| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angeles Almeida, Irene Sánchez-Morán, Cristina Rodrígue. Mitochondrial-nuclear p53 trafficking controls neuronal susceptibility in stroke. IUBMB life. vol 73. issue 3. 2021-09-21. PMID:33615665. |
over the last years, subcellular localization of p53 has emerged as an important regulator of ischemia-induced neuronal apoptosis. |
2021-09-21 |
2023-08-13 |
human |
| Angeles Almeida, Irene Sánchez-Morán, Cristina Rodrígue. Mitochondrial-nuclear p53 trafficking controls neuronal susceptibility in stroke. IUBMB life. vol 73. issue 3. 2021-09-21. PMID:33615665. |
moreover, the identification of a human single nucleotide polymorphism at codon 72 of the tp53 gene that controls p53 mitochondrial localization and cell susceptibility to apoptosis supports the important role of the p53 mitochondrial program in neuronal survival and functional recovery after stroke. |
2021-09-21 |
2023-08-13 |
human |
| Xinran Liu, Yiping Zhang, Yijie Wang, Meiwen Yang, Fenfang Hong, Shulong Yan. Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway. Biomolecules. vol 11. issue 7. 2021-09-21. PMID:34356634. |
phosphorylation of key proteins, including p38 mapk, erk, pi3k, stat3, and p53, modified by no in various signaling pathways affects different cancer-related processes including cell apoptosis, proliferation, angiogenesis, metastasis, and several cancer therapies. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhibiao Zhong, Weilan Su, Hongmei Che. MicroRNA‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515323. |
overexpression of mir‑532‑5p downregulated hg‑induced cell insulin secretion, oxidative stress and apoptosis by downregulating ccnd1, which is involved in regulating the expression of p53. |
2021-09-21 |
2023-08-13 |
Not clear |
| Daeun Shim, Lei Duan, Carl G Mak. P53-regulated autophagy and its impact on drug resistance and cell fate. Cancer drug resistance (Alhambra, Calif.). vol 4. 2021-09-21. PMID:34532654. |
p53 inhibits the growth of incipient cancer cells by blocking their proliferation or inducing their death through apoptosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Daeun Shim, Lei Duan, Carl G Mak. P53-regulated autophagy and its impact on drug resistance and cell fate. Cancer drug resistance (Alhambra, Calif.). vol 4. 2021-09-21. PMID:34532654. |
blocking autophagy has been reported in several studies to increase p53-mediated apoptosis, revealing that autophagy can influence cell-fate in response to activated p53 and is a potential target to increase p53-dependent tumor suppression. |
2021-09-21 |
2023-08-13 |
Not clear |
| Nan Wang, Peining Zhu, Renxuan Huang, Liankun Sun, Delu Dong, Yufei Ga. Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide. Experimental and therapeutic medicine. vol 22. issue 5. 2021-09-21. PMID:34539842. |
tmz treatment induced apoptosis in gbm cells by activating the p53 pathway, whilst simultaneously downregulating mitophagy and enhancing mitochondrial fusion. |
2021-09-21 |
2023-08-13 |
Not clear |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Jun Wang, Holly R Thomas, Zhang Li, Nan Cher Florence Yeo, Hannah E Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A Andrabi, John M Paran. Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34193827. |
puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. |
2021-09-20 |
2023-08-13 |
human |
| Jun Wang, Holly R Thomas, Zhang Li, Nan Cher Florence Yeo, Hannah E Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A Andrabi, John M Paran. Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34193827. |
contrary to genotoxic stress, er stress-induced apoptosis requires p63 and puma, but not p53, p73, or noxa. |
2021-09-20 |
2023-08-13 |
human |
| Jun Wang, Holly R Thomas, Zhang Li, Nan Cher Florence Yeo, Hannah E Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A Andrabi, John M Paran. Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34193827. |
in addition, we have also generated a knockout of the negative regulator of p53, mdm2 to further evaluate the p53-induced apoptosis. |
2021-09-20 |
2023-08-13 |
human |
| Jun Wang, Holly R Thomas, Zhang Li, Nan Cher Florence Yeo, Hannah E Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A Andrabi, John M Paran. Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34193827. |
our data indicate that the p53 null allele completely rescues the mdm2 null lethality, while the puma null completely rescues the mdm2 null apoptosis but only partially rescues the phenotype. |
2021-09-20 |
2023-08-13 |
human |
| Xiaohui Tan, Dunpeng Cai, Na Chen, Sihao Du, Dongfang Qiao, Xia Yue, Tao Wang, Jia Li, Weibing Xie, Huijun Wan. Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. Toxicology letters. vol 350. 2021-09-20. PMID:34214594. |
chop inhibits protein kinase b phosphorylation and further inhibits forkhead box class o3a (foxo3a) dephosphorylation, resulting in increased p53 upregulated molecular of apoptosis (puma) transcription. |
2021-09-20 |
2023-08-13 |
human |
| Amr Abdelhamed, Reham Ezz El-Dawla, Ayse S Karadag, Naglaa F Agamia, Bodo C Melni. The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature. Reproductive toxicology (Elmsford, N.Y.). vol 104. 2021-09-20. PMID:34224824. |
isotretinoin is associated with pro-apoptotic signaling in sebaceous glands through upregulated expression of p53, forkhead box o transcription factors (foxo1, foxo3), and tumor necrosis factor-related apoptosis inducing ligand (trail). |
2021-09-20 |
2023-08-13 |
Not clear |
| Xuming Zhu, Matthew Leboeuf, Fang Liu, Marina Grachtchouk, John T Seykora, Edward E Morrisey, Andrzej A Dlugosz, Sarah E Milla. HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53. The Journal of investigative dermatology. 2021-09-20. PMID:34284046. |
in activated gli2-driven pre-basal cell carcinoma, hdac1/2 deletion dramatically reduces proliferation and increases apoptosis, and knockout of either p53 or p16 partially rescues both proliferation and basal cell viability. |
2021-09-20 |
2023-08-13 |
mouse |
| A K Shendge, D Chaudhuri, T Basu, N Manda. A natural flavonoid, apigenin isolated from Clerodendrum viscosum leaves, induces G2/M phase cell cycle arrest and apoptosis in MCF-7 cells through the regulation of p53 and caspase-cascade pathway. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. vol 23. issue 4. 2021-09-17. PMID:32715386. |
a natural flavonoid, apigenin isolated from clerodendrum viscosum leaves, induces g2/m phase cell cycle arrest and apoptosis in mcf-7 cells through the regulation of p53 and caspase-cascade pathway. |
2021-09-17 |
2023-08-13 |
Not clear |
| Bin Li, Nannan Huang, Shengnan Wei, Jie Xv, Qingtao Meng, Michael Aschner, Xiaobo Li, Rui Che. lncRNA TUG1 as a ceRNA promotes PM exposure-induced airway hyper-reactivity. Journal of hazardous materials. vol 416. 2021-09-16. PMID:34492818. |
knockdown of tug1 attenuated hbe cell apoptosis and cell cycle arrest by downregulation of celf1 and protein 53 (p53). |
2021-09-16 |
2023-08-13 |
mouse |
| Erratum: M-ds-P21 induces cell apoptosis in bladder cancer T24 cells through P53 independent pathway. Journal of cancer research and therapeutics. vol 17. issue 4. 2021-09-16. PMID:34528582. |
erratum: m-ds-p21 induces cell apoptosis in bladder cancer t24 cells through p53 independent pathway. |
2021-09-16 |
2023-08-13 |
Not clear |
| Yibiao Wang, Jiannong Zhao, Chaocai Zhang, Pengcheng Wang, Chuixue Huang, Hao Pen. MDM2 promotes the proliferation and inhibits the apoptosis of pituitary adenoma cells by directly interacting with p53. Endokrynologia Polska. vol 71. issue 5. 2021-09-15. PMID:32797477. |
mdm2 promotes the proliferation and inhibits the apoptosis of pituitary adenoma cells by directly interacting with p53. |
2021-09-15 |
2023-08-13 |
mouse |
| Qian Hao, Jiaxiang Chen, Junming Liao, Yingdan Huang, Yu Gan, Sarit Larisch, Shelya X Zeng, Hua Lu, Xiang Zho. p53 induces ARTS to promote mitochondrial apoptosis. Cell death & disease. vol 12. issue 2. 2021-09-14. PMID:33627621. |
p53 induces arts to promote mitochondrial apoptosis. |
2021-09-14 |
2023-08-13 |
mouse |