| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yonghan He, Wen Li, Dongwen Lv, Xin Zhang, Xuan Zhang, Yuma T Ortiz, Vivekananda Budamagunta, Judith Campisi, Guangrong Zheng, Daohong Zho. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging cell. vol 19. issue 3. 2021-05-10. PMID:32064756. |
this degradation increases the levels of p53, which in turn induces the pro-apoptotic proteins puma, noxa, and fas and inhibits the interaction of bcl-xl and bak to selectively induce apoptosis in sncs. |
2021-05-10 |
2023-08-13 |
mouse |
| Zhi-Shuai Hou, Yuan-Ru Xin, Chu Zeng, Hong-Kui Zhao, Yuan Tian, Ji-Fang Li, Hai-Shen We. GHRH-SST-GH-IGF axis regulates crosstalk between growth and immunity in rainbow trout (Oncorhynchus mykiss) infected with Vibrio anguillarum. Fish & shellfish immunology. vol 106. 2021-05-10. PMID:32866610. |
gene enrichment analyses showed functional and signaling pathways associated with apoptosis (such as p53, hif-1 or foxo signaling) were activated. |
2021-05-10 |
2023-08-13 |
Not clear |
| Fümet Duygu Üstündağ, İsmail Ünal, Derya Cansız, Ünsal Veli Üstündağ, Hülya Kara Subaşat, A Ata Alturfan, Pınar Mega Tiber, Ebru Emekli-Alturfa. 3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos. Drug and chemical toxicology. 2021-05-07. PMID:32693643. |
results of our study showed that mptp induced a p53 dependent and bax mediated apoptosis in zebrafish embryos and 3-pyridinylboronic acid restored the locomotor activity and gene expressions related to mitochondrial dysfunction and oxidative stress due to the deleterious effects of mptp, in a dose-dependent manner. |
2021-05-07 |
2023-08-13 |
zebrafish |
| Bahjat Al-Ani, Norah M Alzamil, Peter W Hewett, Fahaid Al-Hashem, Ismaeel Bin-Jaliah, Abdullah S Shatoor, Samaa S Kamar, Noha S Abdel Latif, Mohamed A Haidara, Amal F Dawoo. Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury. Archives of physiology and biochemistry. 2021-05-06. PMID:33439743. |
the link between oxidative stress (ros), apoptosis (p53) and fibrosis (collagen) in type 2 diabetes mellitus (t2dm)-induced cardiac injury in the presence and absence of the antidiabetic drug, metformin has not been investigated before. |
2021-05-06 |
2023-08-13 |
Not clear |
| Hak-Su Kim, Jin-Taek Hwang, Hee Yun, Sung-Gil Chi, Su-Jae Lee, Insug Kang, Kyung-Sik Yoon, Won-Jae Choe, Sung-Soo Kim, Joohun H. Withdrawal: Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53. The Journal of biological chemistry. vol 293. issue 46. 2021-05-05. PMID:30446605. |
withdrawal: inhibition of amp-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53. |
2021-05-05 |
2023-08-13 |
Not clear |
| Wenxia Si, Bisheng Zhou, Wen Xie, Hui Li, Ke Li, Sisi Li, Wenbing Deng, Pengcheng Shi, Chao Yuan, Tie Ke, Xiang Ren, Xin Tu, Xiaomei Zeng, Britta Weigelt, Brian P Rubin, Qiuyun Chen, Chengqi Xu, Qing Kenneth Wan. Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2. Cancer letters. vol 497. 2021-05-05. PMID:33069768. |
aggf1 antagonizes mdm2 function to inhibit p53 ubiquitination, increases the acetylation, phosphorylation, stability and expression levels of p53, activates transcription of p53 target genes, and regulates cell proliferation, cell cycle, and apoptosis. |
2021-05-05 |
2023-08-13 |
human |
| Jayoung Song, Jinha Yu, Lak Shin Jeong, Sang Kook Le. A Novel cytarabine analog evokes synthetic lethality by targeting MK2 in p53-deficient cancer cells. Cancer letters. vol 497. 2021-05-05. PMID:33075425. |
therefore, targeting mk2 may be an effective therapeutic strategy that induces apoptosis for cancers deficient in p53. |
2021-05-05 |
2023-08-13 |
Not clear |
| Hongjing Zhao, Yu Wang, Mengyao Mu, Menghao Guo, Hongxian Yu, Mingwei Xin. Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp ( Food & function. vol 11. issue 10. 2021-05-04. PMID:33026005. |
mechanistically, indicators in the innate immune system (such as toll like receptors (tlrs), tumor necrosis factor-α (tnf-α), interleukin (il)-1β, il-6 and il-8) and the apoptosis pathway (p53, puma, b-cell lymphoma-2 (bcl-2), bcl2-associated x (bax), and caspase-9/3) disclosed adaptive activation under smz exposure; these anomalies returned to normal or close-to-normal levels after lyc coadministration. |
2021-05-04 |
2023-08-13 |
human |
| Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Che. Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33863900. |
p53 can induce apoptosis through mitochondrial membrane permeabilization by interacting with and antagonizing the anti-apoptotic proteins bcl-xl and bcl-2. |
2021-05-03 |
2023-08-13 |
human |
| Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Che. Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33863900. |
however, the mechanisms by which p53 induces mitochondrial apoptosis remain elusive. |
2021-05-03 |
2023-08-13 |
human |
| Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Che. Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33863900. |
mutations at the p53 dimer interface or p53/bcl-xl interface disrupt p53/bcl-xl interaction and p53-mediated apoptosis. |
2021-05-03 |
2023-08-13 |
human |
| Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Che. Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis. Nature communications. vol 12. issue 1. 2021-05-03. PMID:33863900. |
overall, our current findings of the bona fide structure of p53/bcl-xl complex reveal the molecular basis of the interaction between p53 and bcl-xl, and provide insight into p53-mediated mitochondrial apoptosis. |
2021-05-03 |
2023-08-13 |
human |
| Isha Godwin, Nikhil Ponnoor Anto, Smitha V Bava, Mani Shankar Babu, Goodwin G Jines. Targeting K-Ras and apoptosis-driven cellular transformation in cancer. Cell death discovery. vol 7. issue 1. 2021-05-02. PMID:33854056. |
here we draw key evidences from the literature on k-ras-driven cellular transformation in the context of apoptosis to shed light on the key players that are required for cellular transformation and explain how aiming p53 could be useful to target cellular transformation. |
2021-05-02 |
2023-08-13 |
Not clear |
| Isha Godwin, Nikhil Ponnoor Anto, Smitha V Bava, Mani Shankar Babu, Goodwin G Jines. Targeting K-Ras and apoptosis-driven cellular transformation in cancer. Cell death discovery. vol 7. issue 1. 2021-05-02. PMID:33854056. |
the defects in key apoptosis regulators such as p53, bax, and bak lead to apoptosis evasion, cellular transformation, and genomic instability to further lead to stemness, tumorigenesis, and metastasis via c-myc-dependent transcription. |
2021-05-02 |
2023-08-13 |
Not clear |
| Ziad Omran, Mahmood H Dalhat, Omeima Abdullah, Mohammed Kaleem, Salman Hosawi, Fahd A Al-Abbasi, Wei Wu, Hani Choudhry, Mahmoud Alhosi. Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors. Cancers. vol 13. issue 8. 2021-05-02. PMID:33921128. |
the tap73 protein has a high degree of similarity with both p53 function and structure, and it induces the regulation of various genes involved in the cell cycle and apoptosis. |
2021-05-02 |
2023-08-13 |
Not clear |
| Anna Huo-Chang Mei, Kaity Tung, Jessie Han, Deepak Perumal, Alessandro Laganà, Jonathan Keats, Daniel Auclair, Ajai Chari, Sundar Jagannath, Samir Parekh, Hearn Jay Ch. MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21 Oncotarget. vol 11. issue 7. 2021-04-30. PMID:32133047. |
to investigate the mechanisms of these oncogenic functions, we performed gene expression profiling (gep) of p53 wild-type human myeloma cell lines (hmcl) after mage-a knockdown, which identified a set of 201 differentially expressed genes (deg) associated with apoptosis, dna repair, and cell cycle regulation. |
2021-04-30 |
2023-08-13 |
human |
| Hongming Lv, Yuanyuan Liu, Boxi Zhang, Yuwei Zheng, Hong Ji, Shize L. The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy. International immunopharmacology. vol 85. 2021-04-30. PMID:32473572. |
in addition, gtd treatment relieved hepatic apoptosis by the regulation of peroxisome proliferator-activated receptors (ppars), p53 and caspase-3/9. |
2021-04-30 |
2023-08-13 |
mouse |
| Javed Ahmad, Rizwan Wahab, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhair. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 25. issue 2. 2021-04-29. PMID:32124101. |
quantitative real-time pcr data showed that the mrna levels of apoptotic marker genes such as p53, bax, and caspase-3 were upregulated, whereas bcl-2, an anti-apoptotic gene, was downregulated; therefore, apoptosis was mediated through the p53, bax, caspase-3, and bcl-2 pathways, suggesting a possible mechanism by which qds and nps of zno mediate their toxicity.graphic abstract. |
2021-04-29 |
2023-08-13 |
human |
| Xuefei Shao, Xiping Yang, Jun Shen, Sansong Chen, Xiaochun Jiang, Qifu Wang, Qiang D. TNF-α-induced p53 activation induces apoptosis in neurological injury. Journal of cellular and molecular medicine. vol 24. issue 12. 2021-04-29. PMID:32344470. |
tnf-α-induced p53 activation induces apoptosis in neurological injury. |
2021-04-29 |
2023-08-13 |
rat |
| Xuefei Shao, Xiping Yang, Jun Shen, Sansong Chen, Xiaochun Jiang, Qifu Wang, Qiang D. TNF-α-induced p53 activation induces apoptosis in neurological injury. Journal of cellular and molecular medicine. vol 24. issue 12. 2021-04-29. PMID:32344470. |
more importantly, in vitro experiments demonstrated that down-regulation of tnf-α in oxygen-glucose deprivation/reoxygenation (ogd/r) cells increased cell viability and decreased apoptosis and the p53 expression. |
2021-04-29 |
2023-08-13 |
rat |