| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Golnaz Rashidi, Mahsa Rezaeepoor, Chiman Mohammadi, Ghasem Solgi, Rezvan Najaf. Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells. Molecular biology reports. vol 47. issue 9. 2021-05-18. PMID:32888127. |
our data demonstrate that sema4d silencing results in strikingly elevated apoptosis in response to 5-fu treatment and leads to down-regulation of bcl-2 and overexpression of bax, p53, and caspase-3 in protein levels. |
2021-05-18 |
2023-08-13 |
human |
| M R A Hussei. Immunohistological Analysis of CD34-Positive Dermal Dendritic Cells and Microvessel Density in the Genital and Extragenital Lichen Sclerosus. Actas dermo-sifiliograficas. 2021-05-18. PMID:33727063. |
p53 is a tumor suppressor gene important for the regulation of the cell cycle and apoptosis. |
2021-05-18 |
2023-08-13 |
Not clear |
| Hardyanti Eka Putri, Bodee Nutho, Thanyada Rungrotmongkol, Boonchoo Sritularak, Chanida Vinayanuwattikun, Pithi Chanvorachot. Bibenzyl analogue DS-1 inhibits MDM2-mediated p53 degradation and sensitizes apoptosis in lung cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 85. 2021-05-18. PMID:33773191. |
bibenzyl analogue ds-1 inhibits mdm2-mediated p53 degradation and sensitizes apoptosis in lung cancer cells. |
2021-05-18 |
2023-08-13 |
Not clear |
| Etienne Leveille, Nathalie A Johnso. Genetic Events Inhibiting Apoptosis in Diffuse Large B Cell Lymphoma. Cancers. vol 13. issue 9. 2021-05-18. PMID:33946435. |
inhibition of apoptosis can be the result of genetic events inhibiting the intrinsic or extrinsic apoptotic pathways, as well as their modulators, such as the inhibitor of apoptosis proteins, p53, and components of the nf-kb pathway. |
2021-05-18 |
2023-08-13 |
Not clear |
| Jian Gao, Qing-Qing Chen, Ye Huang, Kai-Hang Li, Xiao-Ju Geng, Tao Wang, Qi-Si Lin, Ruo-Si Ya. Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators. Frontiers in pharmacology. vol 12. 2021-05-18. PMID:33995069. |
more importantly, compounds m1, 6b, and 6d could resist high glucose-induced apoptosis of hk-2 cells by activating sirt1 and deacetylation of p53. |
2021-05-18 |
2023-08-13 |
Not clear |
| Yuki Shimizu, Mariko Kiyooka, Toshio Ohshim. Transcriptome Analyses Reveal IL6/Stat3 Signaling Involvement in Radial Glia Proliferation After Stab Wound Injury in the Adult Zebrafish Optic Tectum. Frontiers in cell and developmental biology. vol 9. 2021-05-18. PMID:33996824. |
moreover, transcriptome and pathway analyses based on differentially expressed genes identified various enriched pathways, including apoptosis, the innate immune system, cell proliferation, cytokine signaling, p53 signaling, and il6/jak-stat signaling. |
2021-05-18 |
2023-08-13 |
zebrafish |
| Han Li, Xiaoqing Xu, Yudi Zhang, Xianying Tang, Wenhua L. Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner. European journal of pharmacology. vol 888. 2021-05-17. PMID:32950498. |
moreover, molecular assays indicated that bax and p53 were the key regulators of ms-275/tetrandrine induced apoptosis. |
2021-05-17 |
2023-08-13 |
human |
| Mario Pérez-Sayáns, Alejandro I Lorenzo-Pouso, Cintia M Chamorro-Petronacci, José M Suárez-Peñaranda, Elena Padín-Iruegas, Miguel A González-Moles, Xabier Marichalar-Mendía, Abel García-García, Andrés Blanco-Carrió. Immunoexpression of Apoptosis and Cell-cycle Arrest Markers in Oral Lichen Planus. Applied immunohistochemistry & molecular morphology : AIMM. vol 29. issue 5. 2021-05-17. PMID:33044228. |
the expression pattern of a panel of 5 molecular markers (p53, cyclin d1, ki-67, bcl-2, and bax) was studied in samples from patients with oral lichen planus (olp) and normal oral mucosa (nom) of healthy controls to investigate the implications of cell cycle and apoptosis in olp. |
2021-05-17 |
2023-08-13 |
Not clear |
| Melissa A Fischer, Sharon Y Friedlander, Maria P Arrate, Hua Chang, Agnieszka E Gorska, Londa D Fuller, Haley E Ramsey, Trinayan Kashyap, Christian Argueta, Sophie Debler, Michael Byrne, Matthew T Villaume, Aaron C Shaver, William Senapedis, Yosef Landesman, Erkan Baloglu, Sharon Shacham, Michael R Savon. Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies. Blood advances. vol 4. issue 3. 2021-05-14. PMID:32045477. |
further in vitro analyses showed that this enhanced cell death was the result of an increase in apoptosis that led to a loss of clonogenicity in methylcellulose assays, coinciding with activation of p53 and loss of mcl1. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chen Xu, Wenting Hu, Na Zhang, Yu Qi, Jing-Jun Nie, Nana Zhao, Bingran Yu, Fu-Jian X. Genetically multimodal therapy mediated by one polysaccharides-based supramolecular nanosystem. Biomaterials. vol 248. 2021-05-14. PMID:32283391. |
with the delivery of pkr-p53, p53 and killerred proteins could be expressed simultaneously in the same tumor cell for p53-mediated apoptosis therapy and photodynamic therapy (pdt), where the synergistic effect of killerred and p53 proteins is achieved. |
2021-05-14 |
2023-08-13 |
Not clear |
| Min Sun, Le He, Zhen Fan, Rupei Tang, Jianzhong D. Effective treatment of drug-resistant lung cancer via a nanogel capable of reactivating cisplatin and enhancing early apoptosis. Biomaterials. vol 257. 2021-05-14. PMID:32738659. |
meanwhile, the intracellular ros-p53 crosstalk can be upregulated by diallyl disulfide (up to 8-fold increase of ros) and valproate (up to 18-fold increase of p53) to enhance early apoptosis. |
2021-05-14 |
2023-08-13 |
human |
| Daowen Li, Yan Zhang, Xingyao Pei, Xinyu Liu, Chongshan Dai, Cun Li, Liuan Li, Jianbin Zhang, Xilong Xiao, Shusheng Tan. Molecular mechanism of olaquindox-induced hepatotoxicity and the hepatic protective role of curcumin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 145. 2021-05-14. PMID:32898599. |
in summary, our findings indicated that ola-induced hepatotoxicity involved in mitochondrial apoptosis, autophagy, p53 pathway, nrf2/ho-1 pathways, and curcumin regulated ola-induced liver damage, oxidative stress and apoptosis via activation of nrf2/ho-1 pathway and suppression of p53 and nf-kb pathway. |
2021-05-14 |
2023-08-13 |
mouse |
| Guohai Zhang, Liangping Li, Jingai Bi, Yiming Wu, Erguang L. Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway. European journal of pharmacology. vol 887. 2021-05-14. PMID:32950500. |
na20 bound to dna and p53 identified by a combination of drug tracking, dna relaxation assay and coimmunoprecipitation-mass spectrometry (coip-ms) detection, which led to the p21 activation and the suppression of egfr signal cascading, thereby evoking cell cycle arrest and cell apoptosis, finally leading to cancer cell inhibition both in vitro and in vivo. |
2021-05-14 |
2023-08-13 |
Not clear |
| Eva Kiss, Gertrud Forika, Reka Mohacsi, Zsuzsanna Nemeth, Tibor Krenacs, Magdolna Dan. Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines. International journal of molecular sciences. vol 22. issue 7. 2021-05-14. PMID:33808426. |
the treatment-induced downregulation of p-p53(thr55) was likely to contribute to protecting the nuclear localization and apoptosis inducing functions of p53. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yun Liu, Baohuan Cai, Yating Chong, Hualei Zhang, Chesley-Anne Kemp, Sumin Lu, Chang-Sheng Chang, Mingqiang Ren, John K Cowell, Tianxiang H. Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33082322. |
rna-seq analysis of the resistant clones demonstrates expression changes in cell death pathways centering on the p53 upregulated modulator of apoptosis (puma) protein. |
2021-05-13 |
2023-08-13 |
mouse |
| Sarah A Best, Cassandra J Vandenberg, Etna Abad, Lachlan Whitehead, Laia Guiu, Sheryl Ding, Margs S Brennan, Andreas Strasser, Marco J Herold, Kate D Sutherland, Ana Jani. Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33082333. |
zmat3 (also known as wig-1 or pag608) is one such downstream target of p53, whose loss in hemopoietic stem cells lacking the apoptosis and cell cycle regulators, puma and p21, respectively, promotes the development of leukemia. |
2021-05-13 |
2023-08-13 |
mouse |
| Mehtap Kilic Eren, Nur Betül Kartal, Hatice Pilevnel. Oncogenic WIP1 phosphatase attenuates the DNA damage response and sensitizes p53 mutant Jurkat cells to apoptosis. Oncology letters. vol 21. issue 6. 2021-05-13. PMID:33968195. |
oncogenic wip1 phosphatase attenuates the dna damage response and sensitizes p53 mutant jurkat cells to apoptosis. |
2021-05-13 |
2023-08-13 |
Not clear |
| Jian Zhou, Zaijia Yang, Ruiming Shen, Wangwang Zhong, Huiduan Zheng, Zhenggang Chen, Jianjian Tang, Juan Zh. Resveratrol Improves Mitochondrial Biogenesis Function and Activates PGC-1α Pathway in a Preclinical Model of Early Brain Injury Following Subarachnoid Hemorrhage. Frontiers in molecular biosciences. vol 8. 2021-05-13. PMID:33968980. |
rsv significantly ameliorated the release of apoptosis-related cytokines, namely p53, cleaved caspase-3, cytochrome c, and bax, leading to the amelioration of neuronal apoptosis, brain edema, and neurological impairment 24 h after sah. |
2021-05-13 |
2023-08-13 |
Not clear |
| Paul B Tchounwou, Shaloam Dasari, Felicite K Noubissi, Paresh Ray, Sanjay Kuma. Advances in Our Understanding of the Molecular Mechanisms of Action of Cisplatin in Cancer Therapy. Journal of experimental pharmacology. vol 13. 2021-05-11. PMID:33776489. |
its primary molecular mechanism of action has been associated with the induction of both intrinsic and extrinsic pathways of apoptosis resulting from the production of reactive oxygen species through lipid peroxidation, activation of various signal transduction pathways, induction of p53 signaling and cell cycle arrest, upregulation of pro-apoptotic genes/proteins, and down-regulation of proto-oncogenes and anti-apoptotic genes/proteins. |
2021-05-11 |
2023-08-13 |
human |
| Jing Gan, Lingyi Huang, Yi Qu, Rong Luo, Qianyun Cai, Fengyan Zhao, Dezhi M. Expression and functional analysis of lncRNAs in the hippocampus of immature rats with status epilepticus. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31738000. |
additionally, wgcna identified 667 up-regulated hub lncrnas in turquoise module that were involved in apoptosis, inflammatory responses and angiogenesis via regulation of hif-1, p53 and chemokine signalling pathways and via inflammatory mediator regulation of trp channels. |
2021-05-10 |
2023-08-13 |
rat |