| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyra Laubach, Jin Zhang, Xinbin Che. The p53 Family: A Role in Lipid and Iron Metabolism. Frontiers in cell and developmental biology. vol 9. 2021-08-17. PMID:34395447. |
the p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in many biological processes, such as cell cycle arrest, apoptosis, and differentiation. |
2021-08-17 |
2023-08-13 |
Not clear |
| Nehal M Elsherbiny, Mohamed El-Sherbiny, Sawsan A Zaiton. Diallyl trisulfide potentiates chemotherapeutic efficacy of doxorubicin in experimentally induced mammary carcinoma: Role of Notch signaling. Pathology, research and practice. vol 216. issue 10. 2021-08-16. PMID:32853959. |
the anti-tumorigenic effect of dats was mediated by suppression of notch signaling proteins (notch 1, jag 1 and hes 1), attenuation of tumor inflammation (nfκb, tnf-α, il-6, il-1β) and proliferation (cyclin d1, ki67) and enhancement of apoptosis (caspase 3, p53). |
2021-08-16 |
2023-08-13 |
mouse |
| Andrea Speciale, Paola Monti, Gilberto Fronza, Alberto Izzotti, Paola Menichin. MicroRNA-Mutant P53 Crosstalk in Chemoresistance: A Hint to Monitor Therapy Outcome. MicroRNA (Shariqah, United Arab Emirates). vol 9. issue 5. 2021-08-16. PMID:33297928. |
p53, following cell injuries, can activate the transcription of several target genes crucial for the induction of apoptosis, cell cycle arrest, modulation of senescence, dna repair, autophagy and metabolism. |
2021-08-16 |
2023-08-13 |
human |
| Wataru Nakajima, Kai Miyazaki, Yumi Asano, Satoshi Kubota, Nobuyuki Tanak. Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. Genes. vol 12. issue 4. 2021-08-16. PMID:33918002. |
conventional cytotoxic anticancer agents induce apoptosis primarily through activation of tumor suppressor p53 by causing dna damage and the resulting regulation of b-cell leukemia/lymphoma-2 (bcl-2) family proteins. |
2021-08-16 |
2023-08-13 |
Not clear |
| Bang-Hong Wei, Jia-Hao Ni, Tong Yang, Shuang-Li Hao, Wan-Xi Yan. PIWIs maintain testis apoptosis to remove abnormal germ cells in Eriocheir sinensis. Reproduction (Cambridge, England). vol 162. issue 3. 2021-08-16. PMID:34224392. |
piwi defects significantly inhibited the apoptosis of abnormal germ cells through the caspase-dependent apoptosis pathway and p53 pathway. |
2021-08-16 |
2023-08-13 |
Not clear |
| Marc Lebordais, Juan Manuel Gutierrez-Villagomez, Julien Gigault, Magalie Baudrimont, Valerie S Langloi. Molecular impacts of dietary exposure to nanoplastics combined with arsenic in Canadian oysters (Crassostrea virginica) and bioaccumulation comparison with Caribbean oysters (Isognomon alatus). Chemosphere. vol 277. 2021-08-16. PMID:34384184. |
the investigated gene functions were endocytosis (cltc), oxidative stress (gapdh, sod3, cat), mitochondrial metabolism (12s), cell cycle regulation (gadd45, p53), apoptosis (bax, bcl-2), detoxification (cyp1a, mdr, mt), and energy storage (vit). |
2021-08-16 |
2023-08-13 |
cat |
| Hao Li, Jingjing Shi, Haihang Gao, Xiaoqi Yang, Yang Fu, Yuxuan Peng, Ying Xia, Donghai Zho. Hexavalent Chromium Causes Apoptosis and Autophagy by Inducing Mitochondrial Dysfunction and Oxidative Stress in Broiler Cardiomyocytes. Biological trace element research. 2021-08-14. PMID:34390448. |
the results showed that, compared with the control group, reactive oxygen species (ros) and apoptosis rate in the cr(vi) treatment group increased in a dose-dependent manner, the mrna levels of apoptosis-related genes bax and p53 were significantly increased, and the mrna level of bcl-2 was significantly decreased. |
2021-08-14 |
2023-08-13 |
Not clear |
| I V Kastyro, I V Reshetov, G V Khamidulin, S S Shilin, V I Torshin, M G Kostyaeva, V I Popadyuk, T Y Yunusov, P E Shmaevsky, K P Shalamov, A D Kupryakova, E S Doroginskaya, A D Sedelnikov. Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats. Doklady. Biochemistry and biophysics. vol 497. issue 1. 2021-08-13. PMID:33895923. |
the stress effect of modeling septoplasty in rats, accompanied by sensory deprivation of the peripheral part of the olfactory analyzer, provoked the expression of p53 and the initiation of apoptosis mechanisms in various subfields of the hippocampus. |
2021-08-13 |
2023-08-13 |
rat |
| Bruna Pasqualotto Costa, Marcella Tornquist Nassr, Fernando Mendonça Diz, Leonardo Pfeiff Carlessi, Krist Helen Antunes Fernandes, Fernanda Bordignon Nunes, Gisele Branchini, Jarbas Rodrigues de Oliveir. Fructose-1,6-bisphosphate induces generation of reactive oxygen species and activation of p53-dependent cell death in human endometrial cancer cells. Journal of applied toxicology : JAT. vol 41. issue 7. 2021-08-12. PMID:33078453. |
these harmful stimuli trigger the upregulation of the expression of pro-apoptotic genes (p53 and bax), leading to the reduction of cell proliferation through inducing programmed cell death by apoptosis. |
2021-08-12 |
2023-08-13 |
human |
| Mansoor N Saleh, Manish R Patel, Todd M Bauer, Sanjay Goel, Gerald S Falchook, Geoffrey I Shapiro, Ki Y Chung, Jeffrey R Infante, Robert M Conry, Guilherme Rabinowits, David S Hong, Judy S Wang, Ulrich Steidl, Gurudatta Naik, Vincent Guerlavais, Vojislav Vukovic, D Allen Annis, Manuel Aivado, Funda Meric-Bernsta. Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-Type Clinical cancer research : an official journal of the American Association for Cancer Research. 2021-08-12. PMID:34301750. |
phase 1 trial of alrn-6924, a dual inhibitor of mdmx and mdm2, in patients with solid tumors and lymphomas bearing wild-type we describe the first-in-human dose-escalation trial for alrn-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by mdm2 and mdmx to induce cell cycle arrest or apoptosis in |
2021-08-12 |
2023-08-13 |
Not clear |
| Zhiqing Shen, Aling Shen, Xiaoping Chen, Xiangyan Wu, Jianfeng Chu, Ying Cheng, Meizhong Peng, Youqin Chen, Nathaniel Weygant, Meizhu Wu, Xiaoying Lin, Jun Peng, Keji Che. Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 130. 2021-08-12. PMID:34321167. |
huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and tgf-β1/smad2/3 pathways. |
2021-08-12 |
2023-08-13 |
mouse |
| Zhiqing Shen, Aling Shen, Xiaoping Chen, Xiangyan Wu, Jianfeng Chu, Ying Cheng, Meizhong Peng, Youqin Chen, Nathaniel Weygant, Meizhu Wu, Xiaoying Lin, Jun Peng, Keji Che. Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 130. 2021-08-12. PMID:34321167. |
in support of these findings, hxp attenuated cardiac apoptosis and decreased p53 and bax protein expression, while increasing bcl-2 protein expression in cardiac tissues of mi mice. |
2021-08-12 |
2023-08-13 |
mouse |
| Shun Iida, Sohtaro Mine, Keiji Ueda, Tadaki Suzuki, Hideki Hasegawa, Harutaka Katan. Suberoyl bis-hydroxamic acid reactivates Kaposi's sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cells. Journal of virology. 2021-08-11. PMID:33328303. |
in addition to its effect of kshv reactivation, this study revealed that sbha induces apoptosis in pel cells in a dose-dependent manner, inducing acetylation and phosphorylation of p53, cleavage of caspases, and expression of pro-apoptotic factors such as bim and bax. |
2021-08-11 |
2023-08-13 |
Not clear |
| Guangcheng Huang, Xiaowu Zhong, Lihua Yao, Qiang Ma, Hebin Liao, Lei Xu, Jiang Zou, Ru Sun, Dongsheng Wang, Xiaolan Gu. MicroRNA-449a inhibits cell proliferation and migration by regulating mutant p53 in MDA-MB-468 cells. Experimental and therapeutic medicine. vol 22. issue 3. 2021-08-11. PMID:34373706. |
the present study aimed to investigate the role of microrna (mir)-449a in the proliferation, migration and apoptosis of mda-mb-468 breast cancer cells and examine the association between mir-449a and mutant p53 in these cells. |
2021-08-11 |
2023-08-13 |
Not clear |
| Shanshan Hu, Dongmei Su, Lei Sun, Zhongying Wang, Lina Guan, Shanhe Liu, Baowen Zhao, Yong Liu, Cuige Shi, Jianbo Yu, Xu M. High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene. Molecular medicine (Cambridge, Mass.). vol 26. issue 1. 2021-08-10. PMID:33297931. |
high-expression of rock1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene. |
2021-08-10 |
2023-08-13 |
Not clear |
| Dan Liu, Meng Zeng, Jing-Wen Pi, Mei-Jia Liu, Wei-Zhe Ding, Xue-Ying Mei, Jian-Li Liu, Xiang-Yu Ca. Exploring the Potential Mechanism of Costunolide-Induced MCF-7 Cells Apoptosis by Multi-Spectroscopy, Molecular Docking and Cell Experiments. Chemistry & biodiversity. vol 18. issue 5. 2021-08-10. PMID:33855794. |
the apoptosis mechanism relied on regulating the protein expression of bax, bcl-2, p53, caspase-3 and the activation of p38mapk and nuclear factor κb (nf-κb) pathways. |
2021-08-10 |
2023-08-13 |
Not clear |
| Yi-Cheng Chen, Yu-Chi Chou, Yu-Tung Hsieh, Pin-Yu Kuo, Mei-Lin Yang, Hao-Earn Chong, Chao-Liang Wu, Ai-Li Shiau, Chrong-Reen Wan. Targeting Intra-Pulmonary P53-Dependent Long Non-Coding RNA Expression as a Therapeutic Intervention for Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage. International journal of molecular sciences. vol 22. issue 13. 2021-08-09. PMID:34203338. |
higher expression of p53, lincrna-p21 and cell apoptosis was identified in lung tissues. |
2021-08-09 |
2023-08-13 |
mouse |
| Yi-Cheng Chen, Yu-Chi Chou, Yu-Tung Hsieh, Pin-Yu Kuo, Mei-Lin Yang, Hao-Earn Chong, Chao-Liang Wu, Ai-Li Shiau, Chrong-Reen Wan. Targeting Intra-Pulmonary P53-Dependent Long Non-Coding RNA Expression as a Therapeutic Intervention for Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage. International journal of molecular sciences. vol 22. issue 13. 2021-08-09. PMID:34203338. |
after pristane injection, c57/bl6 mice developed dah with increased pulmonary expression of p53, lincrna-p21 and cell apoptosis. |
2021-08-09 |
2023-08-13 |
mouse |
| Jie Zeng, Yu Zhao, Kexun Li, Daoling Long, Wei Li, Liang Lian. A coordinated ruthenium-rifampicin complex reprogramming the colon carcinoma micro-environment mediated by modulation of p53/AkT/mTOR/VEGF pathway. Toxicology and applied pharmacology. vol 426. 2021-08-06. PMID:34126112. |
along with that, p53 could be modulated by the ruthenium-rifampicin complex to interfere with apoptosis in colon carcinoma, initiated by the intrinsic apoptotic trail facilitated through bcl2 and bax, thus controlling the akt/mtor/vegf pathway coupled through the wnt/β-catenin trail. |
2021-08-06 |
2023-08-13 |
human |
| Ya-Chih Cheng, Ting-Shuan Wu, Ying-Tzu Huang, Yung Chang, Jiann-Jou Yang, Feng-Yih Yu, Biing-Hui Li. Aflatoxin B1 interferes with embryonic liver development: Involvement of p53 signaling and apoptosis in zebrafish. Toxicology. vol 458. 2021-08-05. PMID:34214637. |
aflatoxin b1 interferes with embryonic liver development: involvement of p53 signaling and apoptosis in zebrafish. |
2021-08-05 |
2023-08-13 |
zebrafish |