| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Mirjalili, Ali Khaleghian, Fatemeh Kalalini. Effects of co-administration of arsenic trioxide and Schiff base oxovanadium complex on the induction of apoptosis in acute promyelocytic leukemia cells. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 34. issue 5. 2021-10-11. PMID:34255251. |
flow cytometry and real-time rt-pcr were also performed to investigate the rate of apoptosis and the expression of p53 and p21 genes, respectively. |
2021-10-11 |
2023-08-13 |
Not clear |
| Bhawna Pandey, Aditya Dev, Debamitra Chakravorty, Vishwambhar Vishnu Bhandare, Smarajit Polley, Siddhartha Roy, Gautam Bas. Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules. Biochemical and biophysical research communications. vol 578. 2021-10-11. PMID:34534740. |
interaction between human positive coactivator 4 (pc4), an abundant nuclear protein, and the tumor suppressor protein p53 plays a crucial role in initiating apoptosis. |
2021-10-11 |
2023-08-13 |
human |
| Jie Tang, Lei Chen, Zheng-Hong Qin, Rui Shen. Structure, regulation, and biological functions of TIGAR and its role in diseases. Acta pharmacologica Sinica. vol 42. issue 10. 2021-10-09. PMID:33510458. |
tigar (tp53-induced glycolysis and apoptosis regulator) is the downstream target gene of p53, contains a functional sequence similar to 6-phosphofructose kinase/fructose-2, 6-bisphosphatase (pfkfb) bisphosphatase domain. |
2021-10-09 |
2023-08-13 |
Not clear |
| Juliann G Kian. Exacerbation of Mild Hypoxia on Acute Radiation Syndrome and Subsequent Mortality. Adaptive medicine. vol 9. issue 1. 2021-10-09. PMID:34616568. |
atp depletion, p53 phosphorylation, and caspase-3 activation are found, suggesting cell apoptosis. |
2021-10-09 |
2023-08-13 |
Not clear |
| Adam Kinnaird, Aristeidis E Boukouris, Bruno Saleme, Peter Dromparis, Sotirios D Zervopoulos, Vikram Gurtu, Gopinath Sutendra, Evangelos D Michelaki. Interaction with p53 explains a pro-proliferative function for VHL in cancer. Journal of molecular medicine (Berlin, Germany). vol 98. issue 9. 2021-10-08. PMID:32725274. |
vhl limited the decrease in proliferation and increase in apoptosis caused by p53 activation, independent of prolyl-hydroxylation and hif activity, and its presence in tumors caused a resistance to p53-inducing chemotherapy in vivo. |
2021-10-08 |
2023-08-13 |
Not clear |
| Tiantian Xu, Yinghua Li, Hua-Lian Wu, Haiyang Chen, Houbo Wu, Min Guo, Mingqi Zhao, Changbing Wang, Tao Lin, Zhengfang Lin, Danyang Chen, Wenzhou Xiang, Bing Zh. The inhibition of enterovirus 71 induced apoptosis by Durvillaea antarctica through P53 and STAT1 signaling pathway. Journal of medical virology. vol 93. issue 6. 2021-10-08. PMID:33230830. |
the inhibition of enterovirus 71 induced apoptosis by durvillaea antarctica through p53 and stat1 signaling pathway. |
2021-10-08 |
2023-08-13 |
Not clear |
| Tiantian Xu, Yinghua Li, Hua-Lian Wu, Haiyang Chen, Houbo Wu, Min Guo, Mingqi Zhao, Changbing Wang, Tao Lin, Zhengfang Lin, Danyang Chen, Wenzhou Xiang, Bing Zh. The inhibition of enterovirus 71 induced apoptosis by Durvillaea antarctica through P53 and STAT1 signaling pathway. Journal of medical virology. vol 93. issue 6. 2021-10-08. PMID:33230830. |
moreover, dapp inhibited the vero cells apoptosis induced by ev71 via the p53 signaling pathway. |
2021-10-08 |
2023-08-13 |
Not clear |
| Massumeh Sanaei, Fraidoon Kavoos. Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue S1. 2021-10-08. PMID:33576217. |
effect of valproic acid on the class i histone deacetylase 1, 2 and 3, tumor suppressor genes p21waf1/cip1 and p53, and intrinsic mitochondrial apoptotic pathway, pro- (bax, bak, and bim) and anti- (bcl-2, bcl-xl, and mcl-1) apoptotic genes expression, cell viability, and apoptosis induction in hepatocellular carcinoma hepg2 cell line. |
2021-10-08 |
2023-08-13 |
Not clear |
| Massumeh Sanaei, Fraidoon Kavoos. Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue S1. 2021-10-08. PMID:33576217. |
the present study was designed to investigate the effect of vpa on the class i histone deacetylase (hdac) 1, 2 and 3, tsgs p21and p53, and intrinsic mitochondrial pathway, pro- (bax, bak, and bim) and anti- (bcl-2, bcl-xl, and mcl-1) apoptotic genes, viability, and apoptosis in hcc hepg2 cell line. |
2021-10-08 |
2023-08-13 |
Not clear |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction via the MicroRNA-381-Mediated EGR1/p53 Axis. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34245441. |
we also assessed its effects on neuron apoptosis and production of tnf-α and il-1β in mouse brain tissues as well as expression levels of dna damage-related proteins p53, p21, and γh2ax. |
2021-10-08 |
2023-08-13 |
mouse |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction via the MicroRNA-381-Mediated EGR1/p53 Axis. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34245441. |
mir-381 targeted egr1 and disrupted its interaction with p53, leading to a decline in hippocampal neuron apoptosis, dna damage, neuroinflammation, and cognitive impairment. |
2021-10-08 |
2023-08-13 |
mouse |
| Pingping Xu, Danfeng Sun, Yaqi Gao, Yi Jiang, Ming Zhong, Gang Zhao, Jinxian Chen, Zheng Wang, Qiang Liu, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Jing-Yuan Fan. Germline mutations in a DNA repair pathway are associated with familial colorectal cancer. JCI insight. vol 6. issue 18. 2021-10-08. PMID:34549727. |
functional experiments demonstrated that chek2ko cells showed defective cell cycle arrest and apoptosis, as well as reduced p53 phosphorylation, upon dna damage. |
2021-10-08 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Huey-Jiun Ko, Tzu-Shao Liao, Xiang-Ren Zheng, Po-Hsu Chou, Li-Ting Wang, Ru-Wei Lin, Chung-Hwan Chen, Chihuei Wan. Severe cellular stress activates apoptosis independently of p53 in osteosarcoma. Cell death discovery. vol 7. issue 1. 2021-10-08. PMID:34608124. |
severe cellular stress activates apoptosis independently of p53 in osteosarcoma. |
2021-10-08 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Huey-Jiun Ko, Tzu-Shao Liao, Xiang-Ren Zheng, Po-Hsu Chou, Li-Ting Wang, Ru-Wei Lin, Chung-Hwan Chen, Chihuei Wan. Severe cellular stress activates apoptosis independently of p53 in osteosarcoma. Cell death discovery. vol 7. issue 1. 2021-10-08. PMID:34608124. |
apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting dna, 26s proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type u2os and p53-null mg63 cells. |
2021-10-08 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Huey-Jiun Ko, Tzu-Shao Liao, Xiang-Ren Zheng, Po-Hsu Chou, Li-Ting Wang, Ru-Wei Lin, Chung-Hwan Chen, Chihuei Wan. Severe cellular stress activates apoptosis independently of p53 in osteosarcoma. Cell death discovery. vol 7. issue 1. 2021-10-08. PMID:34608124. |
the combination of doxorubicin with abt-263 could produce synergistic apoptosis in mg63 cells, which lack p53, suggesting that p53 has no role in doxorubicin-induced apoptosis in osteosarcoma. |
2021-10-08 |
2023-08-13 |
Not clear |
| Expression of Concern: Silencing SUMO2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. Bioscience reports. vol 40. issue 8. 2021-10-07. PMID:32857153. |
expression of concern: silencing sumo2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. |
2021-10-07 |
2023-08-13 |
Not clear |
| Subhamita Maitra, Wannapa Sornjai, Duncan R Smith, Bruno Vincen. Phenanthroline impairs βAPP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells. Brain research bulletin. vol 170. 2021-10-07. PMID:33556560. |
furthermore, treatment of cells at concentrations of phenanthroline similar to those inducing increased levels of p53 induced cell cycle arrest leading to apoptosis. |
2021-10-07 |
2023-08-13 |
human |
| M R A Hussei. Immunohistological Analysis of CD34-Positive Dermal Dendritic Cells and Microvessel Density in the Genital and Extragenital Lichen Sclerosus. Actas dermo-sifiliograficas. 2021-10-07. PMID:34030991. |
p53 is a tumor suppressor gene important for the regulation of the cell cycle and apoptosis. |
2021-10-07 |
2023-08-13 |
Not clear |
| Yi Jer Tan, Yeuan Ting Lee, Ricardo L Mancera, Chern Ein Oo. BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT 116 colorectal cancer cells. Life sciences. vol 284. 2021-10-07. PMID:34171380. |
this study provides the first assessment of possible associations of molecular players underlying the cytotoxic activity of bzd9l1, and establishes the links between rcts and apoptosis through the p53 pathway. |
2021-10-07 |
2023-08-13 |
Not clear |
| Da-Wei Li, Xiao-Dan Qi, Chuan-Hui Zhang, Wen-Ping Su. Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions. Neuroreport. vol 32. issue 15. 2021-10-07. PMID:34494994. |
annexin a2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions. |
2021-10-07 |
2023-08-13 |
Not clear |