| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hany E Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Giacomo Pozzoli, Andrea Morrione, Antonio Giordano, Carlo Cenciarell. p53 signaling in cancer progression and therapy. Cancer cell international. vol 21. issue 1. 2021-12-25. PMID:34952583. |
many of these mutant p53 proteins have oncogenic characteristics, and therefore modulate the ability of cancer cells to proliferate, escape apoptosis, invade and metastasize. |
2021-12-25 |
2023-08-13 |
human |
| Elena G Novoselova, Mars G Sharapov, Sergey M Lunin, Svetlana B Parfenyuk, Maxim O Khrenov, Elvira K Mubarakshina, Anna A Kuzekova, Tatyana V Novoselova, Ruslan G Goncharov, Olga V Glushkov. Peroxiredoxin 6 Applied after Exposure Attenuates Damaging Effects of X-ray Radiation in 3T3 Mouse Fibroblasts. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943054. |
our results suggested that prdx6 treatment normalized p53 and nf-κb/p65 expression, p21 levels, dna repair-associated genes (xrcc4, xrcc5, h2ax, apex1), tlr expression, cytokine production (tnf-α and il-6), and apoptosis, as evidenced by decreased caspase 3 level in irradiated 3t3 cells. |
2021-12-24 |
2023-08-13 |
mouse |
| Ruqaia Abbas, Sarit Larisc. Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System. Cells. vol 10. issue 12. 2021-12-24. PMID:34943974. |
specifically, we will review how the stability of p53, bcl-2 family members and iaps (inhibitor of apoptosis proteins) are regulated upon initiation of apoptosis. |
2021-12-24 |
2023-08-13 |
human |
| Javier Quero, Francesco Ruighi, Jesús Osada, M Concepción Gimeno, Elena Cerrada, Maria Jesús Rodriguez-Yold. Gold(I) Complexes Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane Ligands as Thermoresponsive Anticancer Agents in Human Colon Cells. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944664. |
in addition, the cell cycle was altered by the activation of p53, and the complexes produce apoptosis through mitochondrial depolarization and the consequent activation of caspase-3. |
2021-12-24 |
2023-08-13 |
human |
| Hiroshi Shimada, Takayuki Kohno, Takumi Konno, Tadahi Okada, Kimihito Saito, Yuma Shindo, Shin Kikuchi, Mitsuhiro Tsujiwaki, Marie Ogawa, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojim. The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma. Cancers. vol 13. issue 24. 2021-12-24. PMID:34944960. |
moreover, loss of angulin-1/lsr upregulates claudin-1, and loss of apoptosis stimulating p53 protein 2 (aspp2) downregulates angulin-1/lsr. |
2021-12-24 |
2023-08-13 |
Not clear |
| Kenichi Umehara, Yumi Cleary, Stephen Fowler, Neil Parrott, Dietrich W Tuerc. Drug metabolism and disposition: the biological fate of chemicals. 2021-12-23. PMID:34937801. |
idasanutlin is a potent inhibitor of the p53-mdm2 interaction that enables re-activation of the p53 pathway which induces cell cycle arrest and/or apoptosis in tumor cells expressing functional p53. |
2021-12-23 |
2023-08-13 |
human |
| Wan-Atirah Azemin, Nadiawati Alias, Abdul Manaf Ali, Mohd Shahir Shamsi. In silico analysis prediction of HepTH1-5 as a potential therapeutic agent by targeting tumour suppressor protein networks. Journal of biomolecular structure & dynamics. 2021-12-22. PMID:34935583. |
the inhibitor of growth (ing) family members are also shown to directly interact with p53 and promote cell cycle arrest, senescence, apoptosis and participate in dna replication and dna damage responses to suppress the tumour initiation and progression. |
2021-12-22 |
2023-08-13 |
human |
| Junfeng Zhang, Chenchen Li, Qianghua Xue, Xuelian Yin, Yajie Li, Wen He, Xuerui Chen, Jian Zhang, Rui L Reis, Yanli Wan. An Efficient Carbon-Based Drug Delivery System for Cancer Therapy through the Nucleus Targeting and Mitochondria Mediated Apoptotic Pathway. Small methods. vol 5. issue 12. 2021-12-20. PMID:34928029. |
the cpd regulates the expression levels of caspase-3, p53, and bcl-2 genes by increasing intracellular reactive oxygen species (ros) levels and reducing mitochondrial membrane potential, which indicates that mitochondrial-mediated pathways are involved in apoptosis. |
2021-12-20 |
2023-08-13 |
Not clear |
| Jiaqi Liu, Xianzun Tao, Yi Zhu, Chong Li, Kai Ruan, Zoraida Diaz-Perez, Priyamvada Rai, Hongbo Wang, R Grace Zha. NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. eLife. vol 10. 2021-12-17. PMID:34919052. |
nmnat promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosis. |
2021-12-17 |
2023-08-13 |
Not clear |
| Marwa A Mahmoud, Tark M Okda, Gamal A Omran, Mohammad M Abd-Alhasee. Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation. Journal of applied biomedicine. vol 19. issue 4. 2021-12-15. PMID:34907739. |
it also triggered apoptosis by restoring the levels of p53, bcl-2, bax, and caspase-3. |
2021-12-15 |
2023-08-13 |
mouse |
| Anna Neuberger, Christian Menzer, Nadine Volk, Alexander H Enk, Eva N Hadaschik, Anke S Lonsdor. Expression of p53 up-regulated modulator of apoptosis (PUMA) in non-melanoma skin cancer of long-term immunosuppressed solid organ transplant recipients compared to immunocompetent patients. European journal of dermatology : EJD. vol 31. issue 5. 2021-12-14. PMID:34903507. |
expression of p53 up-regulated modulator of apoptosis (puma) in non-melanoma skin cancer of long-term immunosuppressed solid organ transplant recipients compared to immunocompetent patients. |
2021-12-14 |
2023-08-13 |
Not clear |
| Anna Neuberger, Christian Menzer, Nadine Volk, Alexander H Enk, Eva N Hadaschik, Anke S Lonsdor. Expression of p53 up-regulated modulator of apoptosis (PUMA) in non-melanoma skin cancer of long-term immunosuppressed solid organ transplant recipients compared to immunocompetent patients. European journal of dermatology : EJD. vol 31. issue 5. 2021-12-14. PMID:34903507. |
in the skin, p53 up-regulated modulator of apoptosis (puma) is a central regulator of apoptosis in response to uvr damage and immune response regulation. |
2021-12-14 |
2023-08-13 |
Not clear |
| Souvik Roy, Anil Kumar Mondru, Tania Chakraborty, Abhijit Das, Sandipan Dasgupt. Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways. Toxicology and applied pharmacology. 2021-12-13. PMID:34896434. |
ruthenium-phloretin complex could modulate p53 intervene apoptosis in the breast carcinoma, initiated by the trail of intrinsic apoptosis facilitated through bcl2 and bax and at the same time down regulating the pi3k/akt/mtor pathway coupled with mmp9 regulated tumor invasive pathways. |
2021-12-13 |
2023-08-13 |
human |
| Jianlan Zhao, Yinhui Dong, Xingyu Chen, Xiao Xiao, Bo Tan, Gong Chen, Jin Hu, Dashi Qi, Xiaomu Li, Rong Xi. p53 Inhibition Protects against Neuronal Ischemia/Reperfusion Injury by the p53/PRAS40/mTOR Pathway. Oxidative medicine and cellular longevity. vol 2021. 2021-12-13. PMID:34900085. |
we found that the infarction size, neuronal apoptosis, and autophagy were less severe in p53 ko mice and p53 ko neurons after cerebral i/r or ogd/r injury. |
2021-12-13 |
2023-08-13 |
mouse |
| Dan Shao, Peiyong Zhai, Chengchen Hu, Risa Mukai, Sebastiano Sciarretta, Dominic Del Re, Junichi Sadoshim. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Scientific reports. vol 11. issue 1. 2021-12-12. PMID:34873220. |
lats2-induced increases in apoptosis and decreases in survival in cardiomyocytes were inhibited by pifithrin-α, a p53 inhibitor, suggesting that lats2 stimulates apoptosis via a p53-dependent mechanism. |
2021-12-12 |
2023-08-13 |
mouse |
| Christian Marx, Jürgen Sonnemann, Mandy Beyer, Oliver D K Maddocks, Sergio Lilla, Irene Hauzenberger, Andrea Piée-Staffa, Kanstantsin Siniuk, Suneetha Nunna, Lisa Marx-Blümel, Martin Westermann, Tobias Wagner, Felix B Meyer, René Thierbach, Christina S Mullins, Said Kdimati, Michael Linnebacher, Francesco Neri, Thorsten Heinzel, Zhao-Qi Wang, Oliver H Kräme. Mechanistic insights into p53-regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells. Molecular oncology. vol 15. issue 12. 2021-12-11. PMID:34258881. |
while the relevance of p53 c-terminal acetylation for transcriptional regulation is well defined, it is unknown whether this ptm controls mitochondrially mediated apoptosis directly. |
2021-12-11 |
2023-08-13 |
mouse |
| Alyssa M Klein, Lynn Biderman, David Tong, Bita Alaghebandan, Sakina A Plumber, Helen S Mueller, Anne van Vlimmeren, Chen Katz, Carol Prive. MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 44. 2021-12-11. PMID:34716260. |
the p53 tumor suppressor protein, known to be critically important in several processes including cell-cycle arrest and apoptosis, is highly regulated by multiple mechanisms, most certifiably the murine double minute 2-murine double minute x (mdm2-mdmx) heterodimer. |
2021-12-11 |
2023-08-13 |
Not clear |
| Qian Zhou, Jinyao Yin, Jingwen Tan, Shuting Li, Chenglan Jiang, Yuefeng H. Up-regulation of PUMA caused the activation of p53 phosphorylation and acetylation, enhancing the interaction between PUMA and Bcl-X and mediating arsenic-induced apoptosis. Toxicology and applied pharmacology. vol 434. 2021-12-11. PMID:34798143. |
up-regulation of puma caused the activation of p53 phosphorylation and acetylation, enhancing the interaction between puma and bcl-x and mediating arsenic-induced apoptosis. |
2021-12-11 |
2023-08-13 |
Not clear |
| Qian Zhou, Jinyao Yin, Jingwen Tan, Shuting Li, Chenglan Jiang, Yuefeng H. Up-regulation of PUMA caused the activation of p53 phosphorylation and acetylation, enhancing the interaction between PUMA and Bcl-X and mediating arsenic-induced apoptosis. Toxicology and applied pharmacology. vol 434. 2021-12-11. PMID:34798143. |
puma (p53 up-regulated modulator of apoptosis) is a crucial member of the bcl-2 protein family and plays a key role in pro-apoptosis. |
2021-12-11 |
2023-08-13 |
Not clear |
| Anwen Yin, Mengwen Feng, Li Zhang, Zijie Cheng, Yun Li, Lingmei Qia. Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion. Pharmacological research. vol 175. 2021-12-11. PMID:34808368. |
interestingly, pdrl23a was found to interact with 60 s ribosomal protein l26 (rpl26), hampering rpl26-governed p53 translation, and resulting in a reduction in the level of p53 protein, which in turn reduced p53-mediated apoptosis under hypoxic conditions. |
2021-12-11 |
2023-08-13 |
Not clear |