| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingang Xu, Yi Liu, Jie Gao, Xiaojie Shi, Yuchao Yan, Naling Yang, Quanqiong Wang, Qi Zhan. GRAMD4 regulates PEDV-induced cell apoptosis inhibiting virus replication via the endoplasmic reticulum stress pathway. Veterinary microbiology. vol 279. 2023-02-04. PMID:36738512. |
glucosyltransferase rab-like gtpase activator and myotubularin domain containing 4 (gramd4) is a proapoptotic protein, which replaced p53 inducing mitochondrial apoptosis. |
2023-02-04 |
2023-08-14 |
Not clear |
| Xiaoran Guan, Wuquan Li, Yong Wang, Qun Zhao, Xinru Yu, Jing Jiang, Weihua Bian, Cong Xu, Yeying Sun, Chunxiang Zhan. The mechanism of rh-endostatin-induced cardiotoxicity and its protection by dihydromyricetin[in vivo/in vitro, C57BL/6 mice, AC16 and hiPSC-CMs]. Toxicology letters. 2023-02-04. PMID:36739041. |
the results revealed that rh-endostatin dose-dependently enhanced cardiomyocyte apoptosis through apaf-1 apoptotic factor and apoptosis-related proteins such as p53. |
2023-02-04 |
2023-08-14 |
mouse |
| Clare M Adams, Ramkrishna Mitra, Youcai Xiao, Peter Michener, Juan Palazzo, Allen Chao, Jitendra Gour, Joel Cassel, Joseph M Salvino, Christine M Eische. Targeted MDM2 degradation reveals a new vulnerability for p53 inactivated triple negative breast cancer. Cancer discovery. 2023-02-03. PMID:36734633. |
mdm2 loss in p53 mutant/deleted tnbc cells in 2d/3d culture and tnbc patient explants, including relapsed tumors, causes apoptosis, while sparing normal cells. |
2023-02-03 |
2023-08-14 |
mouse |
| Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M Balaramnavar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Gaurav Gupta, Madan Mohan Gupt. Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 42. issue 1. 2023-02-03. PMID:36734954. |
they can synergistically inhibit cancer cell growth through p53 apoptosis in mcf-7 breast cancer cell lines. |
2023-02-03 |
2023-08-14 |
Not clear |
| Mohamed A Tantawy, Aziza B Shalby, Ibrhim El-Bernawy, Shahad W Kattan, Ahmed A Abd-Rabou, Gamal A Elmegee. Anti-cancer Activity, and Molecular Docking of Novel Hybrid Heterocyclic Steroids Revealed Promising Anti-hepatocellular Carcinoma Agent: Implication of Cyclin Dependent kinase-2 Pathway. Steroids. 2023-02-03. PMID:36736802. |
moreover, compound 7 induced apoptosis via upregulating the expression of caspase-3, -8, -9, p53, bax and inhibiting the expression of bcl2, and cdk2 genes. |
2023-02-03 |
2023-08-14 |
human |
| b' Zhijia Wang, Monika Ma\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa1, Andrii Bugai, Sergey G Kuznetsov, Antti Hassinen, Tina Lenasi, Swapnil Potdar, Caroline C Friedel, Matja\\xc5\\xbe Barbori\\xc4\\x8. P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway. Nucleic acids research. 2023-02-02. PMID:36727434.' |
p-tefb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway. |
2023-02-02 |
2023-08-14 |
mouse |
| Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hs. Amentoflavone induces caspase-dependent/-independent apoptosis and dysregulates cyclin-dependent kinase-mediated cell cycle in colorectal cancer in vitro and in vivo. Environmental toxicology. 2023-02-02. PMID:36727907. |
importantly, the apoptosis induction of amentoflavone is not affected by the activity of p53 in crc. |
2023-02-02 |
2023-08-14 |
Not clear |
| Zi-Jian Xu, Meng Liu, Qin-Jian Niu, Yu-Xuan Huang, Ling Zhao, Xin Gen Lei, Lv-Hui Su. Both selenium deficiency and excess impair male reproductive system via inducing oxidative stress-activated PI3K/AKT-mediated apoptosis and cell proliferation signaling in testis of mice. Free radical biology & medicine. 2023-02-02. PMID:36731804. |
moreover, western blotting analysis revealed that sed and see dysregulated pi3k-akt-mediated apoptosis and cell proliferation signaling, including upregulating (p < 0.05) caspase 3, cleaved-caspase 3, bcl-2 and (or) p53 and downregulating (p < 0.05) pi3k, p-akt, p-mtor, 4e-bp1, p-4e-bp1 and (or) p-p70s6k in the testis of mice compared with sea. |
2023-02-02 |
2023-08-14 |
mouse |
| Jingshan Tong, Xiao Tan, Suisui Hao, Kaylee Ermine, Xinyan Lu, Zhaojin Liu, Anupma Jha, Jian Yu, Lin Zhan. Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction. Oncogene. 2023-01-31. PMID:36721000. |
our recent study revealed that selective cdk4/6 inhibitors sensitize colorectal cancer (crc) cells to therapy-induced apoptosis by inducing death receptor 5 (dr5) via the p53 family member p73. |
2023-01-31 |
2023-08-14 |
Not clear |
| Nangwon Yee, Hyeonjin Kim, Eungyung Kim, Yong Ho Cha, Lei Ma, Na Eun Cho, Dongwook Kim, Chae Yeon Kim, Sung-Hyun Kim, Zaeyoung Ryoo, Junkoo Yi, Myoung Ok Ki. Effects of Sangju Honey on Oral Squamous Carcinoma Cells. Journal of cancer prevention. vol 27. issue 4. 2023-01-30. PMID:36713940. |
moreover, sangju honey stimulated apoptosis by increasing the expression of p21, p53, cleaved caspase 3, and caspase 9. |
2023-01-30 |
2023-08-14 |
human |
| Cai-Wen Fan, Mei-Shan Li, Xi-Xi Song, Li Luo, Jing-Chen Jiang, Jia-Zi Luo, Heng-Shan Wan. Discovery of novel 2-oximino-2-indolylacetamide derivatives as potent anticancer agents capable of inducing cell autophagy and ferroptosis. Bioorganic & medicinal chemistry. vol 80. 2023-01-29. PMID:36709571. |
additionally, 4d significantly induced cell apoptosis, caused mitochondrial dysfunction, promoted bax, cleaved-parp and p53 expression and inhibited bcl-2 expression in 5-8f cells. |
2023-01-29 |
2023-08-14 |
mouse |
| Zhao Zhang, Yuze Yang, Lijiao Yan, Xuerui Wan, Kangyongjie Sun, Huitian Gou, Jucai Ding, Jie Peng, Guo Liu, Chuan Wan. Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study. PloS one. vol 18. issue 1. 2023-01-27. PMID:36706149. |
the kyoto encyclopedia of genes and genomes (kegg) analysis indicated the following pathways were linked to matrine-induced toxicity and apoptosis, including cytokine-cytokine receptor interaction pathway, viral protein interaction with cytokine and cytokine receptor, p53 and ppar pathway. |
2023-01-27 |
2023-08-14 |
cattle |
| Saksham Garg, Japneet Singh, Smita Rastogi Verm. Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics. Journal of molecular modeling. vol 29. issue 2. 2023-01-26. PMID:36700982. |
the mutations in the tp53 gene are the most frequent (50-60% of human cancer) genetic alterations in cancer cells, indicating the critical role of wild-type p53 in the regulation of cell proliferation and apoptosis upon oncogenic stress. |
2023-01-26 |
2023-08-14 |
human |
| Saksham Garg, Japneet Singh, Smita Rastogi Verm. Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics. Journal of molecular modeling. vol 29. issue 2. 2023-01-26. PMID:36700982. |
overall, the results of these mutations are single amino acid substitutions in p53 and the production of dysfunctional p53 protein in large amounts, consequently allowing the escape of apoptosis and rapid progression of tumor growth. |
2023-01-26 |
2023-08-14 |
human |
| C Povýšil, J Hojný, M Kaň. Chondrosarcoma with Target-Like Chondrocytes: Update on Molecular Profiling and Specific Morphological Features. Folia biologica. vol 68. issue 3. 2023-01-23. PMID:36689318. |
immunohistochemical examination showed strong positivity for vimentin, factor xiiia, cyclin d1, osteonectin, b-cell lymphoma 2 apoptosis regulator (bcl-2), p53 and p16. |
2023-01-23 |
2023-08-14 |
Not clear |
| Robert L Fine, Yuehua Mao, Richard Dinnen, Ramon V Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W Brandt-Rau. C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672645. |
we previously demonstrated that a synthetic monomer peptide derived from the c-terminus of p53 (aa 361-382) induced preferential apoptosis in mutant p53 malignant cells, but not normal cells. |
2023-01-21 |
2023-08-14 |
human |
| Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najaf. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. Mini reviews in medicinal chemistry. 2023-01-20. PMID:36658710. |
it seems that apigenin enhances apoptosis by inducing anticancer immunity and tumor suppressor genes, like p53 and pten, and also by inhibiting stat3 and nf-κb signaling pathways. |
2023-01-20 |
2023-08-14 |
Not clear |
| Buket Altinok Gunes, Yalda Hekmatshoar, Tulin Ozkan, Sureyya Bozkurt, O Sena Erdogan Aydos, Yahya Buyukasik, Elifcan Aladag, Asuman Sungurogl. Downregulation of Stearoyl-CoA Desaturase 1 (SCD-1) Promotes Resistance to Imatinib in Chronic Myeloid Leukemia. Mediterranean journal of hematology and infectious diseases. vol 15. issue 1. 2023-01-20. PMID:36660357. |
moreover, we analyzed the mrna expression levels of genes responsible for apoptosis, such as bcl-2, p53, and other genes (scd-1, pten). |
2023-01-20 |
2023-08-14 |
Not clear |
| Ying Yang, Yang Zhang, Jiqin Yang, Manman Zhang, Tao Tian, Yuan Jiang, Xuening Liu, Genlong Xue, Xingda Li, Xiaofang Zhang, Shangxuan Li, Xiang Huang, Zheng Li, Yang Guo, Lexin Zhao, Hairong Bao, Zhiwen Zhou, Jiahui Song, Guohui Yang, Lina Xuan, Hongli Shan, Zhiren Zhang, Yanjie Lu, Baofeng Yang, Zhenwei Pa. Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury. Circulation research. vol 132. issue 2. 2023-01-19. PMID:36656967. |
aspp1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor of p53 to promote its transcriptional activity in the nucleus. |
2023-01-19 |
2023-08-14 |
Not clear |
| Ahmed R Hamed, Shaymaa M M Yahya, Heba K Nabi. Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations. Naunyn-Schmiedeberg's archives of pharmacology. 2023-01-18. PMID:36651944. |
additionally, qrt-pcr was used to quantify genes having a role in drug resistance phenotype (abcb1, abcc1, abcc2, abcc3, abcc4, abcc5, and abcg2); apoptosis (caspases-3, and -7, bcl2, bax, and p53); anti-oxidation (nrf2); expression of melatonin receptors (mt1, mt2, and mt3); besides, programmed death receptor pd-1 gene. |
2023-01-18 |
2023-08-14 |
human |