| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Liu, Yuyan Ma, Qihui Yin, Huanyu Zhou, Yan Fan. Association of β-arrestin1 and p53-Mdm2 signaling in the development of missed abortion. The journal of obstetrics and gynaecology research. vol 47. issue 5. 2021-06-21. PMID:33611816. |
our previous studies have confirmed that the elevated expression of p53 and mdm2 may be responsible for apoptosis during missed abortion. |
2021-06-21 |
2023-08-13 |
Not clear |
| Jingwen Xu, Yi Wang, Zhe Wang, Yihai Wang, Xiangjiu H. T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells. Steroids. vol 170. 2021-06-21. PMID:33781788. |
the p53 is essential in the cell cycle arrest induced by t-17, however, the effect of p53 on t-17-induced apoptosis and autophagy is still unclear. |
2021-06-21 |
2023-08-13 |
Not clear |
| Jingwen Xu, Yi Wang, Zhe Wang, Yihai Wang, Xiangjiu H. T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells. Steroids. vol 170. 2021-06-21. PMID:33781788. |
by transfecting p53 sirna into ags cells (p53 wild type cells) or wild-type p53 into kato-iii cells (p53 deficiency cells), t-17 was found to induce apoptosis and autophagy in gastric cancer cells in a p53-independent manner. |
2021-06-21 |
2023-08-13 |
Not clear |
| Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Jorrit De Waele, Christophe Hermans, Hilde Lambrechts, Bart Cuypers, Kris Laukens, Esther Bartholomeus, Vasiliki Siozopoulou, Winnok H De Vos, Marc Peeters, Evelien L J Smits, Christophe Debe. Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer. Redox biology. vol 42. 2021-06-21. PMID:33812801. |
our data provides novel insights on af as a potent, clinically available, off-patent cancer drug by targeting mutant p53 cancer cells through distinct cell death mechanisms (apoptosis and ferroptosis). |
2021-06-21 |
2023-08-13 |
Not clear |
| Kamila Buzun, Agnieszka Gornowicz, Roman Lesyk, Krzysztof Bielawski, Anna Bielawsk. Autophagy Modulators in Cancer Therapy. International journal of molecular sciences. vol 22. issue 11. 2021-06-21. PMID:34071600. |
the relationship between apoptosis and autophagy on the level of molecular regulation of the expression of selected proteins such as p53, bcl-2/beclin 1, p62, atg proteins, and caspases was discussed. |
2021-06-21 |
2023-08-13 |
Not clear |
| Eman Taha Mohammed, Khalid S Hashem, Ahmed Z Abdelazem, Fatma A M A Fod. Prospective Protective Effect of Ellagic Acid as a SIRT1 Activator in Iron Oxide Nanoparticle-Induced Renal Damage in Rats. Biological trace element research. vol 198. issue 1. 2021-06-18. PMID:31933277. |
in the present study, the potent antioxidant and antiapoptotic effects of ea were indicated by the significant overexpression of sirt1 in renal tissues that leads to significant decreases in renal mda content, p53 protein level and forkhead-box transcription factor1 (foxo1) expression, and significant increases in renal gsh level, catalase activity, growth arrest and dna damage-inducible protein 45 alpha (gaddα45), and renal inhibition of apoptosis protein (kiap) gene expression levels in the ea + ionp-treated group. |
2021-06-18 |
2023-08-13 |
rat |
| Jia-Nan Wang, Qin Yang, Chen Yang, Yu-Ting Cai, Tian Xing, Li Gao, Fang Wang, Xin Chen, Xue-Qi Liu, Xiao-Yan He, Biao Wei, Ling Jiang, Chao Li, Juan Jin, Jia-Gen Wen, Tao-Tao Ma, Hai-Yong Chen, Jun Li, Xiao-Ming Men. Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production. Redox biology. vol 32. 2021-06-18. PMID:32143149. |
mechanistically, smad3 binds to p53 and enhances p53 activity in cells treated with hg and h/r, which may lead to tecs apoptosis. |
2021-06-18 |
2023-08-13 |
mouse |
| John Tower, Laura C D Pomatto, Kelvin J A Davie. Sex differences in the response to oxidative and proteolytic stress. Redox biology. vol 31. 2021-06-18. PMID:32201219. |
the p53 and forkhead box (fox)-family genes, heat shock proteins (hsps), and the apoptosis and autophagy pathways appear particularly important in mediating sex differences in stress response. |
2021-06-18 |
2023-08-13 |
Not clear |
| Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsk. Cardiomyocyte specific deletion of p53 decreases cell injury during ischemia-reperfusion: Role of Mitochondria. Free radical biology & medicine. vol 158. 2021-06-18. PMID:32711023. |
ischemia-reperfusion increased the truncation of mature aif (apoptosis inducing factor, an indicator of mitochondrial calpain1 activation) in wild type but not in p53 deletion mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Kimia Ahmadi, Shiva Roshan-Milani, Fatemeh Asgharzadeh, Masoumeh Pourjabali, Amin Abdollahzade Far. In Vitro and In Vivo Pretreatment with Selenium Mitigates Tetrahydrocannabinol-Induced Testicular Cell Apoptosis: the Role of AKT and p53 Pathways. Biological trace element research. vol 199. issue 6. 2021-06-18. PMID:32815089. |
in vitro and in vivo pretreatment with selenium mitigates tetrahydrocannabinol-induced testicular cell apoptosis: the role of akt and p53 pathways. |
2021-06-18 |
2023-08-13 |
mouse |
| Kimia Ahmadi, Shiva Roshan-Milani, Fatemeh Asgharzadeh, Masoumeh Pourjabali, Amin Abdollahzade Far. In Vitro and In Vivo Pretreatment with Selenium Mitigates Tetrahydrocannabinol-Induced Testicular Cell Apoptosis: the Role of AKT and p53 Pathways. Biological trace element research. vol 199. issue 6. 2021-06-18. PMID:32815089. |
at the end of the experiments, sertoli cells and testis tissue samples were collected for biochemical (akt, p53), cell apoptosis, and histological analyses. |
2021-06-18 |
2023-08-13 |
mouse |
| Kimia Ahmadi, Shiva Roshan-Milani, Fatemeh Asgharzadeh, Masoumeh Pourjabali, Amin Abdollahzade Far. In Vitro and In Vivo Pretreatment with Selenium Mitigates Tetrahydrocannabinol-Induced Testicular Cell Apoptosis: the Role of AKT and p53 Pathways. Biological trace element research. vol 199. issue 6. 2021-06-18. PMID:32815089. |
the results of the in vitro study revealed that thc significantly decreases the cell viability (p < 0.001) and expression of the p-akt protein (p < 0.05) and increases sertoli cells' apoptosis (p < 0.001) and p53 protein expression (p < 0.001). |
2021-06-18 |
2023-08-13 |
mouse |
| Chun-Yan Wang, Qi Zhang, Zhe Xun, Lin Yuan, Ruonan Li, Xiang Li, Shu-Yu Tian, Na Xin, Ye X. Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models. Redox biology. vol 36. 2021-06-18. PMID:32828017. |
syringin reduced neuronal apoptosis independently of p53. |
2021-06-18 |
2023-08-13 |
mouse |
| Mohd Jahir Khan, Abrar Ahmad, Mahmood Ahmad Khan, Sahabjada Siddiqu. Zinc Oxide Nanoparticle Induces Apoptosis in Human Epidermoid Carcinoma Cells Through Reactive Oxygen Species and DNA Degradation. Biological trace element research. vol 199. issue 6. 2021-06-18. PMID:32840725. |
thus zno-nps induce apoptosis in a431 cells through dna degradation and generation of reactive oxygen species via p53, bax/bcl-2, and caspase pathways. |
2021-06-18 |
2023-08-13 |
human |
| Shao-Bo Liang, Fang Wang, Min Luo, Hong Zhang, Shao-Cong Wu, Zhen Chen, Li-Wu F. PBA2, a novel compound, enhances radiosensitivity in various carcinoma cells by activating the p53 pathway in vitro and in vivo. Free radical biology & medicine. vol 161. 2021-06-18. PMID:33080341. |
the underlying mechanism might involve increasing dna damage and cell apoptosis via activating the p53 pathway. |
2021-06-18 |
2023-08-13 |
mouse |
| Yue Zhou, Lian-Jun Cai, Li-Hui Xu, Yu Guo, Nuo Chen, Qing Ya. The role of sirt1 in the retinal ganglion cells cultured by high glucose. International ophthalmology. vol 41. issue 3. 2021-06-18. PMID:33174070. |
after 48 h of infection, the viability of rgc was detected by cck8 kit, the apoptosis rate was detected by fcm analysis, and the protein expression of p53, foxo3a, nf-κ b, caspase-3 was detected by western blot. |
2021-06-18 |
2023-08-13 |
Not clear |
| Sheau-Fung Thai, Carlton P Jones, Brian L Robinette, Hongzu Ren, Beena Vallanat, Anna A Fisher, Kirk T Kitchi. Effects of Silver Nanoparticles and Silver Nitrate on mRNA and microRNA Expression in Human Hepatocellular Carcinoma Cells (HepG2). Journal of nanoscience and nanotechnology. vol 21. issue 11. 2021-06-18. PMID:33980351. |
nano ag-s also affected p53 signaling, survival, apoptosis, tissue repair, lipid synthesis, angiogenesis, liver fibrosis and tumor development. |
2021-06-18 |
2023-08-13 |
human |
| Sheau-Fung Thai, Carlton P Jones, Brian L Robinette, Hongzu Ren, Beena Vallanat, Anna A Fisher, Kirk T Kitchi. Effects of Silver Nanoparticles and Silver Nitrate on mRNA and microRNA Expression in Human Hepatocellular Carcinoma Cells (HepG2). Journal of nanoscience and nanotechnology. vol 21. issue 11. 2021-06-18. PMID:33980351. |
microrna target filter analysis revealed additional affected pathways that were not reflected in the mrna expression response alone, including dna damage signaling, genomic stability, ros, cell cycle, ubiquitination, dna methylation, cell proliferation and fibrosis for agno₃; and cell cycle regulation, p53 signaling, cell proliferation, survival, apoptosis, tissue repair and so on for nano ag-s. |
2021-06-18 |
2023-08-13 |
human |
| Timur Yagudin, Yue Zhao, Haiyu Gao, Yang Zhang, Ying Yang, Xiaofang Zhang, Wenbo Ma, Tolessa Muleta Daba, Vladimir Ishmetov, Kai Kang, Baofeng Yang, Zhenwei Pa. iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33128543. |
iaspp protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. |
2021-06-17 |
2023-08-13 |
mouse |
| Timur Yagudin, Yue Zhao, Haiyu Gao, Yang Zhang, Ying Yang, Xiaofang Zhang, Wenbo Ma, Tolessa Muleta Daba, Vladimir Ishmetov, Kai Kang, Baofeng Yang, Zhenwei Pa. iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. Acta biochimica et biophysica Sinica. vol 53. issue 1. 2021-06-17. PMID:33128543. |
inhibitor of apoptosis-stimulating protein of p53 (iaspp) is a member of the aspp family proteins and an evolutionarily preserved inhibitor of p53 that is involved in many cellular processes, including apoptosis of cancer cells. |
2021-06-17 |
2023-08-13 |
mouse |