| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marielle Margier, Chisaka Kuehnemann, Nicolas Hulo, Jazmin Morales, Prasanna Vadhana Ashok Kumaar, Cecile Cros, Helene Cannelle, Julie Charmetant, Eric Verdin, Matthias Canault, Alessia Grozi. Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice. Cells. vol 12. issue 1. 2023-01-08. PMID:36611902. |
in the heart, nmn prevented doxo-induced transcriptomic changes related to mitochondrial function, apoptosis, oxidative stress, inflammation and p53, and promyelocytic leukemia nuclear body pathways. |
2023-01-08 |
2023-08-14 |
mouse |
| Immacolata Maietta, Francesca Del Peschio, Preziosa Buonocore, Eleonora Viscusi, Stefano Laudati, Giuseppe Iannaci, Michele Minopoli, Maria Letizia Motti, Valentina De Falc. p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors. Cancers. vol 15. issue 1. 2023-01-08. PMID:36612117. |
a pharmacological inhibitor of p90rsk, bi-d1870, decreases mdm2 phosphorylation, and restores p53 function, which in turn transcriptionally increases the expression of cell cycle inhibitor p21 and of pro-apoptotic protein bax and downregulates the anti-apoptotic protein bcl-2, causing a block of cell proliferation, measured by a brdu assay and growth curve, and promoting apoptosis, measured by a tunel assay. |
2023-01-08 |
2023-08-14 |
Not clear |
| Elmira Roshani Asl, Davoud Rostamzadeh, Pascal H G Duijf, Sahar Mafi, Behnaz Mansoori, Shirin Barati, William C Cho, Behzad Mansoor. Mutant P53 in the formation and progression of the tumor microenvironment: Friend or foe. Life sciences. 2023-01-07. PMID:36608871. |
it encodes the tumor suppressor protein p53, which suppresses tumorigenesis by acting as a critical transcription factor that can induce the expression of many genes controlling a plethora of fundamental cellular processes, including cell cycle progression, survival, apoptosis, and dna repair. |
2023-01-07 |
2023-08-14 |
human |
| Baowei Ji, Junchao Liu, Yanli Ma, Ye Yin, Hong Xu, Qian Shen, Jian Y. Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways. International immunopharmacology. vol 115. 2023-01-06. PMID:36608441. |
through rna sequencing and related experiments, we found minnelide could ameliorate fibrosis and apoptosis by inhibiting tgf-β1-smad2 and p53 pathways in angptl3 knockout mice with an, respectively. |
2023-01-06 |
2023-08-14 |
mouse |
| Yuan Zhao, Jian Zhang, Yidan Zhang, Shuyue Li, Ya Gao, Cui Chang, Xiang Liu, Lei Xu, Guofeng Yan. Proteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp + -Induced Toxicity via downregulating P53 pathway in N2A Cells. Proteome science. vol 21. issue 1. 2023-01-03. PMID:36597095. |
p53 is a multifunctional protein implicated in numerous cellular processes, including apoptosis, dna repair, mitochondrial functions, redox homeostasis, autophagy and protein aggregations. |
2023-01-03 |
2023-08-14 |
Not clear |
| Pritam Biswas, Surbhi Swaroop, Naibedya Dutta, Aditi Arya, Suvranil Ghosh, Sukhamoy Dhabal, Payel Das, Chirantan Majumder, Mahadeb Pal, Ashish Bhattacharje. IL-13 and the hydroperoxy fatty acid 13(S)HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis. Free radical biology & medicine. 2023-01-02. PMID:36592660. |
our observations demonstrated that il-13/13(s)hpode stimulate mao-a-mediated intracellular ros production and p53 as well as p21 induction which play a crucial role in il-13-stimulated a549 cell apoptosis. |
2023-01-02 |
2023-08-14 |
mouse |
| Pritam Biswas, Surbhi Swaroop, Naibedya Dutta, Aditi Arya, Suvranil Ghosh, Sukhamoy Dhabal, Payel Das, Chirantan Majumder, Mahadeb Pal, Ashish Bhattacharje. IL-13 and the hydroperoxy fatty acid 13(S)HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis. Free radical biology & medicine. 2023-01-02. PMID:36592660. |
we further showed that 13(s)hpode promotes apoptosis of hct116 and ccf52 cells through the up-regulation of p53 and p21 expression. |
2023-01-02 |
2023-08-14 |
mouse |
| Pritam Biswas, Surbhi Swaroop, Naibedya Dutta, Aditi Arya, Suvranil Ghosh, Sukhamoy Dhabal, Payel Das, Chirantan Majumder, Mahadeb Pal, Ashish Bhattacharje. IL-13 and the hydroperoxy fatty acid 13(S)HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis. Free radical biology & medicine. 2023-01-02. PMID:36592660. |
in addition, we observed that pparγ plays a vital role in apoptosis as well as in p53 and p21 expression in a549 cells in the presence of il-13. |
2023-01-02 |
2023-08-14 |
mouse |
| Wengang Jian, Wei Xue, Tengda Wang, Yongchun Yu, Licheng Cai, Yuyang Meng, Zhinan Xia, Cheng Zhan. RBM4 inhibits the growth of clear cell renal cell carcinoma by enhancing the stability of p53 mRNA. Molecular carcinogenesis. 2022-12-31. PMID:36585906. |
rbm4-oe significantly reduced the proliferation of ccrcc cells by controlling the p53 signaling pathway, inhibited cell cycle progression and promoted apoptosis. |
2022-12-31 |
2023-08-14 |
Not clear |
| Naglaa Fathi Agamia, Khalid Fawzi El Mulla, Naglaa Mohamed Alsayed, Rasha Mohamed Ghazala, Rania Elsayed Abdel El Maksoud, Iman Mohamed Abdelmeniem, Iman Mamdouh Talaat, Inass Ibrahim Zaki, Rana Mohamed Sabah, Bodo Clemens Melni. Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris. Archives of dermatological research. 2022-12-31. PMID:36585988. |
under clinical conditions, isotretinoin induced the expression of p53, which controls multiple transcription factors involved in the pathogenesis of acne vulgaris including foxo1, androgen receptor and critical genes involved in the induction of autophagy and apoptosis. |
2022-12-31 |
2023-08-14 |
human |
| Xinyu Wu, Baoshi Xu, Huizhen Chen, Jingchao Qiang, Huimiao Feng, Xueqing Li, Mingyi Chu, Enzhuang Pan, Jingquan Don. Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp. Fish & shellfish immunology. 2022-12-29. PMID:36581253. |
the tunel test clearly showed that difenoconazole induced apoptosis in the kidney and vastly raised the transcript levels of apoptosis-related genes p53, caspase9, caspase3, and bax while inhibiting the expression of bcl-2, fas, capsase8. |
2022-12-29 |
2023-08-14 |
cat |
| Hyun Min Ko, Wona Jee, Duckgue Lee, Hyeung-Jin Jang, Ji Hoon Jun. Ophiopogonin D increase apoptosis by activating p53 Frontiers in pharmacology. vol 13. 2022-12-26. PMID:36569330. |
ophiopogonin d increase apoptosis by activating p53 ophiopogonin d (op-d), which is extracted from the root tuber of |
2022-12-26 |
2023-08-14 |
Not clear |
| Mitsuko Akaihata, Ikuko Takahashi, Yuko Kakuda, Takuya Kawata, Takashi Mukaigawa, Testuro Onitsuka, Shigeyuki Murayama, Yuji Ishid. Head pleomorphic sarcoma showing murine double minute 2 amplification without a well-differentiated liposarcoma component in a pediatric patient. Cancer reports (Hoboken, N.J.). 2022-12-26. PMID:36572546. |
murine double minute 2 (mdm2) is an oncogene that inhibits p53, leading to decreased apoptosis. |
2022-12-26 |
2023-08-14 |
Not clear |
| Qian Hao, Jiaxiang Chen, Hua Lu, Xiang Zho. The ARTS of p53-dependent mitochondrial apoptosis. Journal of molecular cell biology. 2022-12-24. PMID:36565718. |
the tumor-suppressive activity of p53 is largely attributed to its ability to induce cell death, including apoptosis through transcription-dependent and -independent mechanisms. |
2022-12-24 |
2023-08-14 |
Not clear |
| Qian Hao, Jiaxiang Chen, Hua Lu, Xiang Zho. The ARTS of p53-dependent mitochondrial apoptosis. Journal of molecular cell biology. 2022-12-24. PMID:36565718. |
on the one hand, nuclear p53 transcriptionally activates the expression of a myriad of pro-apoptotic bcl-2 family genes, such as noxa, puma, bid, bad, bik, bax, etc., whereas inactivates the expression of anti-apoptotic bcl-2, bcl-xl, and mcl1, leading to mitochondrial apoptosis. |
2022-12-24 |
2023-08-14 |
Not clear |
| Qian Hao, Jiaxiang Chen, Hua Lu, Xiang Zho. The ARTS of p53-dependent mitochondrial apoptosis. Journal of molecular cell biology. 2022-12-24. PMID:36565718. |
on the other hand, cytoplasmic p53 also promotes mitochondrial apoptosis by directly associating with multiple bcl-2 family proteins in the mitochondria. |
2022-12-24 |
2023-08-14 |
Not clear |
| Qian Hao, Jiaxiang Chen, Hua Lu, Xiang Zho. The ARTS of p53-dependent mitochondrial apoptosis. Journal of molecular cell biology. 2022-12-24. PMID:36565718. |
arts in turn binds to p53, drives its mitochondrial localization, and enhances the interaction between p53 and bcl-xl, thereby promoting mitochondrial apoptosis. |
2022-12-24 |
2023-08-14 |
Not clear |
| Yuqi Zhang, Enze Yao, Yijing Liu, Yining Zhang, Mengyang Ding, Jingyu Liu, Xiaoming Chen, Sairong Fa. FUT2 Facilitates Autophagy and Suppresses Apoptosis via p53 and JNK Signaling in Lung Adenocarcinoma Cells. Cells. vol 11. issue 24. 2022-12-23. PMID:36552800. |
fut2 facilitates autophagy and suppresses apoptosis via p53 and jnk signaling in lung adenocarcinoma cells. |
2022-12-23 |
2023-08-14 |
Not clear |
| Ambritha Balasundaram, C George Priya Dos. Unraveling the Structural Changes in the DNA-Binding Region of Tumor Protein p53 ( International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555140. |
unraveling the structural changes in the dna-binding region of tumor protein p53 ( the vital tissue homeostasis regulator p53 forms a tetramer when it binds to dna and regulates the genes that mediate essential biological processes such as cell-cycle arrest, senescence, dna repair, and apoptosis. |
2022-12-23 |
2023-08-14 |
Not clear |
| Jiaying Fu, Sihang Yu, Xiyao Zhao, Chaoke Zhang, Luyan Shen, Yanan Liu, Huimei Y. Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555672. |
p53 and cisplatin not only induce tumor cell apoptosis, but also regulate the tumor cell metabolism. |
2022-12-23 |
2023-08-14 |
Not clear |