11-03 |
2023-08-13 |
mouse |
| Xiaobo Zheng, Li Feng, Yunfan Yin, Chune Yu, Xiujing He, Jiao Zhu, Ming Zhang, Jing Yu, Mingqing X. Comprehensive analysis of aberrant alternative splicing related to carcinogenesis and prognosis of papillary thyroid cancer. Aging. vol 13. issue 19. 2021-11-03. PMID:34628367. |
parent genes with cases remarkably enriched in the pathways were linked with carcinogenesis, such as p53, kras, il6-jak-stat3, apoptosis, and myc signaling. |
2021-11-03 |
2023-08-13 |
Not clear |
| Anna Rita Fetoni, Fabiola Paciello, Diana Troian. Cisplatin chemotherapy and cochlear damage: otoprotective and chemosensitization properties of polyphenols. Antioxidants & redox signaling. 2021-11-03. PMID:34731023. |
recent advances: cisplatin ototoxicity results from several mechanisms, including: redox imbalance caused by reactive oxygen species (ros) production and lipid peroxidation, activation of inflammation, p53 and its downstream pathways that culminate in apoptosis. |
2021-11-03 |
2023-08-13 |
Not clear |
| Peifang Cong, Teng Wang, Changci Tong, Ying Liu, Lin Shi, Shun Mao, Xiuyun Shi, Hongxu Jin, Yunen Liu, Mingxiao Ho. Resveratrol ameliorates thoracic blast exposure-induced inflammation, endoplasmic reticulum stress and apoptosis in the brain through the Nrf2/Keap1 and NF-κB signaling pathway. Injury. vol 52. issue 10. 2021-11-02. PMID:34454721. |
we also examined the mice for histopathological changes by hematoxylin-eosin staining; the expressions of inflammatory-related factors by elisa; endoplasmic reticulum stress in brain tissue via the generation of reactive oxygen species (ros) and the expressions of inositol-requiring enzyme-α (ire-α) and c/ebp homologous protein (chop); apoptosis by measuring levels of bax, p53 and bcl-2. |
2021-11-02 |
2023-08-13 |
mouse |
| Mayu Morishita, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Kyohei Niimura, Hiroaki Iwasa, Junichi Maruyama, Yuichi Hiraoka, Kohei Yamamoto, Masanobu Kitagawa, Norio Miyamura, Hiroshi Nishina, Yutaka Hat. Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-κB signaling. Genes to cells : devoted to molecular & cellular mechanisms. 2021-11-02. PMID:34652874. |
we have reported using human cancer cell lines that rassf6 induces apoptosis and cell cycle arrest via p53 and plays tumor suppressive roles. |
2021-11-02 |
2023-08-13 |
mouse |
| Sijing Li, Xiaohui Wei, Jinyong He, Quanquan Cao, Danyu Du, Xiaoman Zhan, Yuqi Zeng, Shengtao Yuan, Li Su. The comprehensive landscape of miR-34a in cancer research. Cancer metastasis reviews. vol 40. issue 3. 2021-11-01. PMID:33959850. |
also, the targets are implicated in critical signaling pathways, such as mapk, notch, wnt, pi3k/akt, p53, and ras, as well as apoptosis, cell cycle, and emt-related pathways. |
2021-11-01 |
2023-08-13 |
human |
| Marwa H El-Wakil, Marwa Ahmed Meheissen, Marwa M Abu-Seri. Nitrofurazone repurposing towards design and synthesis of novel apoptotic-dependent anticancer and antimicrobial agents: Biological evaluation, kinetic studies and molecular modeling. Bioorganic chemistry. vol 113. 2021-11-01. PMID:34051413. |
data of the bioactivity studies indicated that the potent anticancer activity of 7 is mainly through increasing intracellular ros levels and induction of apoptosis via significantly down-regulating the expression of bcl-2 while up-regulating bax, p53 and caspase 3 expression levels. |
2021-11-01 |
2023-08-13 |
Not clear |
| Eric Haines, Yuki Nishida, Michael I Carr, Rafael Heinz Montoya, Lauren B Ostermann, Weiguo Zhang, Frank T Zenke, Andree Blaukat, Michael Andreeff, Lyubomir T Vassile. DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia. Scientific reports. vol 11. issue 1. 2021-11-01. PMID:34108527. |
m3814 synergistically sensitized p53 wild-type, but not p53-deficient, aml cells to killing by dsb-inducing agents via p53-dependent apoptosis involving both intrinsic and extrinsic effector pathways. |
2021-11-01 |
2023-08-13 |
Not clear |
| Chiao-Che Chen, Jen-Hao Yang, Shu-Ling Fu, Wey-Jinq Lin, Chao-Hsiung Li. Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells. International journal of molecular sciences. vol 22. issue 18. 2021-11-01. PMID:34575922. |
heterogeneous nuclear ribonucleoprotein k (hnrnpk) is an rna/dna binding protein involved in diverse cell processes; it is also a p53 coregulator that initiates apoptosis under dna damage conditions. |
2021-11-01 |
2023-08-13 |
Not clear |
| Nada F Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H Eis. Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34639002. |
moreover, quinacrine significantly blocked cisplatin-induced apoptosis, which was made evident by downregulating renal apoptotic proteins (bax and p53) and upregulating the renal anti-apoptotic protein bcl2, compared with the cisplatin group. |
2021-11-01 |
2023-08-13 |
rat |
| Qian Zhang, Linping Wang, Guoliang Chen, Mingxing Wang, Tingzhang H. Cylindrospermopsin impairs vascular smooth muscle cells by P53-mediated apoptosis due to ROS overproduction. Toxicology letters. vol 353. 2021-10-30. PMID:34687773. |
taken together, cyn may induce ros overproduction, leading to increased p53 expression and ultimately promoting vsmc apoptosis. |
2021-10-30 |
2023-08-13 |
cat |
| Maria Agnese Della-Fazia, Marilena Castelli, Danilo Piobbico, Stefania Pieroni, Giuseppe Servill. HOPS and p53: thick as thieves in life and death. Cell cycle (Georgetown, Tex.). vol 19. issue 22. 2021-10-29. PMID:33112208. |
many investigations revealed the significant role of p53 in the cytoplasm, acting in a transcriptional-independent manner in important processes related to cell homeostasis such as; apoptosis, autophagy, metabolism control, drug, and oxidative stress response. |
2021-10-29 |
2023-08-13 |
Not clear |