| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Gao, Yun Ji, Lulu Wang, Meixia He, Xiaojing Yang, Yibing Qiu, Xu Sun, Zhenyu Ji, Guanrui Yang, Jianying Zhang, Shanshan Li, Liping Dai, Liguo Zhan. Suppression of Esophageal Squamous Cell Carcinoma Development by Mechanosensitive Protein Piezo1 Downregulation. ACS omega. vol 6. issue 15. 2021-09-28. PMID:34056174. |
the protein levels of p53, downstream factor bax, apoptosis executioner cleaved-caspase3, and caspase3 were significantly upregulated by the downregulation of piezo1. |
2021-09-28 |
2023-08-13 |
mouse |
| Hui Zhang, Huixia Zhang, Shengliang Cao, Chao Sui, Yinuo Song, Yiran Zhao, Sidang Li. Knockout of p53 leads to a significant increase in ALV-J replication. Poultry science. vol 100. issue 10. 2021-09-28. PMID:34411963. |
as the most extensive tumor suppressor gene in cancer research, p53 can control multiple functions such as that of dna repair, induction of apoptosis, cell cycle arrest and so on. |
2021-09-28 |
2023-08-13 |
Not clear |
| Hui Zhang, Huixia Zhang, Shengliang Cao, Chao Sui, Yinuo Song, Yiran Zhao, Sidang Li. Knockout of p53 leads to a significant increase in ALV-J replication. Poultry science. vol 100. issue 10. 2021-09-28. PMID:34411963. |
the results showed that p53 knockout prevented g0/g1 and g2 m phase arrest induced by alv-j, and substantially decreased the rate of apoptosis. |
2021-09-28 |
2023-08-13 |
Not clear |
| Mahdi Taghadosi, Mehrnoosh Adib, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhad. The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes. Immunologic research. vol 69. issue 3. 2021-09-27. PMID:33983569. |
p53 is a transcription factor that regulates many signaling pathways like apoptosis, cell cycle, dna repair, and cellular stress responses. |
2021-09-27 |
2023-08-13 |
Not clear |
| Mahdi Taghadosi, Mehrnoosh Adib, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhad. The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes. Immunologic research. vol 69. issue 3. 2021-09-27. PMID:33983569. |
p53 is a modulator of the apoptosis and proliferation processes through regulating multiple anti and pro-apoptotic genes. |
2021-09-27 |
2023-08-13 |
Not clear |
| Mahdi Taghadosi, Mehrnoosh Adib, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhad. The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes. Immunologic research. vol 69. issue 3. 2021-09-27. PMID:33983569. |
given the critical role of p53 in inflammation, apoptosis, and cell proliferation, lack of p53 function (due to mutation or low expression) exerts a prominent role for this gene in the pathogenesis of ra. |
2021-09-27 |
2023-08-13 |
Not clear |
| Muhammad Daniyal, Yongbei Liu, Yupei Yang, Feng Xiao, Jialong Fan, Huanghe Yu, Yixing Qiu, Bin Liu, Wei Wang, Qin Yuhu. Anti-gastric cancer activity and mechanism of natural compound "Heilaohulignan C" isolated from Kadsura coccinea. Phytotherapy research : PTR. vol 35. issue 7. 2021-09-27. PMID:34155704. |
western blot analysis confirmed that (b-6) decrease the level of bcl-2 and increase the level of p53, bax, and cleaved caspase-3, this confirms that the b-6 doing the apoptosis through caspase and cytochrome c apoptotic pathways. |
2021-09-27 |
2023-08-13 |
mouse |
| Mubashir Mintoo, Sameer Khan, Abubakar Wani, Sumera Malik, Deendyal Bhurta, Sandip Bharate, Fayaz Malik, Dilip Mondh. A rohitukine derivative IIIM-290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells. Molecular carcinogenesis. vol 60. issue 10. 2021-09-27. PMID:34324743. |
a rohitukine derivative iiim-290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells. |
2021-09-27 |
2023-08-13 |
Not clear |
| Mubashir Mintoo, Sameer Khan, Abubakar Wani, Sumera Malik, Deendyal Bhurta, Sandip Bharate, Fayaz Malik, Dilip Mondh. A rohitukine derivative IIIM-290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells. Molecular carcinogenesis. vol 60. issue 10. 2021-09-27. PMID:34324743. |
interestingly, the elevation in proapoptotic markers was p53 dependent-the silencing of p53 abrogated apoptosis (programmed cell death) triggered by iiim-290 in molt-4 cells. |
2021-09-27 |
2023-08-13 |
Not clear |
| Yajie Zhu, Miao Hu, Jonas Ngowo, Xu Gao, Xi Chen, Huihui Yan, Wei Y. Deacetylation of BmAda3 is required for cell apoptosis caused by Bombyx mori nucleopolyhedrovirus infection. Archives of insect biochemistry and physiology. vol 108. issue 2. 2021-09-27. PMID:34350621. |
since p53 is a proapoptotic factor, cell apoptosis was detected. |
2021-09-27 |
2023-08-13 |
Not clear |
| Erika Rimondi, Elisabetta Melloni, Arianna Romani, Veronica Tisato, Fabio Casciano, Gian Matteo Rigolin, Daniela Milani, Claudio Celeghini, Giorgio Zauli, Paola Secchiero, Rebecca Volta. Overcoming of Microenvironment Protection on Primary Chronic Lymphocytic Leukemia Cells after Treatment with BTK and MDM2 Pharmacological Inhibitors. Current oncology (Toronto, Ont.). vol 28. issue 4. 2021-09-24. PMID:34287267. |
we observed that primary b-cll cells cultivated in microenvironment mimicking conditions were protected from apoptosis by the up-regulation of c-myc and of p53. |
2021-09-24 |
2023-08-13 |
Not clear |
| Erika Rimondi, Elisabetta Melloni, Arianna Romani, Veronica Tisato, Fabio Casciano, Gian Matteo Rigolin, Daniela Milani, Claudio Celeghini, Giorgio Zauli, Paola Secchiero, Rebecca Volta. Overcoming of Microenvironment Protection on Primary Chronic Lymphocytic Leukemia Cells after Treatment with BTK and MDM2 Pharmacological Inhibitors. Current oncology (Toronto, Ont.). vol 28. issue 4. 2021-09-24. PMID:34287267. |
moreover, the combination induced high p53 levels and a significant dissipation of the mitochondrial membrane potential, together with bax cleavage in the more active p18 form and phospho-bad down-regulation, that are key components of the mitochondrial apoptotic pathway, enhancing the apoptosis level. |
2021-09-24 |
2023-08-13 |
Not clear |
| Bo Yang, Bin Zhang, Zhifei Cao, Xingdong Xu, Zihe Huo, Pan Zhang, Shufen Xiang, Zhe Zhao, Chunping Lv, Mei Meng, Gaochuan Zhang, Liang Dong, Shucheng Shi, Lan Yang, Quansheng Zho. The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy. Cell death and differentiation. vol 27. issue 8. 2021-09-23. PMID:32144382. |
strikingly, further diminution of the vulnerable lxr-srebf1-pnkp signaling pathway using a small molecule triptonide, a new lxr antagonist identified in this investigation, at a concentration of 8 nm robustly activated tumor-suppressor p53 and readily elevated cancer cell dna strand breaks over an apoptotic threshold, and selectively induced pc cell apoptosis, resulting in almost complete elimination of tumors in xenograft mice without obvious complications. |
2021-09-23 |
2023-08-13 |
mouse |
| Sang Ah Yi, Dong Hoon Lee, Go Woon Kim, Hyun-Wook Ryu, Jong Woo Park, Jaecheol Lee, Jihoon Han, Jee Hun Park, Hwamok Oh, Jieun Lee, Junjeong Choi, Hyun-Soo Kim, Hyeok Gu Kang, Da-Hyun Kim, Kyung-Hee Chun, Jueng Soo You, Jeung-Whan Han, So Hee Kwo. HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53. Cell death and differentiation. vol 27. issue 9. 2021-09-23. PMID:32203172. |
downregulation of ube2l3 by overexpression of hp1γ suppressed ube2l3-dependent p53 degradation-promoting apoptosis of cervical cancer cells. |
2021-09-23 |
2023-08-13 |
human |
| Bao Zhang, Xiaocui Nie, Xinxin Miao, Shuo Wang, Jing Li, Shengke Wan. Development and verification of an immune-related gene pairs prognostic signature in ovarian cancer. Journal of cellular and molecular medicine. vol 25. issue 6. 2021-09-23. PMID:33543590. |
as suggested by a functional study, some biological pathways, including the toll-like receptor and chemokine signalling pathways, were significantly negatively correlated with risk scores; however, pathways such as the p53 and apoptosis signalling pathways had a positive correlation. |
2021-09-23 |
2023-08-13 |
Not clear |
| Xiaolei Yao, Hui Shen, Qinghua Peng, Jingsheng Y. TP53/miR-129/MDM2/4/TP53 feedback loop modulates cell proliferation and apoptosis in retinoblastoma. Cell cycle (Georgetown, Tex.). vol 20. issue 5-6. 2021-09-23. PMID:33678118. |
mir-129 directly targeted mdm2/4 to inhibit expression, therefore counteracting mdm2/4-mediated p53 signaling suppression and modulating rb cell proliferation and apoptosis. |
2021-09-23 |
2023-08-13 |
human |
| Yixin Tong, Yuan Huang, Yuchao Zhang, Xiangtai Zeng, Mei Yan, Zhongsheng Xia, Dongming La. DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration. Cell death & disease. vol 12. issue 6. 2021-09-22. PMID:34023852. |
dpp3 depletion could induce cell apoptosis by upregulating the expression of bid, bim, caspase3, caspase8, hsp60, p21, p27, p53, and smac. |
2021-09-22 |
2023-08-13 |
human |
| Shahira M Ezzat, Heba M I Abdallah, Noha N Yassen, Rasha A Radwan, Eman S Mostafa, Maha M Salama, Mohamed A Sale. Phenolics from Physalis peruviana fruits ameliorate streptozotocin-induced diabetes and diabetic nephropathy in rats via induction of autophagy and apoptosis regression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34385108. |
the results suggest that the phenolic-rich fraction has a protective effects against diabetic nephropathy presumably via enhancing autophagy (ampk/mtor pathway) and prevention of apoptosis (p53 suppression). |
2021-09-22 |
2023-08-13 |
rat |
| Angeles Almeida, Irene Sánchez-Morán, Cristina Rodrígue. Mitochondrial-nuclear p53 trafficking controls neuronal susceptibility in stroke. IUBMB life. vol 73. issue 3. 2021-09-21. PMID:33615665. |
the tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, dna repair, senescence, and apoptosis. |
2021-09-21 |
2023-08-13 |
human |
| Angeles Almeida, Irene Sánchez-Morán, Cristina Rodrígue. Mitochondrial-nuclear p53 trafficking controls neuronal susceptibility in stroke. IUBMB life. vol 73. issue 3. 2021-09-21. PMID:33615665. |
after stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis through both transcriptional-dependent and -independent programs. |
2021-09-21 |
2023-08-13 |
human |