| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joseph Bekisz, Samuel Baron, Corey Balinsky, Angel Morrow, Kathryn C Zoo. Antiproliferative Properties of Type I and Type II Interferon. Pharmaceuticals (Basel, Switzerland). vol 3. issue 4. 2021-10-20. PMID:20664817. |
ifn treatment induces the tumor suppressor gene p53, which plays a role in apoptosis for some tumors, but it is not essential for the apoptotic response. |
2021-10-20 |
2023-08-12 |
human |
| Ruth C Borghaei, Mariah Chamber. Expression of transcription factor zinc-binding protein-89 (ZBP-89) is inhibited by inflammatory cytokines. Pathology and laboratory medicine international. vol 1. 2021-10-20. PMID:20686646. |
it is over-expressed in several cancers, but has been shown to be involved in apoptosis and to have a negative influence on cell growth in part by interactions with p53. |
2021-10-20 |
2023-08-12 |
human |
| Martin L Smith, M A Suresh Kuma. The "Two faces" of Tumor Suppressor p53-revisited. Molecular and cellular pharmacology. vol 2. issue 3. 2021-10-20. PMID:20686673. |
we coined the term "the two faces of tumor suppressor p53" to illustrate that p53 can on one hand induce apoptosis leading to cell sensitivity, but p53 can also enhance the rate of dna repair thereby protecting cells from dna damage. |
2021-10-20 |
2023-08-12 |
Not clear |
| Yanhong Zhang, Ariane Scoumanne, Xinbin Che. G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery. Molecular and cellular pharmacology. vol 2. issue 3. 2021-10-20. PMID:20686680. |
moreover, we found that a lack of gpr87 triggers an increase in p53, concomitant with a decrease in akt, which results in the sensitization of tumor cells to dna damage-induced apoptosis and growth suppression. |
2021-10-20 |
2023-08-12 |
human |
| James J Driscoll, Steven Gauerke, Brian C Monaha. Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. Case reports in oncology. vol 2. issue 1. 2021-10-20. PMID:20740144. |
the p63 gene contains 2 separate promoters which express at least 6 major transcripts that lead to 2 fundamentally different classes of proteins; 3 isoforms (tap63alpha, beta and gamma) encode proteins that induce apoptosis, whereas the other 3 isoforms (deltanp63alpha, beta and gamma) may exert inhibitory effects on p53. |
2021-10-20 |
2023-08-12 |
Not clear |
| Haitao Luo, Gary O Rankin, Zhaoliang Li, Laura Depriest, Yi Charlie Che. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food chemistry. vol 128. issue 2. 2021-10-20. PMID:21625365. |
kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. |
2021-10-20 |
2023-08-12 |
Not clear |
| Murali K Mamidi, William E Samsa, Lindsay A Bashur, Yuqing Chen, Ricky Chan, Brendan Lee, Guang Zho. The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity. Journal of cellular physiology. vol 236. issue 8. 2021-10-19. PMID:33393086. |
gene set enrichment analysis revealed that key targets inhibited by jab1 includes p53, bmp/transforming growth factor beta, and apoptosis pathways. |
2021-10-19 |
2023-08-13 |
mouse |
| Lujia Zhang, Li Dong, Liuqing Yang, Yinghua Luo, Fang Che. MiR-27a-5p regulates acrylamide-induced mitochondrial dysfunction and intrinsic apoptosis via targeting Btf3 in rats. Food chemistry. vol 368. 2021-10-19. PMID:34416489. |
the knockdown of btf3 increases the cleaved parp1 level and the phosphorylation of atm and p53, which results in mitochondria-dependent apoptosis. |
2021-10-19 |
2023-08-13 |
rat |
| Shiva Najjary, Reza Mohammadzadeh, Behzad Mansoori, Fatemeh Vahidian, Ali Mohammadi, Mohammad Amin Doustvandi, Vahid Khaze, Khalil Hajiasgharzadeh, Behzad Baradara. Combination therapy with miR-34a and doxorubicin synergistically induced apoptosis in T-cell acute lymphoblastic leukemia cell line. Medical oncology (Northwood, London, England). vol 38. issue 12. 2021-10-18. PMID:34655330. |
then the synergic effects of mir-34a in combination with doxorubicin were investigated on cell death of acute t-cell lymphoblastic leukemia jurkat cell line, as well as the expression of some genes including caspase-3, bcl-2, and p53 which are involved in apoptosis. |
2021-10-18 |
2023-08-13 |
Not clear |
| Ju-Ha Kim, Ji Hoon Jung, Hyo-Jung Lee, Deok-Yong Sim, Eunji Im, Jieon Park, Woon-Yi Park, Chi-Hoon Ahn, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Ki. UBE2M Drives Hepatocellular Cancer Progression as a p53 Negative Regulator by Binding to MDM2 and Ribosomal Protein L11. Cancers. vol 13. issue 19. 2021-10-16. PMID:34638383. |
herein, ube2m depletion suppressed viability and proliferation and induced cell cycle arrest and apoptosis via cleavages of parp and caspase 3 and upregulation of p53, bax and puma in hepg2, huh7 and hep3b cells. |
2021-10-16 |
2023-08-13 |
mouse |
| Mengling Zhang, Jian Liu, Rui Zhang, Zengenni Liang, Shenghua Ding, Huanling Yu, Yang Sha. Nobiletin, a hexamethoxyflavonoid from citrus pomace, attenuates G1 cell cycle arrest and apoptosis in hypoxia-induced human trophoblast cells of JEG-3 and BeWo via regulating the p53 signaling pathway. Food & nutrition research. vol 65. 2021-10-16. PMID:34650395. |
nobiletin, a hexamethoxyflavonoid from citrus pomace, attenuates g1 cell cycle arrest and apoptosis in hypoxia-induced human trophoblast cells of jeg-3 and bewo via regulating the p53 signaling pathway. |
2021-10-16 |
2023-08-13 |
human |
| Meng-Hao Pan, Cheng-Cheng Zhu, Jia-Qian Ju, Yi Xu, Shi-Ming Luo, Shao-Chen Sun, Xiang-Hong O. Single-cell transcriptome analysis reveals that maternal obesity affects DNA repair, histone methylation, and autophagy level in mouse embryos. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33368268. |
genome-wide analysis indicated that obesity altered the expression of more than 1100 genes in 2-cell embryos, including the genes which were related to the p53 signaling pathway and apoptosis. |
2021-10-14 |
2023-08-13 |
mouse |
| Lanfang Li, Heng Zeng, Xiaochen He, Jian-Xiong Che. Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism. Journal of the American Heart Association. vol 10. issue 5. 2021-10-14. PMID:33586458. |
methods and results exposure of h9c2 cardiomyocyte cell lines to high glucose (hg) (30 mmol/l) resulted in a gradual decrease in sirt3 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (pfkfb3) expression together with increases in p53 acetylation and tp53-induced glycolysis and apoptosis regulator (tigar) expression. |
2021-10-14 |
2023-08-13 |
mouse |
| Yeqing Dong, Yongsheng Huang, Chengyan Fan, Liang Wang, Ran Zhang, Wenhua Li, Zhengguang Guo, Dong Wang, Zhi Zhen. GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33947839. |
in contrast, the ppgl-predisposing vhl mutations had no effect on proliferation and gipc2 expression but caused p53 downregulation and reduced apoptosis in chromaffin cells compared with wild-type vhl. |
2021-10-14 |
2023-08-13 |
mouse |
| Xing Liu, Fangjing Rong, Jinhua Tang, Chunchun Zhu, Xiaoyun Chen, Shuke Jia, Zixuan Wang, Xueyi Sun, Hongyan Deng, Huangyuan Zha, Gang Ouyang, Wuhan Xia. Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage. Cell death and differentiation. 2021-10-13. PMID:34642466. |
p53 is a classic tumor suppressor that functions in maintaining genome stability by inducing either cell arrest for damage repair or cell apoptosis to eliminate damaged cells in response to different types of stress. |
2021-10-13 |
2023-08-13 |
mouse |
| Jia Wang, Aolin Du, Hexilin Wang, Yang L. MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2/STAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells. Clinical and experimental pharmacology & physiology. vol 47. issue 8. 2021-10-12. PMID:32248560. |
cell viability was analyzed by cck-8 assay and trypan blue exclusion assay; the formation of dna fragments was tested by cell death detection elisa plus kit; the incidence of apoptosis was detected by flow cytometry; the expression of p53 and cleaved-caspase 3 (c-caspase 3) was evaluated by western blot. |
2021-10-12 |
2023-08-13 |
human |
| Jia Wang, Aolin Du, Hexilin Wang, Yang L. MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2/STAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells. Clinical and experimental pharmacology & physiology. vol 47. issue 8. 2021-10-12. PMID:32248560. |
the results showed that overexpression of mir-599 increased cell viability, reduced dna fragments, the incidence of apoptosis, as well as the protein levels of p53 and c-caspase 3 in the presence of lps. |
2021-10-12 |
2023-08-13 |
human |
| Özlem Demir, Emilia P Barros, Tavina L Offutt, Mia Rosenfeld, Rommie E Amar. An integrated view of p53 dynamics, function, and reactivation. Current opinion in structural biology. vol 67. 2021-10-11. PMID:33401096. |
the tumor suppressor p53 plays a vital role in responding to cell stressors such as dna damage, hypoxia, and tumor formation by inducing cell-cycle arrest, senescence, or apoptosis. |
2021-10-11 |
2023-08-13 |
human |
| Javier De La Rosa, Alejandro Urdiciain, María V Zelaya, Idoya Zazpe, Bárbara Meléndez, Juan A Rey, Miguel A Idoate, Javier S Castresan. APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells. International journal of oncology. vol 58. issue 3. 2021-10-11. PMID:33650649. |
following the chou‑talalay method it was demonstrated that apr‑246 acts in an additive manner together with the other compounds, reducing clonogenicity and inducing apoptosis in glioblastoma cells independently of p53 status. |
2021-10-11 |
2023-08-13 |
Not clear |
| Maria Rosaria Dello Stritto, Bernd Bauer, Pierre Barraud, Verena Jantsc. DNA topoisomerase 3 is required for efficient germ cell quality control. The Journal of cell biology. vol 220. issue 6. 2021-10-11. PMID:33798260. |
here we show that topoisomerase 3 depletion generates dna lesions in both germline mitotic and meiotic compartments that are less capable of triggering p53 (cep-1)-dependent apoptosis, despite the activation of dna damage and apoptosis signaling. |
2021-10-11 |
2023-08-13 |
caenorhabditis_elegans |