| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annalisa Pecoraro, Antonella Virgilio, Veronica Esposito, Aldo Galeone, Giulia Russo, Annapina Russ. uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells. Biomolecules. vol 10. issue 4. 2021-04-05. PMID:32290083. |
we demonstrate that in p53 deleted colon cancer cells, lq1 causes nucleolar stress, impairs ribosomal rna processing, leading to the accumulation of pre-ribosomal rnas, arrests cells in the g2/m phase and induces early apoptosis. |
2021-04-05 |
2023-08-13 |
human |
| Hyun Kyu Ahn, Young Hwa Lee, Kyo Chul Ko. Current Status and Application of Metformin for Prostate Cancer: A Comprehensive Review. International journal of molecular sciences. vol 21. issue 22. 2021-04-05. PMID:33198356. |
liver kinase b1 (lkb1) and adenosine monophosphate-activated protein kinase (ampk) activation, inhibition of the mammalian target of rapamycin (mtor) activity and protein synthesis, induction of apoptosis and autophagy by p53 and p21, and decreased blood insulin level have been suggested as direct anti-cancer mechanisms of metformin. |
2021-04-05 |
2023-08-13 |
Not clear |
| Suzanne B R Jacobs, Jeanine L Van Nostrand, Margot E Bowen, Julie C Baker, Laura D Attard. Siva plays a critical role in mouse embryonic development. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31164717. |
the siva protein, named after the hindu god of destruction, plays important roles in apoptosis in various contexts, including downstream of death receptor activation or p53 tumor suppressor engagement. |
2021-04-02 |
2023-08-13 |
mouse |
| Jerson L Silva, Carolina G S Lima, Luciana P Rangel, Giulia D S Ferretti, Fernanda P Pauli, Ruan C B Ribeiro, Thais de B da Silva, Fernando C da Silva, Vitor F Ferreir. Recent Synthetic Approaches towards Small Molecule Reactivators of p53. Biomolecules. vol 10. issue 4. 2021-04-02. PMID:32326087. |
its main function is to trigger the process of apoptosis in tumor cells, and approximately 50% of all cancers are related to the inactivation of the p53 protein through mutations in the |
2021-04-02 |
2023-08-13 |
Not clear |
| Shantanu Gupta, Daner A Silveira, José Carlos M Mombac. Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms. DNA repair. vol 96. 2021-03-31. PMID:32987354. |
cell fate decisions happen at cell cycle checkpoints and it is becoming clearer that the p53 pathway is a major regulator of cell fate decisions involving apoptosis or senescence upon dna damage, especially at g1/s. |
2021-03-31 |
2023-08-13 |
Not clear |
| Elena Papale. Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular Simulations. Methods in molecular biology (Clifton, N.J.). vol 2253. 2021-03-31. PMID:33315226. |
the p53 tumor suppressor is a multifaceted context-dependent protein, which is involved in multiple cellular pathways, with the ability to either keep the cells alive or to kill them through mechanisms such as apoptosis. |
2021-03-31 |
2023-08-13 |
Not clear |
| Ayesha Ishtiaq, Tahir Ali, Attia Bakhtiar, Robina Bibi, Kinza Bibi, Iram Mushtaq, Shupeng Li, Wajiha Khan, Uzma Khan, Riffat Aysha Anis, Mariam Anees, Aneesa Sultan, Iram Murtaz. Melatonin abated Bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling. Environmental science and pollution research international. vol 28. issue 14. 2021-03-31. PMID:33398767. |
additionally, bpa treatment increased the expression of puma, p53, and drp-1 resulting in apoptosis in the brain tissue of rats. |
2021-03-31 |
2023-08-13 |
rat |
| Ayesha Ishtiaq, Tahir Ali, Attia Bakhtiar, Robina Bibi, Kinza Bibi, Iram Mushtaq, Shupeng Li, Wajiha Khan, Uzma Khan, Riffat Aysha Anis, Mariam Anees, Aneesa Sultan, Iram Murtaz. Melatonin abated Bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling. Environmental science and pollution research international. vol 28. issue 14. 2021-03-31. PMID:33398767. |
however, melatonin treatment significantly attenuated bpa-induced toxic effects by scavenging ros, boosting antioxidant enzyme activities, and interestingly enervated brain apoptosis by normalizing p53, puma, and drp-1 expressions at both transcriptional and translational level. |
2021-03-31 |
2023-08-13 |
rat |
| Liz J Valente, Amy Tarangelo, Albert Mao Li, Marwan Naciri, Nitin Raj, Anthony M Boutelle, Yang Li, Stephano Spano Mello, Kathryn Bieging-Rolett, Ralph J DeBerardinis, Jiangbin Ye, Scott J Dixon, Laura D Attard. p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen. The Journal of cell biology. vol 219. issue 11. 2021-03-30. PMID:32886745. |
p53 modulates various cellular processes, such as apoptosis and proliferation, which has led to distinct cellular mechanisms being proposed for p53-mediated tumor suppression in different contexts. |
2021-03-30 |
2023-08-13 |
mouse |
| Liz J Valente, Amy Tarangelo, Albert Mao Li, Marwan Naciri, Nitin Raj, Anthony M Boutelle, Yang Li, Stephano Spano Mello, Kathryn Bieging-Rolett, Ralph J DeBerardinis, Jiangbin Ye, Scott J Dixon, Laura D Attard. p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen. The Journal of cell biology. vol 219. issue 11. 2021-03-30. PMID:32886745. |
analysis of mouse and human oncogene-expressing wild-type and p53-deficient cells in physiological oxygen conditions revealed that p53 loss concurrently impacts numerous distinct cellular processes, including apoptosis, genome stabilization, dna repair, metabolism, migration, and invasion. |
2021-03-30 |
2023-08-13 |
mouse |
| Zhe Liu, Douglas R Hurst, Xing Qu, Li-Guang Lu, Chen-Zhou Wu, Yu-Yu Li, Yi L. Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma. Military Medical Research. vol 7. issue 1. 2021-03-30. PMID:33038921. |
re-expression of diras3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma. |
2021-03-30 |
2023-08-13 |
Not clear |
| Feng Chi, Zhou Wang, Yuzhu Li, Ning Chan. Knockdown of GINS2 inhibits proliferation and promotes apoptosis through the p53/GADD45A pathway in non-small-cell lung cancer. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32181475. |
co-transfection with gins2-sirna and sirna against p53 (p53-sirna) or co-transfection with gins2-sirna and sirna against gadd45a (gadd45a-sirna) partially reverses the effects of gins2 knockdown on cell proliferation and apoptosis. |
2021-03-29 |
2023-08-13 |
Not clear |
| Yayu Li, Xue Jiang, Litao Song, Mengdie Yang, Jing Pa. Anti-apoptosis mechanism of triptolide based on network pharmacology in focal segmental glomerulosclerosis rats. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32285909. |
il4 was the target gene of tpl in fsgs and was mainly enriched in the cell apoptosis term and p53 signaling pathway, according to gene ontology (go) and kyoto encyclopedia of genes and genomes (kegg) pathway enrichment analyses. |
2021-03-29 |
2023-08-13 |
rat |
| Yayu Li, Xue Jiang, Litao Song, Mengdie Yang, Jing Pa. Anti-apoptosis mechanism of triptolide based on network pharmacology in focal segmental glomerulosclerosis rats. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32285909. |
tpl inhibited fsgs-induced cell apoptosis in rats and regulated il4, nephrin, podocin, and p53 protein levels via using cck8, tunel, and western blot assays. |
2021-03-29 |
2023-08-13 |
rat |
| Amen H Zaky, Dalia Elsers, Rania Bakry, Mostafa Abdelwanis, Ola Nabih, Rania Hafez, Mahmoud Rez. Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. Pathology oncology research : POR. vol 26. issue 2. 2021-03-26. PMID:31187468. |
p53 is a tumor suppressor gene that contributes to apoptosis and cell cycle control. |
2021-03-26 |
2023-08-13 |
Not clear |
| Amen H Zaky, Dalia Elsers, Rania Bakry, Mostafa Abdelwanis, Ola Nabih, Rania Hafez, Mahmoud Rez. Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. Pathology oncology research : POR. vol 26. issue 2. 2021-03-26. PMID:31187468. |
there is functional interaction between p53 and cox-2, which lead to abrogation of apoptosis and progression of malignancy. |
2021-03-26 |
2023-08-13 |
Not clear |
| Dario Rizzotto, Sara Zaccara, Annalisa Rossi, Matthew D Galbraith, Zdenek Andrysik, Ahwan Pandey, Kelly D Sullivan, Alessandro Quattrone, Joaquín M Espinosa, Erik Dassi, Alberto Ing. Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30. Cell reports. vol 30. issue 13. 2021-03-26. PMID:32234473. |
activation of p53 by the small molecule nutlin can result in a combination of cell cycle arrest and apoptosis. |
2021-03-26 |
2023-08-13 |
Not clear |
| Jialin Qu, Peng Huang, Lin Zhang, Yang Qiu, Huan Qi, Aijing Leng, Dong Shan. Hepatoprotective effect of plant polysaccharides from natural resources: A review of the mechanisms and structure-activity relationship. International journal of biological macromolecules. vol 161. 2021-03-26. PMID:32485257. |
in total, 66 types of polysaccharides from 58 kinds of plant have shown hepatoprotective effect through the pathological process of inflammation, apoptosis and oxidative stress by regulating nf-κb, jak/stat, tgf-β, pi3k/akt, mapk, caspase cascade, p53 and nrf2-keap1 pathways, lipid metabolism as well as cytochrome p450 enzymes. |
2021-03-26 |
2023-08-13 |
Not clear |
| Ying Xin, Keming Li, Mo Yang, Youhua Ta. Fluid Shear Stress Induces EMT of Circulating Tumor Cells via JNK Signaling in Favor of Their Survival during Hematogenous Dissemination. International journal of molecular sciences. vol 21. issue 21. 2021-03-26. PMID:33143160. |
importantly, the induction of emt suppressed the pro-apoptosis gene p53 upregulated modulator of apoptosis (puma) and enhanced the survival of suspended ctcs in fluid shear stress, which was rescued by overexpressing puma or silencing jnk signaling, suggesting that shear-induced emt promotes ctc survival through puma downregulation and jnk activation. |
2021-03-26 |
2023-08-13 |
Not clear |
| Zhi Yu, Jiayu Liu, Le Sun, Yusheng Wang, Hongmei Men. Combination of Botulinum Toxin and minocycline Ameliorates Neuropathic Pain Through Antioxidant Stress and Anti-Inflammation via Promoting SIRT1 Pathway. Frontiers in pharmacology. vol 11. 2021-03-26. PMID:33762927. |
the combined utilization alleviated sci-induced np and reduced apoptosis, inflammation, and oxidative stress of sci by activating sirt1 and dampening pakt, p53, and p-nf-kb. |
2021-03-26 |
2023-08-13 |
rat |