| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsuan-Cheng Kuo, Lixia Luo, Yan Ma, Nerissa T Williams, Lorraine da Silva Campos, Laura D Attardi, Chang-Lung Lee, David G Kirsc. The p53 Transactivation Domain 1-Dependent Response to Acute DNA Damage in Endothelial Cells Protects against Radiation-Induced Cardiac Injury. Radiation research. 2022-05-05. PMID:35512345. |
p5325,26,53,54 loses the ability to drive transactivation of p53 target genes after irradiation while p5325,26 can induce transcription of a group of non-canonical p53 target genes, but not the majority of classic radiation-induced p53 targets critical for p53-mediated cell cycle arrest and apoptosis. |
2022-05-05 |
2023-08-13 |
mouse |
| Eman I Hassanen, Yasmin A Ebedy, Marwa A Ibrahim, Khaled Y Farroh, M O Elshazl. Insights overview on the possible protective effect of chitosan nanoparticles encapsulation against neurotoxicity induced by carbendazim in rats. Neurotoxicology. 2022-05-05. PMID:35513110. |
cbz also induced apoptosis manifested by up-regulation of jnk and p53 with down-regulation of bcl-2 in brain tissue. |
2022-05-05 |
2023-08-13 |
rat |
| Elisa Guida, Andrea Bisso, Cristina Fenollar-Ferrer, Marco Napoli, Claudio Anselmi, Javier E Girardini, Paolo Carloni, Giannino Del Sa. Editor's Note: Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells. Cancer research. vol 82. issue 9. 2022-05-03. PMID:35502549. |
editor's note: peptide aptamers targeting mutant p53 induce apoptosis in tumor cells. |
2022-05-03 |
2023-08-13 |
Not clear |
| Shouze Liu, Qianqian Zhang, Wenhua Liu, Xianghua Huan. Research on the mechanisms of Shu Yu wan in the treatment of cervical cancer based on network pharmacology analyses and molecular docking technology. Natural product research. 2022-05-03. PMID:35503243. |
the results of go and kegg enrichment analyses suggested that syw exerted pharmacological effects on cc by regulating cellular senescence, p53 signaling pathway, cell cycle, apoptosis, viral carcinogenesis and human papillomavirus infection (hpv) signaling pathway. |
2022-05-03 |
2023-08-13 |
human |
| Tongwang Yang, Cunle Zhu, Ying Shi, Yuntai Shen, Yuxue Gao, Bowen Zhang, Rifeng Jin, Daojie Liu, Yabo Ouyang, Xiaoni Liu, Wenjing Wang, Pengxiang Yang, Qingguo Xu, Jinzhen Cai, Dexi Che. RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2/k18/14-3-3 ternary complex formulation to promote BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular carcinoma. Cancer gene therapy. 2022-05-03. PMID:35504951. |
the apoptosis stimulating protein of p53 2 (aspp2) is a heterozygous insufficient tumor suppressor; however, its molecular mechanism(s) in tumor suppression is not completely understood. |
2022-05-03 |
2023-08-13 |
mouse |
| Jessica J Miller, Kalvin Kwan, Christian Gaiddon, Tim Stor. A role for bioinorganic chemistry in the reactivation of mutant p53 in cancer. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2022-04-30. PMID:35488931. |
the p53 protein plays a critical role in the prevention of genome mutations via initiation of apoptosis, dna repair, cell cycle arrest, anti-angiogenesis, and senescence pathways to avoid propagation of damaged cells. |
2022-04-30 |
2023-08-13 |
Not clear |
| He Li, Linling Liu, Hong-Ying Chen, Xin Yan, Ru-Li Li, Jie Lan, Kun-Yue Xue, Xue Li, Cai-Li Zhuo, Lan Lin, Ling-Yu Li, Zhuang Wu, Die Zhang, Xue-Mei Wang, Wen-Jing Huang, Yingling Wang, Wei Jiang, Liming Zho. Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis. Toxicology and applied pharmacology. 2022-04-30. PMID:35489526. |
in addition, mogrol induced a significant increase in p53 activity in lung cancer cells, accompanied with cell cycle arrest and apoptosis, which could be weakened by p53 silence. |
2022-04-30 |
2023-08-13 |
mouse |
| He Li, Linling Liu, Hong-Ying Chen, Xin Yan, Ru-Li Li, Jie Lan, Kun-Yue Xue, Xue Li, Cai-Li Zhuo, Lan Lin, Ling-Yu Li, Zhuang Wu, Die Zhang, Xue-Mei Wang, Wen-Jing Huang, Yingling Wang, Wei Jiang, Liming Zho. Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis. Toxicology and applied pharmacology. 2022-04-30. PMID:35489526. |
our results indicated that mogrol effectively suppressed lung cancer cells in vivo and in vitro by inducing the excessive autophagy and autophagic cell death via activating ampk signaling pathway, as well as cell cycle arrest and apoptosis via activating p53 pathway. |
2022-04-30 |
2023-08-13 |
mouse |
| Abhishek Maiti, Bing Z Carter, Michael Andreeff, Marina Y Konoplev. Beyond BCL-2 Inhibition in Acute Myeloid Leukemia: Other Approaches to Leverage the Apoptotic Pathway. Clinical lymphoma, myeloma & leukemia. 2022-04-30. PMID:35490155. |
these approaches include targeting the intrinsic and extrinsic apoptotic pathway, inducing apoptosis via p53 activation, and others. |
2022-04-30 |
2023-08-13 |
Not clear |
| Abhishek Maiti, Bing Z Carter, Michael Andreeff, Marina Y Konoplev. Beyond BCL-2 Inhibition in Acute Myeloid Leukemia: Other Approaches to Leverage the Apoptotic Pathway. Clinical lymphoma, myeloma & leukemia. 2022-04-30. PMID:35490155. |
approaches inducing p53-mediated apoptosis are being evaluated using inhibitors of mdm2, dual inhibitor of mdm2/x in tp53 wild-type aml and p53 reactivators in tp53-mutant myeloid disorders. |
2022-04-30 |
2023-08-13 |
Not clear |
| Suyatmi Suyatmi, Ambar Mudigdo, Bambang Purwanto, Dono Indarto, Fikar Arsyad Hakim, Dyah Ika Krisnawat. Brazilin Isolated from Caesalpina Sappan Wood Induces Intrinsic Apoptosis on A549 Cancer Cell Line by Increasing p53, caspase-9, and caspase-3. Asian Pacific journal of cancer prevention : APJCP. vol 23. issue 4. 2022-04-29. PMID:35485694. |
brazilin isolated from caesalpina sappan wood induces intrinsic apoptosis on a549 cancer cell line by increasing p53, caspase-9, and caspase-3. |
2022-04-29 |
2023-08-13 |
Not clear |
| Suyatmi Suyatmi, Ambar Mudigdo, Bambang Purwanto, Dono Indarto, Fikar Arsyad Hakim, Dyah Ika Krisnawat. Brazilin Isolated from Caesalpina Sappan Wood Induces Intrinsic Apoptosis on A549 Cancer Cell Line by Increasing p53, caspase-9, and caspase-3. Asian Pacific journal of cancer prevention : APJCP. vol 23. issue 4. 2022-04-29. PMID:35485694. |
this study evaluated the potency of brazilin isolated from caesalpinia sappan wood to induce apoptosis on non-small lung carcinoma cell line, a549, by examining the expression of p53, caspase-9, and caspase-3. |
2022-04-29 |
2023-08-13 |
Not clear |
| b' Ver\\xc3\\xb3nica Antonio-V\\xc3\\xa9jar, Elizabeth Ortiz-S\\xc3\\xa1nchez, Pedro Rosendo-Chalma, Carlos C Pati\\xc3\\xb1o-Morales, Miriam C Guido-Jim\\xc3\\xa9nez, Eduardo Alvarado-Ortiz, Greco Hern\\xc3\\xa1ndez, Alejandro Garc\\xc3\\xada-Carranc\\xc3\\xa. New insights into the interactions of HPV-16 E6*I and E6*II with p53 isoforms and induction of apoptosis in cancer-derived cell lines. Pathology, research and practice. vol 234. 2022-04-29. PMID:35487028.' |
new insights into the interactions of hpv-16 e6*i and e6*ii with p53 isoforms and induction of apoptosis in cancer-derived cell lines. |
2022-04-29 |
2023-08-13 |
human |
| b' Ver\\xc3\\xb3nica Antonio-V\\xc3\\xa9jar, Elizabeth Ortiz-S\\xc3\\xa1nchez, Pedro Rosendo-Chalma, Carlos C Pati\\xc3\\xb1o-Morales, Miriam C Guido-Jim\\xc3\\xa9nez, Eduardo Alvarado-Ortiz, Greco Hern\\xc3\\xa1ndez, Alejandro Garc\\xc3\\xada-Carranc\\xc3\\xa. New insights into the interactions of HPV-16 E6*I and E6*II with p53 isoforms and induction of apoptosis in cancer-derived cell lines. Pathology, research and practice. vol 234. 2022-04-29. PMID:35487028.' |
an important characteristic of cancers associated with high-risk human papillomaviruses (hr-hpv) is the inability of p53 to activate apoptosis due to the effect of the oncoprotein e6. |
2022-04-29 |
2023-08-13 |
human |
| b' Ver\\xc3\\xb3nica Antonio-V\\xc3\\xa9jar, Elizabeth Ortiz-S\\xc3\\xa1nchez, Pedro Rosendo-Chalma, Carlos C Pati\\xc3\\xb1o-Morales, Miriam C Guido-Jim\\xc3\\xa9nez, Eduardo Alvarado-Ortiz, Greco Hern\\xc3\\xa1ndez, Alejandro Garc\\xc3\\xada-Carranc\\xc3\\xa. New insights into the interactions of HPV-16 E6*I and E6*II with p53 isoforms and induction of apoptosis in cancer-derived cell lines. Pathology, research and practice. vol 234. 2022-04-29. PMID:35487028.' |
however, the effect of hpv-16 e6 splice variant isoforms (namely e6*i and e6*ii), their interaction with the existing p53 isoforms, and their influence on apoptosis is unclear. |
2022-04-29 |
2023-08-13 |
human |
| b' Ver\\xc3\\xb3nica Antonio-V\\xc3\\xa9jar, Elizabeth Ortiz-S\\xc3\\xa1nchez, Pedro Rosendo-Chalma, Carlos C Pati\\xc3\\xb1o-Morales, Miriam C Guido-Jim\\xc3\\xa9nez, Eduardo Alvarado-Ortiz, Greco Hern\\xc3\\xa1ndez, Alejandro Garc\\xc3\\xada-Carranc\\xc3\\xa. New insights into the interactions of HPV-16 E6*I and E6*II with p53 isoforms and induction of apoptosis in cancer-derived cell lines. Pathology, research and practice. vol 234. 2022-04-29. PMID:35487028.' |
additionally, we evaluated the effect of ectopic expression of p53, Δ40p53, and Δ133p53 on apoptosis in a p53 null pulmonary cell line (h1299) co-transfected with e6 isoforms and p53 |
2022-04-29 |
2023-08-13 |
human |
| Feixue Liu, Xueqing Li, Babatunde Kazeem Bello, Tianmeng Zhang, Haitao Yang, Kun Wang, Jingquan Don. Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis. Ecotoxicology and environmental safety. vol 237. 2022-04-29. PMID:35487176. |
in addition, we found that dfz caused excessive apoptosis in spleen tissue by tunel staining and expression levels of apoptosis-related genes (caspase3, caspase8, caspase9, fas, bax, bcl-2, and p53). |
2022-04-29 |
2023-08-13 |
cat |
| Zhangchuan Xia, Ning Kon, Alyssa P Gu, Omid Tavana, Wei G. Deciphering the acetylation code of p53 in transcription regulation and tumor suppression. Oncogene. 2022-04-29. PMID:35487975. |
we also discuss the role of p53 acetylation in differentially regulating its classic activities in cell cycle arrest, senescence and apoptosis as well as newly identified unconventional functions such as cell metabolism and ferroptosis. |
2022-04-29 |
2023-08-13 |
mouse |
| Yi Gong, Tongtong Kong, Jude Juventus Aweya, Hongyu Ma, Yueling Zhang, Shengkang L. p53 Ubiquitination Comediated by HUWE1 and TRAF6 Contributes to White Spot Syndrome Virus Infection in Crustacean. Journal of virology. vol 96. issue 6. 2022-04-28. PMID:35107378. |
moreover, the expression of huwe1 and traf6 was significantly downregulated during white spot syndrome virus (wssv) infection, and therefore the ubiquitination of p53 was interrupted, leading to the activation of apoptosis and reactive oxygen species (ros) signals through p53 accumulation, which eventually suppressed viral invasion in the mud crabs. |
2022-04-28 |
2023-08-16 |
Not clear |
| Almas Jabeen, Nadeem Ahmad, Khalid Raz. Global Gene Expression and Docking Profiling of COVID-19 Infection. Frontiers in genetics. vol 13. 2022-04-28. PMID:35480316. |
the functional changes are mainly associated with these pathways tnf, cytokine, nf-kb, tlr, tcr, bcr, foxo, and tgf signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, erbb, wnt, p53, camp, mapk, pi3k-akt, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways. |
2022-04-28 |
2023-08-13 |
Not clear |