| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fares Al-Mansour, Abdullah Alraddadi, Buwei He, Anes Saleh, Marta Poblocka, Wael Alzahrani, Shaun Cowley, Salvador Maci. Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic. Aging. vol 15. 2023-03-29. PMID:36988504. |
here, we show that cudc-907 was indeed able to selectively induce apoptosis in cells driven to senesce by p53 expression, but not when senescence happened in the absence of p53. |
2023-03-29 |
2023-08-14 |
Not clear |
| Faliang Xing, Yi Qin, Jin Xu, Wei Wang, Bo Zhan. Stress granules dynamics and promising functions in pancreatic cancer. Biochimica et biophysica acta. Reviews on cancer. 2023-03-29. PMID:36990249. |
in this review, we talk about the dynamics of sgs and their positive effects on pancreatic cancer such as sgs promote pdac viability and repress apoptosis, meanwhile emphasizing the connection between sgs in pancreatic cancer and signature mutations such kras, p53, and smad4 as well as the functions of sgs in antitumor drug resistance. |
2023-03-29 |
2023-08-14 |
Not clear |
| Xu-Dong Jiang, Yu Liu, Jian-Fei Wu, San-Ni Gong, Yao Ma, Xiang-Dong Z. Regulation of proliferation, apoptosis, hormone secretion and gene expression by acetyl-L-carnitine in yak (Bos grunniens) granulosa cells. Theriogenology. vol 203. 2023-03-27. PMID:36972666. |
rt‒qpcr results verified that gcs treated with 1 mm alc for 48 h significantly increased the expression of genes related to anti-apoptosis and the cell cycle (bcl-2, pcna, ccnd1 and ccnb1), antioxidants (cat, sod2 and gpx1), and e2 and p4 secretion (star, cyp19a1 and hsd3b1) (p < 0.05), but it significantly decreased the expression of apoptosis genes (bax and p53) (p < 0.05). |
2023-03-27 |
2023-08-14 |
cat |
| Yudong Jia, Fenglin Wang, Yuntao Gao, Hongyu Qin, Changtao Gua. Hypoxia stress induces hepatic antioxidant activity and apoptosis, but stimulates immune response and immune-related gene expression in black rockfish Sebastes schlegelii. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-03-25. PMID:36965427. |
in this study, hepatic anti-oxidant enzymes (superoxide dismutase [sod], catalase [cat], glutathione peroxidase [gsh-px]), aminotransferase (ast) and alanine aminotransferase (alt) activities, lipid peroxidation (lpo), malondialdehyde (mda) and glutathione (gsh) content, immunological parameters and the expression of apoptosis (bax, bcl2, p53, caspase3, xiap) and immune-related genes (c3, il-1β, ccl25, saa, hap, isg15) of black rockfish were determined during hypoxia and reoxygenation to illustrate the underlying defense response mechanisms. |
2023-03-25 |
2023-08-14 |
human |
| Zinaida Vasilyvna Chumak, Volodymyr Victorovich Artyomenko, Mykola Vitaliiovich Shapoval, Liudmyla Volodymyrivna Mnih, Ganna Volodymyrivna Kozhukhar, Serhii Vasilyovich Derisho. Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women. Journal of medicine and life. vol 16. issue 2. 2023-03-20. PMID:36937462. |
this study aimed to investigate the potential role of hypoxia (as indicated by hif-1α) and apoptosis markers (p53 and bcl-2) in the development of hyperplastic processes of the endometrium (hpe). |
2023-03-20 |
2023-08-14 |
Not clear |
| b' Jakub V\\xc3\\xa1vra, Artur Sergunin, Petr Pompach, Dariya Savchenko, Jakub Hran\\xc3\\xad\\xc4\\x8dek, Ivana \\xc5\\xa0loufov\\xc3\\xa1, Toru Shimizu, Mark\\xc3\\xa9ta Mart\\xc3\\xadnkov\\xc3\\xa. Characterization of the interaction between the tumour suppressor p53 and heme and its role in the protein conformational dynamics studied by various spectroscopic techniques and hydrogen/deuterium exchange coupled with mass spectrometry. Journal of inorganic biochemistry. vol 243. 2023-03-19. PMID:36934467.' |
the tumour suppressor p53 regulates the expression of a myriad of proteins that are important for numerous cellular processes, including apoptosis, cell cycle arrest, dna repair, metabolism, and even autophagy and ferroptosis. |
2023-03-19 |
2023-08-14 |
Not clear |
| Ali Akar, Rahime Özlem Öztopuz, Başak Büyük, Mehmet Akif Ovali, Damla Aykora, Ümit Ali Malço. Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage. Molecular neurobiology. 2023-03-18. PMID:36933146. |
in this study, we aimed to investigate the potential therapeutic effects of pic on ob injury following sah at molecular mechanism based on sirt1, inflammatory (tnf-α, il1-β, nf-κb, il-6, tlr4), and apoptosis (p53, bax, bcl-2, caspase-3)-related gene expression markers and histopathology level; 27 male wistar albino rats were used in a pre-chiasmatic subarachnoid hemorrhage model. |
2023-03-18 |
2023-08-14 |
rat |
| Heba K Nabih, Ahmed R Hamed, Shaymaa M M Yahy. Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition. Scientific reports. vol 13. issue 1. 2023-03-17. PMID:36928762. |
this action is initiated through cell cycle arrest at g0/g1 phase via increasing the expression of p53, but independently on apoptosis. |
2023-03-17 |
2023-08-14 |
human |
| Beihui Xu, Qi Li, Jianjun Zhang, Fuxiang Che. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells. Molecular oncology. 2023-03-17. PMID:36931700. |
lim domain-containing protein ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells. |
2023-03-17 |
2023-08-14 |
Not clear |
| Beihui Xu, Qi Li, Jianjun Zhang, Fuxiang Che. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells. Molecular oncology. 2023-03-17. PMID:36931700. |
in conclusion, as a novel p53 negative regulator, ajuba inhibits the apoptosis of crc cells induced by chemotherapeutic drugs and it may be a new therapeutic target for crc treatment. |
2023-03-17 |
2023-08-14 |
Not clear |
| Charlie Marvalim, Arpita Datta, Soo Chin Le. Role of p53 in breast cancer progression: An insight into p53 targeted therapy. Theranostics. vol 13. issue 4. 2023-03-16. PMID:36923534. |
in the presence of genotoxic stress, p53 is activated to facilitate dna repair, cell cycle arrest, and apoptosis. |
2023-03-16 |
2023-08-14 |
Not clear |
| Cuiting Lv, Aihua Lan, Xiao Fan, Caiguo Huang, Gong Yan. Asperolide A induces apoptosis and cell cycle arrest of human hepatoma cells with p53-Y220C mutant through p38 mediating phosphorylation of p53 (S33). Heliyon. vol 9. issue 3. 2023-03-16. PMID:36923828. |
asperolide a induces apoptosis and cell cycle arrest of human hepatoma cells with p53-y220c mutant through p38 mediating phosphorylation of p53 (s33). |
2023-03-16 |
2023-08-14 |
human |
| Cuiting Lv, Aihua Lan, Xiao Fan, Caiguo Huang, Gong Yan. Asperolide A induces apoptosis and cell cycle arrest of human hepatoma cells with p53-Y220C mutant through p38 mediating phosphorylation of p53 (S33). Heliyon. vol 9. issue 3. 2023-03-16. PMID:36923828. |
however, phosphorylation of p53 at s33 by p38 activation could be a principal factor in the aa-induced apoptosis and g2/m cell cycle arrest of huh-7 cells. |
2023-03-16 |
2023-08-14 |
human |
| Enrico Escobar, Fernán Gómez-Valenzuela, Cristian Peñafiel, Eduardo Chimenos-Küstner, Ricardo Pérez-Tomá. Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts. Journal of clinical and experimental dentistry. vol 15. issue 2. 2023-03-13. PMID:36911151. |
bcl-2-associated protein x (bax) and the tumour suppressor protein p53 collectively promote p53-mediated apoptosis. |
2023-03-13 |
2023-08-14 |
Not clear |
| Y G El-Baz, A Moustafa, M A Ali, G E El-Desoky, S M Wabaidur, M M Faisa. An Analysis of the Toxicity, Antioxidant, and Anti-Cancer Activity of Cinnamon Silver Nanoparticles in Comparison with Extracts and Fractions of Cinnamomum Cassia at Normal and Cancer Cell Levels. Nanomaterials (Basel, Switzerland). vol 13. issue 5. 2023-03-11. PMID:36903823. |
the anti-cancer activity depended on apoptosis marker protein levels (caspase3, p53, bax, and pcl2) in normal and cancerous cells. |
2023-03-11 |
2023-08-14 |
cat |
| Siyang Liu, Tianyao Liu, Jiaxuan Jiang, Hongqian Guo, Rong Yan. p53 mutation and deletion contribute to tumor immune evasion. Frontiers in genetics. vol 14. 2023-03-09. PMID:36891151. |
upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. |
2023-03-09 |
2023-08-14 |
human |
| Kun Jia, Haibin Xiong, Wei Yuan, Lirong Huang, Jiaxin Xu, Chen Lu, Ying Hu, Kaijie Huang, Qiang Luo, Jinze Ma, Huiqiang L. Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway. Fish & shellfish immunology. 2023-03-09. PMID:36893927. |
using small-molecule antagonists and p53 morpholino revealed that the nf-κb/p53 pathway was responsible for the apoptosis of hscs upon dfd exposure. |
2023-03-09 |
2023-08-14 |
zebrafish |
| Sulieman Ibraheem Shelash Al-Hawary, Saade Abdalkareem Jasim, Mustafa M Kadhim, Sarah Jaafar Saadoon, Irfan Ahmad, Rosario Mireya Romero Parra, Suzan Hasan Hammoodi, Roua Abulkassim, Noora M Hameed, Waleed K Alkhafaje, Yasser Fakri Mustafa, Mohammad Javed Ansar. Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations. Phytotherapy research : PTR. 2023-03-08. PMID:36883769. |
it can regulate multiple signaling pathways, such as pi3k/akt, wnt/β-catenin, jak/stat, p53, mapks, and nf-ĸb, which are involved in cancer cell proliferation, metastasis, apoptosis, angiogenesis, and autophagy. |
2023-03-08 |
2023-08-14 |
Not clear |
| Tian Jiang, Ye Song Liang, Yue Gu, Fu Cheng Yao, Yi Fan Liu, Kai Xi Zhang, Fei Biao Song, Jun Long Sun, Jian Lu. Different reoxygenation rates induce different metabolic, apoptotic and immune responses in Golden Pompano (Trachinotus blochii) after hypoxic stress. Fish & shellfish immunology. 2023-03-05. PMID:36871632. |
in the aspect of apoptosis, differentially expressed genes (degs) in the rrg were enriched in the p53 signaling pathway, which promoted cell apoptosis, while degs in the grg seem to activate cell apoptosis at early stage of reoxygenation but was restrained latterly. |
2023-03-05 |
2023-08-14 |
Not clear |
| Jia-Luo Cai, Yi-Lin Zhu, Xiao-Ping Li, Xin-Hua Xia, Gui-Ming Deng, Qiao-Zhen Tong, Gang-Qiang Yi, Bo Chen. [Mechanism of Huangjing Qianshi Decoction in treatment of prediabetic mice based on transcriptome sequencing]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 4. 2023-03-05. PMID:36872274. |
therefore, huangjing qianshi decoction can improve the state of prediabetes, and the mechanism may be related to cell cycle and apoptosis, pi3k/akt pathway, p53 pathway, and other biological pathways regulated by il-6, nr3c2, and vegfa. |
2023-03-05 |
2023-08-14 |
mouse |