| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiyuan Ping, Yalan Cheng, Jing Bao, Kexin Shi, Jian Zou, Xingchao Shent. KPNA4 is involved in cataract formation via the nuclear import of p53. Gene. vol 786. 2021-04-29. PMID:33798680. |
as the p53-specific adaptor of the nuclear import, kpna4 upregulated with the same pattern of p53 in hydrogen peroxide-induced apoptosis in human lens epithelia cells. |
2021-04-29 |
2023-08-13 |
human |
| Ren Zhang, Ji Hao, Qingming Wu, Kaiwen Guo, Chao Wang, Wei Kevin Zhang, Wanxin Liu, Qiang Wang, Xinzhou Yan. Dehydrocostus lactone inhibits cell proliferation and induces apoptosis by PI3K/Akt/Bad and ERS signalling pathway in human laryngeal carcinoma. Journal of cellular and molecular medicine. vol 24. issue 11. 2021-04-28. PMID:32319208. |
mechanistically, dhl is capable of inhibiting hep-2 and tu212 cell viability via promoting p53 and p21 function, meanwhile dhl dose-dependently induces hep-2 and tu212 cells apoptosis via activating mitochondrial apoptosis by inhibiting pi3k/akt/bad pathway and stimulating endoplasmic reticulum stress-mediated apoptosis pathway. |
2021-04-28 |
2023-08-13 |
mouse |
| Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhan. Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. International immunopharmacology. vol 85. 2021-04-28. PMID:32492628. |
meanwhile, que significantly inhibited the level of tumor suppressor p53, bax, cleaved-cas3 expressionl and increased bcl-2 expression to reduce apoptosis in vivo and in vitro. |
2021-04-28 |
2023-08-13 |
rat |
| Santa Cirmi, Alessandro Maugeri, Giovanni Enrico Lombardo, Caterina Russo, Laura Musumeci, Sebastiano Gangemi, Gioacchino Calapai, Davide Barreca, Michele Navarr. A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes. Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-04-28. PMID:33808343. |
treatment of differentiated sh-sy5y cells with 6-ohda brought cell death, and specifically, apoptosis, which was significantly inhibited by the preincubation with mje through caspase 3 blockage and the modulation of p53, bax, and bcl-2 genes. |
2021-04-28 |
2023-08-13 |
human |
| Qingqing Xiong, Yang Bai, Run Shi, Jian Wang, Weiguo Xu, Mingming Zhang, Tianqiang Son. Preferentially released miR-122 from cyclodextrin-based star copolymer nanoparticle enhances hepatoma chemotherapy by apoptosis induction and cytotoxics efflux inhibition. Bioactive materials. vol 6. issue 11. 2021-04-28. PMID:33898875. |
the preferentially released mir-122 not only directly induces cell apoptosis by down regulation of bcl-w and enhanced p53 activity, but also increases dox accumulation through inhibiting cytotoxic efflux transporter expression, which realizes synergistic performance on cell inhibition. |
2021-04-28 |
2023-08-13 |
Not clear |
| Bing Z Carter, Po Yee Mak, Hong Mu, Xiangmeng Wang, Wenjing Tao, Duncan H Mak, Elisha J Dettman, Michael Cardone, Oleg Zernovak, Takahiko Seki, Michael Andreef. Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model. Haematologica. vol 105. issue 5. 2021-04-27. PMID:31371419. |
p53 induces apoptosis mainly by modulating bcl-2 family proteins. |
2021-04-27 |
2023-08-13 |
Not clear |
| Marilena Castelli, Danilo Piobbico, Martina Chiacchiaretta, Cinzia Brunacci, Stefania Pieroni, Daniela Bartoli, Marco Gargaro, Francesca Fallarino, Paolo Puccetti, Silvia Soddu, Maria Agnese Della-Fazia, Giuseppe Servill. HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis. EMBO reports. vol 21. issue 2. 2021-04-27. PMID:31867855. |
hops/tmub1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis. |
2021-04-27 |
2023-08-13 |
Not clear |
| Hui Wang, Xuming Song, Yajing Wang, Xuewen Yin, Yingkuan Liang, Te Zhang, Lin Xu, Feng Jiang, Gaochao Don. CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma. Cell death & disease. vol 11. issue 11. 2021-04-27. PMID:33239613. |
in vitro and in vivo studies revealed that ccntnap3 inhibited proliferation and increased apoptosis in p53 wild-type escc cells, but not in mutant cells. |
2021-04-27 |
2023-08-13 |
human |
| Yong Jun Choi, Jongsung Lee, Sang Hoon Ha, Han Ki Lee, Heui Min Lim, Seon-Hak Yu, Chang Min Lee, Myeong Jin Nam, Yung-Hun Yang, Kyungmoon Park, Youn Soo Choi, Kyu Yun Jang, See-Hyoung Par. 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. Environmental toxicology. vol 36. issue 5. 2021-04-27. PMID:33382531. |
6,8-diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. |
2021-04-27 |
2023-08-13 |
human |
| Hui Sun, Qianqian Jiang, Li Sheng, Kai Cu. Downregulation of lncRNA H19 alleviates atherosclerosis through inducing the apoptosis of vascular smooth muscle cells. Molecular medicine reports. vol 22. issue 4. 2021-04-26. PMID:32945413. |
long non‑coding (lnc)rna h19 is reported to accelerate the progression of as by inhibiting the apoptosis of vsmcs, whereas p53 is identified as promoting vsmc apoptosis. |
2021-04-26 |
2023-08-13 |
mouse |
| Hui Sun, Qianqian Jiang, Li Sheng, Kai Cu. Downregulation of lncRNA H19 alleviates atherosclerosis through inducing the apoptosis of vascular smooth muscle cells. Molecular medicine reports. vol 22. issue 4. 2021-04-26. PMID:32945413. |
knockdown of h19 reduced the proliferation and induced apoptosis of vsmcs, and increased the expression of p53, cleaved caspase3 (c‑caspase3) and p53 upregulated modulator of apoptosis, as well as enhancing the interaction between bax and p53 proteins. |
2021-04-26 |
2023-08-13 |
mouse |
| David P Dannheisig, Jana Bächle, Jasmin Tasic, Marina Keil, Astrid S Pfiste. The Wnt/β-Catenin Pathway is Activated as a Novel Nucleolar Stress Response. Journal of molecular biology. vol 433. issue 2. 2021-04-26. PMID:33221336. |
impaired ribosome biogenesis and loss of nucleolar integrity triggers nucleolar stress, which classically stabilizes the tumor suppressor p53 and induces cell cycle arrest and apoptosis. |
2021-04-26 |
2023-08-13 |
human |
| An-Cheng Qin, Hua Jin, Yu Song, Yun Gao, Yi-Fan Chen, Li-Na Zhou, Shu-Sheng Wang, Xing-Sheng L. The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells. Cell death & disease. vol 11. issue 9. 2021-04-23. PMID:32978368. |
importantly, the antioxidant n-acetyl-cysteine and the p53 inhibitor pifithrin-α attenuated a1874-induced cell death and apoptosis in colon cancer cells. |
2021-04-23 |
2023-08-13 |
mouse |
| An-Cheng Qin, Hua Jin, Yu Song, Yun Gao, Yi-Fan Chen, Li-Na Zhou, Shu-Sheng Wang, Xing-Sheng L. The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells. Cell death & disease. vol 11. issue 9. 2021-04-23. PMID:32978368. |
brd4 degradation and p53 protein elevation, as well as apoptosis induction and oxidative stress were detected in a1874-treated colon cancer tissues. |
2021-04-23 |
2023-08-13 |
mouse |
| Jiansheng Zhu, Chunlan Liu, Jingyu Wang, Yinyin Liang, Xing Gong, Lianghui You, Chenbo Ji, Shou-Lin Wang, Chao Wang, Xia Ch. Difenoconazole induces cardiovascular toxicity through oxidative stress-mediated apoptosis in early life stages of zebrafish (Danio rerio). Ecotoxicology and environmental safety. vol 216. 2021-04-21. PMID:33848738. |
cardiovascular apoptosis was triggered through increased expression of p53, bcl-2, bax and caspase 9, while dif suppressed the transcription of key genes involved in calcium signaling and cardiac muscle contraction. |
2021-04-21 |
2023-08-13 |
zebrafish |
| N Muninatha. Amelioration of Combination of Paclitaxel and Di Allyl Sulfide on the Alterations of Bcl2, P53 and Apoptosis Changes Against 7,12 Di Methyl Benz (A) Anthracene Induced Skin Cancer in Experimental Animals. Indian journal of clinical biochemistry : IJCB. vol 36. issue 2. 2021-04-21. PMID:33867704. |
amelioration of combination of paclitaxel and di allyl sulfide on the alterations of bcl2, p53 and apoptosis changes against 7,12 di methyl benz (a) anthracene induced skin cancer in experimental animals. |
2021-04-21 |
2023-08-13 |
Not clear |
| E M Domsa, G A Filip, D Olteanu, I Baldea, S Clichici, A Muresan, L David, B Moldovan, I Para, M Suciu, M Achim, V Negrean, V Andreic. Gold nanoparticles phytoreduced with Cornus mas extract mitigate some of gliadin effects on Caco-2 cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 71. issue 2. 2021-04-20. PMID:32633238. |
measured cellular outcomes included oxidative stress markers (malondialdehyde level, catalase and superoxide dismutase activities), inflammatory response and cellular signaling and transcription factors involved in apoptosis (nfκb, pnfκb, nos2, tnf-α, trail, bax, bcl-2, p53). |
2021-04-20 |
2023-08-13 |
Not clear |
| Alina Muenchow, Sandra Weller, Clemens Hinterleitner, Elke Malenke, Stefanie Bugl, Stefan Wirths, Martin R Müller, Klaus Schulze-Osthoff, Walter E Aulitzky, Hans-Georg Kopp, Frank Essman. The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA. Cell death & disease. vol 11. issue 8. 2021-04-20. PMID:32839432. |
noteworthy, efficient induction of apoptosis by abt-199/bzb was not affected by the p53 status and invariably detected in cell lines and patient-derived tumor cells of several sarcoma types, including rhabdomyo-, leiomyo-, lipo-, chondro-, osteo-, or synovial sarcomas. |
2021-04-20 |
2023-08-13 |
Not clear |
| Sarah Quinlan, Susan May, Ryan Weeks, Hang Yuan, Jennifer Luf. Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes. Frontiers in veterinary science. vol 8. 2021-04-20. PMID:33748203. |
the aim of this study was to determine if cpv2 oncogene e6 similarly affects p53 upon activation by uv radiation, as well as the downstream p53-regulated genes necessary to control growth arrest and apoptosis. |
2021-04-20 |
2023-08-13 |
human |
| Sophia R Chaudhry, Jaime Lopes, Nancy K Levin, Hasini Kalpage, Michael A Tainsk. Germline mutations in apoptosis pathway genes in ovarian cancer; the functional role of a TP53I3 (PIG3) variant in ROS production and DNA repair. Cell death discovery. vol 7. issue 1. 2021-04-17. PMID:33782397. |
tp53i3 is transcriptionally activated by p53 and believed to play a role in dna damage response and reactive oxygen species-induced apoptosis. |
2021-04-17 |
2023-08-13 |
Not clear |