| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Hao, Jiaxiang Chen, Junming Liao, Yingdan Huang, Yu Gan, Sarit Larisch, Shelya X Zeng, Hua Lu, Xiang Zho. p53 induces ARTS to promote mitochondrial apoptosis. Cell death & disease. vol 12. issue 2. 2021-09-14. PMID:33627621. |
altogether, these findings demonstrate that arts collaborates with p53 in mitochondria-engaged apoptosis. |
2021-09-14 |
2023-08-13 |
mouse |
| R Yang, R Wu, J Mei, F-R Hu, C-J Le. Zinc oxide nanoparticles promotes liver cancer cell apoptosis through inducing autophagy and promoting p53. European review for medical and pharmacological sciences. vol 25. issue 3. 2021-09-14. PMID:33629325. |
zinc oxide nanoparticles promotes liver cancer cell apoptosis through inducing autophagy and promoting p53. |
2021-09-14 |
2023-08-13 |
Not clear |
| Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Sh. Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p. Biochemical pharmacology. vol 188. 2021-09-14. PMID:33887260. |
bbr treatment induced dna replication defects and cell cycle arrest, resulting in apoptosis or cell senescence, depending on p53 status, in bca cells. |
2021-09-14 |
2023-08-13 |
human |
| Dan Zhang, Xiaofang Xiao, Daqiang Song, Siwei Chen, Zhuo Zhang, Shousong Cao, Minghua Li. Atractylenolide III induces apoptosis by regulating the Bax/Bcl-2 signaling pathway in human colorectal cancer HCT-116 Cells in vitro and in vivo. Anti-cancer drugs. 2021-09-14. PMID:34261915. |
furthermore, atractylenolide iii also significantly inhibited the tumor growth of hct-116 tumor xenografts bearing in nude mice through inducing apoptosis by upregulation of the expressions of bax, cleaved caspase-3 and p53 but downregulation of the expressions of bcl-2 in hct-116 tumor tissues in vivo. |
2021-09-14 |
2023-08-13 |
mouse |
| María-Aránzazu Martínez, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, Jorge-Enrique Maximiliano, Jose-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Arturo Anadón, Cesar Peteiro, Susana Rubiño, María Horto. Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 156. 2021-09-14. PMID:34348126. |
moreover, g. baccata extract caused up-regulation of gstm2, nrf2, and akt1 gene expressions, as well as g. baccata extract reduced significantly bax, bnip3, apaf1, erk1, jnk1, mapk1, p38, p53, nfκb1, tnfα, il-6, il-1β and ho-1 gene expressions related to apoptosis, proinflammation and oxidative stress induced by tert-booh. |
2021-09-14 |
2023-08-13 |
Not clear |
| Jin Lee, Eun Mi Hong, Jung Han Kim, Jung Hee Kim, Jang Han Jung, Se Woo Park, Dong Hee Koh, Hyun Joo Jan. Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition. Molecular biology reports. vol 48. issue 9. 2021-09-14. PMID:34392440. |
ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and egfr-erk, cox-2, and pi3k-akt pathway inhibition. |
2021-09-14 |
2023-08-13 |
human |
| Jin Lee, Eun Mi Hong, Jung Han Kim, Jung Hee Kim, Jang Han Jung, Se Woo Park, Dong Hee Koh, Hyun Joo Jan. Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition. Molecular biology reports. vol 48. issue 9. 2021-09-14. PMID:34392440. |
in cultured bile duct cancer cells, udca suppressed cell proliferation in bile duct cancer cells by inducing apoptosis and p53 activation, blocking deoxycholic acid (dca)-induced activated egfr-erk signaling and cox-2, inhibiting dca-induced activated pi3k-akt signaling, and suppressing the invasiveness of bile duct cancer cells. |
2021-09-14 |
2023-08-13 |
human |
| Xiao-Fei Zhang, Ting Wang, Zi-Xuan Wang, Kun-Peng Huang, Yun-Wei Zhang, Guo-Liang Wang, Hong-Ji Zhang, Zi-Han Chen, Chang-Yan Wang, Jin-Xiang Zhang, Hui Wan. Hypoxic ucMSC-secreted exosomal miR-125b promotes endothelial cell survival and migration during wound healing by targeting TP53INP1. Molecular therapy. Nucleic acids. vol 26. 2021-09-14. PMID:34513314. |
after being packaged into hypoxic exosomes and transported to endothelial cells, mir-125b targets and suppresses the expression of tumor protein p53 inducible nuclear protein 1 (tp53inp1) and alleviates hypoxia-induced cell apoptosis. |
2021-09-14 |
2023-08-13 |
mouse |
| John R Basile, James T Castle, Robert S Redma. Immunohistochemical profile of the anti-apoptosis, apoptosis and proliferation markers Bcl-2, caspase-3, p53, and Ki-67 in botryoid odontogenic cysts compared to lateral periodontal cysts and gingival cysts of the adult. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 4. 2021-09-13. PMID:32643438. |
immunohistochemical profile of the anti-apoptosis, apoptosis and proliferation markers bcl-2, caspase-3, p53, and ki-67 in botryoid odontogenic cysts compared to lateral periodontal cysts and gingival cysts of the adult. |
2021-09-13 |
2023-08-13 |
Not clear |
| Nabila Bourebaba, Katarzyna Kornicka-Garbowska, Krzysztof Marycz, Lynda Bourebaba, Anna Kowalczu. Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial biogenesis - Possible implication in pharmacotherapy. Mitochondrion. vol 59. 2021-09-13. PMID:34091077. |
the obtained results showed that the bioactive extract of laurus nobilis increased the number of living cells and their proliferation rate, significantly attenuated apoptosis by modulating pro-apoptotic pathways (p21, p53 and bax genes), allowed a relative normalization of caspases-activity, and decreased the expression of inflammatory markers including c-jun, nf-κb and tlr4 transcripts. |
2021-09-13 |
2023-08-13 |
Not clear |
| Christiana M Neophytou, Ioannis P Trougakos, Nuray Erin, Panagiotis Papageorgi. Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance. Cancers. vol 13. issue 17. 2021-09-13. PMID:34503172. |
proteins implicated in the intrinsic pathway of apoptosis, including the bcl-2 superfamily and inhibitors of apoptosis (iap) family members, as well as their regulator, tumor suppressor p53, have been implicated in the development of mdr in many cancer types. |
2021-09-13 |
2023-08-13 |
Not clear |
| Jin Woo Shin, Se-Hee Kim, Jin Young Yoo. PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504554. |
p53 silencing did not affect the ability of pten knockdown to induce apoptosis in cervical cancer cells. |
2021-09-11 |
2023-08-13 |
human |
| Tao Song, Mingyu Zhang, Jun Wu, Fenghua Chen, Ying Wang, Yujie Ma, Zhijie Da. Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo. Investigational new drugs. vol 38. issue 6. 2021-09-10. PMID:32767162. |
after ng treatment, glioma cells resumed the sensitivity to apo2l and cell apoptosis was induced via the activation of caspases, elevation of decoy receptors 4 and 5 (dr4 and dr5) and induction of p53. |
2021-09-10 |
2023-08-13 |
mouse |
| Jingjing Hou, Lin Wang, Jiabao Zhao, Huiqin Zhuo, Jia Cheng, Xin Chen, Wei Zheng, Zhijun Hong, Jianchun Ca. Inhibition of protein PMP22 enhances etoposide-induced cell apoptosis by p53 signaling pathway in Gastric Cancer. International journal of biological sciences. vol 17. issue 12. 2021-09-10. PMID:34421356. |
inhibition of protein pmp22 enhances etoposide-induced cell apoptosis by p53 signaling pathway in gastric cancer. |
2021-09-10 |
2023-08-13 |
mouse |
| Emma B Brandt, Xing Li, Timothy J Nelso. Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs. Journal of stem cell reports. vol 3. issue 1. 2021-09-10. PMID:34485982. |
pharmacological-mediated increase of p53 protein levels with the mdm2 inhibitor nutlin-3a during early (mesoderm to cardiac mesoderm) stages of cardiogenesis resulted in a sizeable loss of cardiomyocytes due to increased apoptosis and cell cycle arrest. |
2021-09-10 |
2023-08-13 |
mouse |
| Emma B Brandt, Xing Li, Timothy J Nelso. Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs. Journal of stem cell reports. vol 3. issue 1. 2021-09-10. PMID:34485982. |
interestingly, increasing p53 levels did not result in apoptosis at later (cardiac progenitor to beating cardiomyocytes) stages of the cardiac differentiation. |
2021-09-10 |
2023-08-13 |
mouse |
| Wei-Gang Qiu, Alla Polotskaia, Gu Xiao, Lia Di, Yuhan Zhao, Wenwei Hu, John Philip, Ronald C Hendrickson, Jill Bargonett. Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer. NPJ breast cancer. vol 3. 2021-09-09. PMID:28232952. |
to target the mutant p53- poly adp-ribose polymerase-minichromosome maintenance axis we treated cells with the poly adp-ribose polymerase inhibitor talazoparib and the alkylating agent temozolomide and detected synergistic activation of apoptosis only in the presence of mutant p53. |
2021-09-09 |
2023-08-13 |
Not clear |
| Arusha Modi, Meenakshi Singh, Gopichand Gutti, Ozasvi R Shanker, Vinay Kumar Singh, Sunita Singh, Sushil Kumar Singh, Satyajit Pradhan, Gopeshwar Naraya. Benzothiazole derivative bearing amide moiety induces p53-mediated apoptosis in HPV16 positive cervical cancer cells. Investigational new drugs. vol 38. issue 4. 2021-09-09. PMID:31432292. |
our data suggest that treatment of a-07 causes p53 and caspase dependent apoptosis in hpv 16 infected siha cells. |
2021-09-09 |
2023-08-13 |
Not clear |
| Wei He, Weiwei Tao, Feng Zhang, Qian Jie, Yun He, Wei Zhu, Jiani Tan, Weixing Shen, Liu Li, Ye Yang, Haibo Cheng, Dongdong Su. Lobetyolin induces apoptosis of colon cancer cells by inhibiting glutamine metabolism. Journal of cellular and molecular medicine. vol 24. issue 6. 2021-09-09. PMID:31990147. |
the inhibition of p53 by pifithrin-α promoted the inhibitory effect of lobetyolin on asct2-mediated apoptosis. |
2021-09-09 |
2023-08-13 |
mouse |
| Wei He, Weiwei Tao, Feng Zhang, Qian Jie, Yun He, Wei Zhu, Jiani Tan, Weixing Shen, Liu Li, Ye Yang, Haibo Cheng, Dongdong Su. Lobetyolin induces apoptosis of colon cancer cells by inhibiting glutamine metabolism. Journal of cellular and molecular medicine. vol 24. issue 6. 2021-09-09. PMID:31990147. |
in conclusion, the present work suggested that lobetyolin could induce the apoptosis via the inhibition of asct2-mediated glutamine metabolism, which was possibly governed by p53. |
2021-09-09 |
2023-08-13 |
mouse |