| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsin-Han Chang, Yi-Hsuan Lin, Tzu-Min Chen, Yu-Ling Tsai, Chien-Rui Lai, Wen-Chiuan Tsai, Yu-Chen Cheng, Ying Che. ONX-0914 Induces Apoptosis and Autophagy with p53 Regulation in Human Glioblastoma Cells. Cancers. vol 14. issue 22. 2022-11-26. PMID:36428804. |
furthermore, the p53 inhibitor pifithrin attenuated apoptosis but enhanced autophagy caused by onx-0914. |
2022-11-26 |
2023-08-14 |
mouse |
| Xinle Han, Jun Du, Dandan Shi, Lingjie Li, Dandan Li, Kun Zhang, Suwen Lin, Jingzhong Zhu, Zoufang Huang, You Zhou, Zhengyu Fan. Improving Reporter Gene Assay Methodology for Evaluating the Ability of Compounds to Restore P53 Activity. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430341. |
tumor suppressor protein p53 induces cycle arrest and apoptosis by mediating the transcriptional expression of its target genes. |
2022-11-26 |
2023-08-14 |
Not clear |
| Mireia Palomar-Siles, Angelos Heldin, Meiqiongzi Zhang, Charlotte Strandgren, Viktor Yurevych, Jip T van Dinter, Sem A G Engels, Damon A Hofman, Susanne Öhlin, Birthe Meineke, Vladimir J N Bykov, Sebastiaan van Heesch, Klas G Wima. Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine. Cell death & disease. vol 13. issue 11. 2022-11-26. PMID:36433934. |
we confirmed that full-length p53 rescued by fur triggers tumor cell death by apoptosis. |
2022-11-26 |
2023-08-14 |
human |
| Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajara. N-(2-hydroxyphenyl)-2-phenazinamine from Nocardiopsis exhalans induces p53-mediated intrinsic apoptosis signaling in lung cancer cell lines. Chemico-biological interactions. 2022-11-25. PMID:36427553. |
moreover, the nhp downregulates the oncogenic genes such as il-8, tnfα, mmps and bcl2 and also upregulates the expression of apoptosis marker genes such as cyto c, p53, p21, caspase 9/3 in a549 and h520 human lung cancer cells. |
2022-11-25 |
2023-08-14 |
human |
| Silu Hou, Yuqiang Cheng, Zhaofei Wang, Luming Xia, Jian Wang, Hengan Wang, Jianhe Sun, Jingjiao Ma, Yaxian Ya. DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-11-25. PMID:36427601. |
don can induce dna damage, which in turn regulates apoptosis by regulating mitochondrial permeability by regulating p53 and in turn the bcl-2 protein family. |
2022-11-25 |
2023-08-14 |
human |
| Blanda Di Luccia, Vittoria Acampora, Anella Saggese, Viola Calabrò, Maria Vivo, Tiziana Angrisano, Loredana Baccigalupi, Ezio Ricca, Alessandra Pollic. Modulation of intestinal epithelial cell proliferation and apoptosis by Lactobacillus gasseri SF1183. Scientific reports. vol 12. issue 1. 2022-11-24. PMID:36424419. |
expanding previous findings, we show that bioactive molecules secreted by sf1183 reduce the proliferation of hct116 cells in a reversible manner determining a variation in cell cycle markers (p21waf, p53, cyclin d1) and resulting in the protection of hct116 cells from tnf-alfa induced apoptosis, an effect potentially relevant for the protection of the epithelial barrier integrity and reconstitution of tissue homeostasis. |
2022-11-24 |
2023-08-14 |
human |
| Brian Berman, Ayman Grada, Daniela K Berma. Profile of Tirbanibulin for the Treatment of Actinic Keratosis. The Journal of clinical and aesthetic dermatology. vol 15. issue 10 Suppl 1. 2022-11-21. PMID:36408375. |
uv-induced mutations in p53, ras, and p16 genes lead to the emergence of abnormal epidermal actinic keratosis (aks) cells, which proliferate while avoiding apoptosis and may lead to invasive squamous cell carcinoma. |
2022-11-21 |
2023-08-14 |
Not clear |
| Fatemeh Jamshidi-Adegani, Shokoofeh Ghaemi, Sulaiman Al-Hashmi, Saeid Vakilian, Juhaina Al-Kindi, Najeeb Ur Rehman, Khurshid Alam, Khamis Al-Riyami, Rene Csuk, Ehsan Arefian, Ahmed Al-Harras. Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer. Scientific reports. vol 12. issue 1. 2022-11-21. PMID:36411309. |
the expression of p53, bax, and bcl2 genes in cancerous cell lines has affirmed that both akba and aba could induce the maximal apoptosis. |
2022-11-21 |
2023-08-14 |
Not clear |
| Xue Rong, Yuli Wang, Fangxin Ouyang, Weixuan Song, Songhua Li, Feng Li, Shancang Zhao, Dapeng L. Combined effects of zearalenone and deoxynivalenol on oxidative stress, hepatotoxicity, apoptosis, and inflammation in zebrafish embryos. The Science of the total environment. 2022-11-20. PMID:36403834. |
besides, the combined treatment of zea and don triggered hepatotoxicity as shown by the changes of fabp10a, gclc, gsr, nqo1 genes, apoptosis through upregulating apoptosis-related genes (p53, caspase-9, caspase-3) and downregulating bcl-2 gene, as well as inflammation by promoting the expression of il-1β, il-6, tnf-α, tlr4, myd88, nf-κbp65 genes. |
2022-11-20 |
2023-08-14 |
cat |
| D V Savitskiy, N S Linkova, I M Kvetnoy, A S Diatlova, G B Saraev, K L Kozlov, E M Paltsev. [Secretory phenotype of the human endothelial cells associated with replicative and induced aging.] Advances in gerontology = Uspekhi gerontologii. vol 35. issue 4. 2022-11-19. PMID:36401855. |
it has been established that the molecules that form sasp during replicative and inflammation-induced aging of huvec are molecules that control apoptosis (p16, p21, p53), adhesion (e-selectin, vcam-1) and some cytokines (il-1β, il-6). |
2022-11-19 |
2023-08-14 |
human |
| Yi Wang, Zi-Wei Wu, Qiao Mou, Lu Chen, Ting Fang, Yu-Qing Zhang, Zongjun Yin, Zhi-Qiang Du, Cai-Xia Yan. Global 3'-UTRome of porcine immature Sertoli cells altered by acute heat stress. Theriogenology. vol 196. 2022-11-19. PMID:36401935. |
these genes with different 3'-utr patterns were mainly enriched in p53, glycolysis/gluconeogenesis, hif-1, apoptosis, pi3k-akt and ampk signaling pathways. |
2022-11-19 |
2023-08-14 |
Not clear |
| Mostafa D Mostafa, Magda A ElKomy, Azza I Othman, Maggie E Amer, Mohamed A El-Missir. Epigallocatechin-3-gallate Enhances Cognitive and Memory Performance and Protects Against Brain Injury in Methionine-induced Hyperhomocysteinemia Through Interdependent Molecular Pathways. Neurotoxicity research. 2022-11-17. PMID:36394770. |
the decreases in both oxidative stress and inflammatory cytokines were significantly associated with upregulation of the antiapoptotic bcl-2 protein and downregulation of the proapoptotic protein bax, caspases 3 and 9, and p53 compared with met-treated animals, indicating a diminution of neuronal apoptosis. |
2022-11-17 |
2023-08-14 |
mouse |
| Hanan R H Mohamed, Maria M H Ibrahim, Ayman Dia. Induction of oxidative DNA damage, cell cycle arrest and p53 mediated apoptosis by calcium titanate nanoparticles in MCF-7 breast cancer cells. Cancer cell international. vol 22. issue 1. 2022-11-15. PMID:36376858. |
induction of oxidative dna damage, cell cycle arrest and p53 mediated apoptosis by calcium titanate nanoparticles in mcf-7 breast cancer cells. |
2022-11-15 |
2023-08-14 |
Not clear |
| Xurde M Caravia, Andres Ramirez-Martinez, Peiheng Gan, Feng Wang, John R McAnally, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N Olso. Loss of function of the nuclear envelope protein LEMD2 causes DNA damage-dependent cardiomyopathy. The Journal of clinical investigation. vol 132. issue 22. 2022-11-15. PMID:36377660. |
cardiomyocytes lacking lemd2 displayed nuclear envelope deformations and extensive dna damage and apoptosis linked to p53 activation. |
2022-11-15 |
2023-08-14 |
mouse |
| Jinfeng Liu, Chang Zhang, Shuang Liu, Xiaokang Wang, Xiongzhi Wu, Jian Ha. Tanshinone IIA promotes apoptosis by downregulating BCL2 and upregulating TP53 in triple-negative breast cancer. Naunyn-Schmiedeberg's archives of pharmacology. 2022-11-14. PMID:36374307. |
tan iia is potentially effective for the treatment of 4t1 breast cancer, and the molecular mechanism may be through enhancing the activity of p53 and decreasing bcl-2 to suppress proliferation and promote apoptosis. |
2022-11-14 |
2023-08-14 |
Not clear |
| b' Sema Bilgin, Secil Erden Tayhan, Asl\\xc4\\xb1 Y\\xc4\\xb1ld\\xc4\\xb1r\\xc4\\xb1m, Esra Ko\\xc3\\xa. Investigation of the effects of isoeugenol-based phenolic compounds on migration and proliferation of HT29 colon cancer cells at cellular and molecular level. Bioorganic chemistry. vol 130. 2022-11-14. PMID:36375352.' |
in addition, mrna expression levels of apoptosis and metastasis-related genes (p53, bcl2, bax, caspase 3, caspase7, caspase8, caspase9, hif1-α, vegf, mmp-2, mmp-9) were examined by quantitative real-time pcr. |
2022-11-14 |
2023-08-14 |
Not clear |
| Takato Inoue, Kazuaki Matsuda, Keisuke Matsusaka, Masaya Nakajima, Yukari Takeno, Toko Miyazaki, Takahiko Shintaku, Natsumi Yoda, Takahiko Saito, Eriko Ikeda, Yasunobu Mano, Kenichi Shinohara, Bahityar Rahmutulla, Masaki Fukuyo, Kazuko Kita, Tetsuhiro Nemoto, Atsushi Kaned. Anti-proliferating and apoptosis-inducing activity of chemical compound FTI-6D in association with p53 in human cancer cell lines. Chemico-biological interactions. 2022-11-14. PMID:36375514. |
fti-6d induced apoptosis via activation of the p53 downstream mitochondria-related apoptotic pathway, characterized by an increased ratio of pro-apoptotic bcl-2 family members to anti-apoptotic members. |
2022-11-14 |
2023-08-14 |
human |
| Xiru Zhao, Ke Fang, Xiaoxu Liu, Ruihuan Yao, Min Wang, Fanfan Li, Shaohua Hao, Jingjing He, Yan Wang, Menghan Fan, Wei Huang, Yiping Li, Chun Gao, Chengqi Lin, Zhuojuan Lu. QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis. Cell death and differentiation. 2022-11-13. PMID:36371602. |
activation of the pro-apoptotic genes by the p53 family is a critical step in induction of apoptosis. |
2022-11-13 |
2023-08-14 |
Not clear |
| Xiru Zhao, Ke Fang, Xiaoxu Liu, Ruihuan Yao, Min Wang, Fanfan Li, Shaohua Hao, Jingjing He, Yan Wang, Menghan Fan, Wei Huang, Yiping Li, Chun Gao, Chengqi Lin, Zhuojuan Lu. QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis. Cell death and differentiation. 2022-11-13. PMID:36371602. |
qser1 knockdown significantly promotes apoptosis in both p53 wild type and mutant cancer cells. |
2022-11-13 |
2023-08-14 |
Not clear |
| Liu XueXia, Liu YaNan, Teng Zi, Zhang YuSheng, Wang ZeLin, Zhu Peng, Xie MeiNa, Liu FuJu. Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice. Chemosphere. 2022-11-13. PMID:36372335. |
these phenotypes may be related to increased cell apoptosis characterized by bax/bcl2 and p53 up-regulation. |
2022-11-13 |
2023-08-14 |
mouse |