| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farnaz Hemmati, Ayuba Akinpelu, Jiyeon Song, Farshad Amiri, Anya McDaniel, Collins McMurray, Alexandros Afthinos, Stelios T Andreadis, Andrew V Aitken, Vinicia C Biancardi, Sharon Gerecht, Panagiotis Mistrioti. Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-06-02. PMID:37267923. |
the results of this study show that continuous exposure to tight confinement can trigger frequent nuclear envelope rupture events, which in turn promote p53 activation and cell apoptosis. |
2023-06-02 |
2023-08-14 |
Not clear |
| Yanxia Wu, Yanxi Sun, Binchu Xu, Mo Yang, Xingwu Wang, Xiaocheng Zha. SCARNA10 regulates p53 acetylation-dependent transcriptional activity. Biochemical and biophysical research communications. vol 669. 2023-06-01. PMID:37262951. |
the tumor suppressor p53 is involved in variety of cell progresses including cell cycle arrest, apoptosis, dna repair, senescence, cell metabolism and ferroptosis. |
2023-06-01 |
2023-08-14 |
Not clear |
| Lei Li, Mingyang Li, Jianyi Zheng, Zeyu Li, Xiaonan Che. Knocking down NSUN5 inhibits the development of clear cell renal cell carcinoma by inhibiting the p53 pathway. Aging. vol 15. 2023-06-01. PMID:37263638. |
nsun5 is highly expressed in ccrcc and inhibits cancer cell invasion, proliferation, and migration while promoting apoptosis by activating the p53 signaling pathway. |
2023-06-01 |
2023-08-14 |
Not clear |
| Riccardo Pecori, Weicheng Ren, Mohammad Pirmoradian, Xianhuo Wang, Dongbing Liu, Mattias Berglund, Wei Li, Rafail Nikolaos Tasakis, Salvatore Di Giorgio, Xiaofei Ye, Xiaobo Li, Annette Arnold, Sandra Wüst, Martin Schneider, Karthika-Devi Selvasaravanan, Yvonne Fuell, Thorsten Stafforst, Rose-Marie Amini, Kristina Sonnevi, Gunilla Enblad, Birgitta Sander, Björn Engelbrekt Wahlin, Kui Wu, Huilai Zhang, Dominic Helm, Marco Binder, F Nina Papavasiliou, Qiang Pan-Hammarströ. ADAR1-mediated RNA editing promotes B cell lymphomagenesis. iScience. vol 26. issue 6. 2023-05-31. PMID:37255666. |
rna editing targets transcripts within known disease-driving pathways such as apoptosis, p53 and nf-κb signaling, as well as the rig-i-like pathway. |
2023-05-31 |
2023-08-14 |
Not clear |
| Jinze Shen, Qurui Wang, Yunan Mao, Wei Gao, Shiwei Dua. Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies. MedComm. vol 4. issue 3. 2023-05-31. PMID:37256211. |
tumor suppressor p53 can transcriptionally activate downstream genes in response to stress, and then regulate the cell cycle, dna repair, metabolism, angiogenesis, apoptosis, and other biological responses. |
2023-05-31 |
2023-08-14 |
Not clear |
| Jinze Shen, Qurui Wang, Yunan Mao, Wei Gao, Shiwei Dua. Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies. MedComm. vol 4. issue 3. 2023-05-31. PMID:37256211. |
triap1 is a novel p53 downstream inhibitor of apoptosis. |
2023-05-31 |
2023-08-14 |
Not clear |
| Lacin Yapindi, Tetiana Bowley, Nick Kurtaneck, Rachel L Bergeson, Kylie James, Jillian Wilbourne, Carolyn K Harrod, Brenda Y Hernandez, Brooke M Emerling, Courtney Yates, Robert Harro. Activation of p53-regulated pro-survival signals and hypoxia-independent mitochondrial targeting of TIGAR by human papillomavirus E6 oncoproteins. Virology. vol 585. 2023-05-31. PMID:37257253. |
the viral e6 oncoprotein destabilizes the p53 tumor suppressor, inhibits p53 k120-acetylation by the tat-interacting protein of 60 kda (tip60, or kat5), and prevents p53-dependent apoptosis. |
2023-05-31 |
2023-08-14 |
human |
| Jingjing Miao, Boyu Chen, Yunyun Xiao, Runda Huang, Xiao Xiao, Shunzhen Lu, Lu Zhang, Xuguang Wang, Ying Ouyang, Xiangfu Chen, Qiuyan Chen, Yanqun Xiang, Xiang Guo, Xiaowu Deng, Lin Wang, Haiqiang Mai, Chong Zha. Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway. Cancer gene therapy. 2023-05-31. PMID:37258811. |
mechanistically, linc00173 bound with checkpoint kinase 2 (chk2) in nucleus, and impaired the irradiation-induced chk2 phosphorylation, then suppressed the activation of p53 signalling pathway, which eventually inhibiting apoptosis and leading to radioresistance in npc cells. |
2023-05-31 |
2023-08-14 |
Not clear |
| Xiaohong Chen, Meiying Zhou, Shouye Ma, Huifang Wu, Hui Ca. KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma. Experimental cell research. 2023-05-29. PMID:37247719. |
cdca5 facilitated proliferation, invasion, and metastasis and disrupted mitochondrial-mediated endogenous apoptosis by activating the cell cycle pathway and inhibiting the p53 pathway in eoc cells. |
2023-05-29 |
2023-08-14 |
Not clear |
| b' Berrin Tu\\xc4\\x9frul, Erdal Balcan, Z\\xc3\\xbcbeyde \\xc3\\x96ztel, Fatih \\xc3\\x87\\xc3\\xb6ll\\xc3\\xbc, Beyhan G\\xc3\\xbcrc\\xc3\\xb. Prion protein-dependent regulation of p53-MDM2 crosstalk during endoplasmic reticulum stress and doxorubicin treatments might be essential for cell fate in human breast cancer cell line, MCF-7. Experimental cell research. 2023-05-28. PMID:37245583.' |
in this study, we investigated the effect of doxorubicin and tunicamycin treatment alone or in combination on mdm-, cul9-and prion protein (prp)-mediated subcellular regulation of p53 in the context of apoptosis and autophagy. |
2023-05-28 |
2023-08-14 |
human |
| Qi Wang, Jia-Fei Xie, Ting-Ting Yao, Xu-Xu Wang, Qian-Wen Guo, Lu-Shan Wang, Yue Yu, Li-Chun X. MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro. Reproductive toxicology (Elmsford, N.Y.). 2023-05-28. PMID:37245696. |
moreover, in the presence of cyp, the apoptosis regulator p53 expression was also increased in tm4 cells. |
2023-05-28 |
2023-08-14 |
mouse |
| Ruilin Zheng, Danyang Chen, Jingyao Su, Jia Lai, Chenyang Wang, Haitian Chen, Zhihui Ning, Xia Liu, Xingui Tian, Yinghua Li, Bing Zh. Inhibition of HAdV-14 induced apoptosis by selenocystine through ROS-mediated PARP and p53 signaling pathways. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 79. 2023-05-27. PMID:37244045. |
inhibition of hadv-14 induced apoptosis by selenocystine through ros-mediated parp and p53 signaling pathways. |
2023-05-27 |
2023-08-14 |
human |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Hao Dong, Yin Wen, Jiating Lin, Xianxian Zhuang, Ruoting Xian, Ping Li, Shaobing L. Cytotoxicity Induced by Black Phosphorus Nanosheets in Vascular Endothelial Cells via Oxidative Stress and Apoptosis Activation. Journal of functional biomaterials. vol 14. issue 5. 2023-05-26. PMID:37233394. |
furthermore, bpnss caused mitochondrial dysfunction and generated excessive intercellular reactive oxygen species (ros) at tested concentrations after 24 h. bpnss could influence the expression of apoptosis-related genes, including the p53 and bcl-2 family, resulting in the apoptosis of huvecs. |
2023-05-26 |
2023-08-14 |
human |
| Xiu-Juan Liu, Jin-Lei Lv, Xin Zou, Yan-Yan Yu, Hong-Xia Zhou, Yu Wu, Yan-Qiu Geng, Cai-Hua Li. MiR-21 alleviates renal tubular epithelial cells injury induced by ischemia by targeting TLR4. Heliyon. vol 9. issue 5. 2023-05-26. PMID:37234634. |
overexpression of mir-21 decreased the protein expressions of cleaved caspase-3, bax, p53, cell apoptosis and increased bcl-2 expression in hk-2 cells with ogd injury. |
2023-05-26 |
2023-08-14 |
Not clear |
| Fei Zhang, Lei Wei, Lei Wang, Tao Wang, Zhihong Xie, Hong Luo, Fanchao Li, Jian Zhang, Wentao Dong, Gang Liu, Qinglin Kang, Xuesong Zhu, Wuxun Pen. FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells. Bone research. vol 11. issue 1. 2023-05-22. PMID:37217464. |
fos activates the mitochondrial apoptotic pathway by regulating the expression of bcl-2 interacting mediator of cell death (bim) and p53 upregulated modulator of apoptosis (puma) to mediate gc-induced apoptosis of bmecs, which leads to femoral head microcirculation dysfunction and femoral head necrosis. |
2023-05-22 |
2023-08-14 |
Not clear |
| Chosita Norkaew, Paweena Subkorn, Chawalit Chatupheeraphat, Sittiruk Roytrakul, Dalina Tanyon. Pinostrobin, a fingerroot compound, regulates miR-181b-5p and induces acute leukemic cell apoptosis. Scientific reports. vol 13. issue 1. 2023-05-19. PMID:37208425. |
a bioinformatics approach and protein-protein interaction (ppi) network analysis revealed that ataxia-telangiectasia mutated kinase (atm), one of the p53 activators that responds to dna damage-induced apoptosis, is a crucial target of pn. |
2023-05-19 |
2023-08-14 |
Not clear |
| Jeyalakshmi Kandhavelu, Kumar Subramanian, Vivash Naidoo, Giulia Sebastianelli, Phuong Doan, Saravanan Konda Mani, Hande Yapislar, Ebru Haciosmanoglu, Leman Arslan, Samed Ozer, Ramesh Thiyagarajan, Nuno R Candeias, Clement Penny, Meenakshisundaram Kandhavelu, Akshaya Murugesa. A novel EGFR Inhibitor, HNPMI regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer. British journal of pharmacology. 2023-05-15. PMID:37183661. |
a novel egfr inhibitor, hnpmi regulates apoptosis and oncogenesis by modulating bcl-2/bax and p53 in colon cancer. |
2023-05-15 |
2023-08-14 |
Not clear |
| Rebai Ben Amma. Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings. Molecules (Basel, Switzerland). vol 28. issue 9. 2023-05-14. PMID:37175079. |
in addition, gnl induces apoptosis and cell cycle arrest, modulates multiple molecular targets, including p53 and stat3, activates caspases, and modulates inflammation via transcriptional regulation. |
2023-05-14 |
2023-08-14 |
Not clear |
| Wentao Ma, Xiaoqian Tan, Zhongcheng Xie, Jiang Yu, Pin Li, Xiaoyan Lin, Siyu Ouyang, Zhiyang Liu, Qin Hou, Nan Xie, Tianhong Peng, Liang Li, Zhu Dai, Xi Chen, Wei Xi. P53: A Key Target in the Development of Osteoarthritis. Molecular biotechnology. 2023-05-08. PMID:37154864. |
this review highlights the effects of p53 on senescence, apoptosis, and autophagy of chondrocytes and its role in the development of oa. |
2023-05-08 |
2023-08-14 |
Not clear |