| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chung-Jen Chiang, Yan-Hong Hon. In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy. Scientific reports. vol 11. issue 1. 2021-11-25. PMID:34518590. |
it caused the cell cycle arrest at the g1 phase and induced the mitochondrial apoptosis pathway independent of p53. |
2021-11-25 |
2023-08-13 |
mouse |
| Ihn Han, Seung Ah Choi, Seul I Kim, Eun Ha Choi, Young Joo Lee, Youngsun Ki. Improvement of Cell Growth of Uterosacral Ligament Fibroblast Derived from Pelvic Organ Prolapse Patients by Cold Atmospheric Plasma Treated Liquid. Cells. vol 10. issue 10. 2021-11-25. PMID:34685708. |
our results suggest that ptl protects huslf cells from cell apoptosis by controlling the p53 pathway and improves cell viability, implying that ptl is a promising application for pop therapy. |
2021-11-25 |
2023-08-13 |
human |
| Zhitao Ren, Nishikant A Raut, Temitope O Lawal, Shital R Patel, Simon M Lee, Gail B Mahad. Peonidin-3-O-glucoside and cyanidin increase osteoblast differentiation and reduce RANKL-induced bone resorption in transgenic medaka. Phytotherapy research : PTR. vol 35. issue 11. 2021-11-25. PMID:34704297. |
in addition, treatment of serum starvation of hfob osteoblasts with anthocyanins and resveratrol at 1.0 μg/ml reduced apoptosis, the bax/bcl-2 ratio, p53, and hdac1 expression, but increased sirt1/3 and pgc1α mrna expression, suggesting mitochondrial and epigenetic regulation. |
2021-11-25 |
2023-08-13 |
human |
| Amber Naz, Shasha Zhang, Lin An, Zongpei Song, Zhenguo Zi, Jian Wu, Shuaiwei Lai, Haniya Mazhar, Mingqing Xu, Yingyu Chen, Yunzeng Zou, Lin He, Hongxin Zh. Muscle-specific programmed cell death 5 deletion attenuates cardiac aging. International journal of cardiology. vol 345. 2021-11-25. PMID:34710491. |
taken together, our results reveal that pdcd5 deficiency attenuates cardiac aging by reducing cellular senescence and apoptosis, and increasing parkin-mediated mitophagy, likely through p53. |
2021-11-25 |
2023-08-13 |
mouse |
| Zhixiang Xu, Dimeng Zhao, Xianyao Zheng, Bin Huang, Xuejun Pan, Xueshan Xi. Low concentrations of 17β-estradiol exacerbate tamoxifen resistance in breast cancer treatment through membrane estrogen receptor-mediated signaling pathways. Environmental toxicology. 2021-11-25. PMID:34821461. |
moreover, the generation of tamoxifen resistance involved in apoptosis escape via a reactive oxygen species-regulated p53 signaling pathway. |
2021-11-25 |
2023-08-13 |
Not clear |
| Jiahui Yuan, Xiaomei Li, Yuqi Zhang, Gongye Zhang, Weipeng Cheng, Weiwei Wang, Yongbin Lei, Gang Son. USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53. Cell biology and toxicology. 2021-11-25. PMID:34822033. |
further studies show that usp39 regulates cisplatin-induced apoptosis dependent on p53. |
2021-11-25 |
2023-08-13 |
Not clear |
| Sang-Hyun Park, Sanggil Kim, Hyun Soo Lee, Injae Shi. Real-Time Spatial and Temporal Analysis of the Translocation of the Apoptosis-Inducing Factor in Cells. ACS chemical biology. vol 16. issue 11. 2021-11-24. PMID:34694772. |
we found that apoptosis inducers, including apoptozole, 2-phenylethynesulfonamide (pes), myricetin, bam7, reactivating p53 and inducing tumor apoptosis (rita), brefeldin a, and carbonyl cyanide- |
2021-11-24 |
2023-08-13 |
Not clear |
| Rajesh Kumar Manne, Yashika Agrawal, Sunil K Malonia, Shahid Banday, Sarathkumar Edachery, Asha Patel, Avinash Kumar, Praveenkumar Shetty, Manas Kumar Santr. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34587475. |
puma (p53 upregulated modulator of apoptosis) and bax (bcl2-associated x protein) are among the most well-known inducers of apoptosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Gehad Lotfy, Yasmine M Abdel Aziz, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Marwa M Abu-Serie, Mohamed Teleb, Alexander Dömling, Assem Baraka. Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators. Bioorganic chemistry. vol 117. 2021-11-23. PMID:34794098. |
the nci-selected derivatives were screened for cytotoxic activities against normal fibroblasts, mda-mb 231, hepg-2, and caco-2 cells via mtt assay, subjected to mechanistic apoptosis studies for assessment of p53, bcl2, p21, and caspase 3/7 status, then evaluated for potential mdm2 inhibition utilizing mst assay. |
2021-11-23 |
2023-08-13 |
Not clear |
| Sahar Sadegh-Nejadi, Reza Afrisham, Solaleh Emamgholipour, Pantea Izadi, Neda Eivazi, Behnoosh Tahbazlahafi, Maliheh Pakneja. Influence of plasma circulating exosomes obtained from obese women on tumorigenesis and tamoxifen resistance in MCF-7 cells. IUBMB life. vol 72. issue 9. 2021-11-22. PMID:32542981. |
for evaluating resistance to tamoxifen, the cell viability, apoptosis, and the p53 protein were evaluated using the mtt assay, flow cytometry, and western blot methods, respectively. |
2021-11-22 |
2023-08-13 |
Not clear |
| E A Klimentova, I A Suchkov, A A Egorov, R E Kalini. Apoptosis and Cell Proliferation Markers in Inflammatory-Fibroproliferative Diseases of the Vessel Wall (Review). Sovremennye tekhnologii v meditsine. vol 12. issue 4. 2021-11-20. PMID:34795999. |
the main markers of apoptosis (fas, fas ligand, p53, bcl-2, bax) and cell proliferation (toll receptor) have been considered in the current review. |
2021-11-20 |
2023-08-13 |
rabbit |
| Tingting Liang, Jiayu Xie, Jingsong Zhao, Wenxin Huang, Zhongyan Xu, Peng Tian, Chenyang Mi, Mengyuan Dai, Shuming Zhang, Huidong Zhan. Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblastic cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway. Cell biology and toxicology. vol 37. issue 6. 2021-11-18. PMID:33566220. |
subsequently, the upregulated p53 facilitated sat1 transcription and enhanced sat1-catalyzed spermine metabolism, which further resulted in trophoblastic cell apoptosis and induced miscarriage. |
2021-11-18 |
2023-08-13 |
human |
| Tingting Liang, Jiayu Xie, Jingsong Zhao, Wenxin Huang, Zhongyan Xu, Peng Tian, Chenyang Mi, Mengyuan Dai, Shuming Zhang, Huidong Zhan. Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblastic cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway. Cell biology and toxicology. vol 37. issue 6. 2021-11-18. PMID:33566220. |
p53 promotes sat1 transcription and reduces its cellular spermine content, resulting in cell apoptosis. |
2021-11-18 |
2023-08-13 |
human |
| Nongyao Nonpanya, Kittipong Sanookpan, Keerati Joyjamras, Duangdao Wichadakul, Boonchoo Sritularak, Chatchai Chaotham, Pithi Chanvorachot. Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells. PloS one. vol 16. issue 8. 2021-11-18. PMID:34383763. |
in addition, norcycloartocarpin activated apoptosis caspase cascade associating with restoration of p53, down-regulated bcl-2 and augmented bax in a549 and h460 cells. |
2021-11-18 |
2023-08-13 |
human |
| Jorge Antonio Silva-Gomez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Hipolito Otoniel Miranda-Roblero, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borund. Hepatocarcinogenesis Prevention by Pirfenidone Is PPARγ Mediated and Involves Modification of Nuclear NF-kB p65/p50 Ratio. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34768791. |
caspase-3, p53, and parp-1 were used as apoptosis markers, pcna for proliferation. |
2021-11-18 |
2023-08-13 |
human |
| Qi Zhang, Xinqi Zhang, Weiguo Don. TRAF7 contributes to tumor progression by promoting ubiquitin-proteasome mediated degradation of P53 in hepatocellular carcinoma. Cell death discovery. vol 7. issue 1. 2021-11-18. PMID:34775479. |
the rescue assays further proved that the function of traf7 in inhibiting apoptosis and promoting tumor development was depended on p53 in hcc. |
2021-11-18 |
2023-08-13 |
human |
| Yajun Li, Kaisa Cui, Qiang Zhang, Xu Li, Xingrong Lin, Yi Tang, Edward V Prochownik, Youjun L. FBXL6 degrades phosphorylated p53 to promote tumor growth. Cell death and differentiation. vol 28. issue 7. 2021-11-17. PMID:33568778. |
fbxl6 depletion inhibits proliferation of p53 wild-type (wt) crc cells by inducing cell cycle arrest and apoptosis. |
2021-11-17 |
2023-08-13 |
human |
| Margot E Bowen, Abigail S Mulligan, Aryo Sorayya, Laura D Attard. Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects. Cell death and differentiation. vol 28. issue 7. 2021-11-17. PMID:33574585. |
whether p53 activation drives these developmental phenotypes by triggering apoptosis, cell cycle arrest, or other p53 cellular responses, however, has remained elusive. |
2021-11-17 |
2023-08-13 |
Not clear |
| Margot E Bowen, Abigail S Mulligan, Aryo Sorayya, Laura D Attard. Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects. Cell death and differentiation. vol 28. issue 7. 2021-11-17. PMID:33574585. |
together, our results indicate that p53-driven craniofacial, neuronal and pigmentation defects can arise in the absence of apoptosis and cell cycle arrest, suggesting that p53 hyperactivation can act via alternative pathways to trigger developmental phenotypes. |
2021-11-17 |
2023-08-13 |
Not clear |
| Abouzar Babaei, Hoorieh Soleimanjahi, Masoud Soleimani, Ehsan Arefia. Mesenchymal stem cells loaded with oncolytic reovirus enhances antitumor activity in mice models of colorectal cancer. Biochemical pharmacology. vol 190. 2021-11-17. PMID:34090878. |
higher anticancer impact of mscs loaded with ov was associated with induction of apoptosis, cell cycle arrests, p53 expression in tumor sections, and reduced tumor growth and size. |
2021-11-17 |
2023-08-13 |
mouse |