| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steffen Hanselmann, Dörthe Gertzmann, Woo Jin Shin, Carsten P Ade, Stefan Gaubat. Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus. Cell cycle (Georgetown, Tex.). 2022-09-22. PMID:36135961. |
activation of p53 by prc1 results in cellular senescence but not in apoptosis. |
2022-09-22 |
2023-08-14 |
Not clear |
| Tianmeng Zhang, Zhuhua Dong, Feixue Liu, Enzhuang Pan, Nana He, Fenfen Ma, Xinyu Wu, Yan Wang, Jingquan Don. Non-target toxic effects of avermectin on carp spleen involve oxidative stress, inflammation, and apoptosis. Pesticide biochemistry and physiology. vol 187. 2022-09-20. PMID:36127050. |
in addition, tunel detected that the apoptosis rate increased significantly with the increase of avermectin dosage, and the transcription levels of apoptosis-related genes bax, p53, and caspase 3/9 also increased in a dose-dependent manner. |
2022-09-20 |
2023-08-14 |
cat |
| Chandrakant Bagul, Garikapati Koteswara Rao, Immadi Veena, Ravindra Kulkarni, Jaki R Tamboli, Ravikumar Akunuri, Siddiq Pasha Shaik, Manika Pal-Bhadra, Ahmed Kama. Benzimidazole-linked pyrazolo[1,5-a]pyrimidine conjugates: synthesis and detail evaluation as potential anticancer agents. Molecular diversity. 2022-09-17. PMID:36114912. |
western blot analysis demonstrated an elevated level of apoptotic proteins such as p53, p21, bax, whereas a decrease in the antiapoptotic protein bcl-2 and procaspase-9, confirming the ability of these conjugates to trigger cell death by apoptosis. |
2022-09-17 |
2023-08-14 |
Not clear |
| Lijun Mo, Bijia Su, Lili Xu, Zhiming Hu, Hongwei Li, Hongyan Du, Jinlong L. MCM7 supports the stemness of bladder cancer stem-like cells by enhancing autophagic flux. iScience. vol 25. issue 9. 2022-09-16. PMID:36111256. |
ampk activation can trigger switch from autophagy to apoptosis, through increasing bcl2/beclin1 interaction and inducing p53 accumulation. |
2022-09-16 |
2023-08-14 |
Not clear |
| Weifeng Gao, Zhen Yuan, Xuanzhu Zhao, Shuyuan Wang, Sizhen Lai, Kemin Ni, Yixiang Zhan, Zhaoce Liu, Lina Liu, Ran Xin, Xin Yin, Xingyu Zhou, Xinyu Liu, Xipeng Zhang, Qinghuai Zhang, Guoxun Li, Wenhong Wang, Chunze Zhan. The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumours: a meta-analysis and TCGA data review. Expert review of molecular diagnostics. 2022-09-16. PMID:36111690. |
the prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumours: a meta-analysis and tcga data review. |
2022-09-16 |
2023-08-14 |
human |
| Weifeng Gao, Zhen Yuan, Xuanzhu Zhao, Shuyuan Wang, Sizhen Lai, Kemin Ni, Yixiang Zhan, Zhaoce Liu, Lina Liu, Ran Xin, Xin Yin, Xingyu Zhou, Xinyu Liu, Xipeng Zhang, Qinghuai Zhang, Guoxun Li, Wenhong Wang, Chunze Zhan. The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumours: a meta-analysis and TCGA data review. Expert review of molecular diagnostics. 2022-09-16. PMID:36111690. |
previous studies have reported the prognostic value of p53 upregulated modulator of apoptosis (puma) in numerous human tumours, but the conclusions have not been consistent. |
2022-09-16 |
2023-08-14 |
human |
| Felix Oppel, Senyao Shao, Sarah Gendreizig, Mark W Zimmerman, Matthias Schürmann, Flavian Viyof Ful, Peter Goon, Susan N Chi, Jon C Aster, Holger Sudhoff, A Thomas Loo. p53 pathway inactivation drives SMARCB1-deficient p53-wildtype epithelioid sarcoma onset indicating therapeutic vulnerability through MDM2 inhibition. Molecular cancer therapeutics. 2022-09-13. PMID:36099437. |
to leverage this possibility for the treatment of human epithelioid sarcoma, we tested small molecule-mediated disruption of the p53-mdm2 interaction, which stabilized p53 protein leading to p53-pathway reactivation, cell cycle arrest and increased apoptosis. |
2022-09-13 |
2023-08-14 |
human |
| Marina Francis, Anis Ahmad, Larry Bodgi, Patrick Azzam, Tarek Youssef, Alaa Abou Daher, Assaad A Eid, Alessia Fornoni, Alan Pollack, Brian Marples, Youssef H Zeida. SMPDL3b modulates radiation-induced DNA damage response in renal podocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 10. 2022-09-12. PMID:36094323. |
oe podocytes were protected against radiation-induced apoptosis by increasing the phosphorylation of p53 at serine 15 and attenuating subsequent caspase-3 cleavage. |
2022-09-12 |
2023-08-14 |
mouse |
| Mamata Singh, Virendra Singh, Tushar S Basu Baul, Biplob Koc. TPGS loaded triphenyltin (IV) micelles induced apoptosis by upregulating p53 in breast cancer cells and inhibit tumor progression in T-cell lymphoma bearing mice. Life sciences. 2022-09-11. PMID:36088999. |
tpgs loaded triphenyltin (iv) micelles induced apoptosis by upregulating p53 in breast cancer cells and inhibit tumor progression in t-cell lymphoma bearing mice. |
2022-09-11 |
2023-08-14 |
mouse |
| Shiping Yang, Junliang Luo, Yongxiong Huang, Yunhao Yuan, Shuanghu Ca. Effect of sub-lethal ammonia and nitrite stress on autophagy and apoptosis in hepatopancreas of Pacific whiteleg shrimp Litopenaeusvannamei. Fish & shellfish immunology. 2022-09-11. PMID:36089224. |
the results showed that ammonia stress could induce up-regulated of autophagy (atg3, atg4, atg10 and atg12) and apoptosis (caspase3and p53) genes transcription. |
2022-09-11 |
2023-08-14 |
Not clear |
| Gul-E-Saba Chaudhry, Abdah Md Akim, Yeong Yik Sung, Tengku Sifzizul Tengku Muhamma. Cancer and Apoptosis. Methods in molecular biology (Clifton, N.J.). vol 2543. 2022-09-10. PMID:36087269. |
the dysregulatory or inactivated apoptosis mechanism involve bcl-2 family proteins which include both pro-apoptotic members downregulation and anti-apoptotic upregulation, various inhibitors of apoptosis as inhibitory proteins (iaps), cell cycle dysregulation, dysregulatory repair system, cell progression pathway activation of nf-κb, tumor suppressor (p53) regulation, and death receptors (drs) of the extrinsic pathway. |
2022-09-10 |
2023-08-14 |
Not clear |
| Judith Lind, Roland Hellinger, Petra Kudweis, Herwig P Moll, Jasmin Gattringer, Kathrin Thell, Sophie Edtmayer, Christian W Gruber, Dagmar Stoiber, Karoline Kollman. The nature inspired peptide [T20K]-kalata B1 induces anti-tumor effects in anaplastic large cell lymphoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076504. |
t20k, as a prototype drug candidate, induces apoptosis and a proliferation arrest in human lymphoma t-cell lines (sr786, mac-2a and the jurkat e6.1) in a concentration dependent fashion, at least partially via increased stat5 and p53 signaling. |
2022-09-09 |
2023-08-14 |
mouse |
| Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzaw. The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077459. |
in this study, we investigated the function of lkb1 in ddr induced by cisplatin, a representative dna-damaging agent, and found that lkb1 stabilizes and activates p53 through the c-jun n-terminal kinase (jnk) pathway, which promotes cisplatin-induced apoptosis in human fibrosarcoma cell line ht1080. |
2022-09-09 |
2023-08-14 |
human |
| Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzaw. The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077459. |
on the other hand, we found that ampkα1 and α2 double knockout (dko) cells showed enhanced stabilization of p53 and increased susceptibility to apoptosis induced by cisplatin, suggesting that ampk negatively regulates cisplatin-induced apoptosis. |
2022-09-09 |
2023-08-14 |
human |
| Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzaw. The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077459. |
moreover, the additional stabilization of p53 and subsequent apoptosis in ampk dko cells were clearly canceled by the treatment with the antioxidants, raising the possibility that ampk suppresses the p53 activation mediated by oxidative stress. |
2022-09-09 |
2023-08-14 |
human |
| Margarita L Martinez-Fierro, Idalia Garza-Veloz, Maria Eugenia Castañeda-Lopez, Dorothy Wasike, Claudia Castruita-De la Rosa, Iram Pablo Rodriguez-Sanchez, Ivan Delgado-Enciso, Jose Flores-Mendoz. Evaluation of the Effect of the Fibroblast Growth Factor Type 2 (FGF-2) Administration on Placental Gene Expression in a Murine Model of Preeclampsia Induced by L-NAME. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077527. |
in this study, we aimed to determine the effect of fgf2 administration on the placental gene expression of the vascular endothelial growth factor (vegfa), vegf receptor 2 (vegfr2), placental growth factor, endoglin (eng), superoxide dismutase 1 (sod1), catalase (cat), thioredoxin (txn), tumor protein p53 (p53), bcl2 apoptosis regulator, fas cell surface death receptor (fas), and caspase 3, in a sprague dawley rat pe model, which was induced by l-name. |
2022-09-09 |
2023-08-14 |
rat |
| Jonghae Lee, Hannah Savage, Shinji Maegawa, Riccardo Ballarò, Sumedha Pareek, Bella Samia Guerrouahen, Vidya Gopalakrishnan, Keri Schadle. Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model. Cancers. vol 14. issue 17. 2022-09-09. PMID:36077841. |
a reverse-phase protein array was used to identify canonical p53 apoptotic signaling as a key pathway upregulated by exercise, and we demonstrate increased apoptosis in tumors from exercised mice. |
2022-09-09 |
2023-08-14 |
mouse |
| Yuanzheng Yang, Zhanglong Peng, Elsa R Flores, Eugenie S Kleinerma. Pramlintide: A Novel Therapeutic Approach for Osteosarcoma through Metabolic Reprogramming. Cancers. vol 14. issue 17. 2022-09-09. PMID:36077845. |
here, we showed that osteosarcoma cells have altered p63, p73, and p53, and decreased iapp expression but have the two main iapp receptors, calcr and ramp3, which inhibit glycolysis and induce apoptosis. |
2022-09-09 |
2023-08-14 |
mouse |
| Yu-Ling Wu, Jui-Chih Chang, Hai-Lun Sun, Wen-Ling Cheng, Yu-Pei Yen, Yong-Shiou Lin, Yi-Chun Chao, Ko-Hung Liu, Ching-Shan Huang, Kai-Li Liu, Chin-San Li. Coenzyme Q10 Supplementation Increases Removal of the Nutrients. vol 14. issue 17. 2022-09-09. PMID:36079853. |
the increased survival of purkinje cells was reflected by the reduced abundance of tunel-positive nuclei and apoptosis markers of activated p53, as well as lower levels of cleaved caspase 3 and cleaved poly-adp-ribose polymerase. |
2022-09-09 |
2023-08-14 |
mouse |
| Ke Ding, Youhua He, Jinfen Wei, Shuying Fu, Jiajian Wang, Zixi Chen, Haibo Zhang, Yimo Qu, Keying Liang, Xiaocheng Gong, Li Qiu, Dong Chen, Botao Xiao, Hongli D. A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer. Frontiers in immunology. vol 13. 2022-09-09. PMID:36081518. |
this study points out that the tr-ddr score generally has positive correlations with patients of advanced-stage, genome-instability, and cell proliferation signature, while negative correlations with inflammatory response, apoptosis, and p53 pathway signature. |
2022-09-09 |
2023-08-14 |
Not clear |