| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Da-Wei Li, Xiao-Dan Qi, Chuan-Hui Zhang, Wen-Ping Su. Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions. Neuroreport. vol 32. issue 15. 2021-10-07. PMID:34494994. |
the purpose of this study was to explore the mechanism of p53 dependent dopaminergic cell death and implication of annexin a2 in cellular apoptosis in 1-methyl-4-phenylpyridinium (mpp+)-induced pc12 cells. |
2021-10-07 |
2023-08-13 |
Not clear |
| Joana Moreira, Joana Almeida, Joana B Loureiro, Helena Ramos, Andreia Palmeira, Madalena M Pinto, Lucília Saraiva, Honorina Cidad. A Diarylpentanoid with Potential Activation of the p53 Pathway: Combination of in silico Screening Studies, Synthesis, and Biological Activity Evaluation. ChemMedChem. vol 16. issue 19. 2021-10-06. PMID:34170069. |
the antiproliferative effect of this compound was associated with induction of cell cycle arrest, apoptosis, parp cleavage and increased p53 and its transcriptional targets, p21 and puma, in hct116 cells. |
2021-10-06 |
2023-08-13 |
Not clear |
| Liang Wei, Cheng Yang, Guangxue Wang, Keqin Li, Yanfei Zhang, Hongxin Guan, Zhiyang Sun, Chunlong Zhon. Interleukin Enhancer Binding Factor 2 Regulates Cell Viability and Apoptosis of Human Brain Vascular Smooth Muscle Cells. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32748330. |
rt-qpcr results showed that ilf2 knock-down downregulated the expression levels of bcl2 apoptosis regulator (bcl2), transcriptional regulator myc-like (c-myc), and caspase 1 (ice) whereas upregulated the expression levels of cd95, p21, p53, and interleukin-13 (il-13). |
2021-10-05 |
2023-08-13 |
human |
| Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Don. Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis. Molecular medicine reports. vol 24. issue 1. 2021-10-05. PMID:33955500. |
the mechanism underlying ea (gv20‑gb7) treatment may involve inhibition of p53, an overlapping protein of autophagy and apoptosis. |
2021-10-05 |
2023-08-13 |
Not clear |
| Jing Qu, Shan-Zhong Yang, Yi Zhu, Ting Guo, Victor J Thannickal, Yong Zho. Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice. The Journal of experimental medicine. vol 218. issue 5. 2021-10-04. PMID:33688918. |
gain of p53 function activates a gene program that sensitizes lung myofibroblasts to apoptosis and promotes the clearance of apoptotic myofibroblasts by macrophages. |
2021-10-04 |
2023-08-13 |
mouse |
| Wenjing Wang, Huanju Li, Yongle Qiu, Kunshan Li, Yueting Lu, Qianlan Deng, Tiejun Li. Maternally expressed 3 inhibits the biological activity of oral squamous cell carcinoma SCC25 and CAL27 cell lines. Oncology letters. vol 22. issue 5. 2021-10-02. PMID:34594425. |
overexpression of lncrna meg3 inhibited the proliferation, migration, and invasion of scc25 and cal27 cell lines, induced apoptosis and promoted the expression of p53 gene. |
2021-10-02 |
2023-08-13 |
Not clear |
| Yimin Liang, Renpeng Zhou, Xiujun Fu, Chen Wang, Danru Wan. HOXA5 counteracts the function of pathological scar-derived fibroblasts by partially activating p53 signaling. Cell death & disease. vol 12. issue 1. 2021-10-01. PMID:33414417. |
interestingly, silencing p53 in these pathological scar-derived fibroblasts partially attenuated hoxa5-mediated growth inhibition effect and hoxa5-induced apoptosis. |
2021-10-01 |
2023-08-13 |
Not clear |
| Tongsen Zheng, Jiabei Wang, Xuan Song, Xianzhi Meng, Shangha Pan, Hongchi Jiang, Lianxin Li. Correction to: Nutlin-3 cooperates with doxorubicin to induce apoptosis of human hepatocellular carcinoma cells through p53 or p73 signaling pathways. Journal of cancer research and clinical oncology. vol 147. issue 11. 2021-10-01. PMID:33528639. |
correction to: nutlin-3 cooperates with doxorubicin to induce apoptosis of human hepatocellular carcinoma cells through p53 or p73 signaling pathways. |
2021-10-01 |
2023-08-13 |
human |
| Adrian Kwan Ho Loe, Roshane Francis, Jieun Seo, Lutao Du, Yunshan Wang, Ji-Eun Kim, Shaheed W Hakim, Jung-Eun Kim, Housheng Hansen He, Haiyang Guo, Tae-Hee Ki. Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy. The Journal of experimental medicine. vol 218. issue 6. 2021-10-01. PMID:33822841. |
establishing a novel mouse model that reflects the arid1a heterozygous mutations found in the majority of human gc cases, we demonstrated that arid1a heterozygosity facilitates tumor progression through a global loss of enhancers and subsequent suppression of the p53 and apoptosis pathways. |
2021-10-01 |
2023-08-13 |
mouse |
| Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chan. RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572430. |
in addition, nsc139021 also increased the apoptosis of glioblastoma cells by activating the p53 signaling pathway and increasing the levels of bax and cleaved caspase 3. |
2021-10-01 |
2023-08-13 |
mouse |
| Yu-Hao He, Ming-Hsin Yeh, Hsiao-Fan Chen, Tsu-Shing Wang, Ruey-Hong Wong, Ya-Ling Wei, Thanh Kieu Huynh, Dai-Wei Hu, Fang-Ju Cheng, Jhen-Yu Chen, Shu-Wei Hu, Chia-Chen Huang, Yeh Chen, Jiaxin Yu, Wei-Chung Cheng, Pei-Chun Shen, Liang-Chih Liu, Chih-Hao Huang, Ya-Jen Chang, Wei-Chien Huan. ERα determines the chemo-resistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions. Molecular therapy. Nucleic acids. vol 25. 2021-10-01. PMID:34589276. |
mutant p53 (mutp53) commonly loses its dna binding affinity to p53 response elements (p53res) and fails to induce apoptosis fully. |
2021-10-01 |
2023-08-13 |
Not clear |
| V V Gandhi, K A Gandhi, L B Kumbhare, J S Goda, V Gota, K I Priyadarsini, A Kunwa. 3,3'-Diselenodipropionic acid (DSePA) induces reductive stress in A549 cells triggering p53-independent apoptosis: A novel mechanism for diselenides. Free radical biology & medicine. vol 175. 2021-09-30. PMID:34425189. |
in conclusion, above results suggest that dsepa induces apoptosis in a p53 independent manner by involving extrinsic and intrinsic pathways together with er stress which can an interesting strategy for lung cancer therapy. |
2021-09-30 |
2023-08-13 |
mouse |
| Jingwen Xu, Yihai Wang, Yi Wang, Zhe Wang, Xiangjiu H. A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells. Chemico-biological interactions. vol 348. 2021-09-30. PMID:34506766. |
a-24, a steroidal saponin from allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells. |
2021-09-30 |
2023-08-13 |
Not clear |
| Jingwen Xu, Yihai Wang, Yi Wang, Zhe Wang, Xiangjiu H. A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells. Chemico-biological interactions. vol 348. 2021-09-30. PMID:34506766. |
we previously reported that the active compound a-24 induces apoptosis and autophagy in p53 wild-type gastric cancer cells through the pi3k/akt/mtor pathway. |
2021-09-30 |
2023-08-13 |
Not clear |
| Jingwen Xu, Yihai Wang, Yi Wang, Zhe Wang, Xiangjiu H. A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells. Chemico-biological interactions. vol 348. 2021-09-30. PMID:34506766. |
taken together, our results indicate that a-24 induced apoptosis and autophagy via the ros-pi3k/akt/mtor pathway in p53 wild-type gastric cancer cells and through the ros-mtor pathway in p53-deficient gastric cancer cells. |
2021-09-30 |
2023-08-13 |
Not clear |
| Dong Hoon Lee, Go Woon Kim, Jung Yoo, Sang Wu Lee, Yu Hyun Jeon, So Yeon Kim, Hyeok Gu Kang, Da-Hyun Kim, Kyung-Hee Chun, Junjeong Choi, So Hee Kwo. Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc. Cell death & disease. vol 12. issue 1. 2021-09-29. PMID:33462212. |
conversely, depletion or inhibition of kdm4c promotes p53 target gene expression and induces apoptosis in glioblastoma. |
2021-09-29 |
2023-08-13 |
human |
| Yanqing Liu, Wei G. The complexity of p53-mediated metabolic regulation in tumor suppression. Seminars in cancer biology. 2021-09-29. PMID:33785447. |
although the classic activities of p53 including induction of cell-cycle arrest, senescence, and apoptosis are well accepted as critical barriers to cancer development, accumulating evidence suggests that loss of these classic activities is not sufficient to abrogate the tumor suppression activity of p53. |
2021-09-29 |
2023-08-13 |
Not clear |
| Emiko Sano, Akira Kazaana, Hisashi Tadakuma, Toshiaki Takei, Sodai Yoshimura, Yuya Hanashima, Yoshinari Ozawa, Atsuo Yoshino, Yutaka Suzuki, Takuya Ued. Interleukin-6 sensitizes TNF-α and TRAIL/Apo2L dependent cell death through upregulation of death receptors in human cancer cells. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 7. 2021-09-29. PMID:33839168. |
these findings indicate that il-6 could contribute to the enhancement of tnf-α or trail induced apoptosis through p53 dependent upregulation of dr-4 and dr-5. |
2021-09-29 |
2023-08-13 |
human |
| Xueying Pei, Mingxu Chu, Peng Tang, Hongyan Zhang, Xinyu Zhang, Xiang Zheng, Jie Li, Jie Mei, Tao Wang, Shaowu Yi. Effects of acute hypoxia and reoxygenation on oxygen sensors, respiratory metabolism, oxidative stress, and apoptosis in hybrid yellow catfish "Huangyou-1". Fish physiology and biochemistry. vol 47. issue 5. 2021-09-29. PMID:34313912. |
the expressions of genes related to apoptosis (apaf-1, bax, caspase 3, caspase 9, and p53) were higher than those in control during hypoxic exposure, while the expressions of bcl-2 and cyt c were decreased. |
2021-09-29 |
2023-08-13 |
cat |
| Rasha M Hussein, Saed M Al-Dalai. Betaine downregulates microRNA 34a expression via a p53-dependent manner in cisplatin-induced nephrotoxicity in rats. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34318554. |
in this study, the protective effect of betaine against cisplatin-induced nephrotoxicity through modulating the expression of microrna 34a (mirna 34a), p53, apoptosis, and inflammation was investigated. |
2021-09-29 |
2023-08-13 |
rat |