| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ibrahim Bozgeyik, Mehtap Koparal, Bilal Ege, Esra Bozgeyik, Muhammed Yusuf Kurt, Onur Ceyla. Deciphering miRNAs associated with cellular stress response and apoptosis mechanisms regulated by p53 activity in patients with lower lip cancer. Pathology, research and practice. vol 236. 2022-06-20. PMID:35724459. |
also, defects in the cellular stress response and apoptosis mechanisms regulated by p53 activity is an important hallmark of cancer cells. |
2022-06-20 |
2023-08-14 |
Not clear |
| Ibrahim Bozgeyik, Mehtap Koparal, Bilal Ege, Esra Bozgeyik, Muhammed Yusuf Kurt, Onur Ceyla. Deciphering miRNAs associated with cellular stress response and apoptosis mechanisms regulated by p53 activity in patients with lower lip cancer. Pathology, research and practice. vol 236. 2022-06-20. PMID:35724459. |
here, we aimed to decipher mirnas associated with cellular stress response and apoptosis mechanisms regulated by p53 activity in patient with lower lip cancer and reveal the association of these mirnas with the clinical course of the disease. |
2022-06-20 |
2023-08-14 |
Not clear |
| Camilla Cristalli, Maria Cristina Manara, Sergio Valente, Evelin Pellegrini, Alberto Bavelloni, Alessandra De Feo, William Blalock, Elisabetta Di Bello, David Piñeyro, Angelika Merkel, Manel Esteller, Oscar M Tirado, Antonello Mai, Katia Scotland. Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response. Frontiers in endocrinology. vol 13. 2022-06-17. PMID:35712255. |
these effects elicited activation of p53-dependent signaling and apoptosis in p53wt cells, while in p53 mutated cells, persistent micronuclei and increased dna instability was observed. |
2022-06-17 |
2023-08-14 |
Not clear |
| Liang Chen, Liu Cao, Mengsi Zhan, Jin Li, Dayuan Wang, Régis Laurent, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Sh. Engineered Stable Bioactive Per Se Amphiphilic Phosphorus Dendron Nanomicelles as a Highly Efficient Drug Delivery System To Take Down Breast Cancer In Vivo. Biomacromolecules. 2022-06-13. PMID:35694854. |
strikingly, we show that the drug-free micelles possess good intrinsic anticancer activity and act collectively with dox to take down breast cancer cells in vitro and the xenografted tumor model in vivo through upregulation of bax, pten, and p53 proteins for enhanced cell apoptosis. |
2022-06-13 |
2023-08-14 |
Not clear |
| Yuki Makino, Hayato Hikita, Kenji Fukumoto, Ji Hyun Sung, Yoshihiro Sakano, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Jumpei Kondo, Shogo Kobayashi, Tomohide Tatsumi, Tetsuo Takehar. Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis. Cancer research. 2022-06-13. PMID:35696550. |
in cld patients, activity of hepatic p53 were positively correlated with the expression of apoptosis, sasp, hpc-associated genes and tumor incidence in the liver after biopsy. |
2022-06-13 |
2023-08-14 |
mouse |
| Yen-Chun Wang, Li-Ting Wang, Ta I Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wan. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53. Cell death discovery. vol 8. issue 1. 2022-06-10. PMID:35680784. |
severe cellular stress drives apoptosis through a dual control mechanism independently of p53. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yen-Chun Wang, Li-Ting Wang, Ta I Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wan. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53. Cell death discovery. vol 8. issue 1. 2022-06-10. PMID:35680784. |
for past two decades, p53 has been claimed as the primary sensor initiating apoptosis. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yen-Chun Wang, Li-Ting Wang, Ta I Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wan. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53. Cell death discovery. vol 8. issue 1. 2022-06-10. PMID:35680784. |
cellular stress determines the expression level of p53, and the amount of p53 corresponds to the magnitude of apoptosis. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yen-Chun Wang, Li-Ting Wang, Ta I Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wan. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53. Cell death discovery. vol 8. issue 1. 2022-06-10. PMID:35680784. |
bim counteracted with bcl-xl to activate apoptosis independently of p53 in response to doxorubicin-induced severe dna damage in prostate cancer. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yen-Chun Wang, Li-Ting Wang, Ta I Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wan. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53. Cell death discovery. vol 8. issue 1. 2022-06-10. PMID:35680784. |
moreover, the transcriptional activity of p53 was more related to cell cycle arrest other than apoptosis for responding to dna damage stress generated by doxorubicin in prostate cancer and glioblastoma. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yen-Chun Wang, Li-Ting Wang, Ta I Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wan. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53. Cell death discovery. vol 8. issue 1. 2022-06-10. PMID:35680784. |
p53 in terms of both protein level and nuclear localization in combining doxorubicin with bortezomib treatment was obviously lower than when using dox alone, inversely correlated with the magnitude of apoptosis in glioblastoma. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yen-Chun Wang, Li-Ting Wang, Ta I Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wan. Severe cellular stress drives apoptosis through a dual control mechanism independently of p53. Cell death discovery. vol 8. issue 1. 2022-06-10. PMID:35680784. |
together, this suggested that p53 might have no role in doxorubicin-induced apoptosis in prostate cancer, glioblastoma and osteosarcoma. |
2022-06-10 |
2023-08-14 |
Not clear |
| Ilan Zaffran, Nadine Landolina, Pratibha Gaur, Tihana Lenac Rovis, Jonjic Stipan, Ofer Mandelboim, Bernhard B Singer, Francesca Levi-Schaffe. Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells. Cancer gene therapy. 2022-06-10. PMID:35681020. |
furthermore, we evaluated the mab mechanism of action and found that binding of ceacam1 with ccm5.01 induced shp1 phosphorylation and p53 activation resulting in melanoma cell apoptosis. |
2022-06-10 |
2023-08-14 |
mouse |
| Meng-Ling Zhang, Qian Yang, Yan-Di Zhu, Ya-Di Zhang, Rui Zhang, Jian Liu, Xiao-Yan Zhao, Qin-Yu Dang, Dong-Xu Huang, Ming-Yuan Zhang, Yu-Chen Wei, Zhuo Hu, Xia-Xia Cai, Li-Fang Gao, Yang Shan, Huan-Ling Y. Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway. Nutrients. vol 14. issue 11. 2022-06-10. PMID:35684132. |
bewo cell lines with p53 knockdown were then constructed using lentiviral transfection, and the p53 signaling pathway was found to be essential for nob to reduce hypoxia-induced apoptosis of the bewo cell lines. |
2022-06-10 |
2023-08-14 |
rat |
| Le Zhang, Ningning Hou, Bing Chen, Chengxia Kan, Fang Han, Jingwen Zhang, Xiaodong Su. Post-Translational Modifications of p53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy. Frontiers in pharmacology. vol 13. 2022-06-10. PMID:35685623. |
the tumor suppressor p53 is a well-known cellular guardian of genomic integrity that blocks cell cycle progression or induces apoptosis upon exposure to cellular stresses. |
2022-06-10 |
2023-08-14 |
Not clear |
| Lin Yan, Shuo Gao, Jun Zhu, Jun Zho. Irf2bp2a regulates liver development via stabilizing P53 protein in zebrafish. Biochimica et biophysica acta. General subjects. 2022-06-10. PMID:35688336. |
here we take advantage of an irf2bp2a knockout line to show that the deficiency of irf2bp2a can induce apoptosis of hepatic cells through aberrant p53 activation at the early stage of embryonic development. |
2022-06-10 |
2023-08-14 |
human |
| Yoshihiro Morimoto, Atsushi Fushimi, Nami Yamashita, Masayuki Hagiwara, Atrayee Bhattacharya, Jingwei Cheng, Thomas C Frost, Rehan Ahmad, Tatsuaki Daimon, Lei Huang, Tsuyoshi Hata, Hidekazu Takahashi, Masaaki Yamamoto, Yozo Suzuki, James A DeCaprio, Donald Kuf. Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment. Oncogene. 2022-06-10. PMID:35688945. |
we show that muc1-c is also necessary for mccp and mccn cell survival by suppressing dna replication stress, the p53 pathway, and apoptosis. |
2022-06-10 |
2023-08-14 |
Not clear |
| Priti Azad, Andrew B Caldwell, Srinivasan Ramachandran, Nathanael J Spann, Ali Akbari, Francisco C Villafuerte, Daniela Bermudez, Helen Zhao, Orit Poulsen, Dan Zhou, Vineet Bafna, Shankar Subramaniam, Gabriel G Hadda. ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease. Experimental & molecular medicine. 2022-06-07. PMID:35672450. |
arid1b kd in non-cms cells led to increased proliferation and epo sensitivity by lowering p53 levels and decreasing apoptosis through gata1 mediation. |
2022-06-07 |
2023-08-14 |
human |
| Orawan Suppramote, Sunisa Prasopporn, Satinee Aroonpruksakul, Ben Ponvilawan, Jiradej Makjaroen, Monthira Suntiparpluacha, Krittiya Korphaisarn, Komgrid Charngkaew, Rawisak Chanwat, Trairak Pisitkun, Seiji Okada, Somponnat Sampattavanich, Siwanon Jirawatnota. The Acquired Vulnerability Caused by CDK4/6 Inhibition Promotes Drug Synergism Between Oxaliplatin and Palbociclib in Cholangiocarcinoma. Frontiers in oncology. vol 12. 2022-06-06. PMID:35664774. |
oxaliplatin treatment suppressed the rpl29 expression in the cdk4/6 inhibitor treated cca cells and triggered rpl5/11-mdm2-dependent p53 activation and cancer apoptosis. |
2022-06-06 |
2023-08-14 |
Not clear |
| Limei Wang, Dongjie Yin, Yanhui Fan, Ting Min, Yang Yi, Hongxun Wan. Molecular mechanism of the anti-gastric cancer activity of 1,2,3,6-tetra-O-galloyl-β-D-glucose isolated from Trapa bispinosa Roxb. shell in vitro. PloS one. vol 17. issue 6. 2022-06-02. PMID:35653387. |
transcriptome sequencing analysis showed that the differentially expressed genes were mainly enriched in the p53 signalling pathway associated with apoptosis. |
2022-06-02 |
2023-08-14 |
Not clear |