| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barbara Łasut-Szyszka, Marek Rusi. The Wheel of p53 Helps to Drive the Immune System. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108808. |
the p53 tumor suppressor protein is best known as an inhibitor of the cell cycle and an inducer of apoptosis. |
2023-04-28 |
2023-08-14 |
Not clear |
| Yi Liu, Li-Jian Chen, Xiu-Wen Li, Jian-Zheng Yang, Jia-Li Liu, Kai-Kai Zhang, Jia-Hao Li, Qi Wang, Jing-Tao Xu, Xu Zh. Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model. Chemico-biological interactions. 2023-04-28. PMID:37116852. |
our results showed that meth exposure altered the p53 and pi3k/akt signaling pathways and modulated the apoptosis pathway in heart tissue, accompanied by elevated levels of bax/bcl-2 expression and cleaved caspase-3 proteins. |
2023-04-28 |
2023-08-14 |
mouse |
| Meixian Wang, Jiahao Wang, Ayinuer Yasen, Bingyan Fan, J Joe Hull, Xingjia She. Determination of Key Components in the Insects. vol 14. issue 4. 2023-04-27. PMID:37103177. |
a homolog of p53, a key apoptosis regulator in vertebrates, has been identified and cloned from |
2023-04-27 |
2023-08-14 |
Not clear |
| Jiaxin Zhu, Kexin Zhang, Ya Zhou, Ruyi Wang, Liangping Gong, Can Wang, Keke Zhong, Wenyuan Liu, Feng Feng, Wei Q. A Carrier-Free Nanomedicine Enables Apoptosis-Ferroptosis Synergistic Breast Cancer Therapy by Targeting Subcellular Organelles. ACS applied materials & interfaces. 2023-04-27. PMID:37104698. |
especially, aa and p induced mitochondrial apoptosis of cancer cells, while sa and p inhibited tnbc by ferroptosis and upregulating p53. |
2023-04-27 |
2023-08-14 |
Not clear |
| Lin Yang, Qiuling Zhao, Ting Chen, Wenbin Liu, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Don. An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma. Clinical and experimental medicine. 2023-04-27. PMID:37106265. |
hpk1 inhibitor treatment increased pd-1, pd-l1, bax, p53 and nk-kb expression but decreased nlrp3 expression, indicating that the hpk1 inhibitor promoted apoptosis and blocked the nlrp3 inflammasome pathway to affect anti-pd-1-mediated t-cell cytotoxicity. |
2023-04-27 |
2023-08-14 |
zebrafish |
| Safieh Ebrahimi, Farshad Mirzavi, Seyed Isaac Hashemy, Maryam Khaleghi Ghadiri, Walter Stummer, Ali Gorj. The in vitro anti-cancer synergy of neurokinin-1 receptor antagonist, aprepitant, and 5-aminolevulinic acid in glioblastoma. BioFactors (Oxford, England). 2023-04-24. PMID:37092793. |
moreover, aprepitant and 5-ala induced apoptosis and altered the levels of apoptotic genes (up-regulation of bax and p53 along with downregulation of bcl-2). |
2023-04-24 |
2023-08-14 |
human |
| Diana Gomes, Luís A Passarinha, Ângela Sous. E6 Tagged Protein Production, Extraction, and Purification from Escherichia coli Lysate. Methods in molecular biology (Clifton, N.J.). vol 2652. 2023-04-24. PMID:37093468. |
this protein can interfere with p53 tumor suppressor activity, blocking apoptosis of abnormal cells. |
2023-04-24 |
2023-08-14 |
human |
| Hui Zhou, Yuqin Liao, Xiangfei Han, Dean Shuailin Chen, Xuechuan Hong, Kun Zhou, Xingya Jiang, Yuling Xiao, Jinjun Sh. ROS-Responsive Nanoparticle Delivery of mRNA and Photosensitizer for Combinatorial Cancer Therapy. Nano letters. 2023-04-24. PMID:37093620. |
the ros-triggered disassembly of the nps could promote mrna translation efficiency, whereby p53 expression induced apoptosis of lung tumor cells. |
2023-04-24 |
2023-08-14 |
Not clear |
| Jia Guo, Zhi-Dong Li, Chuan-Shi Xiao, Yun-Fei Bia. [Effects of PUMA knockout on the apoptosis of H9C2 cardiomyocytes induced by high glucose]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 5. 2023-04-23. PMID:37088760. |
to investigate the effects of p53 upregulated modulator of apoptosis (puma) on the apoptosis of h9c2 cardiomyocytes induced by high glucose and its mechanisms. |
2023-04-23 |
2023-08-14 |
Not clear |
| Yoon-Jin Lee, Kwan-Sik Park, Su-Hak Heo, Moon-Kyun Cho, Sang-Han Le. Concurrent induction of apoptosis and necroptosis in apigenin‑treated malignant mesothelioma cells: Reversal of Warburg effect through Akt inhibition and p53 upregulation. Oncology reports. vol 49. issue 6. 2023-04-21. PMID:37083070. |
concurrent induction of apoptosis and necroptosis in apigenin‑treated malignant mesothelioma cells: reversal of warburg effect through akt inhibition and p53 upregulation. |
2023-04-21 |
2023-08-14 |
Not clear |
| Bingxin Li, Yaqiong Ye, Longsheng Hong, Wanyan Li, Qingru Wu, Wenjun Liu, Yongjiang Ma, Danning Xu, Yugu L. Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution. Acta biochimica et biophysica Sinica. 2023-04-20. PMID:37078747. |
among them, igfbp5 can reduce the viability, inhibit proliferation and promote apoptosis of mouse medullary thymic epithelial cell line 1 (mtec1) cells through the p53 signaling pathway. |
2023-04-20 |
2023-08-14 |
mouse |
| Hong-Beom Park, Yosuk Min, Sohyun Hwang, Kwang-Hyun Bae. Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-04-16. PMID:37062218. |
moreover, it also known that usp7 functions in the cell cycle, apoptosis, dna repair, chromatin remodeling, and epigenetic regulation through deubiquitination of several substrates including p53, mouse double minute 2 homolog (mdm2), myc, and phosphatase and tensin homolog (pten). |
2023-04-16 |
2023-08-14 |
mouse |
| Yuehao Tan, Can Li, Jiali Zhou, Fengmei Deng, Yilun Li. Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis. Experimental cell research. 2023-04-16. PMID:37062521. |
bbr also markedly induced hsc apoptosis, as indicated by the upregulated expression of the pro-apoptosis markers p53, bax, and cleaved parp and the downregulated expression of the anti-apoptosis marker bcl-2, effects that were reversed by atg5 overexpression. |
2023-04-16 |
2023-08-14 |
mouse |
| Bardia Mortezagholi, Kamyar Nasiri, Emad Movahed, Esmaeel Dadgar, Seyedeh Tabasom Nejati, Pardis Hassani, Mahla Esfahaniani, Sona Rafieya. MiR-34 by targeting p53 induces apoptosis and DNA damage in paclitaxel-resistant human oral squamous carcinoma cells. Chemical biology & drug design. 2023-04-15. PMID:37060268. |
mir-34 by targeting p53 induces apoptosis and dna damage in paclitaxel-resistant human oral squamous carcinoma cells. |
2023-04-15 |
2023-08-14 |
human |
| Bardia Mortezagholi, Kamyar Nasiri, Emad Movahed, Esmaeel Dadgar, Seyedeh Tabasom Nejati, Pardis Hassani, Mahla Esfahaniani, Sona Rafieya. MiR-34 by targeting p53 induces apoptosis and DNA damage in paclitaxel-resistant human oral squamous carcinoma cells. Chemical biology & drug design. 2023-04-15. PMID:37060268. |
the chemosensitive effects of mir-34 is mediated through increasing dna damage and apoptosis in a p53 depended manner. |
2023-04-15 |
2023-08-14 |
human |
| Masumeh Sanaei, Fraidoon Kavoosi, Mohsen Safar. Effect of 5'-Fluoro-2'-Deoxycytidine and Sodium Butyrate on the Gene Expression of the Intrinsic Apoptotic Pathway, p21, p27, and p53 Genes Expression, Cell Viability, and Apoptosis in Human Hepatocellular Carcinoma Cell Lines. Advanced biomedical research. vol 12. 2023-04-14. PMID:37057236. |
effect of 5'-fluoro-2'-deoxycytidine and sodium butyrate on the gene expression of the intrinsic apoptotic pathway, p21, p27, and p53 genes expression, cell viability, and apoptosis in human hepatocellular carcinoma cell lines. |
2023-04-14 |
2023-08-14 |
human |
| Masumeh Sanaei, Fraidoon Kavoosi, Mohsen Safar. Effect of 5'-Fluoro-2'-Deoxycytidine and Sodium Butyrate on the Gene Expression of the Intrinsic Apoptotic Pathway, p21, p27, and p53 Genes Expression, Cell Viability, and Apoptosis in Human Hepatocellular Carcinoma Cell Lines. Advanced biomedical research. vol 12. 2023-04-14. PMID:37057236. |
this study aimed to investigate the effect of 5'-fluoro-2'-deoxycytidine (fdcyd) and sodium butyrate on the genes of intrinsic apoptotic pathway (bax, bak and apaf1, bcl-2, and bcl-xl), p21, p27, and p53 gene expression, cell viability, and apoptosis in human hepatocellular carcinoma hep3b, smmc-7721, and ha22t/vgh cell lines. |
2023-04-14 |
2023-08-14 |
human |
| Yuexin Wei, Yifan Hong, Liuqing Yang, Junke Wang, Tianxin Zhao, Xiangqin Zheng, Lian Kang, Jiadong Chen, Lindong Han, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui We. Single-cell transcriptomic dissection of the toxic impact of di(2-ethylhexyl) phthalate on immature testicular development at the neonatal stage. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-04-14. PMID:37059381. |
elevated oxidative stress and excessive apoptosis mediated by p53 were observed in almost all testicular cells. |
2023-04-14 |
2023-08-14 |
mouse |
| Zhujiang Dai, Jie Zhang, Weimin Xu, Peng Du, Zhongchuan Wang, Yun Li. Single-Cell Sequencing-Based Validation of T Cell-Associated Diagnostic Model Genes and Drug Response in Crohn's Disease. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047025. |
tnf-centered 5-gene diagnostic model not only has excellent diagnostic efficacy, but is also closely associated with kras, p53, and il6/jak/stat3 pathways and physiological processes, such as emt, coagulation, and apoptosis. |
2023-04-13 |
2023-08-14 |
Not clear |
| Xue Wang, Yi Liu, Kaiyuan Li, Zhihui Ha. Roles of p53-Mediated Host-Virus Interaction in Coronavirus Infection. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047343. |
the p53 tumor suppressor molecule is a critical regulator of cell signaling pathways, cellular stress responses, dna repair, and apoptosis. |
2023-04-13 |
2023-08-14 |
Not clear |