| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria-Anna Kyrgiafini, Theologia Sarafidou, Zissis Mamuri. The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis. Biology. vol 11. issue 10. 2022-10-27. PMID:36290414. |
however, pathways involved in general in tumorigenesis and cancer development of all types, such as p53 pathways, apoptosis, and cell death, were also enriched, indicating a link between cancer and male infertility. |
2022-10-27 |
2023-08-14 |
human |
| E G Novoselova, O V Glushkova, M G Sharapov, M O Khrenov, S B Parfenyuk, S M Lunin, T V Novoselova, A K Mubarakshina, R G Goncharov, E E Fesenk. Geldanamycin Enhances the Radioprotective Effect of Peroxyredoxin 6 in Irradiated 3T3 Fibroblasts. Doklady. Biochemistry and biophysics. vol 506. issue 1. 2022-10-27. PMID:36303052. |
another transcription factor, p53, which is an indicator of the level of cell apoptosis and increases upon irradiation, is also reduced by s32a in combination with ga. |
2022-10-27 |
2023-08-14 |
Not clear |
| Rao Yu, Hao Zhang, Rong Wang, Lin Xia. Low expression of MYCN promotes cisplatin resistance by suppressing cisplatin-induced apoptosis in epithelial ovarian cancer. Oncology letters. vol 24. issue 6. 2022-10-26. PMID:36284653. |
mycn enriched the apoptosis and p53 signaling pathways in hallmark gene sets. |
2022-10-26 |
2023-08-14 |
Not clear |
| Bashir Ahmad Malla, Aarif Ali, Irfan Maqbool, Nazir Ahmad Dar, Sheikh Bilal Ahmad, Rana M Alsaffar, Muneeb U Rehma. Insights into molecular docking and dynamics to reveal therapeutic potential of natural compounds against P53 protein. Journal of biomolecular structure & dynamics. 2022-10-25. PMID:36281711. |
p53 is eminent tumour suppressor protein that plays a prominent role in cell cycle arrest, dna repair, senescence, differentiation and initiation of apoptosis. |
2022-10-25 |
2023-08-14 |
Not clear |
| Parvin Ghasemi, Gholamreza Shafiee, Nasrin Ziamajidi, Roghayeh Abbasalipourkabi. Copper Nanoparticles Induce Apoptosis and Oxidative Stress in SW480 Human Colon Cancer Cell Line. Biological trace element research. 2022-10-24. PMID:36274109. |
to investigate the effect of nps on cellular apoptosis, hoechst33258 staining was performed, and the expression of bax, bcl-2, and p53 was evaluated by qrt-pcr. |
2022-10-24 |
2023-08-14 |
human |
| Suryaa Manoharan, Ekambaram Peruma. Potential role of Marine Bioactive Compounds targeting signaling pathways in cancer: A review. European journal of pharmacology. 2022-10-20. PMID:36265609. |
as a result, we concluded that pi3k/akt, ros, and p53 are the three major signaling pathways targeted by the mbcs to induce apoptosis in cancer cells and these pathways are predominantly observed in classes like carbohydrates, peptides, and terpenes. |
2022-10-20 |
2023-08-14 |
Not clear |
| Zhi Wei, Jianfeng Gan, Xuan Feng, Mo Zhang, Zhixian Chen, Hongbo Zhao, Yan D. APOBEC3B is overexpressed in cervical cancer and promotes the proliferation of cervical cancer cells through apoptosis, cell cycle, and p53 pathway. Frontiers in oncology. vol 12. 2022-10-17. PMID:36249021. |
apobec3b is overexpressed in cervical cancer and promotes the proliferation of cervical cancer cells through apoptosis, cell cycle, and p53 pathway. |
2022-10-17 |
2023-08-14 |
Not clear |
| Awik Puji Dyah Nurhayati, Andis Rihandoko, Arif Fadlan, Shabrina Syifa Ghaissani, Nurul Jadid, Edwin Setiawa. Anti-cancer potency by induced apoptosis by molecular docking P53, caspase, cyclin D1, cytotoxicity analysis and phagocytosis activity of trisindoline 1,3 and 4. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 9. 2022-10-17. PMID:36249936. |
anti-cancer potency by induced apoptosis by molecular docking p53, caspase, cyclin d1, cytotoxicity analysis and phagocytosis activity of trisindoline 1,3 and 4. |
2022-10-17 |
2023-08-14 |
Not clear |
| Swati Dahariya, Sanjeev Raghuwanshi, Vasanth Thamodaran, Shaji R Velayudhan, Ravi Kumar Gutt. The Journal of pharmacology and experimental therapeutics. 2022-10-15. PMID:36243404. |
thus, the interaction between hotairm1, p53 and mir-125b is likely involved in controlling cell cycling (cyclin d1), ros production, and apoptosis to support terminal maturation of mks. |
2022-10-15 |
2023-08-14 |
human |
| Gouranga Saha, Sibani Sarkar, Partha S Mohanta, Krishna Kumar, Saikat Chakrabarti, Malini Basu, Mrinal K Ghos. USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma. Oncogene. 2022-10-15. PMID:36243803. |
the induction of apoptosis upon usp7 inhibition is well established in cancer containing wild type p53, which operates through the 'usp7-mdm2-p53' axis. |
2022-10-15 |
2023-08-14 |
Not clear |
| Gouranga Saha, Sibani Sarkar, Partha S Mohanta, Krishna Kumar, Saikat Chakrabarti, Malini Basu, Mrinal K Ghos. USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma. Oncogene. 2022-10-15. PMID:36243803. |
however, in cancers without functional p53, usp7-dependent apoptosis is induced through many other alternative pathways. |
2022-10-15 |
2023-08-14 |
Not clear |
| Gouranga Saha, Sibani Sarkar, Partha S Mohanta, Krishna Kumar, Saikat Chakrabarti, Malini Basu, Mrinal K Ghos. USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma. Oncogene. 2022-10-15. PMID:36243803. |
here, we have identified another critical p53 independent path active under usp7 to regulate apoptosis. |
2022-10-15 |
2023-08-14 |
Not clear |
| André T S Vicente, Jorge A R Salvado. MDM2-Based Proteolysis-Targeting Chimeras (PROTACs): An Innovative Drug Strategy for Cancer Treatment. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232374. |
the incorporation of ligands that recruit mouse double minute 2 (mdm2) into protacs, forming the so-called mdm2-based protacs, has shown promise in cancer treatment due to its dual mechanism of action: a protac that recruits mdm2 prevents its binding to p53, resulting not only in the degradation of poi but also in the increase of intracellular levels of the p53 suppressor, with the activation of a whole set of biological processes, such as cell cycle arrest or apoptosis. |
2022-10-14 |
2023-08-14 |
mouse |
| Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockia. Dysregulation of miRISC Regulatory Network Promotes Hepatocellular Carcinoma by Targeting PI3K/Akt Signaling Pathway. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232606. |
the mir-221/aeg-1 axis silencing induces apoptosis and g2/m phase arrest and inhibits cellular proliferation and angiogenesis by upregulating p57, p53, rb, and pten and downregulating lsf, lc3a, bcl-2, opn, mmp9, pi3k, and akt in hcc cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Mowaffaq Adam Ahmed Adam, Laina Zarisa Muhd Kamal, Mahibub Kanakal, Dinesh Babu, Saad Sabbar Dahham, Yasser Tabana, Bronwyn Lok, Brittany M Bermoy, Muhammad Amir Yunus, Leslie Thian Lung Than, Khaled Barakat, Doblin Sanda. The Effect of Aflatoxin B1 on Tumor-Related Genes and Phenotypic Characters of MCF7 and MCF10A Cells. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233156. |
we hypothesized that, even at low concentrations, ab1 can cause changes in the expression of important genes involved in four pathways, i.e., p53, cancer, cell cycle, and apoptosis. |
2022-10-14 |
2023-08-14 |
Not clear |
| Monika Kadela-Tomanek, Maria Jastrzębska, Elwira Chrobak, Ewa Bębenek, Małgorzata Latoch. Hybrids of 1,4-Quinone with Quinoline Derivatives: Synthesis, Biological Activity, and Molecular Docking with DT-Diaphorase (NQO1). Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36234741. |
selected hybrids were tested for the transcriptional activity of the gene encoding a proliferation marker (h3 histone), cell cycle regulators (p53 and p21) and the apoptosis pathway (bcl-2 and bax). |
2022-10-14 |
2023-08-14 |
human |
| Chien-I Lin, Zan-Chu Chen, Chien-Hung Chen, Yun-Hsuan Chang, Tsai-Chia Lee, Tsai-Tai Tang, Tzu-Wei Yu, Chih-Man Yang, Ming-Chang Tsai, Chi-Chou Huang, Tzu-Wei Yang, Chun-Che Lin, Rou-Hsin Wang, Guang-Yuh Chiou, Yuh-Jyh Jong, Jui-I Cha. Co-inhibition of Aurora A and Haspin kinases enhances survivin blockage and p53 induction for mitotic catastrophe and apoptosis in human colorectal cancer. Biochemical pharmacology. 2022-10-14. PMID:36241092. |
co-inhibition of aurora a and haspin kinases enhances survivin blockage and p53 induction for mitotic catastrophe and apoptosis in human colorectal cancer. |
2022-10-14 |
2023-08-14 |
mouse |
| Chien-I Lin, Zan-Chu Chen, Chien-Hung Chen, Yun-Hsuan Chang, Tsai-Chia Lee, Tsai-Tai Tang, Tzu-Wei Yu, Chih-Man Yang, Ming-Chang Tsai, Chi-Chou Huang, Tzu-Wei Yang, Chun-Che Lin, Rou-Hsin Wang, Guang-Yuh Chiou, Yuh-Jyh Jong, Jui-I Cha. Co-inhibition of Aurora A and Haspin kinases enhances survivin blockage and p53 induction for mitotic catastrophe and apoptosis in human colorectal cancer. Biochemical pharmacology. 2022-10-14. PMID:36241092. |
taken together, co-inhibition of aurora a and haspin enhances survivin inhibition, p53 pathway induction, mitotic catastrophe, apoptosis and tumor inhibition that may provide a potential strategy for crc therapy. |
2022-10-14 |
2023-08-14 |
mouse |
| Ying Wang, Haixu Chen, Junwei Wang, Xin Chen, Lan Che. Exploring the mechanism of Buyang Huanwu Decoction in the treatment of spinal cord injury based on network pharmacology and molecular docking. Medicine. vol 101. issue 40. 2022-10-12. PMID:36221378. |
buyang huanwu decoction cures spinal cord injury primarily by moderating immunological inflammation, apoptosis, and oxidative stress, which involves the cancer pathway, the hif-1 signaling pathway, the p53 signaling pathway, the mapk signaling pathway, and so on. |
2022-10-12 |
2023-08-14 |
Not clear |
| Erkin Aydin, Aysun Cebeci, Ayça Lekesizca. Prevention of cisplatin-induced nephrotoxicity by kidney-targeted sirna delivery. International journal of pharmaceutics. 2022-10-09. PMID:36209978. |
the nanoparticlescontainedsirna against cationic membrane transport (oct1&2) and apoptosis related proteins (p53, pkcδ, and γgt). |
2022-10-09 |
2023-08-14 |
mouse |