| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abdul Sammad, Hanpeng Luo, Lirong Hu, Huabin Zhu, Yachun Wan. Transcriptome Reveals Granulosa Cells Coping through Redox, Inflammatory and Metabolic Mechanisms under Acute Heat Stress. Cells. vol 11. issue 9. 2022-05-19. PMID:35563749. |
downregulation of mdm4, tp53, pidd1, parp3, mapk14 and myc, and upregulation of stk26, stk33, tgfb2, cdkn1a and cdkn2a, at the interface of the mapk and p53 signaling pathway, can be attributed to transient cellular senescence and apoptosis in gcs. |
2022-05-19 |
2024-08-30 |
cat |
| Aakriti Gupta, Sarah A Breedon, Kenneth B Store. Activation of p53 in anoxic freshwater crayfish, Faxonius virilis. The Journal of experimental biology. 2022-05-16. PMID:35574675. |
tumor suppressing transcription factor p53 regulates multiple pathways including dna repair, cell survival, apoptosis, and autophagy. |
2022-05-16 |
2023-08-13 |
Not clear |
| Yixuan Guo, Zhaoyun Liu, Lixiang Duan, Hongli Shen, Kai Ding, Rong F. Selinexor synergizes with azacitidine to eliminate myelodysplastic syndrome cells through p53 nuclear accumulation. Investigational new drugs. 2022-05-16. PMID:35576022. |
this combination also promoted mds cell apoptosis and enhanced p53 accumulation in the nucleus, thereby allowing p53 to be activated and to function as a tumor suppressor. |
2022-05-16 |
2023-08-13 |
Not clear |
| Nayeong Koo, Arun K Sharma, Satya Naraya. Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563397. |
named as the guardian of the genome, p53 is a tumor suppressor that regulates cell function, often through many different mechanisms such as dna repair, apoptosis, cell cycle arrest, senescence, metabolism, and autophagy. |
2022-05-14 |
2023-08-13 |
human |
| Nayeong Koo, Arun K Sharma, Satya Naraya. Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563397. |
when p53 activity is inhibited, damaged cells do not undergo cell cycle arrest or apoptosis. |
2022-05-14 |
2023-08-13 |
human |
| b' Weimin Tang, Sudipta Panja, Chinmay M Jogdeo, Siyuan Tang, Ling Ding, Ao Yu, Kirk W Foster, Del L Dsouza, Yashpal S Chhonker, Heather Jensen-Smith, Hee-Seong Jang, Erika I Boesen, Daryl J Murry, Babu Padanilam, David Oupick\\xc3\\xb. Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury. Biomaterials. vol 285. 2022-05-13. PMID:35552115.' |
apoptosis and metabolic and inflammatory pathways induced by p53 are important pathological mechanisms in the development of aki. |
2022-05-13 |
2023-08-13 |
Not clear |
| Marie-Claude Beauchamp, Alexia Boucher, Yanchen Dong, Loydie J Majewsk. Craniofacial Defects Persist in Eftud2 mutant mice with P53 Deletion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556072. |
altogether, our data suggest that in the presence of p53, eftud2 mutants neural crest cells undergo apoptosis, whereas in the absence of this protein, they undergo cell cycle arrest. |
2022-05-13 |
2023-08-13 |
mouse |
| Emi Hibino, Takeshi Tenno, Hidekazu Hiroak. Relevance of Amorphous and Amyloid-Like Aggregates of the p53 Core Domain to Loss of its DNA-Binding Activity. Frontiers in molecular biosciences. vol 9. 2022-05-13. PMID:35558561. |
the anti-oncogenic protein p53 is a transcription factor that prevents tumorigenesis by inducing gene repair proteins or apoptosis under dna damage. |
2022-05-13 |
2023-08-13 |
Not clear |
| Jieun Kim, Seungbok Lee, Jaemeun Lee, Jong-Chan Park, Kyung Hyun Kim, Jung Min Ko, Sun-Hyun Park, Seung-Ki Kim, Inhee Mook-Jung, Ji Yeoun Le. Neurotoxicity of phenylalanine on human iPSC-derived cerebral organoids. Molecular genetics and metabolism. 2022-05-13. PMID:35562278. |
rna-seq of phenylalanine-treated organoids revealed that gene sets related to apoptosis, p53 signaling pathway, and tnf signaling pathway via nf-kb were enriched in upregulated genes, while those related to cell cycle and amino acid metabolism were enriched in downregulated genes. |
2022-05-13 |
2023-08-13 |
human |
| Chen Yang, Xiaoyu Xie, Hu Tang, Xuyan Dong, Xiaodong Zhang, Fenghong Huan. Transcriptome analysis reveals GA induced apoptosis in HCT116 human colon cancer cells through calcium and p53 signal pathways. RSC advances. vol 8. issue 22. 2022-05-11. PMID:35539409. |
transcriptome analysis reveals ga induced apoptosis in hct116 human colon cancer cells through calcium and p53 signal pathways. |
2022-05-11 |
2023-08-13 |
human |
| Chen Yang, Xiaoyu Xie, Hu Tang, Xuyan Dong, Xiaodong Zhang, Fenghong Huan. Transcriptome analysis reveals GA induced apoptosis in HCT116 human colon cancer cells through calcium and p53 signal pathways. RSC advances. vol 8. issue 22. 2022-05-11. PMID:35539409. |
the results of this study indicate that ga triggers apoptosis in hct116 cells through obstructing the growth of cells in the early phase treatment by down-regulation of calcium channels and then up-regulation of the intrinsic p53 signal pathway through activation of apoptosis caspases, finally leading to the mitochondrial apoptosis pathway. |
2022-05-11 |
2023-08-13 |
human |
| Zuowei Pei, Jiahui Hu, Qianru Bai, Baiting Liu, Dong Cheng, Hainiang Liu, Rongmei Na, Qin Y. Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats. RSC advances. vol 8. issue 26. 2022-05-11. PMID:35540763. |
the addition of thymoquinone inhibited dox-induced cardiac fibrosis (tgf-β, smad3, collagen i, collagen iii, and α-sma) and apoptosis (p53, bcl-2, caspase-3, caspase-9, and bax) in sdr, indicating that thymoquinone may be a potential therapeutic target for cardiac damage caused by dox-induced heart failure. |
2022-05-11 |
2023-08-13 |
rat |
| Thomas M Leissing, Adam P Hardy, Hokfung Chan, Yihua Wang, Anthony Tumber, Rasheduzzaman Chowdhury, Penny Fang, Mathew L Coleman, Matthew E Cockman, Holger B Kramer, Georgina Berridge, Roman Fischer, Benedikt M Kessler, Peter J Ratcliffe, Xin Lu, Christopher J Schofiel. Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins. The Journal of biological chemistry. 2022-05-10. PMID:35537551. |
fih also catalyses the hydroxylation of asparaginyl and other residues in ankyrin repeat domain (ard) containing proteins, including apoptosis stimulating of p53 protein (aspp) family members. |
2022-05-10 |
2023-08-13 |
human |
| Jinghai Wu, Xin Liu, Julie A Wallace Reeser, Anthony J Trimboli, Thierry Pecot, Gina M Sizemore, Shan K Naidu, Soledad A Fernandez, Lianbo Yu, Michael Hallett, Morag Park, Gustavo W Leone, Blake E Hildreth, Michael C Ostrowsk. Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. Molecular cancer research : MCR. 2022-05-09. PMID:35533313. |
stroma-specific p53 deletion increases both epithelial and fibroblast proliferation in mammary glands bearing the krasg12d oncogene in epithelia, while concurrently increasing dna damage and/or dna replication stress and decreasing apoptosis in the tumor cells proper. |
2022-05-09 |
2023-08-13 |
mouse |
| Jinghai Wu, Xin Liu, Julie A Wallace Reeser, Anthony J Trimboli, Thierry Pecot, Gina M Sizemore, Shan K Naidu, Soledad A Fernandez, Lianbo Yu, Michael Hallett, Morag Park, Gustavo W Leone, Blake E Hildreth, Michael C Ostrowsk. Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. Molecular cancer research : MCR. 2022-05-09. PMID:35533313. |
stroma-specific p53 deletion reprogrammed gene expression in both fibroblasts and adjacent epithelium, with p53 targets and chemokine receptors/chemokine signaling pathways in fibroblasts and dna replication, dna damage repair, and apoptosis in epithelia being the most significantly impacted biological processes. |
2022-05-09 |
2023-08-13 |
mouse |
| Hui Wang, Yingchun Shang, Enlin Wang, Xinxin Xu, Qiyue Zhang, Chenxi Qian, Zhuo Yang, Shian Wu, Tao Zhan. MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease. Progress in neurobiology. 2022-05-07. PMID:35525373. |
mechanistically, mst1 associated with p53 and promoted neuronal apoptosis by phosphorylation and activation of p53, while p53 knockout largely reversed mst1-induced ad-like cognitive deficits. |
2022-05-07 |
2023-08-13 |
mouse |
| Rong Wu, Xiaojie Dou, Haidong Li, Zhenguo Sun, Heng Li, Yuxin Shen, Wei Weng, Jikang Mi. Identification of Cell Subpopulations and Interactive Signaling Pathways From a Single-Cell RNA Sequencing Dataset in Osteosarcoma: A Comprehensive Bioinformatics Analysis. Frontiers in oncology. vol 12. 2022-05-06. PMID:35515114. |
the degs between different cell types from primary, metastatic, and recurrent osteosarcomas were mainly enriched in the go terms including "negative regulation of hydrolase activity", "regulation of peptidase activity", "regulation of binding", "negative regulation of proteolysis", and "negative regulation of peptidase activity" and in the kegg pathways including "transcriptional misregulation in cancer", "cellular senescence", "apoptosis", "foxo signaling pathway", "cell cycle", "nf-kappa b signaling pathway", "p53 signaling pathway", "pentose phosphate pathway", and "protein export". |
2022-05-06 |
2023-08-13 |
Not clear |
| Chunhong Zhang, Jia Liu, Fengxing Tao, Yiyi Lu, Qin He, Liang Zhao, Rongying Ou, Yunsheng Xu, Wenfeng L. Retracted Article: The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction. RSC advances. vol 9. issue 21. 2022-05-06. PMID:35516982. |
in the mechanism, gambogic acid promoted nuclear export of tr3, resulting in up-regulation of p53, which leads to the decrease of mitochondrial membrane potential, eventually inducing apoptosis. |
2022-05-06 |
2023-08-13 |
Not clear |
| Wei Yue, Jihong Ma, Yinan Xiao, Pan Wang, Xiaoyang Gu, Bingteng Xie, Mo L. The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP. Frontiers in cell and developmental biology. vol 10. 2022-05-06. PMID:35517499. |
however, the apoptosis is resisted in brca1-deficient cancer cells even though their p53 is proficient. |
2022-05-06 |
2023-08-13 |
Not clear |
| Wei Yue, Jihong Ma, Yinan Xiao, Pan Wang, Xiaoyang Gu, Bingteng Xie, Mo L. The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP. Frontiers in cell and developmental biology. vol 10. 2022-05-06. PMID:35517499. |
the elevated camp not only inhibited dna damage-induced apoptosis through abrogating p53 accumulation, but also suppressed the proliferation of cytotoxic t lymphocytes by enhancing the expression of immunosuppressive factors dkk1. |
2022-05-06 |
2023-08-13 |
Not clear |