| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel H Mansky, Erin A Greguske, Dahyun Yu, Nicole Zarate, Taylor A Intihar, Wei Tsai, Taylor G Brown, Mackenzie N Thayer, Kompal Kumar, Rocio Gomez-Pasto. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Cell reports. vol 42. issue 3. 2023-03-03. PMID:36867535. |
p53 and hsf1 are two major transcription factors involved in cell proliferation and apoptosis, whose dysregulation contributes to cancer and neurodegeneration. |
2023-03-03 |
2023-08-14 |
mouse |
| Chunyan Hu, Elena Priceputu, Marc Cool, Pavel Chrobak, Nathalie Bouchard, Clara Forestier, Clifford A Lowell, Serge Bénichou, Zaher Hanna, Virginie Royal, Paul Jolicoeu. NEF-INDUCED HIV-ASSOCIATED NEPHROPATHY THROUGH HCK/LYN. The American journal of pathology. 2023-03-03. PMID:36868467. |
studies of gene-deficient tg mice revealed that the presence of b and t cells and that of several genes was dispensable for the development of hivan: those involved in apoptosis (p53, trail, tnf-α, tnf-r2, bax), in immune cell recruitment (mip-1α, mcp-1, ccr-2, ccr-5 and cx3cr-1), in no formation (enos, inos) or in cell signaling (fyn, lck, hck/fgr). |
2023-03-03 |
2023-08-14 |
mouse |
| Fei Xu, Jingtao Zhang, Lingyun Ji, Wenqiang Cui, Jie Cui, Zhao Tang, Ning Sun, Guangming Zhang, Minghao Guo, Baojun Liu, Jingcheng Don. Inhibition of Non-small Cell Lung Cancer by Ferroptosis and Apoptosis Induction through P53 and GSK-3β/Nrf2 Signal Pathways using Qingrehuoxue Formula. Journal of Cancer. vol 14. issue 3. 2023-03-02. PMID:36860928. |
inhibition of non-small cell lung cancer by ferroptosis and apoptosis induction through p53 and gsk-3β/nrf2 signal pathways using qingrehuoxue formula. |
2023-03-02 |
2023-08-14 |
mouse |
| Shuxian Zou, Chongchong Zhang, Huan Xu, Zhihui Liu, Yongliang Hu, Wei Wang, Kun Liu, Qin Wen, Lun Son. ISG20L1 acts as a co-activator of DAPK1 in the activation of p53 dependent cell death pathway. Journal of cell science. 2023-03-01. PMID:36855954. |
under chemotherapeutic agents (such as arsenite, 5-fu, vp-16) exposure, dapk1 functions as novel p53 kinase, which induces phosphorylation of p53 at ser15 and transactivates p53 target, ets-1, to synergistically repress ikkβ dependent mdm2 stability, and ultimately removes the inhibitory effect of mdm2 on gadd45α, resulting in gadd45α accumulation and cell apoptosis. |
2023-03-01 |
2023-08-14 |
Not clear |
| Haolan Wang, Ming Guo, Hudie Wei, Yongheng Che. Targeting p53 pathways: mechanisms, structures, and advances in therapy. Signal transduction and targeted therapy. vol 8. issue 1. 2023-03-01. PMID:36859359. |
the p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability, and is widely regarded as the "guardian of the genome". |
2023-03-01 |
2023-08-14 |
human |
| Li Yang, Jianyong Cheng, Dejun Xu, Zelin Zhang, Rongmao Hua, Huali Chen, Jiaxin Duan, Xiaoya Li, Qingwang L. Melatonin Ameliorates Diquat-Induced Testicular Toxicity via Reducing Oxidative Stress, Inhibiting Apoptosis, and Maintaining the Integrity of Blood-Testis Barrier in Mice. Toxics. vol 11. issue 2. 2023-02-28. PMID:36851035. |
melatonin treatment also attenuated diquat-induced spermatogonia apoptosis in vivo and in vitro by modulating the expression of apoptosis-related proteins, including p53, cleaved-caspase3, and bax/bcl2. |
2023-02-28 |
2023-08-14 |
mouse |
| Kyung-A Byun, Hyun Jun Park, Seyeon Oh, Sosorburam Batsukh, Hye Jin Sun, Taehui Kim, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byu. High-Intensity Focused Ultrasound Decreases Subcutaneous Fat Tissue Thickness by Increasing Apoptosis and Autophagy. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830763. |
heat can induce adipocyte apoptosis and autophagy, and it is known that nuclear or mitochondrial p53 is involved in apoptosis and autophagy. |
2023-02-25 |
2023-08-14 |
Not clear |
| Kyung-A Byun, Hyun Jun Park, Seyeon Oh, Sosorburam Batsukh, Hye Jin Sun, Taehui Kim, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byu. High-Intensity Focused Ultrasound Decreases Subcutaneous Fat Tissue Thickness by Increasing Apoptosis and Autophagy. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830763. |
in conclusion, hifu led to nuclear and mitochondrial p53 expression, which led to apoptosis and autophagy, and eventually decreased sat thickness in hfd-fed animals. |
2023-02-25 |
2023-08-14 |
Not clear |
| Robert L Fine, Yuehua Mao, Dario Garcia-Carracedo, Gloria H Su, Wanglong Qiu, Uri Hochfeld, Gwen Nichols, Yong-Liang Li, Richard D Dinnen, Anthony Raffo, Paul W Brandt-Rau. Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines. vol 11. issue 2. 2023-02-25. PMID:36830797. |
gene therapy with p14/tbid induces selective and synergistic apoptosis in mutant ras and mutant p53 cancer cells in vitro and in vivo. |
2023-02-25 |
2023-08-14 |
Not clear |
| Sreerama Shetty, Steven Idel. Caveolin-1-Related Intervention for Fibrotic Lung Diseases. Cells. vol 12. issue 4. 2023-02-25. PMID:36831221. |
we found that increased caveolin-1 and tumor suppressor protein, p53 expression, and apoptosis in aecs occur prior to and then with the proliferation of flfs in fibrotic lungs. |
2023-02-25 |
2023-08-14 |
mouse |
| Sreerama Shetty, Steven Idel. Caveolin-1-Related Intervention for Fibrotic Lung Diseases. Cells. vol 12. issue 4. 2023-02-25. PMID:36831221. |
aecs with elevated p53 typically undergo apoptosis. |
2023-02-25 |
2023-08-14 |
mouse |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Ling Wu, Guodong Xu, Ni Li, Linwen Zhu, Guofeng Sha. Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-23. PMID:36814470. |
curcumin analog, ho-3867, induces both apoptosis and ferroptosis via multiple mechanisms in nsclc cells with wild-type p53. |
2023-02-23 |
2023-08-14 |
Not clear |
| Suguru Saito, Shin-Ichiro Ohno, Yuichirou Harada, Yoshihiko Kanno, Masahiko Kurod. MiR-34a induces myofibroblast differentiation from renal fibroblasts. Clinical and experimental nephrology. 2023-02-22. PMID:36808381. |
mir-34a is a transcriptional target of p53, which regulates the cell cycle and apoptosis. |
2023-02-22 |
2023-08-14 |
Not clear |
| b' Hamit Emre K\\xc4\\xb1z\\xc4\\xb1l, Cihan G\\xc3\\xbcr, Adnan Ayna, Ekrem Darendelio\\xc4\\x9flu, Sefa K\\xc3\\xbc\\xc3\\xa7\\xc3\\xbckler, Sevda Sa\\xc4\\x9. Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF-induced Testicular Toxicity. Chemistry & biodiversity. 2023-02-22. PMID:36808882.' |
naf supplementation caused apoptosis in the testes by upregulating p53, nfkb, caspase-3 , caspase-6, caspase-9, and bax and downregulating bcl-2. |
2023-02-22 |
2023-08-14 |
rat |
| Yin Yang, Chen Mei, Hong Xian, Xue Zhang, Jun Li, Zhi-Xuan Liang, Yan Zhi, Yue Ma, Hong-Jun Wan. Toosendanin-induced apoptosis in canine mammary tumor CMT-U27 cells is mediated through the mitochondrial apoptotic pathway. Veterinary and comparative oncology. 2023-02-22. PMID:36809669. |
tsn induced cell apoptosis by upregulating bax, cleaved caspase-3, cleaved caspase-9, p53, and cytochrome c (cytosolic) protein expression, and downregulating bcl-2 and cytochrome c (mitochondrial) expression. |
2023-02-22 |
2023-08-14 |
human |
| Ferdane Danişman-Kalindemirtaş, Dilşad Özerkan, İshak Afşin Kariper, Huri Bulu. The Novel 5-Fluorouracil Loaded Ruthenium-based Nanocarriers Enhanced Anticancer and Apoptotic Efficiency while Reducing Multidrug Resistance in Colorectal Cancer Cells. Journal of fluorescence. 2023-02-22. PMID:36811696. |
apoptotic cells were detected by hoechst/propidium iodide double staining, and the expression levels of bax/bcl-2 and p53 proteins, in which apoptosis occurred intrinsically, were revealed. |
2023-02-22 |
2023-08-14 |
human |
| Qiangsheng Wang, Qiqin Shi, Yingchao Chen, Gang Wang, Lijing She. Recombinant human p53 adenovirus injection combined with Bortezomib inhibits proliferation and promotes apoptosis in multiple myeloma. Leukemia research. vol 127. 2023-02-21. PMID:36801701. |
recombinant human p53 adenovirus injection combined with bortezomib inhibits proliferation and promotes apoptosis in multiple myeloma. |
2023-02-21 |
2023-08-14 |
human |
| Yuying Cui, Yu Wen, Chao Lv, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wan. [Corrigendum] Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway. Molecular medicine reports. vol 27. issue 3. 2023-02-17. PMID:36799157. |
[corrigendum] decreased rna‑binding protein igf2bp2 downregulates nt5dc2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large b‑cell lymphoma cells by regulating the p53 signaling pathway. |
2023-02-17 |
2023-08-14 |
Not clear |
| Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek A Singh, Rachana Garg, Amit Mandoli, Dinesh Kuma. Discovery of fluorinated 2‑Styryl 4(3H)-quinazolinone as potential therapeutic hit for oral cancer. Bioorganic & medicinal chemistry. vol 81. 2023-02-16. PMID:36796126. |
subsequent rna-seq analysis revealed that the compound induces the activation of molecular pathways involved in apoptosis (such as tnf signalling through nf-κb, p53 pathways) and cell differentiation and suppresses the pathways of cellular growth and development (such as kras signaling) in cal-27 cancer cells. |
2023-02-16 |
2023-08-14 |
Not clear |