| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bijing Yang, Yingwei Liu, Yangwei Li, Shanshan Zhu, Yuanliang Li, Jiangnan Yi, Zhuanxu Ouyang, Bingxian Liu, Khalid Mehmood, Riaz Hussain, Jiaqiang Pan, Lianmei Hu, Zhaoxin Tang, Guanhua Wang, Ying Li, Hui Zhan. Exposure to the herbicide butachlor activates hepatic stress signals and disturbs lipid metabolism in mice. Chemosphere. vol 283. 2021-09-09. PMID:34146870. |
the results on the mechanisms of liver toxicity indicated that butachlor induced overexpression of apaf-1, bax, caspase-3, caspase-9, cyt-c, p53, beclin-1, atg-5, and lc3, whereas decreases the expression of bcl-2 and p62 suggesting abnormal processes of apoptosis and autophagy. |
2021-09-09 |
2023-08-13 |
mouse |
| Kazuaki Yoshikaw. Necdin: A purposive integrator of molecular interaction networks for mammalian neuron vitality. Genes to cells : devoted to molecular & cellular mechanisms. vol 26. issue 9. 2021-09-09. PMID:34338396. |
necdin interacts directly with a number of regulatory proteins including e2f1, p53, neurotrophin receptors, sirt1 and pgc-1α, which serve as major hubs of protein-protein interaction networks for mitosis, apoptosis, differentiation, neuroprotection and energy homeostasis. |
2021-09-09 |
2023-08-13 |
mouse |
| Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A Gelle. iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice. Molecular medicine (Cambridge, Mass.). vol 26. issue 1. 2021-09-08. PMID:32517688. |
ischemia and reperfusion (i/r) induces cytokines, and up-regulates inducible nitric oxide synthase (inos), interferon regulatory factor-1(irf1) and p53 up-regulated modulator of apoptosis (puma), which contribute to cell death and tissue injury. |
2021-09-08 |
2023-08-13 |
mouse |
| David C Plachetzki, M Sabrina Pankey, Matthew D MacManes, Michael P Lesser, Charles W Walke. The Genome of the Softshell Clam Mya arenaria and the Evolution of Apoptosis. Genome biology and evolution. vol 12. issue 10. 2021-09-08. PMID:32653903. |
we show that the ancestral bilaterian p53 locus, a master regulator of apoptosis, possessed a complex domain structure, in contrast to that of extant ecdysozoan p53s. |
2021-09-08 |
2023-08-13 |
Not clear |
| David C Plachetzki, M Sabrina Pankey, Matthew D MacManes, Michael P Lesser, Charles W Walke. The Genome of the Softshell Clam Mya arenaria and the Evolution of Apoptosis. Genome biology and evolution. vol 12. issue 10. 2021-09-08. PMID:32653903. |
finally, phylogenetic exploration of apoptosis gene copy number reveals a striking linkage with p53 domain complexity across species. |
2021-09-08 |
2023-08-13 |
Not clear |
| Hossein Khadem Haghighian, Neda Ketabchi, Maria Kavianpou. The Role of the Curcumin for Inducing Apoptosis in Acute Lymphoblastic Leukemia Cells: A Systematic Review. Nutrition and cancer. vol 73. issue 7. 2021-09-08. PMID:32657624. |
curcumin induces apoptosis in pre b- all and t- all cells by decreased nf-kb levels, increased p53 levels, parp-1 cleavage. |
2021-09-08 |
2023-08-13 |
human |
| Monika Kadela-Tomanek, Maria Jastrzębska, Krzysztof Marciniec, Elwira Chrobak, Ewa Bębenek, Małgorzata Latocha, Dariusz Kuśmierz, Stanisław Boryczk. Design, synthesis and biological activity of 1,4-quinone moiety attached to betulin derivatives as potent DT-diaphorase substrate. Bioorganic chemistry. vol 106. 2021-09-08. PMID:33272711. |
the transcriptional activity of the gene encoding a proliferation marker (h3 histone), cell cycle regulators (p53 and p21) and apoptosis pathway (bcl-2 and bax) for selected compounds were determined. |
2021-09-08 |
2023-08-13 |
human |
| Nak Yoon Sung, Deok Jeong, Youn Young Shim, Zubair Ahmed Ratan, Young-Jin Jang, Martin J T Reaney, Sarah Lee, Byoung-Hee Lee, Jong-Hoon Kim, Young-Su Yi, Jae Youl Ch. The Anti-Cancer Effect of Linusorb B3 from Flaxseed Oil through the Promotion of Apoptosis, Inhibition of Actin Polymerization, and Suppression of Src Activity in Glioblastoma Cells. Molecules (Basel, Switzerland). vol 25. issue 24. 2021-09-08. PMID:33322712. |
lob3 induced apoptosis and suppressed the proliferation of c6 cells by inhibiting the expression of anti-apoptotic genes, b cell lymphoma 2 (bcl-2) and p53, as well as promoting the activation of pro-apoptotic caspases, caspase-3 and -9. |
2021-09-08 |
2023-08-13 |
Not clear |
| Young Mi Kim, Sung-Hwa Ko, Yong-Il Shin, Yeonye Kim, Taehyung Kim, Jaehoon Jung, Sang-Yull Lee, Nam Gyun Kim, Kyoung-Jun Park, Ji Hyeon Ry. Light-emitting diode irradiation induces AKT/mTOR-mediated apoptosis in human pancreatic cancer cells and xenograft mouse model. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32749680. |
herein, we demonstrated that blue led of 460 nm regulated pancreatic cancer cell proliferation and apoptosis by suppressing the expression of apoptosis-related factors, such as mutant p53 and b-cell lymphoma 2 (bcl-2), and decreasing the expression of rac-β serine/threonine kinase 2 (akt2), the phosphorylation of protein kinase b (akt), and mammalian target of rapamycin (mtor). |
2021-09-07 |
2023-08-13 |
mouse |
| Qi Wu, Ke-Jia Zhang, Shi-Min Jiang, Lu Fu, Yue Shi, Ru-Bin Tan, Jie Cui, Yao Zho. p53: A Key Protein That Regulates Pulmonary Fibrosis. Oxidative medicine and cellular longevity. vol 2020. 2021-09-07. PMID:33312337. |
p53 is a tumor suppressor gene with crucial roles in cell cycle, apoptosis, tumorigenesis, and malignant transformation. |
2021-09-07 |
2023-08-13 |
Not clear |
| Chang Woo Han, Han Na Lee, Mi Suk Jeong, So Young Park, Se Bok Jan. Structural basis of the p53 DNA binding domain and PUMA complex. Biochemical and biophysical research communications. vol 548. 2021-09-07. PMID:33631672. |
p53 elicits mitochondrial apoptosis via transcription-dependent and independent mechanisms. |
2021-09-07 |
2023-08-13 |
human |
| Chang Woo Han, Han Na Lee, Mi Suk Jeong, So Young Park, Se Bok Jan. Structural basis of the p53 DNA binding domain and PUMA complex. Biochemical and biophysical research communications. vol 548. 2021-09-07. PMID:33631672. |
p53 is known to induce apoptosis via the transcriptional induction of puma, which encodes proapoptotic bh3-only members of the bcl-2 protein family. |
2021-09-07 |
2023-08-13 |
human |
| Oleksi Petrenko, Jinyu Li, Velasco Cimica, Patricio Mena-Taboada, Ha Youn Shin, Stephen D'Amico, Nancy C Reic. IL-6 promotes MYC-induced B cell lymphomagenesis independent of STAT3. PloS one. vol 16. issue 3. 2021-09-07. PMID:33651821. |
the eμ-myc transgenic mouse expresses elevated levels of c-myc in the b cell lineage and develops b cell lymphomas with associated mutations in p53 or other genes linked to apoptosis. |
2021-09-07 |
2023-08-13 |
mouse |
| Retraction: Effects of microRNA-374 on proliferation, migration, invasion and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 41. issue 4. 2021-09-07. PMID:33889953. |
retraction: effects of microrna-374 on proliferation, migration, invasion and apoptosis of human scc cells by targeting gadd45a through p53 signaling pathway. |
2021-09-07 |
2023-08-13 |
human |
| Xinghe Wang, Yang He, Jinlong Tian, Ishfaq Muhammad, Mingchun Liu, Changde Wu, Chang Xu, Xiaohuan Zhan. Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2/GST pathway and regulating mitochondrial pathway. Ecotoxicology and environmental safety. vol 224. 2021-09-07. PMID:34416636. |
iv) afb1-induced hepatocyte apoptosis, the high expression of p53, bax, cyt-c, caspase-9, caspase-3, and the low expression of bcl-2 were all restored by fa. |
2021-09-07 |
2023-08-13 |
rat |
| Narges Dastmalchi, Behzad Baradaran, Seyed Mahdi Banan Khojasteh, Mohammadali Hosseinpourfeizi, Reza Safaralizade. miR-424: A novel potential therapeutic target and prognostic factor in malignancies. Cell biology international. vol 45. issue 4. 2021-09-06. PMID:33325141. |
mir-424 is involved in modulating p53, pi3k/akt, wnt, and other molecular pathways, thereby regulating cellular growth, apoptosis, differentiation, chemoresistance, and cancer immunity. |
2021-09-06 |
2023-08-13 |
Not clear |
| Somayeh Najafi Dorcheh, Soheila Rahgozar, Daryush Tale. 6-Shogaol induces apoptosis in acute lymphoblastic leukaemia cells by targeting p53 signalling pathway and generation of reactive oxygen species. Journal of cellular and molecular medicine. 2021-09-04. PMID:33939282. |
6-shogaol induces apoptosis in acute lymphoblastic leukaemia cells by targeting p53 signalling pathway and generation of reactive oxygen species. |
2021-09-04 |
2023-08-13 |
mouse |
| Jingyu Zhang, Yandong Xie, Qingling Fan, Cheng Wan. Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 3. 2021-09-03. PMID:32580584. |
colon tissues were investigated using tunel analysis of apoptosis; histopathological assessment including number of aberrant crypt foci (acf); immunohistochemical staining for bcl-2-associated x protein (bax), b-cell lymphoma 2 (bcl2), p53 and proliferating cell nuclear antigen (pcna); and antioxidant assay in vivo. |
2021-09-03 |
2023-08-13 |
rat |
| Hamid Cheshomi, Ahmad Reza Bahrami, Maryam M Mati. Ellagic acid and human cancers: a systems pharmacology and docking study to identify principal hub genes and main mechanisms of action. Molecular diversity. vol 25. issue 1. 2021-09-02. PMID:32410114. |
generally, it turned out that ea probably exerts most of its anticancer activities, through induction of apoptosis, as well as p53 and wnt signaling pathways, and also by affecting the expression of several hub genes such as cdkn1a, cdk4, cdk2, cdk6, tp53, jun, ccna2, mapk14, cdk1, and ccnb1 and especially interactions with some related proteins including p53, cdk6, and mapk14. |
2021-09-02 |
2023-08-13 |
human |
| Expression of concern: Effects of microRNA-374 on proliferation, migration, invasion and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 40. issue 8. 2021-09-02. PMID:32840312. |
expression of concern: effects of microrna-374 on proliferation, migration, invasion and apoptosis of human scc cells by targeting gadd45a through p53 signaling pathway. |
2021-09-02 |
2023-08-13 |
human |