| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Min Kim, Sang Eun Ha, Ho Jeong Lee, Shailima Rampogu, Preethi Vetrivel, Hun Hwan Kim, Venu Venkatarame Gowda Saralamma, Keun Woo Lee, Gon Sup Ki. Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells. Nutrients. vol 12. issue 8. 2021-03-25. PMID:32824273. |
inhibition of p53 degradation led to both autophagy and apoptosis in hepg2 cells. |
2021-03-25 |
2023-08-13 |
human |
| Seong Min Kim, Sang Eun Ha, Ho Jeong Lee, Shailima Rampogu, Preethi Vetrivel, Hun Hwan Kim, Venu Venkatarame Gowda Saralamma, Keun Woo Lee, Gon Sup Ki. Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells. Nutrients. vol 12. issue 8. 2021-03-25. PMID:32824273. |
p53 translocation led to sin-induced autophagy, whereas p53 translocation inhibited sin-induced apoptosis. |
2021-03-25 |
2023-08-13 |
human |
| Chengzhu Liao, Yuming Jin, Yuchao Li, Sie Chin Tjon. Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity. International journal of molecular sciences. vol 21. issue 17. 2021-03-25. PMID:32878253. |
these ros-mediated responses induce caspase-dependent apoptosis via the activation of b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), ccaat/enhancer-binding protein homologous protein (chop), and phosphoprotein p53 gene expressions. |
2021-03-25 |
2023-08-13 |
mouse |
| Takayoshi Matsumura, Ayako Nakamura-Ishizu, Siva Sai Naga Anurag Muddineni, Darren Qiancheng Tan, Chelsia Qiuxia Wang, Kenji Tokunaga, Roberto Tirado-Magallanes, Stephanie Sian, Touati Benoukraf, Tsukasa Okuda, Norio Asou, Masao Matsuoka, Motomi Osato, Toshio Sud. Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia. Blood. vol 136. issue 17. 2021-03-24. PMID:32573733. |
furthermore, loss of runx1 r233/r237 methylation suppressed endoplasmic reticulum stress-induced unfolded protein response genes, including atf4, ddit3, and gadd34; the radiation-induced p53 downstream genes bbc3, pmaip1, and cdkn1a; and subsequent apoptosis in hscs. |
2021-03-24 |
2023-08-13 |
mouse |
| Lydie Da Costa, Thierry Leblanc, Narla Mohanda. Diamond-Blackfan anemia. Blood. vol 136. issue 11. 2021-03-24. PMID:32702755. |
the salient feature of classical dba is a defect in ribosomal rna maturation that generates nucleolar stress, leading to stabilization of p53 and activation of its targets, resulting in cell-cycle arrest and apoptosis. |
2021-03-24 |
2023-08-13 |
Not clear |
| Ji Hoon Jung, Hyemin Lee, Shelya X Zeng, Hua L. RBM10, a New Regulator of p53. Cells. vol 9. issue 9. 2021-03-24. PMID:32947864. |
the tumor suppressor p53 acts as a transcription factor that regulates the expression of a number of genes responsible for dna repair, cell cycle arrest, metabolism, cell migration, angiogenesis, ferroptosis, senescence, and apoptosis. |
2021-03-24 |
2023-08-13 |
human |
| Ho Soo Yoo, Sae Bom Won, Young Hye Kwo. Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway. Nutrition and cancer. 2021-03-24. PMID:33757400. |
luteolin exhibited its anticancer effect by increasing p53 phosphorylation and p53 target gene expression, leading to apoptosis and cell cycle arrest in hct116 cells. |
2021-03-24 |
2023-08-13 |
Not clear |
| Ho Soo Yoo, Sae Bom Won, Young Hye Kwo. Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway. Nutrition and cancer. 2021-03-24. PMID:33757400. |
we identified that luteolin can induce autophagy in p53 wild-type cells but not in p53 mutant cells, suggesting that luteolin-induced autophagy is p53-dependent; however, chloroquine-mediated inhibition of autophagy did not alter cytotoxicity and apoptosis of cells treated with luteolin. |
2021-03-24 |
2023-08-13 |
Not clear |
| Mounir El Maï, Marta Marzullo, Inês Pimenta de Castro, Miguel Godinho Ferreir. Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. eLife. vol 9. 2021-03-23. PMID:32427102. |
opposing p53 and mtor/akt promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. |
2021-03-23 |
2023-08-13 |
zebrafish |
| Myung Jin Son, Seung Bae Rho, Kwangbae Kim, Mijung Oh, Chaeyeon Son, Sang Yong Song, Kyoungsook Par. Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis. Cells. vol 9. issue 8. 2021-03-23. PMID:32784646. |
previously, we demonstrated that the homeoprotein msx1 interaction with p53 inhibited tumor growth by inducing apoptosis. |
2021-03-23 |
2023-08-13 |
mouse |
| Lixia Shi, Qing Chen, Xiaofen G. Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-22. PMID:32654289. |
downregulation of linc00337 results in increased bax level, decreased fscn1, bcl-2, vegf, and p53 levels, in addition to diminished cell proliferation, migration, invasion and tumor growth, with accelerated cell apoptosis by upregulating mir-145. |
2021-03-22 |
2023-08-13 |
Not clear |
| Youhua Wei, Zhijun Wang, Li Wei, Shen Li, Xuemei Qiu, Chengwen Li. MicroRNA-874-3p promotes testosterone-induced granulosa cell apoptosis by suppressing HDAC1-mediated p53 deacetylation. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-20. PMID:33732332. |
microrna-874-3p promotes testosterone-induced granulosa cell apoptosis by suppressing hdac1-mediated p53 deacetylation. |
2021-03-20 |
2023-08-13 |
Not clear |
| Youhua Wei, Zhijun Wang, Li Wei, Shen Li, Xuemei Qiu, Chengwen Li. MicroRNA-874-3p promotes testosterone-induced granulosa cell apoptosis by suppressing HDAC1-mediated p53 deacetylation. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-20. PMID:33732332. |
collectively, the results of the present study indicated that mir-874-3p was upregulated in pcos and promoted testosterone-induced gc apoptosis by suppressing hdac1-mediated p53 deacetylation. |
2021-03-20 |
2023-08-13 |
Not clear |
| Tamás Vancsik, Domokos Máthé, Ildikó Horváth, Anett Anna Várallyaly, Anett Benedek, Ralf Bergmann, Tibor Krenács, Zoltán Benyó, Andrea Balog. Modulated Electro-Hyperthermia Facilitates NK-Cell Infiltration and Growth Arrest of Human A2058 Melanoma in a Xenograft Model. Frontiers in oncology. vol 11. 2021-03-20. PMID:33732640. |
in conclusion, meht monotherapy of melanoma xenograft tumors induced irreversible heat and cell stress leading to caspase dependent apoptosis to be driven by p53. |
2021-03-20 |
2023-08-13 |
mouse |
| b' Mar\\xc3\\xada A Rodr\\xc3\\xadguez-Hern\\xc3\\xa1ndez, Raquel Chapresto-Garz\\xc3\\xb3n, Miryam Cadenas, Elena Navarro-Villar\\xc3\\xa1n, Mar\\xc3\\xada Negrete, Miguel A G\\xc3\\xb3mez-Bravo, Victor M Victor, Francisco J Padillo, Jordi Muntan\\xc3\\xa. Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells. Cell death & disease. vol 11. issue 5. 2021-03-18. PMID:32382022.' |
the administration of regular used in vitro dose (10 µm) in 3d and 2d cultures, as well as the dose-response analysis in 2d cultures showed sorafenib and regorafenib were increasingly effective in reducing cell proliferation, and inducing apoptosis in well-differentiated and expressing wild-type p53 in hcc cells. |
2021-03-18 |
2023-08-13 |
Not clear |
| Gleb I Sutula, Bashar A Alhasan, Mikhail L Vorobev, Irina V Guzhova, Irina I Suvorov. Inducible Ulk1 expression activates the p53 protein in mouse embryonic stem cells. Biochemical and biophysical research communications. vol 532. issue 2. 2021-03-18. PMID:32868073. |
escs tolerated the activated p53 and did not undergo apoptosis or cell cycle blockade upon ulk1 overexpression. |
2021-03-18 |
2023-08-13 |
mouse |
| Xiang Jin, Xingang Liu, Zhen Zhang, Lijun X. NT5DC2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962856. |
importantly, we found that nt5dc2 knockdown-restrained cell proliferation and -induced apoptosis was almost abrogated by p53 down-regulation in nsclc cells, demonstrating that nt5dc2-regulated cell proliferation and apoptotic cell death in nsclc was p53-dependent. |
2021-03-18 |
2023-08-13 |
Not clear |
| Katarina Kapralova, Ondrej Jahoda, Pavla Koralkova, Jan Gursky, Lucie Lanikova, Dagmar Pospisilova, Vladimir Divoky, Monika Horvathov. Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia. International journal of molecular sciences. vol 21. issue 24. 2021-03-18. PMID:33348919. |
molecular pathophysiology of diamond-blackfan anemia (dba) involves disrupted erythroid-lineage proliferation, differentiation and apoptosis; with the activation of p53 considered as a key component. |
2021-03-18 |
2023-08-13 |
Not clear |
| Seo-Hyun Choi, Dong-In Koh, Haemin Ahn, Jin Young Kim, Youngsoo Kim, Man-Wook Hu. Cell fate decisions by c-Myc depend on ZBTB5 and p53. Biochemical and biophysical research communications. vol 533. issue 4. 2021-03-17. PMID:33051058. |
in the absence of p53, zbtb5 is acetylated at k597 by interacting with p300, and activates transcription of noxa, which induces apoptosis. |
2021-03-17 |
2023-08-13 |
Not clear |
| Chin-Hu Lai, Parthasarathi Barik, Dennis Jine-Yuan Hsieh, Cecilia Husan Day, Tsung-Jung Ho, Ray-Jade Chen, Wei-Wen Kuo, V Vijaya Padma, Marthandam Asokan Shibu, Chih-Yang Huan. Inhibition of cell death-inducing p53 target 1 through miR-210-3p overexpression attenuates reactive oxygen species and apoptosis in rat adipose-derived stem cells challenged with Angiotensin II. Biochemical and biophysical research communications. vol 532. issue 3. 2021-03-16. PMID:32888650. |
inhibition of cell death-inducing p53 target 1 through mir-210-3p overexpression attenuates reactive oxygen species and apoptosis in rat adipose-derived stem cells challenged with angiotensin ii. |
2021-03-16 |
2023-08-13 |
rat |