| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shweta Umar, Rina Soni, Sunil D Durgapal, Subhangi Soman, Suresh Balakrishna. A synthetic coumarin derivative (4-flourophenylacetamide-acetyl coumarin) impedes cell cycle at G0/G1 stage, induces apoptosis, and inhibits metastasis via ROS-mediated p53 and AKT signaling pathways in A549 cells. Journal of biochemical and molecular toxicology. vol 34. issue 10. 2021-06-08. PMID:32578917. |
a synthetic coumarin derivative (4-flourophenylacetamide-acetyl coumarin) impedes cell cycle at g0/g1 stage, induces apoptosis, and inhibits metastasis via ros-mediated p53 and akt signaling pathways in a549 cells. |
2021-06-08 |
2023-08-13 |
Not clear |
| Sruthi Sritharan, Nageswaran Sivalinga. Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines. Journal of biochemical and molecular toxicology. vol 35. issue 1. 2021-06-08. PMID:32864863. |
curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines. |
2021-06-08 |
2023-08-13 |
Not clear |
| Kais Ghedira, Soumaya Kouidhi, Yosr Hamdi, Houcemeddine Othman, Sonia Kechaou, Sadri Znaidi, Sghaier Haïtham, Imen Rabh. Pathway Maps of Orphan and Complex Diseases Using an Integrative Computational Approach. BioMed research international. vol 2020. 2021-06-08. PMID:33376724. |
among the most shared significant pathways between ods and cds, we found pathways in cancer, p53 signaling, mismatch repair, mtor signaling, b cell receptor signaling, and apoptosis pathways. |
2021-06-08 |
2023-08-13 |
Not clear |
| Sho Watanabe, Shuji Hibiya, Nobuhiro Katsukura, Sayuki Kitagawa, Ayako Sato, Ryuichi Okamoto, Mamoru Watanabe, Kiichiro Tsuchiy. Influence of chronic inflammation on the malignant phenotypes and the plasticity of colorectal cancer cells. Biochemistry and biophysics reports. vol 26. 2021-06-08. PMID:34095556. |
chronic inflammation induced apoptosis and suppressed the proliferation and stemness of these cancer cells via the action of p53. |
2021-06-08 |
2023-08-13 |
Not clear |
| Shemani Vishalya Jagoda, Katie Marie Dixo. Protective effects of 1,25 dihydroxyvitamin D Redox report : communications in free radical research. vol 25. issue 1. 2021-06-07. PMID:32093585. |
moreover, following acute uv exposure, 1,25d has been demonstrated to increase p53 levels in skin, which would presumably allow for repair of cells with damaged dna, or apoptosis of cells with irreparably damaged dna. |
2021-06-07 |
2023-08-13 |
Not clear |
| Jihui Wang, Nazim Muhammad, Tongtong Li, Han Wang, Yujia Liu, Bingnan Liu, Honglei Zha. Hyaluronic Acid-Coated Camptothecin Nanocrystals for Targeted Drug Delivery to Enhance Anticancer Efficacy. Molecular pharmaceutics. vol 17. issue 7. 2021-06-07. PMID:32437163. |
the possible molecular mechanism regarding this novel drug formulation might be linked to intrinsic mitochondria-mediated apoptosis by an increase of bax to bcl-2 ratio and upregulation of p53. |
2021-06-07 |
2023-08-13 |
Not clear |
| Wenning Cao, Lan M. Effect and mechanism of rapamycin on proliferation and apoptosis of human lung cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 6. 2021-06-07. PMID:33040787. |
in conclusion, rapa can induce apoptosis of nci-h446 cells by down-regulating bcl-2 gene expression, up-regulating p53 and bax gene expression, and increasing intracellular ca2+ concentration and its apoptosis induction effect have timeliness and dose-effect. |
2021-06-07 |
2023-08-13 |
human |
| Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He, Ying Ji. Schisandra chinensis protects against dopaminergic neuronal oxidative stress, neuroinflammation and apoptosis Food & function. vol 12. issue 9. 2021-06-07. PMID:33977962. |
sch effectively suppressed apoptosis by decreasing expressions of caspase 3, caspase 9, and p53 in the pd mouse model. |
2021-06-07 |
2023-08-13 |
mouse |
| Tilahun Ayane Debele, Ping-Ching Wu, Yu-Feng Wei, Jian-Ying Chuang, Kwang-Yu Chang, Jui-Hung Tsai, Wen-Pin S. Transferrin Modified GSH Sensitive Hyaluronic Acid Derivative Micelle to Deliver HSP90 Inhibitors to Enhance the Therapeutic Efficacy of Brain Cancers. Cancers. vol 13. issue 10. 2021-06-05. PMID:34069106. |
in addition, the treatment group induced caspase-dependent parp cleavage and the upregulation of p53 expression, which plays a key role in apoptosis of brain cancer cells. |
2021-06-05 |
2023-08-13 |
mouse |
| Xiaoxuan Wang, Yoshiyuki Yamamoto, Mamiko Imanishi, Xiaochen Zhang, Masashi Sato, Akinori Sugaya, Mitsuaki Hirose, Shinji Endo, Yukikazu Natori, Toshikazu Moriwaki, Kenji Yamato, Ichinosuke Hyod. Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type Oncology letters. vol 22. issue 1. 2021-06-05. PMID:34084225. |
enhanced g1 arrest and apoptosis via mdm4/mdm2 double knockdown and mek inhibition in wild-type murine double minute homolog 2 (mdm2) is an oncoprotein that induces p53 degradation via ubiquitin-ligase activity. |
2021-06-05 |
2023-08-13 |
Not clear |
| K N Chidambara Murthy, G K Jayaprakasha, Stephen Safe, Bhimanagouda S Pati. Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells. Food & function. vol 12. issue 3. 2021-06-04. PMID:33427831. |
in addition, treatment with 60 μm lna resulted in the activation of akt-associated signals to induce apoptosis, and the same was confirmed by the effects of the compounds on pakt, p53, vegf and caspase proteins. |
2021-06-04 |
2023-08-13 |
human |
| Yan Zhou Tran, Rezan Minozada, Xiaofang Cao, Henrik J Johansson, Rui M Branca, Brinton Seashore-Ludlow, Lukas M Orr. Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC. Molecular & cellular proteomics : MCP. vol 19. issue 6. 2021-06-03. PMID:32234966. |
proteomics profiling revealed that bcl6 inhibited transcription of multiple target genes including p53, resulting in reduced apoptosis which implicates bcl6 upregulation as a new egfr inhibitor treatment escape mechanism. |
2021-06-03 |
2023-08-13 |
Not clear |
| Rashid Alijani Ardeshir, Sara Rastgar, Payam Morakabati, Hoda Mojiri-Forushani, Abdolali Movahedinia, Amir Parviz Salat. Selective induced apoptosis and cell cycle arrest in MCF7 and LNCap cell lines by skin mucus from round goby (Neogobius melanostomus) and common carp (Cyprinus carpio) through P53 expression. Cytotechnology. vol 72. issue 3. 2021-06-02. PMID:32144633. |
selective induced apoptosis and cell cycle arrest in mcf7 and lncap cell lines by skin mucus from round goby (neogobius melanostomus) and common carp (cyprinus carpio) through p53 expression. |
2021-06-02 |
2023-08-13 |
Not clear |
| Rashid Alijani Ardeshir, Sara Rastgar, Payam Morakabati, Hoda Mojiri-Forushani, Abdolali Movahedinia, Amir Parviz Salat. Selective induced apoptosis and cell cycle arrest in MCF7 and LNCap cell lines by skin mucus from round goby (Neogobius melanostomus) and common carp (Cyprinus carpio) through P53 expression. Cytotechnology. vol 72. issue 3. 2021-06-02. PMID:32144633. |
this study was looking for the cytotoxic potential of mucus from the two fish species, including round goby (neogobius melanostomus) and common carp (cyprinus carpio), and inducing apoptosis in mcf7 and lncap cancer cell lines via influencing p53 gene expression and cell cycle arrest. |
2021-06-02 |
2023-08-13 |
Not clear |
| Rashid Alijani Ardeshir, Sara Rastgar, Payam Morakabati, Hoda Mojiri-Forushani, Abdolali Movahedinia, Amir Parviz Salat. Selective induced apoptosis and cell cycle arrest in MCF7 and LNCap cell lines by skin mucus from round goby (Neogobius melanostomus) and common carp (Cyprinus carpio) through P53 expression. Cytotechnology. vol 72. issue 3. 2021-06-02. PMID:32144633. |
in addition, round goby mucus and common carp mucus selectively induced apoptosis in the lncap and mcf7 cells, respectively, through up-regulating p53 gene and arresting cell cycle at the g1 phase. |
2021-06-02 |
2023-08-13 |
Not clear |
| Rashid Alijani Ardeshir, Sara Rastgar, Payam Morakabati, Hoda Mojiri-Forushani, Abdolali Movahedinia, Amir Parviz Salat. Selective induced apoptosis and cell cycle arrest in MCF7 and LNCap cell lines by skin mucus from round goby (Neogobius melanostomus) and common carp (Cyprinus carpio) through P53 expression. Cytotechnology. vol 72. issue 3. 2021-06-02. PMID:32144633. |
taken together, this study suggested that the both mucus types can selectively influence p53 pathway and induce apoptosis in especial cancer cells. |
2021-06-02 |
2023-08-13 |
Not clear |
| Ankita Kaushik, Sandhya Anand, Deepa Bhartiy. Altered Biology of Testicular VSELs and SSCs by Neonatal Endocrine Disruption Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Mice. Stem cell reviews and reports. vol 16. issue 5. 2021-06-02. PMID:32592162. |
transcripts specific for apoptosis (bcl2, bax) remained unaffected but tumor suppressor (p53) and epigenetic regulator (np95) transcripts showed marked disruption. |
2021-06-02 |
2023-08-13 |
mouse |
| Yumiao Li, Aiming Zang, Jiejun Fu, Youchao Ji. Cullin 7 in tumor development: a novel potential anti-cancer target. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33618520. |
moreover, cul7 regulates cell transformation, tumor protein p53 activity, cell senescence, and apoptosis, mutations in cul7 are also involved in the development of tumors, indicating the characteristics of an oncogene. |
2021-06-02 |
2023-08-13 |
mouse |
| Yuanle Deng, Sha Li, Meng Wang, Xiaotong Chen, Li Tian, Liqun Wang, Wenyu Yang, Lezhang Chen, Fang He, Wenya Yi. Flavonoid-rich extracts from okra flowers exert antitumor activity in colorectal cancer through induction of mitochondrial dysfunction-associated apoptosis, senescence and autophagy. Food & function. vol 11. issue 12. 2021-06-01. PMID:33241810. |
we further reveal that afe inhibits crc cell proliferation by inducing mitochondrial dysfunction, which results from the activation of p53 and induction of apoptosis and senescence, and inhibits autophagic degradation. |
2021-06-01 |
2023-08-13 |
mouse |
| Sue Chin Lee, Kuan-Hung Lin, Andrea Balogh, Derek D Norman, Mitul Bavaria, Bryan Kuo, Junming Yue, Louisa Balázs, Zoltán Benyó, Gábor Tigy. Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment. Cellular signalling. vol 78. 2021-06-01. PMID:33253914. |
in particular, intermediates of the sphingolipid and lysophospholipid pathways regulate many cellular responses common to p53 such as cell survival, migration, dna damage repair and apoptosis. |
2021-06-01 |
2023-08-13 |
human |