| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K-W Li, S-H Wang, X Wei, Y-Z Hou, Z-H L. Mechanism of miR-122-5p regulating the activation of PI3K-Akt-mTOR signaling pathway on the cell proliferation and apoptosis of osteosarcoma cells through targeting TP53 gene. European review for medical and pharmacological sciences. vol 24. issue 24. 2021-06-29. PMID:33378012. |
to explore the regulatory mechanism of microrna-122-5p (mir-122-5) targeting tumor protein p53 (tp53) gene to mediate pi3k-akt-mtor signaling pathway on the proliferation and apoptosis of osteosarcoma (os) cells. |
2021-06-29 |
2023-08-13 |
Not clear |
| Ling He, Fuxiang Liu, Juxiang L. Mitochondrial Sirtuins and Doxorubicin-induced Cardiotoxicity. Cardiovascular toxicology. vol 21. issue 3. 2021-06-29. PMID:33438065. |
mitochondrial sirtuins preserve mitochondrial function by increasing mitochondrial metabolism, inhibiting ros generation by activating the antioxidant enzyme manganese-dependent superoxide dismutase (mnsod), decreasing apoptosis by activating the forkhead homeobox type o (foxo) and p53 pathways, and increasing autophagy through amp-activated protein kinase (ampk)/mtor signaling. |
2021-06-29 |
2023-08-13 |
Not clear |
| Ata Abbas, Theodore Witte, William L Patterson, Johannes F Fahrmann, Kai Guo, Junguk Hur, W Elaine Hardman, Philippe T George. Epigenetic Reprogramming Mediated by Maternal Diet Rich in Omega-3 Fatty Acids Protects From Breast Cancer Development in F1 Offspring. Frontiers in cell and developmental biology. vol 9. 2021-06-29. PMID:34179012. |
these epigenetic modifications contribute to differential gene expressions associated with various pathways and molecular mechanisms involved in preventing cancer development, including p53 pathway, g2m checkpoint, dna repair, inflammatory response, and apoptosis. |
2021-06-29 |
2023-08-13 |
mouse |
| Grégoire J-B Philippe, Anna Mittermeier, Nicole Lawrence, Yen-Hua Huang, Nicholas D Condon, Alexander Loewer, David J Craik, Sónia T Henrique. Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells. ACS chemical biology. vol 16. issue 2. 2021-06-28. PMID:33533253. |
angler peptides: macrocyclic conjugates inhibit p53:mdm2/x interactions and activate apoptosis in cancer cells. |
2021-06-28 |
2023-08-13 |
Not clear |
| Omid Toupchian, Shima Abdollahi, Amin Salehi-Abargouei, Javad Heshmati, Cain C T Clark, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Hassan Mozaffari-Khosrav. The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A double-blind controlled randomized trial. Phytotherapy research : PTR. vol 35. issue 6. 2021-06-28. PMID:33580595. |
the present study sought to evaluate the effect of resveratrol supplementation on mrna expression levels of peroxisome proliferator-activated receptor alpha (pparα), p53, p21, p16, and serum levels of cluster of differentiation 163 (cd163) to tnf-like weak inducer of apoptosis (tweak) ratio in patients with type 2 diabetes. |
2021-06-28 |
2023-08-13 |
Not clear |
| Chen-Yi Liao, Shun-Fa Yang, Ting-Jian Wu, Han Chang, Chi-Ying F Huang, Yu-Fan Liu, Chi-Hsiang Wang, Jhong-Chio Liou, Shih-Lan Hsu, Huei Lee, Gwo-Tarng Sheu, Jinghua Tsai Chan. Novel function of PERP-428 variants impacts lung cancer risk through the differential regulation of PTEN/MDM2/p53-mediated antioxidant activity. Free radical biology & medicine. vol 167. 2021-06-28. PMID:33731308. |
the p53 apoptosis effect is related to pmp-22 (perp), a tetraspan membrane protein, and an apoptotic effector protein downstream of p53. |
2021-06-28 |
2023-08-13 |
cat |
| Manjima Chatterjee, Pragasam Viswanatha. Long noncoding RNAs in the regulation of p53-mediated apoptosis in human cancers. Cell biology international. vol 45. issue 7. 2021-06-28. PMID:33760332. |
interestingly, lncrnas interfere with the stages of apoptosis and related pathways involving p53. |
2021-06-28 |
2023-08-13 |
human |
| Manjima Chatterjee, Pragasam Viswanatha. Long noncoding RNAs in the regulation of p53-mediated apoptosis in human cancers. Cell biology international. vol 45. issue 7. 2021-06-28. PMID:33760332. |
although the role of lncrnas in the p53 network and apoptosis has been independently defined, their interplay in activating p53-target genes during cell cycle arrest remains unexplored. |
2021-06-28 |
2023-08-13 |
human |
| Sheau-Fung Thai, Carlton P Jones, Brian L Robinette, Hongzu Ren, Beena Vallant, Anna Fisher, Kirk T Kitchi. Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells. Journal of nanoscience and nanotechnology. vol 21. issue 10. 2021-06-28. PMID:33875094. |
the most significantly altered genes and pathways by cu nps exposure were nrf2 (nuclear factor erythroid 2 related factor 2)-mediated oxidative stress response, protein ubiquitination, tumor protein p53 (p53), phase i and ii metabolizing enzymes, antioxidant proteins and phase iii detoxifying gene pathways.messenger rna-microrna interaction from microrna target filter analyses revealed more signaling pathways altered in cu nps treated samples than transcriptomics alone, including cell proliferation, dna methylation, endoplasmic reticulum (er) stress, apoptosis, autophagy, reactive oxygen species, inflammation, tumorigenesis, extracellular matrix/angiogenesis and protein synthesis. |
2021-06-28 |
2023-08-13 |
human |
| XiaoLi Yang, ZhaoFang Li, RongQiang Zhang, Di Zhang, YongMin Xiong, Chen Wang, XueNa Yang, Qiang L. Dysregulation of Transcription Profile of Selenoprotein in Patients with Kashin-Beck Disease and Its Effect on Se Deficiency-Induced Chondrocyte Apoptosis. Biological trace element research. 2021-06-27. PMID:34176076. |
moreover, in the se deficiency group, the mrna levels of gpx3, dio1, and txnrd1 were downregulated and gpx activity was decreased, but the late apoptosis rate, the mrna levels of bax and p53, and the bax/bcl2 ratio were increased; the opposite trend was observed in the se supplement group. |
2021-06-27 |
2023-08-13 |
Not clear |
| Güven Yenmiş, Nail Beşli, Elif Yaprak Saraç, Fatma Sinem Hocaoğlu Emre, Kazım Şenol, Gönül Kanıgü. Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism Turkish journal of medical sciences. vol 51. issue 2. 2021-06-25. PMID:33350292. |
metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin d1 and upregulation of p53 through an ampk-alpha independent mechanism in the present study we aimed to figure out the effect of metformin on the expression of ampk-alpha, cyclin d1, and tp53, and apoptosis in primary breast cancer cells (pbccs). |
2021-06-25 |
2023-08-13 |
Not clear |
| Jacques Kumutima, Xin-Qiu Yao, Donald Hamelber. p53 Is Potentially Regulated by Cyclophilin D in the Triple-Proline Loop of the DNA Binding Domain. Biochemistry. vol 60. issue 8. 2021-06-25. PMID:33591178. |
the canonical function of p53 is to transcriptionally activate target genes in response to, for example, dna damage that may trigger apoptosis. |
2021-06-25 |
2023-08-13 |
Not clear |
| Hong-Yue Ding, Wan-Yong Yang, Li-Hong Zhang, Li Li, Feng Xie, Hua-Yi Li, Xiao-Yu Chen, Zeng Tu, Yi Li, Yong Chen, Sheng-Yong Yan. 8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway. Cell transplantation. vol 29. 2021-06-24. PMID:32907379. |
after 8-cl-ado exposure, cck-8 assay was performed to determine the cell proliferation; flow cytometry was used to analyze the cell cycle profiles and apoptosis; and the protein levels of adar1, p53, p21, and cyclin d1 were measured by western blotting. |
2021-06-24 |
2023-08-13 |
human |
| Hong-Yue Ding, Wan-Yong Yang, Li-Hong Zhang, Li Li, Feng Xie, Hua-Yi Li, Xiao-Yu Chen, Zeng Tu, Yi Li, Yong Chen, Sheng-Yong Yan. 8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway. Cell transplantation. vol 29. 2021-06-24. PMID:32907379. |
moreover, the cell growth inhibition was rescued, apoptosis was reduced, and p53 and p21 protein levels were downregulated, while cyclin d1 was upregulated when cells were transfected with plasmids expressing adar1 proteins. |
2021-06-24 |
2023-08-13 |
human |
| Libo Liu, Sihui Huang, Man Xu, Yan Gong, Dan Li, Chunxia Wan, Haiming Wu, Qizhu Tan. Isoquercitrin protects HUVECs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation. International journal of molecular medicine. vol 48. issue 1. 2021-06-24. PMID:33982778. |
isoquercitrin protects huvecs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation. |
2021-06-24 |
2023-08-13 |
human |
| Chen-Chu Lin, Wan-Ting Liao, Tsung-Ying Yang, Hsueh-Ju Lu, Shih-Lan Hsu, Chun-Chi W. MicroRNA‑10b modulates cisplatin tolerance by targeting p53 directly in lung cancer cells. Oncology reports. vol 46. issue 2. 2021-06-24. PMID:34165168. |
ectopic expression of mir‑10b‑agomir decreased the expression of p53 and its downstream effectors, such as bax and p53 upregulated modulator of apoptosis. |
2021-06-24 |
2023-08-13 |
Not clear |
| Ibrahim Barnawi, Yousef Hawsawi, Philip Dash, Atif Abdulwahab A Oyouni, Syed Khalid Mustafa, Nahed A Hussien, Osama Al-Amer, Suliman Alomar, Lamjed Mansou. Nitric Oxide Synthase Potentiates the Resistance of Cancer Cell Lines to Anticancer Chemotherapeutics. Anti-cancer agents in medicinal chemistry. 2021-06-24. PMID:34165414. |
the mechanism of the apoptotic mutation of p53 and bcl-2 proteins is commonly associated with increased resistance to apoptosis and, therein, to chemotherapy. |
2021-06-24 |
2023-08-13 |
Not clear |
| Hadile Kobeissy, Rouba Hage-Sleiman, Zeinab Dakdouk, Lina Kozhaya, Ghassan Dbaib. Crosstalk between Noxa, Bcl-2, and ceramide in mediating p53-dependent apoptosis in Molt-4 human T-cell leukemia. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32767230. |
the tumor suppressor p53 stimulates various downstream targets that presumably trigger, individually or in concert, de novo ceramide synthesis and intrinsic apoptosis via mitochondrial outer membrane permeabilization (momp). |
2021-06-23 |
2023-08-13 |
human |
| Hadile Kobeissy, Rouba Hage-Sleiman, Zeinab Dakdouk, Lina Kozhaya, Ghassan Dbaib. Crosstalk between Noxa, Bcl-2, and ceramide in mediating p53-dependent apoptosis in Molt-4 human T-cell leukemia. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32767230. |
among these targets, bh3-only protein noxa was found to be promptly activated by p53 prior to ceramide accumulation and apoptosis in response to irradiation. |
2021-06-23 |
2023-08-13 |
human |
| Hadile Kobeissy, Rouba Hage-Sleiman, Zeinab Dakdouk, Lina Kozhaya, Ghassan Dbaib. Crosstalk between Noxa, Bcl-2, and ceramide in mediating p53-dependent apoptosis in Molt-4 human T-cell leukemia. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32767230. |
to evaluate the relation between noxa and ceramide in irradiation-induced apoptosis, noxa was silenced in molt-4 cells and apoptosis, p53 expression, and ceramide accumulation were assessed in response to irradiation. |
2021-06-23 |
2023-08-13 |
human |