| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Wolska-Washer, Piotr Smolewsk. Targeting Protein Degradation Pathways in Tumors: Focusing on their Role in Hematological Malignancies. Cancers. vol 14. issue 15. 2022-08-12. PMID:35954440. |
in some hematological malignancies, including acute myeloid leukemia, misfolding or aggregation of the wild-type p53 tumor-suppressor renders cells unable to undergo apoptosis, even with an intact p53 dna sequence. |
2022-08-12 |
2023-08-14 |
Not clear |
| Rong-Kung Tsai, Keh-Liang Lin, Chin-Te Huang, Yao-Tseng We. Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955492. |
the network analysis revealed that tbp associated factor 9 (taf9) can bind to p53 to induce tp53-regulated inhibitor of apoptosis 1 (triap1) expression. |
2022-08-12 |
2023-08-14 |
rat |
| Ji Yoon Kim, Seung Yoon Han, Jung Yoo, Go Woon Kim, Yu Hyun Jeon, Sang Wu Lee, Jongsun Park, So Hee Kwo. HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955780. |
in ovarian cancer cells harboring wild-type p53, pci-34051 in combination with acy-241 synergistically represses cell proliferation, enhances apoptosis, and suppresses cell migration. |
2022-08-12 |
2023-08-14 |
Not clear |
| Omer H M Ibrahim, Magdi A A Mousa, Khalid A Asiry, Nabil A Alhakamy, Kamal A M Abo-Elyous. Plants (Basel, Switzerland). vol 11. issue 15. 2022-08-12. PMID:35956468. |
the cytotoxicity of neem mesocarp extract is strongly correlated with the induction of apoptosis, where it caused downregulation of the antiapoptotic bcl2 gene but upregulation of the proapoptotic p53 and bax genes. |
2022-08-12 |
2023-08-14 |
Not clear |
| Sourav Kumar Nandi, Ayan Pradhan, Basudeb Das, Biswajit Das, Sudarshana Basu, Bibekanand Mallick, Amitava Dutta, Diptendra Kumar Sarkar, Ashis Mukhopadhyay, Soma Mukhopadhyay, Rittwika Bhattachary. Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumor explants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways. Pathology, research and practice. vol 237. 2022-08-12. PMID:35961057. |
kaempferol attenuates viability of ex-vivo cultured post-nact breast tumor explants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways. |
2022-08-12 |
2023-08-14 |
Not clear |
| Sourav Kumar Nandi, Ayan Pradhan, Basudeb Das, Biswajit Das, Sudarshana Basu, Bibekanand Mallick, Amitava Dutta, Diptendra Kumar Sarkar, Ashis Mukhopadhyay, Soma Mukhopadhyay, Rittwika Bhattachary. Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumor explants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways. Pathology, research and practice. vol 237. 2022-08-12. PMID:35961057. |
further, in post-nact tnbcs, high-grade tumors showed a preponderance of strong nuclear p53 expression and very low expression of caspase 3, indicating that, altered p53 expression predisposes these tumors to apoptosis escape and up-regulation of stemness markers. |
2022-08-12 |
2023-08-14 |
Not clear |
| Jing Chen, Yaxia Yao, Xiaotong Wang, Yijia Wang, Tianli Li, Juan D. Chloroquine regulates the proliferation and apoptosis of palate development on mice embryo by activating P53 through blocking autophagy in vitro. In vitro cellular & developmental biology. Animal. 2022-08-10. PMID:35947289. |
chloroquine regulates the proliferation and apoptosis of palate development on mice embryo by activating p53 through blocking autophagy in vitro. |
2022-08-10 |
2023-08-14 |
mouse |
| Jing Chen, Yaxia Yao, Xiaotong Wang, Yijia Wang, Tianli Li, Juan D. Chloroquine regulates the proliferation and apoptosis of palate development on mice embryo by activating P53 through blocking autophagy in vitro. In vitro cellular & developmental biology. Animal. 2022-08-10. PMID:35947289. |
cq activates p53 which affects mepc biological characteristics by changing the proliferation and apoptosis of mepcs through inhibiting autophagy. |
2022-08-10 |
2023-08-14 |
mouse |
| Salma Magdy Abdelnasser, Youssri M Ahme. Preventive potential of Bacillus sonorensis exopolysaccharide upon hepatocellular carcinoma and quantitation of tumor suppressor protein p53. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2022-08-08. PMID:35939313. |
p53 is the biomarker of the prognosis and occurrence of severe stages of the tumor and activation of both cell-cycle arrest and apoptosis in cancer cells which are the most targeted cellular processes for the therapy of tumor patients. |
2022-08-08 |
2023-08-14 |
Not clear |
| Fang Hao, Chunguang Shan, Yubo Zhang, Ying Zhang, Zhanwei Ji. Exosomes Derived from microRNA-21 Overexpressing Neural Progenitor Cells Prevent Hearing Loss from Ischemia-Reperfusion Injury in Mice via Inhibiting the Inflammatory Process in the Cochlea. ACS chemical neuroscience. 2022-08-08. PMID:35939349. |
immunofluorescence staining of caspase-3 and parvalbumin was used to detect apoptosis hair cells in the cochlea, and western blot was utilized to detect the relative expressions of p53 and inflammatory cytokines in the cochlea. |
2022-08-08 |
2023-08-14 |
mouse |
| Jessica M Overstreet, Cody C Gifford, Jiaqi Tang, Paul J Higgins, Rohan Samarakoo. Emerging role of tumor suppressor p53 in acute and chronic kidney diseases. Cellular and molecular life sciences : CMLS. vol 79. issue 9. 2022-08-08. PMID:35941392. |
p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. |
2022-08-08 |
2023-08-14 |
mouse |
| Chungun Lim, Peter C W Lee, Sungbo Shim, Sung-Wuk Jan. HS-1793 inhibits cell proliferation in lung cancer by interfering with the interaction between p53 and MDM2. Oncology letters. vol 24. issue 2. 2022-08-05. PMID:35928802. |
the transcription factor or tumor suppressor protein p53 regulates numerous cellular functions, including cell proliferation, invasion, migration, senescence and apoptosis, in various types of cancer. |
2022-08-05 |
2023-08-14 |
mouse |
| Shaojie Fu, Yena Zhou, Cong Hu, Zhonggao Xu, Jie Ho. Network pharmacology and molecular docking technology-based predictive study of the active ingredients and potential targets of rhubarb for the treatment of diabetic nephropathy. BMC complementary medicine and therapies. vol 22. issue 1. 2022-08-05. PMID:35932042. |
the results of the gene enrichment analysis revealed that the pi3k-akt signalling pathway, p53 signalling pathway, age-rage signalling pathway and mapk signalling pathway might be the key pathways for the treatment of dn, and these pathways were involved in podocyte apoptosis, glomerular mesangial cell proliferation, inflammation and renal fibrosis. |
2022-08-05 |
2023-08-14 |
Not clear |
| Deryne Anggia Paramita, Dedy Hermansyah, Desiree Anggia Paramita, Nur Dina Amalin. Regulation of p53 and survivin by Curcuma longa extract to caspase-3 dependent apoptosis in triple negative breast cancer cells. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina. vol 19. issue 2. 2022-08-04. PMID:35924809. |
regulation of p53 and survivin by curcuma longa extract to caspase-3 dependent apoptosis in triple negative breast cancer cells. |
2022-08-04 |
2023-08-14 |
Not clear |
| Deryne Anggia Paramita, Dedy Hermansyah, Desiree Anggia Paramita, Nur Dina Amalin. Regulation of p53 and survivin by Curcuma longa extract to caspase-3 dependent apoptosis in triple negative breast cancer cells. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina. vol 19. issue 2. 2022-08-04. PMID:35924809. |
conclusion p53 and survivin as molecular targets of cl contribute to caspase-3-dependent apoptosis in tnbc cells and this compound represents an attractive p53- and survivin modulating agent in tnbc. |
2022-08-04 |
2023-08-14 |
Not clear |
| Mai Tuyet Nguyen, Min-Ah Lee, Young-Kook Kim, Hyun Kook, Dongtak Jeong, Seung Pil Jang, Tae Hwan Kwak, Woo Jin Par. The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB. PloS one. vol 17. issue 8. 2022-08-02. PMID:35917315. |
when the expression level of p53 was suppressed using a sirna, ccn5 did not induce apoptosis in myofbs. |
2022-08-02 |
2023-08-14 |
Not clear |
| HuSai Ma, GuoWei Liu, Bin Yu, Joshua Wang, YaLi Qi, YiYing Kou, Ying Hu, ShunJun Wang, Fei Wang, Dong Che. RNA-binding protein CELF6 modulates transcription and splicing levels of genes associated with tumorigenesis in lung cancer A549 cells. PeerJ. vol 10. 2022-08-01. PMID:35910766. |
in addition, celf6 regulates the splicing pattern of large number of genes that are enriched in p53 signaling pathway and apoptosis, including tp53 and cd44. |
2022-08-01 |
2023-08-14 |
Not clear |
| Yoon-Jae Kim, Ji-Eun Park, Jin-Yong Chung, Ji Young Kim, Seung Gee Lee, Seung-Jin Lee, Wook-Joon Yu, Hye Young Kim, Hyeon Jun Kim, Hyungjong Koh, Hae-Rahn Bae, Young Hyun Yoo, Jong-Min Ki. Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death. The Journal of toxicological sciences. vol 47. issue 8. 2022-07-31. PMID:35908932. |
the knockdown of cyp1b1 expression resulted in the suppression of dmba-induced apoptosis via reduced p53 activation and caspase-3 activation, suggesting that a final metabolite of dmba (i.e., dmba-de) bioactivated by cyp1b1 induces p53 activation by binding to dna and subsequently causing apoptosis via caspase-3 activation. |
2022-07-31 |
2023-08-14 |
Not clear |
| Qi Tian, Sheng Liu, Shou-Meng Han, Wei Zhang, Xian-Yao Qin, Jun-Hui Chen, Cheng-Li Liu, Yu-Jia Guo, Ming-Chang L. The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage. Neural regeneration research. vol 18. issue 2. 2022-07-28. PMID:35900398. |
neuronal apoptosis occurs through multiple pathways including extrinsic, mitochondrial, endoplasmic reticulum, p53 and oxidative stress. |
2022-07-28 |
2023-08-14 |
Not clear |
| Liangping Li, Pingping Li, Xuesong Ma, Shulan Zeng, Yan Peng, Guohai Zhan. Therapeutic restoring p53 function with small molecule for oncogene-driven non-small cell lung cancer by targeting serine 392 phosphorylation. Biochemical pharmacology. 2022-07-28. PMID:35902040. |
furthermore, we demonstrated that mx-c4 bound to p53 and exerted its anticancer activity through cell cycle arrest at g2/m phase and apoptosis induction. |
2022-07-28 |
2023-08-14 |
Not clear |