| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subramanyam Dasari, Taruni Pandhiri, Tommaso Grassi, Daniel W Visscher, Francesco Multinu, Komal Agarwal, Andrea Mariani, Viji Shridhar, Anirban K Mitr. Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation. Molecular cancer research : MCR. vol 18. issue 8. 2021-07-02. PMID:32350057. |
its mechanism of action was through the upregulation of its targets, secreted protein acidic and cysteine rich (sparc) and bcl2 associated athanogene 5 (bag5), which activated focal adhesion kinase (fak) signaling, promoted mutant p53 gain of function by its stabilization, and inhibited apoptosis. |
2021-07-02 |
2023-08-13 |
Not clear |
| Subramanyam Dasari, Taruni Pandhiri, Tommaso Grassi, Daniel W Visscher, Francesco Multinu, Komal Agarwal, Andrea Mariani, Viji Shridhar, Anirban K Mitr. Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation. Molecular cancer research : MCR. vol 18. issue 8. 2021-07-02. PMID:32350057. |
implications: this study identifies a mirna, mir-4454, which is downregulated by signals from the microenvironment and promotes early and advanced ovarian cancer metastasis through its effects on fak activation, mutant p53 stabilization, and apoptosis inhibition. |
2021-07-02 |
2023-08-13 |
Not clear |
| Abiodun Anifowose, Ayodeji A Agbowuro, Ravi Tripathi, Wen Lu, Chalet Tan, Xiaoxiao Yang, Binghe Wan. Inducing Apoptosis through Upregulation of p53: Structure-Activity Exploration of Anthraquinone Analogs. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. vol 29. issue 7. 2021-07-02. PMID:32719577. |
inducing apoptosis through upregulation of p53: structure-activity exploration of anthraquinone analogs. |
2021-07-02 |
2023-08-13 |
Not clear |
| Shadia Al-Bahlani, Ikram A Burney, Buthaina Al-Dhahli, Safiya Al-Kharusi, Fakhra Al-Kharousi, Amani Al-Kalbani, Ikhlas Ahme. Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway. BMC pharmacology & toxicology. vol 21. issue 1. 2021-07-02. PMID:32867831. |
cisplatin (cddp) is an effective anticancer drug for gastric cancer (gc) that induces apoptosis by altering pro- (p53) and anti-apoptotic (akt and nfkb) proteins; however, chemoresistance remains a big challenge. |
2021-07-02 |
2023-08-13 |
Not clear |
| Zhongming Zha, Jie L. MicroRNA‑125a‑5p regulates liver cancer cell growth, migration and invasion and EMT by targeting HAX1. International journal of molecular medicine. vol 46. issue 5. 2021-07-02. PMID:33000203. |
upregulation of mir‑125a‑5p expression inhibited cell viability, migration, invasion and colony formation of sk‑hep1 cells and reduced the expression of hax1, vegf, n‑cadherin and vimentin, but increased cell apoptosis and the expression of p53 and e‑cadherin. |
2021-07-02 |
2023-08-13 |
Not clear |
| Qian Nie, Huimin Chen, Ming Zou, Ling Wang, Min Hou, Jia-Wen Xiang, Zhongwen Luo, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Shu-Yu Zheng, Yuan Xiao, Yu-Wen Gan, Qian Gao, Yue-Yue Bai, Jing-Miao Wang, Lan Zhang, Xiang-Cheng Tang, Xuebin Hu, Lili Gong, Yizhi Liu, David Wan-Cheng L. The E3 Ligase PIAS1 Regulates p53 Sumoylation to Control Stress-Induced Apoptosis of Lens Epithelial Cells Through the Proapoptotic Regulator Bax. Frontiers in cell and developmental biology. vol 9. 2021-07-02. PMID:34195189. |
the e3 ligase pias1 regulates p53 sumoylation to control stress-induced apoptosis of lens epithelial cells through the proapoptotic regulator bax. |
2021-07-02 |
2023-08-13 |
Not clear |
| Sushil K Jaiswal, John J Oh, Melvin L DePamphili. Cell cycle arrest and apoptosis are not dependent on p53 prior to p53-dependent embryonic stem cell differentiation. Stem cells (Dayton, Ohio). vol 38. issue 9. 2021-07-01. PMID:32478947. |
cell cycle arrest and apoptosis are not dependent on p53 prior to p53-dependent embryonic stem cell differentiation. |
2021-07-01 |
2023-08-13 |
Not clear |
| Sushil K Jaiswal, John J Oh, Melvin L DePamphili. Cell cycle arrest and apoptosis are not dependent on p53 prior to p53-dependent embryonic stem cell differentiation. Stem cells (Dayton, Ohio). vol 38. issue 9. 2021-07-01. PMID:32478947. |
previous efforts to determine whether or not the transcription factor and tumor suppressor protein p53 is required for dna damage-induced apoptosis in pluripotent embryonic stem cells (escs) produced contradictory conclusions. |
2021-07-01 |
2023-08-13 |
Not clear |
| Sushil K Jaiswal, John J Oh, Melvin L DePamphili. Cell cycle arrest and apoptosis are not dependent on p53 prior to p53-dependent embryonic stem cell differentiation. Stem cells (Dayton, Ohio). vol 38. issue 9. 2021-07-01. PMID:32478947. |
the results revealed that doxorubicin (adriamycin [adr]) concentrations 10 to 40 times less than commonly used in previous studies induced the dna damage-dependent g2-checkpoint and completed apoptosis within the same time frame, regardless of the presence or absence of p53, p21, and puma. |
2021-07-01 |
2023-08-13 |
Not clear |
| Sushil K Jaiswal, John J Oh, Melvin L DePamphili. Cell cycle arrest and apoptosis are not dependent on p53 prior to p53-dependent embryonic stem cell differentiation. Stem cells (Dayton, Ohio). vol 38. issue 9. 2021-07-01. PMID:32478947. |
taken together, these results reveal that the multiple roles of p53 in cell cycle regulation and apoptosis are first acquired during pluripotent stem cell differentiation. |
2021-07-01 |
2023-08-13 |
Not clear |
| Li Cao, Yunjing Jiang, Lei Zhu, Wei Xu, Xiaoyan Chu, Yafei Zhang, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wan. Deoxynivalenol Induces Caspase-8-Mediated Apoptosis through the Mitochondrial Pathway in Hippocampal Nerve Cells of Piglet. Toxins. vol 13. issue 2. 2021-07-01. PMID:33498252. |
increasing concentrations of don led to decreased b-cell lymphoma-2 (bcl-2) expression and increased expression of bcl2-associated x (bax) and b-cell lymphoma-2 homology 3 interacting domain death agonist (bid), which in turn increased transcriptional activity of the transcription factors aif and p53 (a tumor suppressor gene, promotes apoptosis). |
2021-07-01 |
2023-08-13 |
Not clear |
| Mohamed Amr El-Missiry, Sameh Shabana, Sara J Ghazala, Azza I Othman, Maggie E Ame. Melatonin exerts a neuroprotective effect against γ-radiation-induced brain injury in the rat through the modulation of neurotransmitters, inflammatory cytokines, oxidative stress, and apoptosis. Environmental science and pollution research international. vol 28. issue 24. 2021-07-01. PMID:33598836. |
immunohistochemical studies demonstrated a remarkable upregulation of caspase-3 and p53 expression, indicating the increased apoptosis in the brain of irradiated rats. |
2021-07-01 |
2023-08-13 |
rat |
| Hyeon-Ju Lee, Se-Young Oh, Inho J. Zearalenone Induces Endothelial Cell Apoptosis through Activation of a Cytosolic Ca Toxins. vol 13. issue 3. 2021-07-01. PMID:33806711. |
zen also increased phosphorylation of erk1/2 and p53, and treatment with the erk1/2 or p53 inhibitor reversed zen-induced ec apoptosis. |
2021-07-01 |
2023-08-13 |
cattle |
| Hyeon-Ju Lee, Se-Young Oh, Inho J. Zearalenone Induces Endothelial Cell Apoptosis through Activation of a Cytosolic Ca Toxins. vol 13. issue 3. 2021-07-01. PMID:33806711. |
transfection of baecs with small interfering rna against erk1/2 or p53 revealed erk1/2 as an upstream target of p53 in zen-stimulated apoptosis. |
2021-07-01 |
2023-08-13 |
cattle |
| Charity Ameh-Mensah, Babatunde Moses Duduyemi, Kweku Bedu-Addo, Elijah Atta Manu, Francis Opoku, Nicholas Titiloy. The Analysis of bcl-2 in Association with p53 and Ki-67 in Triple Negative Breast Cancer and Other Molecular Subtypes in Ghana. Journal of oncology. vol 2021. 2021-07-01. PMID:34188682. |
antiapoptotic bcl-2 (gene) and p53 are known to play roles in apoptosis while ki-67 is a proliferative marker. |
2021-07-01 |
2023-08-13 |
Not clear |
| Jung-Hwan Park, Sang-Ah Park, Young-Ju Lee, Na-Rae Joo, Jongdae Shin, Sang-Muk O. TOPK inhibition accelerates oxidative stress‑induced granulosa cell apoptosis via the p53/SIRT1 axis. International journal of molecular medicine. vol 46. issue 5. 2021-06-30. PMID:32901866. |
co‑treatment with the topk inhibitor, ots514, in combination with h2o2 increased p53 acetylation and its expression, whereas it decreased sirtuin 1 (sirt1) expression, contributing to the promotion of apoptosis. |
2021-06-30 |
2023-08-13 |
human |
| Xinxin Liu, Zhongwen Yuan, Zheng Tang, Qi Chen, Jiarun Huang, Lizhen He, Tianfeng Che. Selenium-driven enhancement of synergistic cancer chemo-/radiotherapy by targeting nanotherapeutics. Biomaterials science. vol 9. issue 13. 2021-06-30. PMID:34019044. |
the combined activity of sed@msn-fa and radiation can promote excessive production of intracellular reactive oxygen species (ros) and induce cell apoptosis by affecting p53, protein kinase b (akt), and mitogen-activated protein kinase (mapk) pathways. |
2021-06-30 |
2023-08-13 |
mouse |
| О V Dolgikh, N V Zaitseva, N A Nikonoshin. Conditions of Aerogenic Exposure to Benzene and Genetic Status as Factors of Formation of Immune Profile Features in Men with Autonomic Regulation Disturbances. Bulletin of experimental biology and medicine. vol 171. issue 2. 2021-06-30. PMID:34173113. |
the immune profile of the surveyed men is characterized by increased specific sensitization (igg to benzene) and activation of apoptosis (tnfr, p53) and phagocytosis. |
2021-06-30 |
2023-08-13 |
Not clear |
| О V Dolgikh, N V Zaitseva, N A Nikonoshin. Conditions of Aerogenic Exposure to Benzene and Genetic Status as Factors of Formation of Immune Profile Features in Men with Autonomic Regulation Disturbances. Bulletin of experimental biology and medicine. vol 171. issue 2. 2021-06-30. PMID:34173113. |
the established features of immune regulation (hyperproduction of igg to benzene, imbalance of apoptosis markers (cd127-, cd3+cd95+, p53, and tnfr) against the background of altered polymorphism of candidate genes (foxp3, sod2) form a complex of genetic and immunological markers of autonomic regulation disorders in men living under conditions of aerogenic exposure to benzene. |
2021-06-30 |
2023-08-13 |
Not clear |
| Retraction. Journal of cellular physiology. 2021-06-30. PMID:34191308. |
retraction: "gadd45a gene silencing by rnai promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway," by li-qian liu, fu-jun tian, ying xiong, yan zhao, jian-bo song, j cell physiol. |
2021-06-30 |
2023-08-13 |
Not clear |