| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liangping Li, Pingping Li, Xuesong Ma, Shulan Zeng, Yan Peng, Guohai Zhan. Therapeutic restoring p53 function with small molecule for oncogene-driven non-small cell lung cancer by targeting serine 392 phosphorylation. Biochemical pharmacology. 2022-07-28. PMID:35902040. |
moreover, p53 activation raised phospho-p53 translocation to mitochondria and subsequently reorganized the bcl-xl-bak complex, thus conformationally activating bak and inducing apoptosis. |
2022-07-28 |
2023-08-14 |
Not clear |
| Qi Tang, Yanghai Zhang, Linxiu Yue, Hongying Ren, Chuanying Pa. Ssc-MiR-21-5p and Ssc-MiR-615 Regulates the Proliferation and Apoptosis of Leydig Cells by Targeting SOX5. Cells. vol 11. issue 14. 2022-07-27. PMID:35883696. |
the results showed that mir-21-5p led to a decrease in tm3 cell density and p53 (apoptosis related protein) expression. |
2022-07-27 |
2023-08-14 |
mouse |
| Shiyao Xu, Yan Xiong, Rui Yao, Rong Tian, Zhuqing Meng, Mohamed Y Zaky, Beibei Fu, Dong Guo, Lulu Wang, Feng Lin, Xiaoyuan Lin, Haibo W. A Novel ERK2 Degrader Z734 Induces Apoptosis of MCF-7 Cells via the HERC3/p53 Signaling Pathway. Molecules (Basel, Switzerland). vol 27. issue 14. 2022-07-27. PMID:35889210. |
we also observed a strong link between herc3 and p53 for the modulation of apoptosis. |
2022-07-27 |
2023-08-14 |
mouse |
| Shiyao Xu, Yan Xiong, Rui Yao, Rong Tian, Zhuqing Meng, Mohamed Y Zaky, Beibei Fu, Dong Guo, Lulu Wang, Feng Lin, Xiaoyuan Lin, Haibo W. A Novel ERK2 Degrader Z734 Induces Apoptosis of MCF-7 Cells via the HERC3/p53 Signaling Pathway. Molecules (Basel, Switzerland). vol 27. issue 14. 2022-07-27. PMID:35889210. |
in summary, our results indicated that z734 actively controls the development of breast cancer through apoptosis, and herc3 may mediate erk2 and p53 signaling, which offers new potential targets for clinical therapy. |
2022-07-27 |
2023-08-14 |
mouse |
| Yuying Cui, Yu Wen, Chao Lv, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wan. Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway. Molecular medicine reports. vol 26. issue 3. 2022-07-27. PMID:35894142. |
decreased rna‑binding protein igf2bp2 downregulates nt5dc2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large b‑cell lymphoma cells by regulating the p53 signaling pathway. |
2022-07-27 |
2023-08-14 |
Not clear |
| Yuying Cui, Yu Wen, Chao Lv, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wan. Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway. Molecular medicine reports. vol 26. issue 3. 2022-07-27. PMID:35894142. |
the present study aimed to determine whether downregulation of igf2bp2 and nt5dc2 suppresses cell proliferation, and induces cell cycle arrest and apoptosis in dlbcl cells by regulating the p53 signaling pathway. |
2022-07-27 |
2023-08-14 |
Not clear |
| Yuying Cui, Yu Wen, Chao Lv, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wan. Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway. Molecular medicine reports. vol 26. issue 3. 2022-07-27. PMID:35894142. |
the expression levels of apoptosis, cell cycle and p53 pathway‑associated proteins were determined by western blotting. |
2022-07-27 |
2023-08-14 |
Not clear |
| Yuying Cui, Yu Wen, Chao Lv, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wan. Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway. Molecular medicine reports. vol 26. issue 3. 2022-07-27. PMID:35894142. |
in conclusion, knockdown of nt5dc2 suppressed cell viability and proliferation, induced cell cycle arrest and promoted apoptosis in dlbcl cells by regulating the p53 signaling pathway and these effects were reversed by upregulation of igf2bp2. |
2022-07-27 |
2023-08-14 |
Not clear |
| Amanda B Kagan, Nicole M Anders, Avelina Hemingway, Eudocia Q Lee, Kevin R Kelly, Hans C Lee, Meng Xu-Welliver, Richard Piekarz, Michelle A Rude. Quantitation of navtemadlin in human plasma and brain tissue by liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2022-07-27. PMID:35895384. |
navtemadlin is an orally bioavailable small molecule that blocks the protein-protein interaction between mdm2 and the tumor suppressor protein p53, leading to p53-mediated cell cycle arrest and apoptosis. |
2022-07-27 |
2023-08-14 |
human |
| Yanli Chen, Ling Su. Inhibition of NEDD8 NEDDylation induced apoptosis in acute myeloid leukemia cells via p53 signaling pathway. Bioscience reports. 2022-07-26. PMID:35880551. |
inhibition of nedd8 neddylation induced apoptosis in acute myeloid leukemia cells via p53 signaling pathway. |
2022-07-26 |
2023-08-14 |
Not clear |
| Yizhu Mao, Qian Zhou, Jinhua Wang, Ruihuan Zhao, Xuefei Yang, Ya Shi, Jinyao Yin, Chenglan Jiang, Yuefeng H. CircP50 functions through the phosphorylation- and acetylation-activated p53 pathway to mediate inorganic arsenic-induced apoptosis in A549 cells. Environmental science and pollution research international. 2022-07-26. PMID:35881289. |
circp50 functions through the phosphorylation- and acetylation-activated p53 pathway to mediate inorganic arsenic-induced apoptosis in a549 cells. |
2022-07-26 |
2023-08-14 |
Not clear |
| Jialin Ming, Muhammad Zeeshan Bhatti, Amjad Ali, Zeqing Zhang, Na Wang, Aisha Mohyuddin, Jiwu Chen, Yongmin Zhang, Faiz-Ur Rahma. Vitamin B6 based Pt(II) complexes: Biomolecule derived potential cytotoxic agents for thyroid cancer. Metallomics : integrated biometal science. 2022-07-25. PMID:35876659. |
these results suggest that these complexes inhibit the growth of ftc cells and induce apoptosis through p53 signaling. |
2022-07-25 |
2023-08-14 |
Not clear |
| Yue Zhan, Xiaolei Zhou, Sylvain Peuget, Madhurendra Singh, Brian D Peyser, Zhimin Fan, Galina Selivanov. Decreased DNA damage and improved p53 specificity of RITA analogs. Molecular cancer therapeutics. 2022-07-25. PMID:35877475. |
a potent p53 reactivating molecule rita, which triggers p53-dependent apoptosis in human tumor cells in vitro and in vivo, exhibit p53-independent cytotoxicity due to modifications by detoxification enzyme sulfotransferase 1a1 (sult1a1), producing a reactive carbocation. |
2022-07-25 |
2023-08-14 |
human |
| Greta Mucignat, Irene Bassan, Mery Giantin, Marianna Pauletto, Anisa Bardhi, Silvia Iori, Rosa Maria Lopparelli, Andrea Barbarossa, Anna Zaghini, Enrico Novelli, Mauro Dacast. Does Bentonite Cause Cytotoxic and Whole-Transcriptomic Adverse Effects in Enterocytes When Used to Reduce Aflatoxin B1 Exposure? Toxins. vol 14. issue 7. 2022-07-25. PMID:35878173. |
the most interesting afb1-targeted pathways for which ben was effective were cell integrity, xenobiotic metabolism and transporters, basal metabolism, inflammation and immune response, p53 biological network, apoptosis and carcinogenesis. |
2022-07-25 |
2023-08-14 |
Not clear |
| Long Ma, Taohua Liu, Yingying Lu, Yanan Dong, Xia Zhao, Shuli Ma. A natural halogenated fluoride adenosine analog 5'-fluorodeoxy adenosine induced anticolon cancer activity in vivo and in vitro. Environmental toxicology. 2022-07-22. PMID:35866996. |
it was found that 5'-fda remarkably increased the protein levels of caspase 3 and cleaved-caspase 9 and decreased cyclin a2 and cdk2 via the regulation of p53 signaling pathway, and increased the protein levels of caspase 8 and cleaved-caspase 8 which participated in apoptosis pathway. |
2022-07-22 |
2023-08-14 |
mouse |
| A-Rum Yoon, Renu Wadhwa, Sunil C Kaul, Chae-Ok Yu. Why is Mortalin a Potential Therapeutic Target for Cancer? Frontiers in cell and developmental biology. vol 10. 2022-07-21. PMID:35859897. |
it is enriched in several types of cancer and contributes to carcinogenesis in various ways, including inactivation of the tumor suppressor p53, deregulation of apoptosis, induction of epithelial-mesenchymal transition, and enhancement of cancer stemness. |
2022-07-21 |
2023-08-14 |
Not clear |
| Koichi Yamamura, Masafumi Nojiri, Kazuaki Nishiki, Ryo Kato, Shohei Shinomiya, Yutaka Takahara, Taku Oikawa, Takeshi Ishizaki, Hirohisa Toga, Shiro Mizun. Serum Derivatives of Reactive Oxygen Metabolites are Associated with Severity of Chronic Obstructive Pulmonary Disease and Affected by a p53 Gene Polymorphism. International journal of chronic obstructive pulmonary disease. vol 17. 2022-07-20. PMID:35854898. |
oxidative stress is known to activate tumor suppressor p53, which inhibits cell cycle progression and induces apoptosis. |
2022-07-20 |
2023-08-14 |
Not clear |
| Yei-Jin Kang, Won-Geun Yang, Weon-Sik Chae, Dae-Won Kim, Seong-Gon Kim, Horatiu Rotar. Administration of 4‑hexylresorcinol increases p53‑mediated transcriptional activity in oral cancer cells with the p53 mutation. Oncology reports. vol 48. issue 3. 2022-07-20. PMID:35856441. |
to determine the effect of 4hr on p53 mutant carcinoma cells, western blot analysis, p53 transcriptional activity analysis, mtt assay and apoptosis immunocytochemistry were performed. |
2022-07-20 |
2023-08-14 |
human |
| Liang Chengcheng, Sayed Haidar Abbas Raza, Yu Shengchen, Zuhair M Mohammedsaleh, Abdullah F Shater, Fayez M Saleh, Muna O Alamoudi, Bandar H Aloufi, Ahmed Mohajja Alshammari, Nicola M Schreurs, Linsen Za. Bioinformatics role of the WGCNA analysis and co-expression network identifies of prognostic marker in lung cancer. Saudi journal of biological sciences. vol 29. issue 5. 2022-07-18. PMID:35844396. |
we screened the 200 genes with the highest correlation in the cyan module for functional enrichment analysis and protein interaction network construction, found that most of them focused on cell division, tumor necrosis factor-mediated signaling pathways, cellular redox homeostasis, reactive oxygen species biosynthesis, and other processes, and were related to the cell cycle, apoptosis, hif-1 signaling pathway, p53 signaling pathway, nf-κb signaling pathway, and several cancer disease pathways are involved. |
2022-07-18 |
2023-08-14 |
human |
| Jogendra S Pawar, Saad Mustafa, Ilora Ghos. Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells. Saudi journal of biological sciences. vol 29. issue 5. 2022-07-18. PMID:35844432. |
chrysin and capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in cervical cancer cells. |
2022-07-18 |
2023-08-14 |
human |