| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Israa F Mosa, Haitham H Abd, Abdelsalam Abuzreda, Nadhom Assaf, Amenh B Yousi. Bio-evaluation of the role of chitosan and curcumin nanoparticles in ameliorating genotoxicity and inflammatory responses in rats' gastric tissue followed hydroxyapatite nanoparticles' oral uptake. Toxicology research. vol 9. issue 4. 2021-08-04. PMID:32905138. |
various pro-inflammatory gene products have been identified that intercede a vital role in proliferation and apoptosis suppression, among these products: tumor suppressor p53, tumor necrosis factor-α and interliukin-6. |
2021-08-04 |
2023-08-13 |
rat |
| Xi Su, Chao Feng, Simeng Wang, Liang Shi, Qingqing Gu, Haihong Zhang, Xinhui Lan, Yuelei Zhao, Wei Qiang, Meiju Ji, Peng Ho. The noncoding RNAs SNORD50A and SNORD50B-mediated TRIM21-GMPS interaction promotes the growth of p53 wild-type breast cancers by degrading p53. Cell death and differentiation. vol 28. issue 8. 2021-08-04. PMID:33742136. |
functional studies showed that snord50a/b deletion strongly inhibited the proliferation, migration, invasion and tumorigenic potential, and induced cell cycle arrest and apoptosis in p53 wild-type breast cancer cells, while exerted the opposite effects in p53 mutated breast cancer cells. |
2021-08-04 |
2023-08-13 |
Not clear |
| Yongxin Yan, Shengjie Yao, Zhiqiang Jia, Junxia Zhao, Li'an Wan. Iso-suillin-induced DNA damage leading to cell cycle arrest and apoptosis arised from p53 phosphorylation in A549 cells. European journal of pharmacology. vol 907. 2021-08-03. PMID:34217708. |
iso-suillin-induced dna damage leading to cell cycle arrest and apoptosis arised from p53 phosphorylation in a549 cells. |
2021-08-03 |
2023-08-13 |
human |
| Wei-Ni Qin, Kai-Cheng Zhang, Ting Geng, Fang-Fang Cheng, Pei-Dong Chen, Wei-Feng Yao, Li Zhang, Yu-Dan Ca. The toxicity mechanism of toxic compounds from Euphorbiae pekinensis Radix on zebrafish embryos. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-08-03. PMID:34311525. |
also, four compounds could provoke apoptosis by up-regulating the expression level of p53, mdm2, bax, bcl-2 and activating the activity of caspase-3, caspase-9. |
2021-08-03 |
2023-08-13 |
zebrafish |
| Wenjie Ge, Yudong Wang, Shanliang Zheng, Dong Zhao, Xingwen Wang, Xiaoshi Zhang, Ying H. Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB. Cell death discovery. vol 7. issue 1. 2021-08-03. PMID:34312379. |
the results showed that iaspp inhibits apoptosis under conditions when p53 is activated, while it can also elicit a proapoptotic effect when nf-κbp65 alone is activated. |
2021-08-03 |
2023-08-13 |
Not clear |
| Katarzyna Kuryłowicz, Agnieszka Cierniak, Ewelina Madej, Łukasz Skalniak, Agnieszka Wolnicka-Głubis. Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells. Acta biochimica Polonica. vol 67. issue 4. 2021-08-02. PMID:33108147. |
we confirm that phip-induced apoptosis is p53 and caspase 3/7 dependent. |
2021-08-02 |
2023-08-13 |
human |
| Ruju Vashi, Bhoomika M Pate. Roles of ARF tumour suppressor protein in lung cancer: time to hit the nail on the head! Molecular and cellular biochemistry. vol 476. issue 3. 2021-08-02. PMID:33392921. |
p14arf has a basic mechanism to inhibit mouse double minute 2 protein that exhibits inhibitory action on p53, a phosphoprotein tumour suppressor, thus playing a role in various tumour-related activities such as growth inhibition, dna damage, autophagy, apoptosis, cell cycle arrest and others. |
2021-08-02 |
2023-08-13 |
mouse |
| Yan Li, Qing Meng, Ling Wang, Yongjian Cu. TRIM27 protects against cardiac ischemia-reperfusion injury by suppression of apoptosis and inflammation via negatively regulating p53. Biochemical and biophysical research communications. vol 557. 2021-08-02. PMID:33865220. |
trim27 protects against cardiac ischemia-reperfusion injury by suppression of apoptosis and inflammation via negatively regulating p53. |
2021-08-02 |
2023-08-13 |
Not clear |
| Sathisaran Umamaheswari, Sheela Priyadarshinee, Krishna Kadirvelu, Mathan Rames. Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34126101. |
polystyrene microplastics induce apoptosis via ros-mediated p53 signaling pathway in zebrafish. |
2021-08-02 |
2023-08-13 |
zebrafish |
| Yang Zhang, Maria A Yapryntseva, Alexander Vdovin, Polina Maximchik, Boris Zhivotovsky, Vladimir Gogvadz. Modeling hypoxia facilitates cancer cell survival through downregulation of p53 expression. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34126102. |
here we show that one of the reasons for apoptosis suppression is downregulation of p53 expression under hypoxic conditions, and, as a result, attenuation of the expression of pro-apoptotic bcl-2 family proteins. |
2021-08-02 |
2023-08-13 |
Not clear |
| Ivie L Conlon, Brandon Drennen, Maryanna E Lanning, Samuel Hughes, Rebecca Rothhaas, Paul T Wilder, Alexander D MacKerell, Steven Fletche. Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2. ChemMedChem. vol 15. issue 18. 2021-07-30. PMID:32583936. |
p53, a tumor-suppressor protein, also has a pivotal role in apoptosis and is negatively regulated by its e3 ubiquitin ligase hdm2. |
2021-07-30 |
2023-08-13 |
Not clear |
| Guochang Zhang, Nan Zhai, Xiaofen Zhan. Alkannin represses growth of pancreatic cancer cells based on the down regulation of miR-199a. BioFactors (Oxford, England). vol 46. issue 5. 2021-07-29. PMID:31967380. |
alkannin counteracted the growth of panc-1 cells through inhibiting proliferation, migration, and invasion and facilitating apoptosis, which was evidenced by the modulation on pcna, cyclind1, p53, and cleavage of caspases. |
2021-07-29 |
2023-08-13 |
Not clear |
| Yael Ben-Nun, Hyuk-Soo Seo, Edward P Harvey, Zachary J Hauseman, Thomas E Wales, Catherine E Newman, Ann M Cathcart, John R Engen, Sirano Dhe-Paganon, Loren D Walensk. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure (London, England : 1993). vol 28. issue 7. 2021-07-28. PMID:32359398. |
p53 is a critical tumor-suppressor protein that guards the human genome against mutations by inducing cell-cycle arrest or apoptosis. |
2021-07-28 |
2023-08-13 |
human |
| Yunyun Wang, Wei Shi, Chenliang Wu, Lin Wan, Yuxun Zhao, Chenglong Zhang, Wen Gu, Shifa Wan. Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-28. PMID:34243605. |
the study on molecular mechanism suggested that compound 3b induced apoptosis via activation of caspase-3 and parp, also via decreasing of bcl-2 and increasing of bax and p53. |
2021-07-28 |
2023-08-13 |
Not clear |
| Expression of Concern: Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. The Journal of biological chemistry. vol 295. issue 26. 2021-07-27. PMID:32591457. |
expression of concern: notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting akt/hdm2-mediated p53 degradation and up-regulating p53-dependent dr5 expression. |
2021-07-27 |
2023-08-13 |
human |
| Mei L. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. vol 26. issue 5-6. 2021-07-27. PMID:33783663. |
the role of p53 up-regulated modulator of apoptosis (puma) in ovarian development, cardiovascular and neurodegenerative diseases. |
2021-07-27 |
2023-08-13 |
Not clear |
| Mei L. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. vol 26. issue 5-6. 2021-07-27. PMID:33783663. |
p53 up-regulated modulator of apoptosis (puma), a pro-apoptotic bcl-2 homology 3 (bh3)-only member of the bcl-2 family, is a direct transcriptional target of p53 that elicits mitochondrial apoptosis under treatment with radiation and chemotherapy. |
2021-07-27 |
2023-08-13 |
Not clear |
| Chunmei Wang, Runzi Qi, Nan Li, Zhengxin Wang, Huazhang An, Qinghua Zhang, Yizhi Yu, Xuetao Ca. Withdrawal: Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. The Journal of biological chemistry. vol 296. 2021-07-27. PMID:34237907. |
withdrawal: notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting akt/hdm2-mediated p53 degradation and up-regulating p53-dependent dr5 expression. |
2021-07-27 |
2023-08-13 |
human |
| Xanthene Miles, Charlot Vandevoorde, Alistair Hunter, Julie Bolcae. MDM2/X Inhibitors as Radiosensitizers for Glioblastoma Targeted Therapy. Frontiers in oncology. vol 11. 2021-07-27. PMID:34307171. |
in response to cellular stressors, such as dna damage, the tumor suppression protein p53 is activated and responds by mediating cellular damage through dna repair, cell cycle arrest and apoptosis. |
2021-07-27 |
2023-08-13 |
Not clear |
| Atefeh Babaei, Sajjad Moradi, Zohreh Hoseinkhani, Davood Rezazadeh, Sadat Dokaneheifard, Reza Asadpour, Gaurav Sharma, Kamran Mansour. Expression of Hypoxia-Inducible Factor1-α in Varicocele Disease: a Comprehensive Systematic Review. Reproductive sciences (Thousand Oaks, Calif.). 2021-07-27. PMID:34313997. |
expression of hif-1α regulates the expression of many genes, including vegf, p53, glut, bax, and caspase-3, that could be involved in many of the varicocele pathophysiological effects such as dna fragmentation and apoptosis of sperm cells. |
2021-07-27 |
2023-08-13 |
human |