| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shi Yin, Wenchang Qin, Bin Wang, Jingwen Zhou, Liuqing Yang, Xianrong Xiong, Jian L. Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF-1. Reproduction in domestic animals = Zuchthygiene. vol 55. issue 9. 2021-07-15. PMID:32497285. |
in addition, sirt1-mediated p53 acetylation was not responsible for the cell apoptosis in cattleyak testis. |
2021-07-15 |
2023-08-13 |
cattle |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
induction of cell cycle arrest and apoptosis by cpuc002 through stabilization of p53 and suppression of stat3 signaling pathway in multiple myeloma. |
2021-07-15 |
2023-08-13 |
human |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
in mechanism, cpuc002 triggered apoptosis by stabilizing p53 in nci-h929 cells which expressed wt-p53. |
2021-07-15 |
2023-08-13 |
human |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
knockdown of p53 partially suppressed cpuc002-induced apoptosis. |
2021-07-15 |
2023-08-13 |
human |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
together these findings indicate that cpuc002 induces apoptosis and g0/g1 cell cycle arrest in multiple myeloma cells by stabilizing p53 and inhibiting the stat3 signaling pathway. |
2021-07-15 |
2023-08-13 |
human |
| Christoph Roser, Csaba Tóth, Marcus Renner, Esther Herpel, Peter Schirmache. Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin. Cell communication and signaling : CCS. vol 19. issue 1. 2021-07-15. PMID:33579312. |
expression of apoptosis repressor with caspase recruitment domain (arc) in familial adenomatous polyposis (fap) adenomas and its correlation with dna mismatch repair proteins, p53, bcl-2, cox-2 and beta-catenin. |
2021-07-15 |
2023-08-13 |
Not clear |
| Yameng Fan, Jiaqiao Li, Yuxuan Yang, Xiaodan Zhao, Yamei Liu, Yude Jiang, Long Zhou, Yang Feng, Yan Yu, Yilong Chen. Resveratrol modulates the apoptosis and autophagic death of human lung adenocarcinoma A549 cells via a p53‑dependent pathway: Integrated bioinformatics analysis and experimental validation. International journal of oncology. vol 57. issue 4. 2021-07-14. PMID:32945383. |
pifithrin‑α, an inhibitor of p53, partially reduced rsv‑induced apoptosis and autophagy. |
2021-07-14 |
2023-08-13 |
human |
| Yameng Fan, Jiaqiao Li, Yuxuan Yang, Xiaodan Zhao, Yamei Liu, Yude Jiang, Long Zhou, Yang Feng, Yan Yu, Yilong Chen. Resveratrol modulates the apoptosis and autophagic death of human lung adenocarcinoma A549 cells via a p53‑dependent pathway: Integrated bioinformatics analysis and experimental validation. International journal of oncology. vol 57. issue 4. 2021-07-14. PMID:32945383. |
on the whole, the results of the present study demonstrated that rsv initiates the apoptosis and autophagic death of a549 cells via the activation of the p53 signaling pathway, further highlighting the potential of rsv for the treatment of nsclc. |
2021-07-14 |
2023-08-13 |
human |
| Ming Chen, Meng Zhao, Yan Hou, Bin Zh. Expression of lncRNA CCAT2 in children with neuroblastoma and its effect on cancer cell growth. Molecular and cellular biochemistry. vol 476. issue 4. 2021-07-14. PMID:33475889. |
then a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay was carried out to analyze the cell proliferation, migration, and invasion ability, a flow cytometry to detect cell apoptosis, and a western blotting (wb) assay to quantify p53 and bcl-2 proteins. |
2021-07-14 |
2023-08-13 |
human |
| Abeer A Ibrahim, Mohanad M Kareem, Taghreed H Al-Noor, Tahani Al-Muhimeed, Abeer A AlObaid, Salim Albukhaty, Ghassan M Sulaiman, Majid Jabir, Zainab J Taqi, Usama I Sahi. Pt(II)-Thiocarbohydrazone Complex as Cytotoxic Agent and Apoptosis Inducer in Caov-3 and HT-29 Cells through the P53 and Caspase-8 Pathways. Pharmaceuticals (Basel, Switzerland). vol 14. issue 6. 2021-07-14. PMID:34073459. |
pt(ii)-thiocarbohydrazone complex as cytotoxic agent and apoptosis inducer in caov-3 and ht-29 cells through the p53 and caspase-8 pathways. |
2021-07-14 |
2023-08-13 |
Not clear |
| Yan-Lu Liu, Wen-Hao Yang, Bao-Yi Chen, Juan Nie, Zi-Ren Su, Jing-Na Zheng, Shi-Ting Gong, Jian-Nan Chen, Dongbo Jiang, Yucui L. miR‑29b suppresses proliferation and induces apoptosis of hepatocellular carcinoma ascites H22 cells via regulating TGF‑β1 and p53 signaling pathway. International journal of molecular medicine. vol 48. issue 2. 2021-07-14. PMID:34184070. |
mir‑29b suppresses proliferation and induces apoptosis of hepatocellular carcinoma ascites h22 cells via regulating tgf‑β1 and p53 signaling pathway. |
2021-07-14 |
2023-08-13 |
mouse |
| Yan-Lu Liu, Wen-Hao Yang, Bao-Yi Chen, Juan Nie, Zi-Ren Su, Jing-Na Zheng, Shi-Ting Gong, Jian-Nan Chen, Dongbo Jiang, Yucui L. miR‑29b suppresses proliferation and induces apoptosis of hepatocellular carcinoma ascites H22 cells via regulating TGF‑β1 and p53 signaling pathway. International journal of molecular medicine. vol 48. issue 2. 2021-07-14. PMID:34184070. |
in summary, these data indicated that mir‑29b has an important role in proliferation and apoptosis of h22 cells by regulating the tgf‑β1 signaling pathway, the p53‑dependent apoptotic pathway, and the crosstalk between tgf‑β1 and p53. |
2021-07-14 |
2023-08-13 |
mouse |
| Anouar Feriani, Meriam Tir, Ana María Gómez-Caravaca, María Del Mar Contreras, Amani Taamalli, Antonio Segura-Carretero, Lakhdar Ghazouani, Afoua Mufti, Nizar Tlili, Abdelfattah El Feki, Abdel Halim Harrath, Mohamed Salah Allagu. Zygophyllum album leaves extract prevented hepatic fibrosis in rats, by reducing liver injury and suppressing oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways. Exploring of bioactive compounds using HPLC-DAD-ESI-QTOF-MS/MS. Inflammopharmacology. vol 28. issue 6. 2021-07-13. PMID:32206981. |
furthermore, z. album reduced dlm-induced apoptosis by attenuating caspase 3 and p53 mrna activation. |
2021-07-13 |
2023-08-13 |
rat |
| Xu Liu, Lu Wang, Qianwen Wang, Jingjing Zhao, Hongtao Chang, Ruixia Zh. Association Between Genetic Variants in the lncRNA-p53 Regulatory Network and Ischemic Stroke Prognosis. Neurotoxicity research. vol 39. issue 4. 2021-07-13. PMID:33797738. |
p53 rs1042522 and linc-ror rs2027701 may exert combined effects on is recurrence, and tug1 rs2240183 may be a new biomarker to predict short-term is outcomes as it modulates p53-mediated apoptosis. |
2021-07-13 |
2023-08-13 |
Not clear |
| Orsolya Galamb, Alexandra Kalmár, Anna Sebestyén, Titanilla Dankó, Csilla Kriston, István Fűri, Péter Hollósi, István Csabai, Barnabás Wichmann, Tibor Krenács, Barbara Kinga Barták, Zsófia Brigitta Nagy, Sára Zsigrai, Gábor Barna, Zsolt Tulassay, Péter Igaz, Béla Molná. Promoter Hypomethylation and Increased Expression of the Long Non-coding RNA LINC00152 Support Colorectal Carcinogenesis. Pathology oncology research : POR. vol 26. issue 4. 2021-07-12. PMID:32307642. |
dkk1 dickkopf wnt signalling pathway inhibitor 1, perp p53 apoptosis effector) (adjusted p < 0.05). |
2021-07-12 |
2023-08-13 |
Not clear |
| Haoren Qin, Heng Zhang, Xipeng Zhang, Shiwu Zhang, Siwei Zhu, Hui Wan. Resveratrol attenuates radiation enteritis through the SIRT1/FOXO3a and PI3K/AKT signaling pathways. Biochemical and biophysical research communications. vol 554. 2021-07-12. PMID:33812084. |
resveratrol improved radiation-induced oxidative stress and cell apoptosis via upregulating antioxidant enzymes and downregulating p53 acetylation. |
2021-07-12 |
2023-08-13 |
mouse |
| Umiey Fahietah Mohd Fisall, Noor Zafirah Ismail, Ismail Abiola Adebayo, Hasni Arsa. Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions. Molecular biology reports. vol 48. issue 5. 2021-07-12. PMID:34086162. |
dichloromethane fraction of moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (mcf7) by induction of apoptosis via upregulation of bax, p53 and caspase 8 expressions. |
2021-07-12 |
2023-08-13 |
Not clear |
| Umiey Fahietah Mohd Fisall, Noor Zafirah Ismail, Ismail Abiola Adebayo, Hasni Arsa. Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions. Molecular biology reports. vol 48. issue 5. 2021-07-12. PMID:34086162. |
the apoptosis study was conducted using annexin v-fitc analysis and confirmed by western blotting using selected proteins, which are p53, bax, cytochrome c and caspase 8. |
2021-07-12 |
2023-08-13 |
Not clear |
| Umiey Fahietah Mohd Fisall, Noor Zafirah Ismail, Ismail Abiola Adebayo, Hasni Arsa. Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions. Molecular biology reports. vol 48. issue 5. 2021-07-12. PMID:34086162. |
it also induced early apoptosis and increased the expressions of pro-apoptotic proteins bax, caspase 8 and p53 in mcf7 cells. |
2021-07-12 |
2023-08-13 |
Not clear |
| L Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J Afzal, Andrew D Hamilton, Sunil Kumar, Mazin Magzou. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nature communications. vol 12. issue 1. 2021-07-12. PMID:34172723. |
moreover, adh-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. |
2021-07-12 |
2023-08-13 |
human |