| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daowen Li, Xingyao Pei, Xiaoling Qin, Xinyu Liu, Cun Li, Liuan Li, Chongshan Dai, Xilong Xiao, Shusheng Tan. Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381272. |
the cell model in vitro further demonstrated that p53 knockout or knockdown in the hct116 cell and l02 cell significantly inhibited cell apoptosis and increased cell viability, presented by suppressing ros production, oxidative stress, and the nrf2/ho-1 pathway. |
2021-09-02 |
2023-08-13 |
mouse |
| Akihiro Nita, Yoshiharu Muto, Yuta Katayama, Akinobu Matsumoto, Masaaki Nishiyama, Keiichi I Nakayam. The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells. Cell reports. vol 34. issue 5. 2021-09-02. PMID:33535054. |
conditional deletion of chd8 specifically in mouse bone marrow induces cell cycle arrest, apoptosis, and a differentiation block in hscs in association with upregulation of the expression of p53 target genes. |
2021-09-02 |
2023-08-13 |
mouse |
| Zhaowei Tu, Chen Wang, Ashley K Davis, Mengwen Hu, Chuntao Zhao, Mei Xin, Q Richard Lu, Yi Zhen. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. vol 138. issue 3. 2021-09-02. PMID:34292326. |
chd8 forms a complex with atm and its deficiency increases chromatin accessibility and drives genomic instability in hspcs causing an activation of atm kinase that further stabilizes p53 protein by phosphorylation and leads to increased hspc apoptosis. |
2021-09-02 |
2023-08-13 |
mouse |
| Gaetana Paolella, Antonio M Romanelli, Stefania Martucciello, Silvia Sposito, Marilena Lepretti, Carla Esposito, Anna Capaldo, Ivana Caput. The mechanism of cytotoxicity of 4-nonylphenol in a human hepatic cell line involves ER-stress, apoptosis, and mitochondrial dysfunction. Journal of biochemical and molecular toxicology. vol 35. issue 7. 2021-09-01. PMID:33957011. |
we found that 4-np, in a range of concentration from 50 to 100 μm, significantly reduced cell viability; it caused a partial block of proliferation and induced apoptosis with activation of caspase-3 and overexpression of p53. |
2021-09-01 |
2023-08-13 |
human |
| Nema A Soliman, Rehab E Abo El Gheit, Muhammad T Abdel Ghafar, Norhan A AbuoHashish, Marwa A A Ibrahim, Hend S Abo Safia, Mervat H El-Saka, Amira M Elsham. Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-κB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34047412. |
cardiac injury markers, heart tissue oxidative stress indices, interferon-gamma (inf-γ), tumor necrosis factor-like weak inducer of apoptosis (tweak), upregulated modulator of apoptosis (puma), p53 and nuclear factor kappa-b p65 (nf-κb p65) levels as well as messenger rna gene expression of rac1 and fibroblast growth factor-inducible protein 14 (fn14) were assayed, besides the assay of dna damage, histopathological changes, survivin immunohistochemistry and electron microscopic examination. |
2021-09-01 |
2023-08-13 |
rat |
| Lian Zeng, Fuyu Zhang, Zhen Zhang, Min Xu, Yang Xu, Ying Liu, Hongxia Xu, Xiaodong Sun, Ming Sang, Huiyu Lu. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34091999. |
p53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. |
2021-09-01 |
2023-08-13 |
Not clear |
| Lian Zeng, Fuyu Zhang, Zhen Zhang, Min Xu, Yang Xu, Ying Liu, Hongxia Xu, Xiaodong Sun, Ming Sang, Huiyu Lu. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34091999. |
as an important signaling molecule to activate apoptosis, p53 has been proved to be involved in the neurotoxicity induced by las, but the mechanism is unclear. |
2021-09-01 |
2023-08-13 |
Not clear |
| Lian Zeng, Fuyu Zhang, Zhen Zhang, Min Xu, Yang Xu, Ying Liu, Hongxia Xu, Xiaodong Sun, Ming Sang, Huiyu Lu. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34091999. |
in this study, we explored the effect of pifithrin-α (pft-α), a p53 inhibitor, on apoptosis by ropivacaine (rop) in vivo and in vitro. |
2021-09-01 |
2023-08-13 |
Not clear |
| Lian Zeng, Fuyu Zhang, Zhen Zhang, Min Xu, Yang Xu, Ying Liu, Hongxia Xu, Xiaodong Sun, Ming Sang, Huiyu Lu. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34091999. |
cell viability and apoptosis detected by cck-8 and a jc-1 apoptosis detection kit, the changes of spinal cord structure observed after hematoxylin and eosin staining, apoptosis of the spinal cord measured by terminal deoxynucleotidyl transferase dutp nick end labeling staining, behavioral assessment of the nerve injury evaluated by the detection of sciatic nerve conduction velocity (sncv) andmechanical withdrawal threshold (mwt), the expression of p53 and many apoptosis-related genes included bax, bcl-2, and caspase-3 detected by quantitative real-time polymerase chain reaction, western blot analysis, immunofluorescence, and immunohistochemistry. |
2021-09-01 |
2023-08-13 |
Not clear |
| Lian Zeng, Fuyu Zhang, Zhen Zhang, Min Xu, Yang Xu, Ying Liu, Hongxia Xu, Xiaodong Sun, Ming Sang, Huiyu Lu. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway. Journal of biochemical and molecular toxicology. vol 35. issue 8. 2021-09-01. PMID:34091999. |
apoptosis rate and many proapoptotic genes include p53, bax, caspase-3 messenger rna, and proteins were increased by rop, but pft-α could decrease it. |
2021-09-01 |
2023-08-13 |
Not clear |
| Ana Tadijan, Ivana Samaržija, Jonathan D Humphries, Martin J Humphries, Andreja Ambriović-Risto. KANK family proteins in cancer. The international journal of biochemistry & cell biology. vol 131. 2021-08-31. PMID:33309958. |
most of the data have been collected for kank1 protein whose expression promotes apoptosis and cell-cycle arrest while kank3 was identified as hypoxia-inducible proapoptotic target of p53. |
2021-08-31 |
2023-08-13 |
Not clear |
| Ji-Young Yoo, Han-Byeol Kim, Tai-Kyoung Baik, Jun-Ho Lee, Ran-Sook Wo. Neuregulin 1/ErbB4/Akt signaling attenuates cytotoxicity mediated by the APP-CT31 fragment of amyloid precursor protein. Experimental and molecular pathology. vol 120. 2021-08-30. PMID:33684392. |
the expression of apoptosis-related proteins, such as p53, puma (p53 up-regulated modulator of apoptosis), and cleaved was investigated by immunofluorescence analysis and western blotting. |
2021-08-30 |
2023-08-13 |
Not clear |
| Yen-Ting Chiang, Yi-Chung Chien, Yu-Heng Lin, Hui-Hsuan Wu, Dung-Fang Lee, Yung-Luen Y. The Function of the Mutant p53-R175H in Cancer. Cancers. vol 13. issue 16. 2021-08-30. PMID:34439241. |
wild-type p53 is known as "the guardian of the genome" because of its function of inducing dna repair, cell-cycle arrest, and apoptosis, preventing the accumulation of gene mutations. |
2021-08-30 |
2023-08-13 |
Not clear |
| Chen-Chen Sun, Zuo-Qiong Zhou, Zhang-Lin Chen, Run-Kang Zhu, Dong Yang, Xi-Yang Peng, Lan Zheng, Chang-Fa Tan. Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. vol 10. issue 8. 2021-08-30. PMID:34439993. |
gene ontology and kegg enrichment analysis revealed that the upregulated genes were enriched in autophagy, homeostasis, circadian rhythm, response to oxidative stress, apoptosis, the p53 signaling pathway, and the foxo signaling pathway. |
2021-08-30 |
2023-08-13 |
zebrafish |
| Daniel Nguyen, Kun Yang, Lucia Chiao, Yun Deng, Xiang Zhou, Zhen Zhang, Shelya X Zeng, Hua L. Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy. Journal of molecular cell biology. vol 12. issue 9. 2021-08-27. PMID:32285119. |
the tumor suppressr p73 is a homolog of p53 and is capable of inducing cell cycle arrest and apoptosis. |
2021-08-27 |
2023-08-13 |
Not clear |
| G A Puzanov, V N Senchenk. [SCP Phosphatases and Oncogenesis]. Molekuliarnaia biologiia. vol 55. issue 4. 2021-08-27. PMID:34432772. |
in addition, the substrates of scp phosphatases include smad transcription modulators; akt1 protein kinase, which regulates the cell cycle, apoptosis, and angiogenesis; the twist1 and c-myc transcription factors; ras family proteins, which are involved in signaling pathways regulating the cell growth and apoptosis; cdca3, which is associated with cell division; the cyclin-dependent kinase inhibitor p21; and the promyelocytic leukemia protein (pml), which is involved in regulation of the tumor suppressors p53, pten, and mtor. |
2021-08-27 |
2023-08-13 |
Not clear |
| Bin He, Qi Yue Li, Yuan Yuan Wu, Jing Ling Ruan, Xiao Ming Teng, Da Jin Li, Chuan Ling Tan. Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK/p38 signaling pathways. Reproductive biology and endocrinology : RB&E. vol 18. issue 1. 2021-08-26. PMID:33046085. |
cyclosporin a protects jeg-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and jnk/p38 signaling pathways. |
2021-08-26 |
2023-08-13 |
Not clear |
| Nazim Muhammad, He Zhao, Wenjing Song, Mingyang Gu, Qian Li, Yujia Liu, Cheng Li, Jihui Wang, Honglei Zha. Silver nanoparticles functionalized Paclitaxel nanocrystals enhance overall anti-cancer effect on human cancer cells. Nanotechnology. vol 32. issue 8. 2021-08-26. PMID:33197899. |
the potential acting mechanism and molecular basis of these novel drug nanocrystals is relevant to the regulation of mitochondria-mediated apoptosis with a greater bax-to-bcl-2 ratio and the activation of pro-apoptotic p53 and caspase 3. |
2021-08-26 |
2023-08-13 |
human |
| Yiran Liang, Hong Liu, Jiaming Zhu, Nana Song, Zhihui Lu, Yi Fang, Jie Teng, Yan Dai, Xiaoqiang Din. Inhibition of p53/miR-34a/SIRT1 axis ameliorates podocyte injury in diabetic nephropathy. Biochemical and biophysical research communications. vol 559. 2021-08-26. PMID:33932899. |
sirt1 overexpression also impacts age induced apoptosis through deacetylating p53, whereas silencing of sirt1 by ex527 attenuated the cytoprotective functions of mir-34a knockdown. |
2021-08-26 |
2023-08-13 |
mouse |
| Yiran Liang, Hong Liu, Jiaming Zhu, Nana Song, Zhihui Lu, Yi Fang, Jie Teng, Yan Dai, Xiaoqiang Din. Inhibition of p53/miR-34a/SIRT1 axis ameliorates podocyte injury in diabetic nephropathy. Biochemical and biophysical research communications. vol 559. 2021-08-26. PMID:33932899. |
moreover, blockade of p53 acetylation significantly rescued mir-34a-induced apoptosis through sirt1 restoration. |
2021-08-26 |
2023-08-13 |
mouse |