| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monika E Grabowska, Bryan Chun, Raquel Moya, Jeffrey J Saucerma. Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity. Journal of molecular and cellular cardiology. vol 155. 2021-08-25. PMID:33667419. |
knockdown simulations identified ap1, ask1, jnk, mek47, p53, and ros as positive functional regulators of sorafenib-induced apoptosis of cardiomyocytes. |
2021-08-25 |
2023-08-13 |
Not clear |
| T Takeda, M Tsubak, S Genno, T Matsuda, Y Yamamoto, E Ueda, M Imano, T Satou, S Nishid. CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 71. issue 4. 2021-08-24. PMID:33214335. |
furthermore, we clarified that cd49d- and cd49e-mediated cam-dr could be attributed to an increase in the expression of b cell leukemia-xl (bcl-xl) and survivin proteins, and a decrease in the expression of bcl-2 associated x (bax), bcl-2 interacting mediator (bim) and p53 upregulated modulator of apoptosis (puma) proteins via nuclear factor kappab (nf-κb) activation. |
2021-08-24 |
2023-08-13 |
Not clear |
| Lidawani Lambuk, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Anna Peresypkina, Anna Pobeda, Nafeeza Mohd Ismai. Magnesium acetyltaurate prevents retinal damage and visual impairment in rats through suppression of NMDA-induced upregulation of NF-κB, p53 and AP-1 (c-Jun/c-Fos). Neural regeneration research. vol 16. issue 11. 2021-08-24. PMID:33818520. |
in conclusion, pre-treatment with mgat prevents nmda induced retinal injury by inhibiting nmda-induced neuronal apoptosis via downregulation of transcriptional activity of nf-κb, p53 and ap-1-mediated c-jun/c-fos. |
2021-08-24 |
2023-08-13 |
rat |
| Yanan Zhang, Huan Liu, Xialu Lin, Feng'e Zhang, Peilin Meng, Sijia Tan, Mikko J Lammi, Xiong Gu. Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An Frontiers in genetics. vol 12. 2021-08-24. PMID:34421989. |
dysregulation of cells cycle and apoptosis in human induced pluripotent stem cells chondrocytes through p53 pathway by ht-2 toxin: an kashin-beck disease (kbd) mainly damages growth plate of adolescents and is susceptible to both gene and gene-environmental risk factors. |
2021-08-24 |
2023-08-13 |
human |
| Yanan Zhang, Huan Liu, Xialu Lin, Feng'e Zhang, Peilin Meng, Sijia Tan, Mikko J Lammi, Xiong Gu. Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An Frontiers in genetics. vol 12. 2021-08-24. PMID:34421989. |
these findings confirmed that ht-2 is an environmental risk factor of kbd and that p53 pathway interacted with ht-2 toxin, causing damaged ultrastructure of organelles, accelerating cell cycle in g1 phase, and increasing late apoptosis in kbd hipsc chondrocytes. |
2021-08-24 |
2023-08-13 |
human |
| Kejie Zhang, Yuanbin Zhang, Cong Zhang, Limin Zh. Upregulation of P53 promotes nucleus pulposus cell apoptosis in intervertebral disc degeneration through upregulating NDRG2. Cell biology international. vol 45. issue 9. 2021-08-23. PMID:34051015. |
upregulation of p53 promotes nucleus pulposus cell apoptosis in intervertebral disc degeneration through upregulating ndrg2. |
2021-08-23 |
2023-08-13 |
mouse |
| Kejie Zhang, Yuanbin Zhang, Cong Zhang, Limin Zh. Upregulation of P53 promotes nucleus pulposus cell apoptosis in intervertebral disc degeneration through upregulating NDRG2. Cell biology international. vol 45. issue 9. 2021-08-23. PMID:34051015. |
p53 is an apoptosis marker which is involved in determining nucleus pulposus (np) cell fate. |
2021-08-23 |
2023-08-13 |
mouse |
| Kejie Zhang, Yuanbin Zhang, Cong Zhang, Limin Zh. Upregulation of P53 promotes nucleus pulposus cell apoptosis in intervertebral disc degeneration through upregulating NDRG2. Cell biology international. vol 45. issue 9. 2021-08-23. PMID:34051015. |
collectively, this study suggests that elevated p53 in np cells stimulates apoptosis of the cells by upregulating ndrg2 expression, thereby exacerbating ivdd. |
2021-08-23 |
2023-08-13 |
mouse |
| Monika Czech, Maria Konopacka, Jacek Rogoliński, Zbigniew Maniakowski, Magdalena Staniszewska, Łukasz Łaczmański, Danuta Witkowska, Andrzej Gamia. The Genotoxic and Pro-Apoptotic Activities of Advanced Glycation End-Products (MAGE) Measured with Micronuclei Assay Are Inhibited by Their Low Molecular Mass Counterparts. Genes. vol 12. issue 5. 2021-08-23. PMID:34068126. |
with regard to apoptosis, it is induced with the hmw-mage compounds, in the p53 independent way, whereas the low molecular mass product inhibits the apoptosis induction. |
2021-08-23 |
2023-08-13 |
human |
| Chloé Maurizy, Claire Abeza, Bénédicte Lemmers, Monica Gabola, Ciro Longobardi, Valérie Pinet, Marina Ferrand, Conception Paul, Julie Bremond, Francina Langa, François Gerbe, Philippe Jay, Céline Verheggen, Nicola Tinari, Dominique Helmlinger, Rossano Lattanzio, Edouard Bertrand, Michael Hahne, Bérengère Pradet-Balad. The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Nature communications. vol 12. issue 1. 2021-08-23. PMID:34376666. |
proliferative stem cells and progenitors deficient for rpap3 failed to import rna polymerase ii into the nucleus and they induced p53, cell cycle arrest and apoptosis. |
2021-08-23 |
2023-08-13 |
mouse |
| Xiaoli Guo, Aijun Ma, Zhihui Huang, Xin-An Wang, Kai Yang, Zhifeng Liu, Jinsheng Zhang, Wenxiao Cu. Molecular characterization of ubiquitin-conjugating enzyme gene ube2h and siRNA-mediated regulation on targeting p53 in turbot, Scophthalmus maximus. Journal of thermal biology. vol 99. 2021-08-23. PMID:34420605. |
p53 has important control of cell cycle arrest and apoptosis in response to cellular stress; these modifications are critical for the stability and transcriptional activity of p53 as the protein activates downstream target genes that dictate the cellular response. |
2021-08-23 |
2023-08-13 |
Not clear |
| Kunlun Yin, Jordan Lee, Zhaoli Liu, Hyeoncheol Kim, David R Martin, Dandan Wu, Meilian Liu, Xiang Xu. Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production. Cell death and differentiation. vol 28. issue 8. 2021-08-21. PMID:33723373. |
in contrast, pink1 deletion decreased apoptosis, increased glycolysis, and reduced mitochondrial respiration and p53 signaling. |
2021-08-21 |
2023-08-13 |
mouse |
| Chibuisi G Alimba, Ashwinkumar P Rudrashetti, Saravanadevi Sivanesan, Kannan Krishnamurth. Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell. Environmental science and pollution research international. 2021-08-21. PMID:34417692. |
there was significant increase in fold change of the up-regulated genes; apoptosis inducing factor mitochondrion-associated 2 (aifm2), fas-associated death domain (fadd), caspase-2, caspase-6, bh3 interacting domain death agonist (bid), tumor suppressor (p53), and bcl2 associated agonist of cell death (bad) and down-regulation of apoptosis inhibitor 5 (api5). |
2021-08-21 |
2023-08-13 |
human |
| Si-Yang Li, Jin Shang, Xiao-Mei Mao, Rui Fan, Hui-Qi Li, Rui-Han Li, Dong-Yan She. Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer. European journal of pharmacology. vol 908. 2021-08-20. PMID:34324855. |
here, we reported that dsg inhibited proliferation of crc cells in dose- and time-dependent manner, induced apoptosis by modulating p53 and bcl-2 family proteins expression to mediate mitochondrial apoptosis pathway, suppressed migration and invasion by reducing mmp-9 (matrix metalloproteinase) and decreased aerobic glycolysis by mediating glucose transporter (glut) like glut3 and glut4, and pyruvate carboxylase pc downregulation. |
2021-08-20 |
2023-08-13 |
mouse |
| Yunlong Meng, Keyuan Zhong, Suping Chen, Yong Huang, You Wei, Juan Wu, Juan Liu, Zhaopeng Xu, Jing Guo, Fasheng Liu, Huiqiang L. Cardiac toxicity assessment of pendimethalin in zebrafish embryos. Ecotoxicology and environmental safety. vol 222. 2021-08-19. PMID:34280841. |
in addition, pnd increased the expression of reactive oxygen species and malondialdehyde and reduced the activity of superoxide dismutase (antioxidant enzymes); we examined the expression of cardiac development-related genes and the apoptosis markers, and found changes of the following marker: vmhc, nppa, tbx5a, nkx2.5, gata4, tbx2b and foxo1, bax, bcl-2, p53, casp-9, casp-3. |
2021-08-19 |
2023-08-13 |
zebrafish |
| Xiaoxiao Liu, Li Zhang, Pyone Myat Thu, Wenjian Min, Peng Yang, Ji Li, Ping Li, Xiaojun X. Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53. Science China. Life sciences. vol 64. issue 8. 2021-08-18. PMID:33165811. |
consistent with the previous results, sodium cantharidinate treatment decreased bcl-2 and mitochondrial cytochrome-c protein expression, as well as phosphorylation of mdm2; meanwhile, it increased the levels of cleaved-caspase-3, cleaved-caspase-9, cleaved-parp, bax, and phosphorylated p53, thus inducing the apoptosis of pancreatic cancer cells. |
2021-08-18 |
2023-08-13 |
human |
| Ji-Eun Seo, Xiaoqing Guo, Dayton M Petibone, Sharon D Shelton, Ying Chen, Xilin Li, Volodymyr Tryndyak, Stephanie L Smith-Roe, Kristine L Witt, Nan Mei, Mugimane G Manjanath. Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 182. issue 1. 2021-08-18. PMID:33856461. |
a g1/s arrest in tk6 cells exposed to 125 µg/ml bce (24 h) was accompanied by apoptosis and increased expression of γh2a.x, p-chk1, p-chk2, p53, and p21. |
2021-08-18 |
2023-08-13 |
mouse |
| Wenshuang Wu, Tao Wei, ZhiHui Li, Jingqiang Zh. p53-dependent apoptosis is essential for the antitumor effect of paclitaxel response to DNA damage in papillary thyroid carcinoma. International journal of medical sciences. vol 18. issue 14. 2021-08-18. PMID:34400889. |
recombinant adenovirus-p53 (rad-p53) was used to increase the level of p53, which significantly increased the sensitivity of ptc cells to ptx by inducing s arrest, g2/m arrest and apoptosis. |
2021-08-18 |
2023-08-13 |
Not clear |
| Wenshuang Wu, Tao Wei, ZhiHui Li, Jingqiang Zh. p53-dependent apoptosis is essential for the antitumor effect of paclitaxel response to DNA damage in papillary thyroid carcinoma. International journal of medical sciences. vol 18. issue 14. 2021-08-18. PMID:34400889. |
rad-p53 + ptx increased the levels of cleaved-parp-1, cleaved -caspase 3, and bax and decreased the level of bcl-xl, suggesting p53 regulates the expression of bax/bcl-xl to mediate dna damage-induced apoptosis in ptc cells. |
2021-08-18 |
2023-08-13 |
Not clear |
| Awny M Elsayed, Naglaa M Sherif, Nahla S Hassan, Fayez Althobaiti, Nemany A N Hanafy, Heba A Sahyo. Novel quercetin encapsulated chitosan functionalized copper oxide nanoparticles as anti-breast cancer agent via regulating p53 in rat model. International journal of biological macromolecules. vol 185. 2021-08-17. PMID:34147524. |
the cuo-chnps-q treatment had induced apoptosis via increased p53 gene, arrested the cell-cycle, and increased both cytochrome c and caspase-3 levels leading to mammary carcinoma cell death. |
2021-08-17 |
2023-08-13 |
human |