| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Xu, F Qian, L Su. [Dibenzyl trisulfide inhibits proliferation and induces apoptosis of HN30 cells via Akt/ p53 signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 41. issue 6. 2021-07-12. PMID:34238736. |
[dibenzyl trisulfide inhibits proliferation and induces apoptosis of hn30 cells via akt/ p53 signaling pathway]. |
2021-07-12 |
2023-08-13 |
human |
| Mohammad Afkhami-Ardakani, Shapour Hasanzadeh, Rasoul Shahrooz, Norouz Delirezh, Hasan Malekineja. Spirulina platensis (Arthrospira platensis) attenuates Cyclophosphamide-induced reproductive toxicity in male Wistar rats: Evidence for sperm apoptosis and p53/Bcl-2 expression. Journal of food biochemistry. 2021-07-10. PMID:34245022. |
following 28 days, two flow cytometry techniques were used to determine sperm apoptosis and testicular protein expression of tumor protein (p53) and b-cell lymphoma 2 (bcl-2). |
2021-07-10 |
2023-08-13 |
rat |
| Mohammad Afkhami-Ardakani, Shapour Hasanzadeh, Rasoul Shahrooz, Norouz Delirezh, Hasan Malekineja. Spirulina platensis (Arthrospira platensis) attenuates Cyclophosphamide-induced reproductive toxicity in male Wistar rats: Evidence for sperm apoptosis and p53/Bcl-2 expression. Journal of food biochemistry. 2021-07-10. PMID:34245022. |
p53 is a tumor suppressor protein that causes the cell to enter the apoptosis cycle after dna damage and bcl-2 is an anti-apoptotic protein that acts through the mitochondrial pathway of apoptosis. |
2021-07-10 |
2023-08-13 |
rat |
| Mohammad Afkhami-Ardakani, Shapour Hasanzadeh, Rasoul Shahrooz, Norouz Delirezh, Hasan Malekineja. Spirulina platensis (Arthrospira platensis) attenuates Cyclophosphamide-induced reproductive toxicity in male Wistar rats: Evidence for sperm apoptosis and p53/Bcl-2 expression. Journal of food biochemistry. 2021-07-10. PMID:34245022. |
co-administration of spirulina plantesis with cyclophosphamide reduces sperm apoptosis also decreases p53 protein expression and increases bcl-2 protein expression. |
2021-07-10 |
2023-08-13 |
rat |
| Jung-Hwan Park, Sang-Ah Park, Young-Ju Lee, Hwan-Woo Park, Sang-Muk O. PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells. FEBS open bio. vol 10. issue 5. 2021-07-09. PMID:32237067. |
pbk knockdown increased apoptosis, autophagy, p53 level, and lc3 puncta upon paclitaxel treatment. |
2021-07-09 |
2023-08-13 |
Not clear |
| X Y Shi, Z Q Guan, J N Yu, H L Li. Follicle Stimulating Hormone Inhibits the Expression of p53 Up-Regulated Modulator of Apoptosis Induced by Reactive Oxygen Species Through PI3K/Akt in Mouse Granulosa Cells. Physiological research. vol 69. issue 4. 2021-07-08. PMID:32584135. |
follicle stimulating hormone inhibits the expression of p53 up-regulated modulator of apoptosis induced by reactive oxygen species through pi3k/akt in mouse granulosa cells. |
2021-07-08 |
2023-08-13 |
mouse |
| X Y Shi, Z Q Guan, J N Yu, H L Li. Follicle Stimulating Hormone Inhibits the Expression of p53 Up-Regulated Modulator of Apoptosis Induced by Reactive Oxygen Species Through PI3K/Akt in Mouse Granulosa Cells. Physiological research. vol 69. issue 4. 2021-07-08. PMID:32584135. |
therefore, we examined whether fsh inhibits the expression of p53 up-regulated modulator of apoptosis (puma) induced by reactive oxygen species (ros) through phosphoinositide 3-kinase (pi3k) / protein kinase b (akt) in mouse gcs. |
2021-07-08 |
2023-08-13 |
mouse |
| Xiaonan Dong, Kin Ming Kwa. Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32703236. |
the yy1 deleted neuroepithelial cells underwent cell cycle arrest and apoptosis, with the concurrent changes of cell cycle regulatory genes expression, as well as activation of the p53 pathway. |
2021-07-08 |
2023-08-13 |
mouse |
| Juanjuan Liu, Huimin Wang, Mingjun Zheng, Lu Deng, Xue Zhang, Bei Li. p53 and ANXA4/NF‑κB p50 complexes regulate cell proliferation, apoptosis and tumor progression in ovarian clear cell carcinoma. International journal of molecular medicine. vol 46. issue 6. 2021-07-08. PMID:33125094. |
p53 and anxa4/nf‑κb p50 complexes regulate cell proliferation, apoptosis and tumor progression in ovarian clear cell carcinoma. |
2021-07-08 |
2023-08-13 |
Not clear |
| Juanjuan Liu, Huimin Wang, Mingjun Zheng, Lu Deng, Xue Zhang, Bei Li. p53 and ANXA4/NF‑κB p50 complexes regulate cell proliferation, apoptosis and tumor progression in ovarian clear cell carcinoma. International journal of molecular medicine. vol 46. issue 6. 2021-07-08. PMID:33125094. |
the cbioportal database was used to construct a protein‑protein interaction network between anxa4, nf‑κb p50 and p53, and functional pathway analysis indicated that the genes were predominantly enriched in the cell cycle and during apoptosis. |
2021-07-08 |
2023-08-13 |
Not clear |
| Yun Kyung Lee, Yuseong Chung, Ji Hye Lee, Jin Mi Chun, Jun Hong Par. The Intricate Role of p53 in Adipocyte Differentiation and Function. Cells. vol 9. issue 12. 2021-07-08. PMID:33297294. |
for more than three decades, numerous studies have demonstrated the function of p53 in cell cycle, cellular senescence, autophagy, apoptosis, and metabolism. |
2021-07-08 |
2023-08-13 |
Not clear |
| Yun Kyung Lee, Yuseong Chung, Ji Hye Lee, Jin Mi Chun, Jun Hong Par. The Intricate Role of p53 in Adipocyte Differentiation and Function. Cells. vol 9. issue 12. 2021-07-08. PMID:33297294. |
among diverse functions, the essential role of p53 is to maintain cellular homeostatic response to stress by regulating proliferation and apoptosis. |
2021-07-08 |
2023-08-13 |
Not clear |
| Yingying Zhang, Chengxian Xu, Qing Ye, Lingxiao Tong, Hong Jiang, Xiujuan Zhu, Limin Huang, Weiqiang Lin, Haidong Fu, Jingjing Wang, Pontus B Persson, En Yin Lai, Jianhua Ma. Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1. Acta physiologica (Oxford, England). vol 232. issue 1. 2021-07-07. PMID:33615732. |
podocyte apoptosis in diabetic nephropathy by basp1 activation of the p53 pathway via wt1. |
2021-07-07 |
2023-08-13 |
mouse |
| Roberta Napolitano, Serena De Matteis, Silvia Carloni, Samantha Bruno, Giulia Abbati, Laura Capelli, Martina Ghetti, Maria Teresa Bochicchio, Chiara Liverani, Laura Mercatali, Daniele Calistri, Antonio Cuneo, Krishna Menon, Gerardo Musuraca, Giovanni Martinelli, Giorgia Simonett. Kevetrin induces apoptosis in TP53 wild‑type and mutant acute myeloid leukemia cells. Oncology reports. vol 44. issue 4. 2021-07-06. PMID:32945487. |
after continuous treatment, significant cell growth arrest and apoptosis were observed in all cell lines, with tp53‑mutant models displaying a higher sensitivity and p53 induction. |
2021-07-06 |
2023-08-13 |
Not clear |
| Anne H Moxley, David Reisma. Context is key: Understanding the regulation, functional control, and activities of the p53 tumour suppressor. Cell biochemistry and function. vol 39. issue 2. 2021-07-06. PMID:32996618. |
by upregulating apoptosis, cell cycle arrest, and dna damage repair in normal cells, p53 prevents the propagation of cells with tumorigenic potential; therefore, mutations in p53 are associated with carcinogenic transformation and can be accompanied by the accumulation of a novel gain-of-function oncogenic protein, mutant p53. |
2021-07-06 |
2023-08-13 |
Not clear |
| Yan-Bo Peng, Wei He, Qiang Niu, Can Tao, Xiao-Lan Zhong, Cai-Ping Tan, Ping Zha. Mitochondria-targeted cyclometalated rhodium(III) complexes: synthesis, characterization and anticancer research. Dalton transactions (Cambridge, England : 2003). vol 50. issue 26. 2021-07-06. PMID:34113944. |
further studies illustrated that the rhodium complexes caused cell cycle arrest at the g2/m phase, upregulated the expression of p53 and reduced the ratio of b-cell lymphoma-2 (bcl-2)/bcl-2-associated x (bax), which ultimately resulted in cellular apoptosis. |
2021-07-06 |
2023-08-13 |
Not clear |
| Wei Liang, Junfeng Shi, Haiyan Xia, Xiaowei We. A Novel Ruthenium-Fluvastatin Complex Downregulates SNCG Expression to Modulate Breast Carcinoma Cell Proliferation and Apoptosis via Activating the PI3K/Akt/mTOR/VEGF/MMP9 Pathway. Oxidative medicine and cellular longevity. vol 2021. 2021-07-06. PMID:34221232. |
in addition, the complex was able to modify p53 expressions to interfere with apoptosis in the carcinoma of the breast, stimulated by the intrinsic apoptotic path assisted by bcl2 and bax in vivo, yet at the same point, controlling the pi3k/akt/mtor/vegf pathway, as obtained from western blotting, correlates with the mmp9-regulated tumor mechanisms. |
2021-07-06 |
2023-08-13 |
Not clear |
| Rachel Addison, Sophie C Weatherhead, Anandika Pawitri, Graham R Smith, Ashley Rider, Henry J Grantham, Simon J Cockell, Nick J Reynold. Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. Redox biology. vol 41. 2021-07-05. PMID:33812333. |
dna damage response pathways, nrf2-mediated oxidative stress response and p53 signalling were key nodes, interconnecting apoptosis and cell cycle arrest. |
2021-07-05 |
2023-08-13 |
human |
| Wei Yuan, Zhaopeng Xu, You Wei, Wuting Lu, Kun Jia, Jing Guo, Yunlong Meng, Yuyang Peng, Zhanfeng Wu, Zulin Zhu, Fei Ma, Fenghua Wei, Guiyou Tian, Zhou Liu, Qiang Luo, Jinze Ma, Hao Zhang, Wenjin Liu, Huiqiang L. Effects of sulfometuron-methyl on zebrafish at early developmental stages. Ecotoxicology and environmental safety. vol 220. 2021-07-05. PMID:34082241. |
the numbers of cell apoptosis were significantly increased at 20, and 40 mg/l and the highest concentration group induced the substantial increment (p < 0.001) of apoptosis-related genes including p53, bax/bcl-2, caspase-9, and caspase-3. |
2021-07-05 |
2023-08-13 |
zebrafish |
| Ping Li, Hualian Jiang, Hong Peng, Weijie Zeng, Yongheng Zhong, Miao He, Luyang Xie, Junhai Chen, Deyin Guo, Junyu Wu, Chun-Mei L. Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis. Virologica Sinica. 2021-07-05. PMID:34224111. |
non-structural protein 5 of zika virus interacts with p53 in human neural progenitor cells and induces p53-mediated apoptosis. |
2021-07-05 |
2023-08-13 |
human |