| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hadile Kobeissy, Rouba Hage-Sleiman, Zeinab Dakdouk, Lina Kozhaya, Ghassan Dbaib. Crosstalk between Noxa, Bcl-2, and ceramide in mediating p53-dependent apoptosis in Molt-4 human T-cell leukemia. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32767230. |
in irradiation-induced, p53-dependent pathways of apoptosis, the pro-apoptotic noxa represents one of several, yet to be identified, pathways simultaneously triggered by p53 to produce mitochondrial ceramide accumulation and apoptosis. |
2021-06-23 |
2023-08-13 |
human |
| Alison M Taylor, Elizabeth R Macari, Iris T Chan, Megan C Blair, Sergei Doulatov, Linda T Vo, David M Raiser, Kavitha Siva, Anindita Basak, Mehdi Pirouz, Arish N Shah, Katherine McGrath, Jessica M Humphries, Emma Stillman, Blanche P Alter, Eliezer Calo, Richard I Gregory, Vijay G Sankaran, Johan Flygare, Benjamin L Ebert, Yi Zhou, George Q Daley, Leonard I Zo. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Science translational medicine. vol 12. issue 566. 2021-06-23. PMID:33087503. |
higher p53 activity is thought to contribute to dba phenotypes by inducing apoptosis during red blood cell differentiation. |
2021-06-23 |
2023-08-13 |
zebrafish |
| Mohammed A Attia, Eman T Enan, Abdullah A Hashish, Sherif M H El-Kannishy, Ahmed R Gardouh, Mona K Tawfik, Salwa Faisal, Amr El-Mistekawy, Ayman Salama, Suliman Y Alomar, Amira H Eltrawy, Sheka Yagub Aloyouni, Sawsan A Zaiton. Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis. Biomolecules. vol 11. issue 1. 2021-06-23. PMID:33467560. |
chemopreventive effect of 5-flurouracil polymeric hybrid plga-lecithin nanoparticles against colon dysplasia model in mice and impact on p53 apoptosis. |
2021-06-23 |
2023-08-13 |
mouse |
| Xiao-Yun Kang, Jing Zhang, Ling Tang, Liu Huang, Jin Tong, Qiang F. OTU deubiquitinase 5 inhibits the progression of non-small cell lung cancer via regulating p53 and PDCD5. Chemical biology & drug design. vol 96. issue 2. 2021-06-22. PMID:32248621. |
otu deubiquitinase 5 (otud5), a deubiquitinating enzyme, can enhance the stability of p53 and programmed cell death 5 (pdcd5), a protein related to the apoptosis, by deubiquitination. |
2021-06-22 |
2023-08-13 |
Not clear |
| Xiao-Yun Kang, Jing Zhang, Ling Tang, Liu Huang, Jin Tong, Qiang F. OTU deubiquitinase 5 inhibits the progression of non-small cell lung cancer via regulating p53 and PDCD5. Chemical biology & drug design. vol 96. issue 2. 2021-06-22. PMID:32248621. |
the knockdown of otud5 inactivated p53 and pdcd5, promoting the proliferation and metastasis of nsclc cells while inhibiting their apoptosis. |
2021-06-22 |
2023-08-13 |
Not clear |
| Xianda Chen, Jue Wang, Yu Nie, Maoping Ch. The long noncoding RNA NR_045363 involves cardiomyocyte apoptosis and cardiac repair via p53 signal pathway. Cell biology international. vol 44. issue 9. 2021-06-22. PMID:32374467. |
the long noncoding rna nr_045363 involves cardiomyocyte apoptosis and cardiac repair via p53 signal pathway. |
2021-06-22 |
2023-08-13 |
mouse |
| Xianda Chen, Jue Wang, Yu Nie, Maoping Ch. The long noncoding RNA NR_045363 involves cardiomyocyte apoptosis and cardiac repair via p53 signal pathway. Cell biology international. vol 44. issue 9. 2021-06-22. PMID:32374467. |
these data suggest that nr_045363 is involved in cm apoptosis and that nr_045363 overexpression exerts positive effects on cardiac repair by alleviating cm apoptosis through the inhibition of the p53 pathway. |
2021-06-22 |
2023-08-13 |
mouse |
| Xiaoye Fan, Wenjing Gu, Yun Gao, Ning Ma, Changqing Fan, Xinxin C. Daphnetin ameliorated GM-induced renal injury through the suppression of oxidative stress and apoptosis in mice. International immunopharmacology. vol 96. 2021-06-22. PMID:33812255. |
gm upregulated the expression levels of nox4, cleaved caspase-3 and p53 and the bax/bcl2 ratio in vivo to stimulate oxidative stress and apoptosis. |
2021-06-22 |
2023-08-13 |
mouse |
| Weiwei Qiao, Pei Huang, Xinhuan Wang, Liuyan Men. Susceptibility to DNA damage caused by abrogation of Rad54 homolog B: A putative mechanism for chemically induced cleft palate. Toxicology. vol 456. 2021-06-22. PMID:33823233. |
the expression level of dna repair protein rad54 homolog b (rad54b) was significantly decreased while those of the dna double-strand breaks (dsbs) marker γ-h2a.x, apoptosis marker caspase-3 and p53 were significantly increased in the palatal shelves upon exposure to atra and tcdd relative to the control. |
2021-06-22 |
2023-08-13 |
mouse |
| Weiwei Qiao, Pei Huang, Xinhuan Wang, Liuyan Men. Susceptibility to DNA damage caused by abrogation of Rad54 homolog B: A putative mechanism for chemically induced cleft palate. Toxicology. vol 456. 2021-06-22. PMID:33823233. |
the loss of rad54b increased the sensitivity of mepms to dsbs inducers, promoted apoptosis, and suppressed the proliferation of mepms by inhibiting the degradation of p53. |
2021-06-22 |
2023-08-13 |
mouse |
| Celso F Balthazar, Nelci A de Moura, Guilherme R Romualdo, Ramon S Rocha, Tatiana C Pimentel, Erick A Esmerino, Mônica Q Freitas, Antonella Santillo, Marcia Cristina Silva, Luis F Barbisan, Adriano G Cruz, Marzia Albenzi. Synbiotic sheep milk ice cream reduces chemically induced mouse colon carcinogenesis. Journal of dairy science. vol 104. issue 7. 2021-06-22. PMID:33934866. |
at wk 4, a significant reduction in micronucleated colonocytes was observed in prob and synb groups, and a significant decrease in both p53 expression and apoptosis indexes in colonic crypts was observed in synb group. |
2021-06-22 |
2023-08-13 |
mouse |
| Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Son. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. Toxicology. vol 457. 2021-06-22. PMID:33961949. |
notably, p53 activation coordinated cell cycle progression, alleviated dna damage and ultimately mitigated apoptosis in bv2 cells. |
2021-06-22 |
2023-08-13 |
Not clear |
| Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Son. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. Toxicology. vol 457. 2021-06-22. PMID:33961949. |
finally, antioxidant n-acetyl-l-cysteine (nac) inhibited p53 activation upon pbdeq exposure, and then ameliorated pbdeq-induced dna damage, cell cycle arrest and apoptosis, which illustrated that pbdeq-induced dna damage and p53 activation were mediated by reactive oxygen species (ros). |
2021-06-22 |
2023-08-13 |
Not clear |
| Ying-Chen Qian, Yun-Xia Xie, Chao-Shan Wang, Zhu-Mei Shi, Cheng-Fei Jiang, Yun-Yi Tang, Xu Qian, Lin Wang, Bing-Hua Jian. Asian journal of andrology. vol 22. issue 4. 2021-06-21. PMID:31489847. |
to identify specific gene(s) involved, we performed digital gene expression profiling (dge) and pathway analysis via gene set enrichment analysis (gsea) and the kyoto encyclopedia of genes and genomes (kegg) database, and we found that mkrn2 inhibits p53 apoptosis effector related to pmp22 (perp) expression and that levels of the protein in sperm samples have an inverse correlation with infertility levels. |
2021-06-21 |
2023-08-13 |
mouse |
| Lei Wang, Wenbin Shi, Xuewei Gao, Nagaraja SreeHarsha, Daisong Zhan. Cardioprotective role of metformin against sodium arsenite-induced oxidative stress, inflammation, and apoptosis. IUBMB life. vol 72. issue 4. 2021-06-21. PMID:31587475. |
in addition, sa provoked the apoptosis by expanding the p53 and bax levels, terminal deoxynucleotidyl transferase dutp nick end labeling, and expression of caspase-3. |
2021-06-21 |
2023-08-13 |
rat |
| Jianping Chen, Xiaohuang Cao, Xiaoming Qin, Hai Liu, Suhua Chen, Saiyi Zhong, Yinghua L. Proteomic analysis of the molecular mechanism of curcumin/β-cyclodextrin polymer inclusion complex inhibiting HepG2 cells growth. Journal of food biochemistry. vol 44. issue 2. 2021-06-21. PMID:31868930. |
prdx6 and npm1 were down-regulated, thereby improving the expression level of phosphorylated p53 and ros content, which regulated cell apoptosis. |
2021-06-21 |
2023-08-13 |
human |
| Brittany J Holmes, Rie von Eyben, Laura D Attardi, Christina S Kong, Quynh-Thu Le, Cherie-Ann O Natha. Pilot study of loss of the p53/p63 target gene PERP at the surgical margin as a potential predictor of local relapse in head and neck squamous cell carcinoma. Head & neck. vol 42. issue 11. 2021-06-21. PMID:33034918. |
perp (p53 apoptosis effector related to pmp22) localizes to desmosomes and suppresses squamous cell carcinoma development. |
2021-06-21 |
2023-08-13 |
Not clear |
| Larissa Berloffa Belardin, Maria Beatriz Ribeiro de Andrade, Paula Intasqui, Deborah Montagnini Spaine, Ricardo Pimenta Bertolla, Mariana Pereira Antoniass. Restoration of the apoptosis pathways' proteins levels after orchiectomy in testicular tumour patients. Andrologia. vol 52. issue 11. 2021-06-21. PMID:33070399. |
comparing pre- and post-orchiectomy groups, just the apoptosis pathways' proteins presented different levels, in which bad was lower and bcl2, akt, caspase-9, p53 and caspase-8 were higher after orchiectomy. |
2021-06-21 |
2023-08-13 |
Not clear |
| Larissa Berloffa Belardin, Maria Beatriz Ribeiro de Andrade, Paula Intasqui, Deborah Montagnini Spaine, Ricardo Pimenta Bertolla, Mariana Pereira Antoniass. Restoration of the apoptosis pathways' proteins levels after orchiectomy in testicular tumour patients. Andrologia. vol 52. issue 11. 2021-06-21. PMID:33070399. |
regarding the apoptosis pathway, lower levels of jnk, bcl2, akt, caspase-9, p53 and caspase-8 and higher levels of bad were observed before orchiectomy. |
2021-06-21 |
2023-08-13 |
Not clear |
| Jerry D Monroe, Satya A Moolani, Elvin N Irihamye, Joshua S Speed, Yann Gibert, Michael E Smit. RNA-Seq Analysis of Cisplatin and the Monofunctional Platinum(II) Complex, Phenanthriplatin, in A549 Non-Small Cell Lung Cancer and IMR90 Lung Fibroblast Cell Lines. Cells. vol 9. issue 12. 2021-06-21. PMID:33302475. |
we found that phenanthriplatin may regulate the genes gprc5a, tff1, and tnfrsf10d, which act through p53 to control apoptosis, differently or to a greater extent than cisplatin, and that it, unlike cisplatin, could upregulate atp5md, a gene which signals through the wnt/β catenin pathway. |
2021-06-21 |
2023-08-13 |
Not clear |