| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunsun Jiang, Gang Liu, Lu Cai, Jessy Deshane, Veena Antony, Victor J Thannickal, Rui-Ming Li. Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. The American journal of pathology. vol 191. issue 7. 2021-07-26. PMID:33887217. |
in vitro studies using pai-1 sirna and active pai-1 protein indicated that pai-1 promoted atii cell apoptosis but protected fibroblasts from apoptosis, likely through dichotomous regulation of p53 expression. |
2021-07-26 |
2023-08-13 |
mouse |
| Chunsun Jiang, Gang Liu, Lu Cai, Jessy Deshane, Veena Antony, Victor J Thannickal, Rui-Ming Li. Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. The American journal of pathology. vol 191. issue 7. 2021-07-26. PMID:33887217. |
deletion of pai-1 in adult mice led to a reduction in p53, p21, and bax protein expression, as well as apoptosis sensitivity in atii cells, and their increase in the lung fibroblasts, as indicated by in vivo studies. |
2021-07-26 |
2023-08-13 |
mouse |
| Jazmin Calyeca, Yalbi I Balderas-Martínez, Moisés Selman, Annie Pard. Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways. Aging. vol 13. issue 9. 2021-07-26. PMID:33982668. |
using the mirnet database we identified tnfα, mtor, tgfβ, wnt, foxo, apoptosis, cell cycle, and p53 signaling pathways as the potential targets of several of the dysregulated mirnas supporting that old lungs have increased susceptibility for apoptosis, inflammation, and fibrosis. |
2021-07-26 |
2023-08-13 |
mouse |
| Pariyakorn Udomwan, Chamsai Pientong, Panwad Tongchai, Ati Burassakarn, Nuchsupha Sunthamala, Sittiruk Roytrakul, Supawadee Suebsasana, Tipaya Ekalaksanana. Proteomics Analysis of Andrographolide-Induced Apoptosis via the Regulation of Tumor Suppressor p53 Proteolysis in Cervical Cancer-Derived Human Papillomavirus 16-Positive Cell Lines. International journal of molecular sciences. vol 22. issue 13. 2021-07-26. PMID:34202736. |
proteomics analysis of andrographolide-induced apoptosis via the regulation of tumor suppressor p53 proteolysis in cervical cancer-derived human papillomavirus 16-positive cell lines. |
2021-07-26 |
2023-08-13 |
human |
| Christopher Chronowski, Viktor Akhanov, Doug Chan, Andre Catic, Milton Finegold, Ergün Sahi. Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss. Metabolites. vol 11. issue 6. 2021-07-24. PMID:34204343. |
we find that telomere shortening in telomerase knockout mice (tko) imparts a pronounced susceptibility to fructose as reflected in the activation of p53, increased apoptosis, and senescence, despite lower hepatic fat accumulation in tko mice compared to wild type mice with long telomeres. |
2021-07-24 |
2023-08-13 |
mouse |
| Mojtaba Moradi, Nader Goodarzi, Azita Faramarzi, Hadi Cheraghi, Amir Hossein Hashemian, Cyrus Jalil. Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33752059. |
more importantly, melatonin therapy suppressed bep-evoked apoptosis by modulating bcl-2, bax, caspase-3, p53, and tnf-α expression in testes. |
2021-07-22 |
2023-08-13 |
rat |
| Anthony M Boutelle, Laura D Attard. p53 and Tumor Suppression: It Takes a Network. Trends in cell biology. vol 31. issue 4. 2021-07-21. PMID:33518400. |
though originally characterized as a critical regulator for responses to acute dna damage (activation of apoptosis and cell cycle arrest), recent studies have highlighted new pathways and transcriptional targets downstream of p53 regulating genomic integrity, metabolism, redox biology, stemness, and non-cell autonomous signaling in tumor suppression. |
2021-07-21 |
2023-08-13 |
mouse |
| Jia Wen, Donglai Wan. Deciphering the PTM codes of the tumor suppressor p53. Journal of molecular cell biology. 2021-07-21. PMID:34289043. |
the genome guardian p53 functions as a transcription factor that senses numerous cellular stresses and orchestrates the corresponding transcriptional events involved in determining various cellular outcomes, including cell cycle arrest, apoptosis, senescence, dna repair, and metabolic regulation. |
2021-07-21 |
2023-08-13 |
Not clear |
| Zahra Changizi, Azam Moslehi, Ali Haeri Rohani, Akram Eid. Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice. Journal of biochemical and molecular toxicology. vol 35. issue 2. 2021-07-20. PMID:33058431. |
chlorogenic acid induces 4t1 breast cancer tumor's apoptosis via p53, bax, bcl-2, and caspase-3 signaling pathways in balb/c mice. |
2021-07-20 |
2023-08-13 |
mouse |
| Christina B Marney, Erik S Anderson, Mutayyaba Adnan, Kai-Lin Peng, Ya Hu, Nils Weinhold, Adam M Schmit. p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino. Cell reports. vol 35. issue 13. 2021-07-20. PMID:34192538. |
loss of one or two alleles of dino impairs p53 signaling and apoptosis, resulting in a haplo-insufficient tumor suppressor phenotype in genetically defined mouse models of tumorigenesis. |
2021-07-20 |
2023-08-13 |
mouse |
| Wanling Xu, Ziyang Huang, Yifeng Gan, Rongrong Chen, Yisha Huang, Bin Xue, Songfu Jiang, Zhijie Yu, Kang Yu, Shenghui Zhan. Casein kinase 1α inhibits p53 downstream of MDM2‑mediated autophagy and apoptosis in acute myeloid leukemia. Oncology reports. vol 44. issue 5. 2021-07-19. PMID:32901886. |
casein kinase 1α inhibits p53 downstream of mdm2‑mediated autophagy and apoptosis in acute myeloid leukemia. |
2021-07-19 |
2023-08-13 |
Not clear |
| Wanling Xu, Ziyang Huang, Yifeng Gan, Rongrong Chen, Yisha Huang, Bin Xue, Songfu Jiang, Zhijie Yu, Kang Yu, Shenghui Zhan. Casein kinase 1α inhibits p53 downstream of MDM2‑mediated autophagy and apoptosis in acute myeloid leukemia. Oncology reports. vol 44. issue 5. 2021-07-19. PMID:32901886. |
our findings indicate that ck1α promotes aml by suppressing p53 downstream of mdm2‑mediated autophagy and apoptosis, suggesting that targeting ck1α provides a therapeutic opportunity to treat aml. |
2021-07-19 |
2023-08-13 |
Not clear |
| Tongtong Wang, Yaoxing Dou, Guoshu Lin, Qiaoping Li, Juan Nie, Baoyi Chen, Jianhui Xie, Ziren Su, Huifang Zeng, Jiannan Chen, Youliang Xi. The anti-hepatocellular carcinoma effect of Brucea javanica oil in ascitic tumor-bearing mice: The detection of brusatol and its role. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-07-19. PMID:33341052. |
bjo and be-bjo significantly induced h22 cell apoptosis by upregulating the mirna-29b gene level and p53 expression. |
2021-07-19 |
2023-08-13 |
mouse |
| Gabriella D'Oraz. Recent Advances in p53. Biomolecules. vol 11. issue 2. 2021-07-19. PMID:33546313. |
tumor suppressor protein p53 (tp53) is a key transcription factor that, in response to various stress signals, regulates numerous genes involved in a broad range of cellular functions including dna repair, apoptosis, cell cycle arrest, senescence, metabolism, etc [...]. |
2021-07-19 |
2023-08-13 |
Not clear |
| Surendar Aravindhan, Laith A Younus, Methaq Hadi Lafta, Alexander Markov, Yulianna Ivanovna Enina, Natalya A Yushchenkо, Lakshmi Thangavelu, Seyed Mojtaba Mostafavi, Michail V Pokrovskii, Majid Ahmad. P53 long noncoding RNA regulatory network in cancer development. Cell biology international. vol 45. issue 8. 2021-07-19. PMID:33760334. |
the protein p53 as a transcription factor with strong tumor-suppressive activities is known to trigger apoptosis via multiple pathways and is directly involved in the recognition of dna damage and dna repair processes. |
2021-07-19 |
2023-08-13 |
mouse |
| Surendar Aravindhan, Laith A Younus, Methaq Hadi Lafta, Alexander Markov, Yulianna Ivanovna Enina, Natalya A Yushchenkо, Lakshmi Thangavelu, Seyed Mojtaba Mostafavi, Michail V Pokrovskii, Majid Ahmad. P53 long noncoding RNA regulatory network in cancer development. Cell biology international. vol 45. issue 8. 2021-07-19. PMID:33760334. |
here, we review how several classes of lncrnas and p53 pathways are linked together in controlling the cell cycle and apoptosis in various cancer cells in both human and mouse model systems. |
2021-07-19 |
2023-08-13 |
mouse |
| So-Ra Jeong, Kwang-Won Le. Methylglyoxal-Derived Advanced Glycation End Product (AGE4)-Induced Apoptosis Leads to Mitochondrial Dysfunction and Endoplasmic Reticulum Stress through the RAGE/JNK Pathway in Kidney Cells. International journal of molecular sciences. vol 22. issue 12. 2021-07-19. PMID:34207084. |
moreover, our results showed that age4 induced the expression of apoptosis markers, such as bax, p53, and kidney injury molecule-1, but downregulated bcl-2 and cyclin d1 levels. |
2021-07-19 |
2023-08-13 |
human |
| Yue Li, Xiaoqin He, Xiaoyu Zhang, Yangtao Xu, Wenliang Chen, Xin Liu, Ximing X. RMI2 is a prognostic biomarker and promotes tumor growth in hepatocellular carcinoma. Clinical and experimental medicine. 2021-07-18. PMID:34275027. |
in summary, these results indicate that rmi2 promotes the growth of hcc cells and suppresses their apoptosis by inhibiting the p53 signaling pathway. |
2021-07-18 |
2023-08-13 |
human |
| Yaxin Wang, Xiangzhi Fang, Yiyi Yang, Lin Chen, Wei Xiong, Limin Song, Bo Li, Ting Zhou, Yuan Yu, Xiaobo Yang, Huaqing Shu, Shiying Yuan, Shanglong Yao, You Shan. Death-Associated Protein Kinase 1 Promotes Alveolar Epithelial Cell Apoptosis and Ventilator-Induced Lung Injury Through P53 Pathway. Shock (Augusta, Ga.). 2021-07-16. PMID:34265832. |
death-associated protein kinase 1 promotes alveolar epithelial cell apoptosis and ventilator-induced lung injury through p53 pathway. |
2021-07-16 |
2023-08-13 |
Not clear |
| Yaxin Wang, Xiangzhi Fang, Yiyi Yang, Lin Chen, Wei Xiong, Limin Song, Bo Li, Ting Zhou, Yuan Yu, Xiaobo Yang, Huaqing Shu, Shiying Yuan, Shanglong Yao, You Shan. Death-Associated Protein Kinase 1 Promotes Alveolar Epithelial Cell Apoptosis and Ventilator-Induced Lung Injury Through P53 Pathway. Shock (Augusta, Ga.). 2021-07-16. PMID:34265832. |
in this study, we explored whether death associated protein kinase 1 (dapk1) mediated cyclic stretch (cs) induced aec apoptosis and vili though p53 pathway. |
2021-07-16 |
2023-08-13 |
Not clear |