| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Doil Park, Ji Hoon Jung, Hyun Min Ko, Wona Jee, Hyungsuk Kim, Hyeung-Jin Jan. Antitumor Effect of Cycloastragenol in Colon Cancer Cells via p53 Activation. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499536. |
altogether, our findings suggest that cy induces apoptosis via p53 activation and inhibits the proliferation of colon cancer cells. |
2022-12-11 |
2023-08-14 |
Not clear |
| Dongjie Wang, Qiujie Wang, Zhiheng Zuo, Zaijie Dong, Jiayang He, Xiangchen Ye, Huijuan Tang, Jixing Zo. Koumine induces apoptosis in Cyprinus carpio liver cells by regulating JAK-STAT and p53 signaling pathways. Fish & shellfish immunology. 2022-12-10. PMID:36496140. |
koumine induces apoptosis in cyprinus carpio liver cells by regulating jak-stat and p53 signaling pathways. |
2022-12-10 |
2023-08-14 |
Not clear |
| Qianwen Nie, Xuan Huan, Jing Kang, Jiangyan Yin, Jiahui Zhao, Yi Li, ZhengYi Zhan. MG149 Inhibits MOF-Mediated p53 Acetylation to Attenuate X-Ray Radiation-Induced Apoptosis in H9c2 Cells. Radiation research. vol 198. issue 6. 2022-12-09. PMID:36481803. |
mg149 inhibits mof-mediated p53 acetylation to attenuate x-ray radiation-induced apoptosis in h9c2 cells. |
2022-12-09 |
2023-08-14 |
Not clear |
| Qianwen Nie, Xuan Huan, Jing Kang, Jiangyan Yin, Jiahui Zhao, Yi Li, ZhengYi Zhan. MG149 Inhibits MOF-Mediated p53 Acetylation to Attenuate X-Ray Radiation-Induced Apoptosis in H9c2 Cells. Radiation research. vol 198. issue 6. 2022-12-09. PMID:36481803. |
we evaluated the potential mediating role of males absent on the first (mof) in the association between epigenetic activation of p53 lysine 120 (p53k120) and x-ray radiation-induced apoptosis in h9c2 cells. |
2022-12-09 |
2023-08-14 |
Not clear |
| Shuntai Chen, Qing Wang, Sarah Ming, Honggang Zheng, Baojin Hua, Hsin-Sheng Yan. Platycodin D induces apoptosis through JNK1/AP-1/PUMA pathway in non-small cell lung cancer cells: A new mechanism for an old compound. Frontiers in pharmacology. vol 13. 2022-12-09. PMID:36483740. |
to understand the mechanism by which platycodin d induces apoptosis, the expression levels of apoptosis-related proteins were examined, and we found that the expression of puma (p53 upregulated modulator of apoptosis) was upregulated upon platycodin d treatment. |
2022-12-09 |
2023-08-14 |
Not clear |
| Katherine E Redd Bowman, Lisa Ahne, Liam O'Brien, Erica R Vander Mause, Phong Lu, Bryce Wallis, Kimberley J Evason, Carol S Li. p53-Bad* Fusion Gene Therapy Induces Apoptosis In Vitro and Reduces Zebrafish Tumor Burden in Hepatocellular Carcinoma. Molecular pharmaceutics. 2022-12-09. PMID:36490361. |
p53-bad* localized to the mitochondria regardless of the p53 mutation status and demonstrated superior apoptotic activity over wt p53 in early, middle, and late apoptosis assays. |
2022-12-09 |
2023-08-14 |
zebrafish |
| Katherine E Redd Bowman, Lisa Ahne, Liam O'Brien, Erica R Vander Mause, Phong Lu, Bryce Wallis, Kimberley J Evason, Carol S Li. p53-Bad* Fusion Gene Therapy Induces Apoptosis In Vitro and Reduces Zebrafish Tumor Burden in Hepatocellular Carcinoma. Molecular pharmaceutics. 2022-12-09. PMID:36490361. |
p53-bad* can induce apoptosis in a panel of liver cancer cell lines with varying p53 mutation statuses and induce apoptosis/reduce hcc tumor burden in vivo in zebrafish. |
2022-12-09 |
2023-08-14 |
zebrafish |
| Jing Wang, Jing Zhao, Fang Ma, Liuyun Gong, Yinliang Lu, Weiping Xiao, Hanmin Tang, Chengyi Gao, Yuetong Chen, Jun Ma, Zhan Gao, Jin Yan, Suxia Ha. One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy. Small (Weinheim an der Bergstrasse, Germany). 2022-12-09. PMID:36494177. |
furthermore, a peptide targeting crm1, is assembled into the supermolecule, which successfully activates p53 and apoptosis pathway, thereby further sensitizing radiotherapy. |
2022-12-09 |
2023-08-14 |
Not clear |
| Nguyen Xuong Duong, Minh-Khang Le, Tetsuo Kondo, Takahiko Mitsu. Heterogeneity of Hippo signalling activity in different histopathologic subtypes of renal cell carcinoma. Journal of cellular and molecular medicine. 2022-12-08. PMID:36478130. |
the hippo pathway (hr = 0.29; 95% ci = 0.17-0.50, p < 0.001), apoptosis (hr = 6.02; 95% ci = 1.47-24.61; p = 0.013) and the p53 pathway (hr = 0.09; 95% ci = 0.02-0.36; p < 0.001) were identified as independent prognostic factors for ccrcc. |
2022-12-08 |
2023-08-14 |
Not clear |
| Sherif A El-Kafrawy, Mai M El-Daly, Leena H Bajrai, Thamir A Alandijany, Arwa A Faizo, Mohammad Mobashir, Sunbul S Ahmed, Sarfraz Ahmed, Shoaib Alam, Raja Jeet, Mohammad Amjad Kamal, Syed Tauqeer Anwer, Bushra Khan, Manal Tashkandi, Moshahid A Rizvi, Esam Ibraheem Azha. Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma. Frontiers in genetics. vol 13. 2022-12-08. PMID:36479247. |
pi3k, camp, tgf, tnf, rap1, nf-kb, apoptosis, longevity regulating pathway, signaling pathways regulating pluripotency of stem cells, cytokine-cytokine receptor interaction, p53 signaling, wnt signaling, toll-like receptor signaling, and hippo signaling pathways are just a few of the most commonly enriched pathways. |
2022-12-08 |
2023-08-14 |
human |
| Motohiko Okano, Feng He, Ning Ma, Hatasu Kobayashi, Shinji Oikawa, Komei Nishimura, Isao Tawara, Mariko Murat. Taurine induces upregulation of p53 and Beclin1 and has antitumor effect in human nasopharyngeal carcinoma cells in vitro and in vivo. Acta histochemica. vol 125. issue 1. 2022-12-05. PMID:36470150. |
ihc analyses also revealed that taurine promoted apoptosis, as evidenced by an increase in cleaved caspase-3, accompanied by upregulation of p53. |
2022-12-05 |
2023-08-14 |
mouse |
| Jingwen Cao, Ran Xu, Fuhan Wang, Yuan Geng, Tianchao Xu, Mengran Zhu, Hongli Lv, Shiwen Xu, Meng-Yao Gu. Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills. Fish & shellfish immunology. 2022-12-05. PMID:36470402. |
the results showed that polyethylene microplastics increased the expression of the nuclear factor-κb (nf-κb) pathway (nf-κb p65, ikkα, ikkβ) and apoptosis biomarkers (p53, caspase-3, caspase-9, and bax). |
2022-12-05 |
2023-08-14 |
Not clear |
| Yi Liu, Jing Guo, Wenjin Liu, Fengjie Yang, Yunyun Deng, Yunlong Meng, Bo Cheng, Jianping Fu, June Zhang, Xinjun Liao, Lili Wei, Huiqiang L. Effects of haloxyfop-p-methyl on the developmental toxicity, neurotoxicity, and immunotoxicity in zebrafish. Fish & shellfish immunology. 2022-12-03. PMID:36462742. |
furthermore, haloxyfop-p-methyl could induce neutrophils apoptosis, accompanied with the upregulation of the expression of proapoptotic protein such as bax and p53 and the downregulation of the expression of antiapoptotic protein bcl-2. |
2022-12-03 |
2023-08-14 |
cat |
| AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghami. The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines. Scientific reports. vol 12. issue 1. 2022-12-03. PMID:36463254. |
micro culture tetrazolium test assessed proliferative inhibitory effect; and prostate biomarker (klk2), emt (e-cadherin and snail), angiogenesis genes (vegf-a/vegf-c), apoptosis genes (bax/bcl2, p53) and osteopontin variants (opna/b, and c) mrna levels were studied by realtime pcr method. |
2022-12-03 |
2023-08-14 |
Not clear |
| Gokhan Nur, Emrah Caylak, Pinar Aksu Kilicle, Safak Sandayuk, Ozlem Onen Celeb. Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-12-02. PMID:36457797. |
the p53 protein antagonizes bcl-2, an anti-apoptotic protein character, and induces apoptosis by causing mitochondrial membrane permeability. |
2022-12-02 |
2023-08-14 |
Not clear |
| Mingyue Dong, Yan Ding, Yingying Liu, Zeqiong Xu, Huachang Hong, Hongjie Sun, Xianfeng Huang, Xinwei Yu, Qiang Che. Molecular insights of 2,6-dichlorobenzoquinone-induced cytotoxicity in zebrafish embryo: Activation of ROS-mediated cell cycle arrest and apoptosis. Environmental toxicology. 2022-12-01. PMID:36454668. |
to explore this mechanism, we assessed the levels of reactive oxygen species (ros), acridine orange (ao) staining, and the mrna transcriptions of genes (chk2, cdk2, ccna, ccnb and ccne) involved in cell-cycle and genes (p53, bax, bcl-2 and caspase 3) involved in apoptosis in zebrafish embryo, after exposed to different concentrations (10, 30, 60, 90 and 120 μg/l) of 2,6-dcbq for 72 h. |
2022-12-01 |
2023-08-14 |
zebrafish |
| Zdenek Andrysik, Kelly D Sullivan, Jeffrey S Kieft, Joaquin M Espinos. PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response. Nature communications. vol 13. issue 1. 2022-12-01. PMID:36456590. |
we demonstrate that dual inhibition of mdm2 and ppm1d induces apoptosis in multiple cancer cell types via amplification of the p53 transcriptional program through the eif2α-atf4 pathway. |
2022-12-01 |
2023-08-14 |
mouse |
| Max J Carlsson, Anastasia S Vollmer, Philipp Demuth, Daniel Heylmann, Diana Reich, Caroline Quarz, Birgit Rasenberger, Teodora Nikolova, Thomas G Hofmann, Markus Christmann, Julia A Fuhlbrueck, Simone Stegmüller, Elke Richling, Alexander T Cartus, Jörg Fahre. p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol. Cell death & disease. vol 13. issue 11. 2022-11-29. PMID:36446765. |
p53 triggers mitochondrial apoptosis following dna damage-dependent replication stress by the hepatotoxin methyleugenol. |
2022-11-29 |
2023-08-14 |
human |
| Fanwei Meng, Junfeng Ke, Jinze Li, Changhui Zhao, Jiaqing Yan, Liping Wan. A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo. Experimental cell research. 2022-11-28. PMID:36442518. |
dhhp-3 could reduce ros, down-regulate apoptotic proteins, suppress p53 phosphorylation, attenuate the dna damage response (ddr), and inhibit apoptosis in sh-sy5y cells subjected to oxygen-glucose deprivation/re-oxygenation (ogd/r) and in the brain of sprague dawley rats subjected to transient middle cerebral artery occlusion. |
2022-11-28 |
2023-08-14 |
human |
| Hsin-Han Chang, Yi-Hsuan Lin, Tzu-Min Chen, Yu-Ling Tsai, Chien-Rui Lai, Wen-Chiuan Tsai, Yu-Chen Cheng, Ying Che. ONX-0914 Induces Apoptosis and Autophagy with p53 Regulation in Human Glioblastoma Cells. Cancers. vol 14. issue 22. 2022-11-26. PMID:36428804. |
onx-0914 induces apoptosis and autophagy with p53 regulation in human glioblastoma cells. |
2022-11-26 |
2023-08-14 |
mouse |